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J."},{"key":"D6TB00761A\/cit112\/1","doi-asserted-by":"crossref","first-page":"7605","DOI":"10.2147\/IJN.S465965","volume":"19","author":"Pu","year":"2024","journal-title":"Int. J. Nanomed."},{"key":"D6TB00761A\/cit113\/1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.micpath.2016.12.013","volume":"104","author":"Lakhundi","year":"2017","journal-title":"Microb. Pathog."},{"key":"D6TB00761A\/cit114\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/831502","volume":"2012","author":"Wong","year":"2012","journal-title":"J. Ophthalmol."},{"key":"D6TB00761A\/cit115\/1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ajo.2007.06.037","volume":"144","author":"Stapleton","year":"2007","journal-title":"Am. J. 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Musculoskeletal Dis."},{"key":"D6TB00761A\/cit125\/1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0002-9394(00)00659-0","volume":"130","author":"Jabs","year":"2000","journal-title":"Am. J. Ophthalmol."},{"key":"D6TB00761A\/cit126\/1","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3390\/biomedicines12051106","volume":"12","author":"Abu Arif","year":"2024","journal-title":"Biomedicines"},{"key":"D6TB00761A\/cit127\/1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.ajo.2005.03.057","volume":"140","author":"Jabs","year":"2005","journal-title":"Am. J. Ophthalmol."},{"key":"D6TB00761A\/cit128\/1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ophtha.2017.11.017","volume":"125","author":"Dick","year":"2018","journal-title":"Ophthalmology"},{"key":"D6TB00761A\/cit129\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0960-0760(02)00263-7","volume":"83","author":"Schaaf","year":"2002","journal-title":"J. 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