{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:07:16Z","timestamp":1790168836474,"version":"4.1.0"},"reference-count":52,"publisher":"Royal Society of Chemistry (RSC)","issue":"36","license":[{"start":{"date-parts":[[2027,8,18]],"date-time":"2027-08-18T00:00:00Z","timestamp":1818547200000},"content-version":"am","delay-in-days":594,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/523(0100)\/2021-EMR-I"],"award-info":[{"award-number":["09\/523(0100)\/2021-EMR-I"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>\n                    Media-dependent release of Cu\n                    <jats:sup>2+<\/jats:sup>\n                    and Zn\n                    <jats:sup>2+<\/jats:sup>\n                    from the chitosan-proline scaffold governs therapeutic ion availability, thereby promoting fibroblast and keratinocyte migration, collagen deposition, and expression of VEGF, HSP47, and Col1\u03b11.\n                  <\/jats:p>","DOI":"10.1039\/d6tb00788k","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:43:33Z","timestamp":1787042613000},"page":"11285-11297","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Controlled delivery of Cu\n                    <sup>2+<\/sup>\n                    and Zn\n                    <sup>2+<\/sup>\n                    ions from chitosan scaffolds: media-dependent release of ions and its influence on cellular responses relevant to wound healing"],"prefix":"10.1039","volume":"14","author":[{"given":"M. C.","family":"Linju","sequence":"first","affiliation":[{"name":"Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Poojappura, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1008-4928","authenticated-orcid":false,"given":"M. R.","family":"Rekha","sequence":"additional","affiliation":[{"name":"Division of Biosurface Technology, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Poojappura, Thiruvananthapuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6TB00788K\/cit1\/1","doi-asserted-by":"crossref","first-page":"a023267","DOI":"10.1101\/cshperspect.a023267","volume":"5","author":"Takeo","year":"2015","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"D6TB00788K\/cit2\/1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41580-024-00715-1","volume":"25","author":"Pe\u00f1a","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"D6TB00788K\/cit3\/1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nm.3887","volume":"21","author":"Wong","year":"2015","journal-title":"Nat. Med."},{"key":"D6TB00788K\/cit4\/1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s12325-017-0478-y","volume":"34","author":"Han","year":"2017","journal-title":"Adv. Ther."},{"key":"D6TB00788K\/cit5\/1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1046\/j.1524-475X.1999.00433.x","volume":"7","author":"Yager","year":"1999","journal-title":"Wound Repair Regen."},{"key":"D6TB00788K\/cit6\/1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/BF02992716","volume":"26\u201327","author":"Nielsen","year":"1990","journal-title":"Biol. Trace Elem. Res."},{"key":"D6TB00788K\/cit7\/1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1098\/rsif.2011.0611","volume":"9","author":"Mouri\u00f1o","year":"2012","journal-title":"J. R. Soc., Interface"},{"key":"D6TB00788K\/cit8\/1","first-page":"87","volume":"36","author":"Reiisi","year":"2025","journal-title":"J. Mater. Sci.: Mater. Med."},{"key":"D6TB00788K\/cit9\/1","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1089\/wound.2022.0128","volume":"12","author":"Mai","year":"2023","journal-title":"Adv. Wound Care"},{"key":"D6TB00788K\/cit10\/1","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/wrr.12537","volume":"25","author":"Momen-Heravi","year":"2017","journal-title":"Wound Repair Regen."},{"key":"D6TB00788K\/cit11\/1","first-page":"88","volume":"26","author":"Yang","year":"2023","journal-title":"Bioact. Mater."},{"key":"D6TB00788K\/cit12\/1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/01.shk.0000068318.49350.3a","volume":"20","author":"Bar-Or","year":"2003","journal-title":"Shock"},{"key":"D6TB00788K\/cit13\/1","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.bcp.2012.07.014","volume":"84","author":"Tsai","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"D6TB00788K\/cit14\/1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3109\/03008207.2012.665970","volume":"53","author":"Philips","year":"2012","journal-title":"Connect. Tissue Res."},{"key":"D6TB00788K\/cit15\/1","first-page":"102","volume":"29","author":"Kogan","year":"2017","journal-title":"Wounds"},{"key":"D6TB00788K\/cit16\/1","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1007\/s00775-011-0797-4","volume":"16","author":"Fukada","year":"2011","journal-title":"J. Biol. Inorg. Chem."},{"key":"D6TB00788K\/cit17\/1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1467-2494.1993.tb00072.x","volume":"15","author":"Lansdown","year":"1993","journal-title":"Int. J. Cosmet. Sci."},{"key":"D6TB00788K\/cit18\/1","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1046\/j.1365-2133.1999.02603.x","volume":"140","author":"Tenaud","year":"1999","journal-title":"Br. J. Dermatol."},{"key":"D6TB00788K\/cit19\/1","doi-asserted-by":"crossref","first-page":"124688","DOI":"10.1016\/j.ijbiomac.2023.124688","volume":"242","author":"Linju","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"D6TB00788K\/cit20\/1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.3390\/coatings10111052","volume":"10","author":"Tan","year":"2020","journal-title":"Coatings"},{"key":"D6TB00788K\/cit21\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/10717540590889781","volume":"12","author":"Prabaharan","year":"2004","journal-title":"Drug Delivery"},{"key":"D6TB00788K\/cit22\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.seppur.2003.10.004","volume":"38","author":"Guibal","year":"2004","journal-title":"Sep. Purif. Technol."},{"key":"D6TB00788K\/cit23\/1","doi-asserted-by":"crossref","first-page":"51883","DOI":"10.1039\/C5RA08029K","volume":"5","author":"Lind\u00e9n","year":"2015","journal-title":"RSC Adv."},{"key":"D6TB00788K\/cit24\/1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.5539\/ijc.v12n1p29","volume":"12","author":"Najim","year":"2019","journal-title":"Int. J. Chem."},{"key":"D6TB00788K\/cit25\/1","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3892\/br.2015.481","volume":"3","author":"Li","year":"2015","journal-title":"Biomed. Rep."},{"key":"D6TB00788K\/cit26\/1","author":"Richard","unstructured":"W.Richard  and  K. F.Cutting , World Wide Wounds 1 (2006) (accessed June 23, 2024)"},{"key":"D6TB00788K\/cit27\/1","doi-asserted-by":"crossref","first-page":"16071","DOI":"10.1038\/natrevmats.2016.71","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"D6TB00788K\/cit28\/1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/03639049709148487","volume":"23","author":"Efentakis","year":"1997","journal-title":"Drug Dev. Ind. Pharm."},{"key":"D6TB00788K\/cit29\/1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3390\/ph13110338","volume":"13","author":"Bojarska","year":"2020","journal-title":"Pharmaceuticals"},{"key":"D6TB00788K\/cit30\/1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s00726-024-03410-9","volume":"56","author":"Umumararungu","year":"2024","journal-title":"Amino Acids"},{"key":"D6TB00788K\/cit31\/1","doi-asserted-by":"crossref","first-page":"nwac033","DOI":"10.1093\/nsr\/nwac033","volume":"9","author":"Hu","year":"2022","journal-title":"Natl. Sci. Rev."},{"key":"D6TB00788K\/cit32\/1","doi-asserted-by":"crossref","first-page":"12016","DOI":"10.1021\/acsomega.0c00164","volume":"5","author":"Mahinthichaichan","year":"2020","journal-title":"ACS Omega"},{"key":"D6TB00788K\/cit33\/1","doi-asserted-by":"crossref","first-page":"8795","DOI":"10.1021\/acsomega.9b00251","volume":"4","author":"Pinto Ramos","year":"2019","journal-title":"ACS Omega"},{"key":"D6TB00788K\/cit34\/1","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4103\/0975-7406.199346","volume":"8","author":"Chhabra","year":"2016","journal-title":"J. Pharm. BioAllied Sci."},{"key":"D6TB00788K\/cit35\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03639045.2016.1254240","volume":"43","author":"Motiei","year":"2017","journal-title":"Drug Dev. Ind. Pharm."},{"key":"D6TB00788K\/cit36\/1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1021\/bm301720g","volume":"14","author":"Layek","year":"2013","journal-title":"Biomacromolecules"},{"key":"D6TB00788K\/cit37\/1","doi-asserted-by":"crossref","first-page":"137081","DOI":"10.1016\/j.ijbiomac.2024.137081","volume":"282","author":"Torkaman","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D6TB00788K\/cit38\/1","first-page":"57","volume":"34","author":"Begum","year":"2017","journal-title":"J. Polym. Mater."},{"key":"D6TB00788K\/cit39\/1","first-page":"1","author":"Sasula","year":"2026","journal-title":"Mol. Cell. Biochem."},{"key":"D6TB00788K\/cit40\/1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.carbpol.2003.08.005","volume":"55","author":"Varma","year":"2004","journal-title":"Carbohydr. Polym."},{"key":"D6TB00788K\/cit41\/1","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s11274-004-6559-5","volume":"21","author":"Guibal","year":"2005","journal-title":"World J. Microbiol. Biotechnol."},{"key":"D6TB00788K\/cit42\/1","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/S0043-1354(98)00469-2","volume":"33","author":"Juang","year":"1999","journal-title":"Water Res."},{"key":"D6TB00788K\/cit43\/1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/rmb2.12024","volume":"16","author":"Yao","year":"2017","journal-title":"Reprod. Med. Biol."},{"key":"D6TB00788K\/cit44\/1","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/sj.jid.5700786","volume":"127","author":"Werner","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"D6TB00788K\/cit45\/1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3390\/bioengineering8050063","volume":"8","author":"Mathew-Steiner","year":"2021","journal-title":"Bioengineering"},{"key":"D6TB00788K\/cit46\/1","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1007\/s11033-021-06403-z","volume":"48","author":"Chung","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"D6TB00788K\/cit47\/1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3109\/03008200903288431","volume":"51","author":"Philips","year":"2010","journal-title":"Connect. Tissue Res."},{"key":"D6TB00788K\/cit48\/1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1034\/j.1600-0625.2000.009006407.x","volume":"9","author":"Tenaud","year":"2000","journal-title":"Exp. Dermatol."},{"key":"D6TB00788K\/cit49\/1","first-page":"50","volume":"2","author":"Fleck","year":"2010","journal-title":"J. Am. Col. Certif. Wound Spec."},{"key":"D6TB00788K\/cit50\/1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/B978-0-12-386471-0.00009-2","volume":"499","author":"Ishida","year":"2011","journal-title":"Methods Enzymol."},{"key":"D6TB00788K\/cit51\/1","doi-asserted-by":"crossref","first-page":"18529","DOI":"10.1038\/s41598-022-23304-8","volume":"12","author":"Shams","year":"2022","journal-title":"Sci. Rep."},{"key":"D6TB00788K\/cit52\/1","doi-asserted-by":"crossref","first-page":"H1821","DOI":"10.1152\/ajpheart.01015.2001","volume":"282","author":"Sen","year":"2002","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/TB\/article-pdf\/doi\/10.1039\/D6TB00788K\/0\/D6TB00788K.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:45:53Z","timestamp":1790167553000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/TB\/article-lookup\/doi\/10.1039\/D6TB00788K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":52,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2026,9,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d6tb00788k","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}