{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:09:06Z","timestamp":1793311746469,"version":"4.5.0"},"reference-count":59,"publisher":"Royal Society of Chemistry (RSC)","issue":"25","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":152,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/Y001486\/1"],"award-info":[{"award-number":["EP\/Y001486\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"publisher","award":["SBF009\\1019"],"award-info":[{"award-number":["SBF009\\1019"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>Surface-modified curcumin nanocrystals with hyaluronic acid significantly enhance mucosal penetration and drug deposition, offering an advanced targeted delivery platform.<\/jats:p>","DOI":"10.1039\/d6tb00506c","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:46:08Z","timestamp":1780440368000},"page":"7769-7783","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Covalent grafting of hyaluronic acid on drug nanocrystals for mucosal delivery"],"prefix":"10.1039","volume":"14","author":[{"given":"Marta G.","family":"Fuster","sequence":"first","affiliation":[{"name":"School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio E.","family":"Fandi\u00f1o","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhil","family":"Ramesh","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonnathan A.","family":"Coulter","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0414-8972","authenticated-orcid":false,"given":"Alejandro J.","family":"Paredes","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6TB00506C\/cit1\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejpb.2011.01.007","volume":"78","author":"M\u00fcller","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D6TB00506C\/cit2\/1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2147\/ijn.s595","volume":"3","author":"Junghanns","year":"2008","journal-title":"Int. J. Nanomed."},{"issue":"36","key":"D6TB00506C\/cit3\/1","doi-asserted-by":"publisher","first-page":"47124","DOI":"10.1021\/acsami.4c07669","volume":"16","author":"Udabe","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6TB00506C\/cit4\/1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/978-3-032-10238-6_8","volume-title":"Nanocrystals","author":"Fuster","year":"2026","unstructured":"M. G.Fuster ,  Y.Tao ,  M.Sangalli ,  L.Lopez-Vidal  and  A. J.Paredes ,  Overcoming the Challenges of Mucosal Tissues Using Drug Nanocrystals , in  Nanocrystals ,  Springer Nature Switzerland ,  Cham ,  2026 ,  pp. 195\u2013211 10.1007\/978-3-032-10238-6_8"},{"key":"D6TB00506C\/cit5\/1","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1038\/sj.clpt.6100400","volume":"83","author":"Zhang","year":"2008","journal-title":"Clin. Pharmacol. Ther."},{"key":"D6TB00506C\/cit6\/1","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.addr.2006.09.009","volume":"58","author":"Torchilin","year":"2006","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6TB00506C\/cit7\/1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ejpb.2018.04.020","volume":"128","author":"Pelikh","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D6TB00506C\/cit8\/1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.actbio.2020.10.031","volume":"119","author":"Priyanka","year":"2021","journal-title":"Acta Biomater."},{"key":"D6TB00506C\/cit9\/1","doi-asserted-by":"publisher","first-page":"101607","DOI":"10.1016\/j.jddst.2020.101607","volume":"56","author":"Liu","year":"2020","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"D6TB00506C\/cit10\/1","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.ajps.2019.11.002","volume":"15","author":"Wu","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"key":"D6TB00506C\/cit11\/1","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1021\/acs.molpharmaceut.3c01186","volume":"21","author":"Fuster","year":"2024","journal-title":"Mol. Pharmaceutics"},{"key":"D6TB00506C\/cit12\/1","doi-asserted-by":"publisher","first-page":"113784","DOI":"10.1016\/j.jconrel.2025.113784","volume":"383","author":"Rodella","year":"2025","journal-title":"J. Controlled Release"},{"key":"D6TB00506C\/cit13\/1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.engreg.2020.10.001","volume":"1","author":"Dovedytis","year":"2020","journal-title":"Eng. Regener."},{"key":"D6TB00506C\/cit14\/1","doi-asserted-by":"publisher","first-page":"142486","DOI":"10.1016\/j.ijbiomac.2025.142486","volume":"308","author":"Al Jayoush","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D6TB00506C\/cit15\/1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.addr.2008.11.002","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6TB00506C\/cit16\/1","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","volume":"161","author":"Danhier","year":"2012","journal-title":"J. Controlled Release"},{"key":"D6TB00506C\/cit17\/1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/mp700113r","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharmaceutics"},{"key":"D6TB00506C\/cit18\/1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2147\/BTAT.S17244","volume":"1","author":"Beevers","year":"2011","journal-title":"Botanics"},{"key":"D6TB00506C\/cit19\/1","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1021\/acs.jafc.6b04815","volume":"65","author":"Kharat","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"D6TB00506C\/cit20\/1","doi-asserted-by":"publisher","first-page":"100471","DOI":"10.1016\/j.mtbio.2022.100471","volume":"17","author":"Bianchi","year":"2022","journal-title":"Mater. Today Bio"},{"key":"D6TB00506C\/cit21\/1","doi-asserted-by":"publisher","first-page":"123585","DOI":"10.1016\/j.ijpharm.2023.123585","volume":"648","author":"Zhang","year":"2023","journal-title":"Int. J. Pharm."},{"key":"D6TB00506C\/cit22\/1","doi-asserted-by":"publisher","first-page":"114860","DOI":"10.1016\/j.colsurfb.2025.114860","volume":"254","author":"Wang","year":"2025","journal-title":"Colloids Surf., B"},{"key":"D6TB00506C\/cit23\/1","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jcis.2022.05.121","volume":"624","author":"Wu","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"D6TB00506C\/cit24\/1","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1039\/c9bm01605h","volume":"8","author":"Ji","year":"2020","journal-title":"Biomater. Sci."},{"key":"D6TB00506C\/cit25\/1","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.3390\/nano12132248","volume":"12","author":"Zerrillo","year":"2022","journal-title":"Nanomaterials"},{"key":"D6TB00506C\/cit26\/1","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.ijbiomac.2020.06.193","volume":"162","author":"Seo","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"D6TB00506C\/cit27\/1","doi-asserted-by":"publisher","first-page":"e10143","DOI":"10.1002\/btm2.10143","volume":"4","author":"Anselmo","year":"2019","journal-title":"Bioeng. Transl. Med."},{"key":"D6TB00506C\/cit28\/1","doi-asserted-by":"publisher","first-page":"2781","DOI":"10.1021\/acs.molpharmaceut.3c01186","volume":"21","author":"Fuster","year":"2024","journal-title":"Mol. Pharmaceutics."},{"key":"D6TB00506C\/cit29\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5402\/2012\/195727","volume":"2012","author":"Savjani","year":"2012","journal-title":"ISRN Pharm."},{"key":"D6TB00506C\/cit30\/1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ces.2014.08.046","volume":"125","author":"Lee","year":"2015","journal-title":"Chem. Eng. Sci."},{"key":"D6TB00506C\/cit31\/1","doi-asserted-by":"publisher","first-page":"123585","DOI":"10.1016\/j.ijpharm.2023.123585","volume":"648","author":"Zhang","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"25","key":"D6TB00506C\/cit32\/1","doi-asserted-by":"publisher","first-page":"100471","DOI":"10.1016\/j.mtbio.2022.100471","volume":"17","author":"Bianchi","year":"2022","journal-title":"Mater. Today Bio"},{"key":"D6TB00506C\/cit33\/1","first-page":"71","volume":"72","author":"Yutaka","year":"1999","journal-title":"J. Jpn. Soc."},{"key":"D6TB00506C\/cit34\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/adfm.202106999","volume":"32","author":"Tekko","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"D6TB00506C\/cit35\/1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0168-3659(02)00009-3","volume":"82","author":"Kabanov","year":"2002","journal-title":"J. Controlled Release"},{"key":"D6TB00506C\/cit36\/1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.4314\/tjpr.v12i2.19","volume":"12","author":"Honary","year":"2013","journal-title":"Trop. J. Pharm. Res."},{"key":"D6TB00506C\/cit37\/1","doi-asserted-by":"publisher","first-page":"2411","DOI":"10.1021\/acs.molpharmaceut.0c00161","volume":"17","author":"Wang","year":"2020","journal-title":"Mol. Pharmaceutics"},{"key":"D6TB00506C\/cit38\/1","doi-asserted-by":"publisher","first-page":"117497","DOI":"10.1016\/j.carbpol.2020.117497","volume":"256","author":"Wang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"D6TB00506C\/cit39\/1","doi-asserted-by":"publisher","first-page":"5837","DOI":"10.2147\/IJN.S166901","volume":"13","author":"Zariwala","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"D6TB00506C\/cit40\/1","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1002\/jps.24060","volume":"103","author":"Laffleur","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"D6TB00506C\/cit41\/1","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1016\/j.foodchem.2008.08.014","volume":"113","author":"G\u00f6ren","year":"2009","journal-title":"Food Chem."},{"key":"D6TB00506C\/cit42\/1","doi-asserted-by":"publisher","first-page":"112001","DOI":"10.1088\/1757-899X\/254\/11\/112001","volume":"254","author":"Campos","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"D6TB00506C\/cit43\/1","doi-asserted-by":"publisher","first-page":"178764","DOI":"10.1016\/j.tca.2020.178764","volume":"693","author":"Puiggal\u00ed","year":"2020","journal-title":"Thermochim. Acta"},{"key":"D6TB00506C\/cit44\/1","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.ijbiomac.2016.07.055","volume":"92","author":"Lewandowska","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"D6TB00506C\/cit45\/1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.nano.2009.05.004","volume":"6","author":"Yan","year":"2010","journal-title":"Nanomedicine"},{"key":"D6TB00506C\/cit46\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-57666-8","volume":"10","author":"Thach","year":"2020","journal-title":"Sci. Rep."},{"key":"D6TB00506C\/cit47\/1","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nri3738","volume":"14","author":"Mowat","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"D6TB00506C\/cit48\/1","doi-asserted-by":"publisher","first-page":"2371","DOI":"10.3390\/polym15102371","volume":"15","author":"Drozdova","year":"2023","journal-title":"Polymers"},{"key":"D6TB00506C\/cit49\/1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jconrel.2022.01.030.Particle","volume":"343","author":"Sharma","year":"2024","journal-title":"J. Controlled Release"},{"key":"D6TB00506C\/cit50\/1","doi-asserted-by":"publisher","first-page":"1901182","DOI":"10.1002\/adhm.201901182","volume":"8","author":"Rios","year":"2019","journal-title":"Adv. Healthcare Mater."},{"key":"D6TB00506C\/cit51\/1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3389\/fimmu.2015.00201","volume":"6","author":"Misra","year":"2015","journal-title":"Front. Immunol."},{"key":"D6TB00506C\/cit52\/1","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1021\/ja02086a003","author":"Noyes","year":"1897","journal-title":"J. Am. Chem. Soc."},{"key":"D6TB00506C\/cit53\/1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.nantod.2015.06.006","volume":"10","author":"Herd","year":"2015","journal-title":"Nano Today"},{"key":"D6TB00506C\/cit54\/1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1111\/fcp.12594","volume":"35","author":"Liu","year":"2021","journal-title":"Fundam. Clin. Pharmacol."},{"key":"D6TB00506C\/cit55\/1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s40005-019-00453-z","volume":"49","author":"Blasi","year":"2019","journal-title":"J. Pharm. Invest."},{"key":"D6TB00506C\/cit56\/1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3109\/10611860903450023","volume":"18","author":"Wadhwa","year":"2010","journal-title":"J. Drug Targeting"},{"key":"D6TB00506C\/cit57\/1","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1111\/j.1742-4658.2011.08071.x","volume":"278","author":"Misra","year":"2011","journal-title":"FEBS J."},{"key":"D6TB00506C\/cit58\/1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.addr.2008.11.002","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6TB00506C\/cit59\/1","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/nmat3776","volume":"12","author":"Mura","year":"2013","journal-title":"Nat. Mater."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2026\/TB\/D6TB00506C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:19:49Z","timestamp":1782937189000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D6TB00506C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":59,"journal-issue":{"issue":"25","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1039\/d6tb00506c","relation":{"has-review":[{"id-type":"doi","id":"10.1039\/D6TB00506C\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6TB00506C\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6TB00506C\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6TB00506C\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6TB00506C\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1039\/D6TB00506C\/v2\/response1","asserted-by":"object"}]},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}