{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:42:39Z","timestamp":1787161359324,"version":"build-2736575974"},"reference-count":38,"publisher":"Royal Society of Chemistry (RSC)","issue":"32","license":[{"start":{"date-parts":[[2027,8,5]],"date-time":"2027-08-05T00:00:00Z","timestamp":1817424000000},"content-version":"am","delay-in-days":581,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100010829","name":"Xinjiang Uygur Autonomous Region Department of Education","doi-asserted-by":"publisher","award":["XJEDU2023P017"],"award-info":[{"award-number":["XJEDU2023P017"]}],"id":[{"id":"10.13039\/501100010829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010829","name":"Xinjiang Uygur Autonomous Region Department of Education","doi-asserted-by":"publisher","award":["2023B02030-1"],"award-info":[{"award-number":["2023B02030-1"]}],"id":[{"id":"10.13039\/501100010829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>\n                    The construction of 3-\n                    <jats:italic>n<\/jats:italic>\n                    -butylphthalide-based nanoagent and its neuroprotective mechanism against cerebral ischemia and reperfusion injury.\n                  <\/jats:p>","DOI":"10.1039\/d6tb01047d","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T16:44:21Z","timestamp":1785948261000},"page":"10226-10238","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A 3-\n                    <i>n<\/i>\n                    -butylphthalide-based nanoagent modulates PINK1\/Parkin-associated mitophagy signaling in ischemia\u2013reperfusion brain injury"],"prefix":"10.1039","volume":"14","author":[{"given":"Dingyang","family":"Li","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Institute of Materia Medica, Xinjiang University, Urumqi, 830017, China"},{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukai","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Institute of Materia Medica, Xinjiang University, Urumqi, 830017, China"},{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5751-9530","authenticated-orcid":false,"given":"Zhongxiong","family":"Fan","sequence":"additional","affiliation":[{"name":"Uygur Medicine Hospital of Xinjiang Uygur Autonomous Region (The Second People's Hospital of Xinjiang Uygur Autonomous Region), Urumqi, 830049, China"},{"name":"Xinjiang Key Laboratory of Evidence-Based and Translation, Hospital Preparation of Traditional Chinese Medicine, Urumqi, 830049, China"},{"name":"School of Pharmaceutical Sciences, Institute of Materia Medica, Xinjiang University, Urumqi, 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujie","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Institute of Materia Medica, Xinjiang University, Urumqi, 830017, China"},{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liao","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Institute of Materia Medica, Xinjiang University, Urumqi, 830017, China"},{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lele","family":"Kou","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Institute of Materia Medica, Xinjiang University, Urumqi, 830017, China"},{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Uygur Medical Research, Xinjiang Institute of Materia Medica, Urumqi, 830004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Li","sequence":"additional","affiliation":[{"name":"Uygur Medicine Hospital of Xinjiang Uygur Autonomous Region (The Second People's Hospital of Xinjiang Uygur Autonomous Region), Urumqi, 830049, China"},{"name":"Xinjiang Key Laboratory of Evidence-Based and Translation, Hospital Preparation of Traditional Chinese Medicine, Urumqi, 830049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6TB01047D\/cit1\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-med-050823-094312","volume":"76","author":"Ho","year":"2025","journal-title":"Annu. Rev. Med."},{"key":"D6TB01047D\/cit2\/1","doi-asserted-by":"crossref","first-page":"e076161","DOI":"10.1136\/bmj-2023-076161","volume":"389","author":"Sharma","year":"2025","journal-title":"BMJ"},{"key":"D6TB01047D\/cit3\/1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/s12974-017-0889-3","volume":"14","author":"Benusa","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"D6TB01047D\/cit4\/1","doi-asserted-by":"crossref","first-page":"100932","DOI":"10.1016\/j.yfrne.2021.100932","volume":"63","author":"Cui","year":"2021","journal-title":"Front. Neuroendocrinol."},{"key":"D6TB01047D\/cit5\/1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/joim.13425","volume":"291","author":"Wasselius","year":"2022","journal-title":"J. Intern. Med."},{"key":"D6TB01047D\/cit6\/1","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s13311-023-01377-1","volume":"20","author":"Zubair","year":"2023","journal-title":"Neurotherapeutics"},{"key":"D6TB01047D\/cit7\/1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S1474-4422(22)00519-1","volume":"22","author":"Tsivgoulis","year":"2023","journal-title":"Lancet Neurol."},{"key":"D6TB01047D\/cit8\/1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.7150\/thno.43895","volume":"11","author":"Jiang","year":"2021","journal-title":"Theranostics"},{"key":"D6TB01047D\/cit9\/1","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/CIRCRESAHA.123.323882","volume":"134","author":"Mendoza","year":"2024","journal-title":"Circ. Res."},{"key":"D6TB01047D\/cit10\/1","doi-asserted-by":"crossref","first-page":"155239","DOI":"10.1016\/j.metabol.2022.155239","volume":"134","author":"Sun","year":"2022","journal-title":"Metabolism"},{"key":"D6TB01047D\/cit11\/1","doi-asserted-by":"crossref","first-page":"101382","DOI":"10.1016\/j.mam.2025.101382","volume":"104","author":"Li","year":"2025","journal-title":"Mol. Aspects Med."},{"key":"D6TB01047D\/cit12\/1","doi-asserted-by":"crossref","first-page":"e210086","DOI":"10.1212\/WNL.0000000000210086","volume":"103","author":"Nicolini","year":"2024","journal-title":"Neurology"},{"key":"D6TB01047D\/cit13\/1","doi-asserted-by":"crossref","first-page":"102258","DOI":"10.1016\/j.redox.2022.102258","volume":"51","author":"Yoval-Sanchez","year":"2022","journal-title":"Redox Biol."},{"key":"D6TB01047D\/cit14\/1","doi-asserted-by":"crossref","first-page":"101254","DOI":"10.1016\/j.redox.2019.101254","volume":"26","author":"Lin","year":"2019","journal-title":"Redox Biol."},{"key":"D6TB01047D\/cit15\/1","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat. Cell Biol."},{"key":"D6TB01047D\/cit16\/1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"D6TB01047D\/cit17\/1","doi-asserted-by":"crossref","first-page":"20230063","DOI":"10.1002\/EXP.20230063","volume":"4","author":"Qian","year":"2024","journal-title":"Exploration"},{"key":"D6TB01047D\/cit18\/1","doi-asserted-by":"crossref","first-page":"156928","DOI":"10.1016\/j.phymed.2025.156928","volume":"145","author":"Guo","year":"2025","journal-title":"Phytomedicine"},{"key":"D6TB01047D\/cit19\/1","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1016\/j.apsb.2024.05.012","volume":"14","author":"Zhou","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"D6TB01047D\/cit20\/1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41419-021-03752-2","volume":"12","author":"Anzell","year":"2021","journal-title":"Cell Death Dis."},{"key":"D6TB01047D\/cit21\/1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1186\/s12967-022-03642-x","volume":"20","author":"Hu","year":"2022","journal-title":"J. Transl. Med."},{"key":"D6TB01047D\/cit22\/1","doi-asserted-by":"crossref","first-page":"216621","DOI":"10.1016\/j.canlet.2024.216621","volume":"587","author":"Luo","year":"2024","journal-title":"Cancer Lett."},{"key":"D6TB01047D\/cit23\/1","doi-asserted-by":"crossref","first-page":"102049","DOI":"10.1016\/j.redox.2021.102049","volume":"45","author":"Wang","year":"2021","journal-title":"Redox Biol."},{"key":"D6TB01047D\/cit24\/1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12951-023-02045-4","volume":"21","author":"Lei","year":"2023","journal-title":"J Nanobiotechnol."},{"key":"D6TB01047D\/cit25\/1","doi-asserted-by":"crossref","first-page":"e2308477","DOI":"10.1002\/adma.202308477","volume":"36","author":"Liu","year":"2024","journal-title":"Adv. Mater."},{"key":"D6TB01047D\/cit26\/1","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1038\/mt.2011.164","volume":"19","author":"Zhuang","year":"2011","journal-title":"Mol. Ther."},{"key":"D6TB01047D\/cit27\/1","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.2147\/DDDT.S189472","volume":"12","author":"Chen","year":"2018","journal-title":"Drug Des., Dev. Ther."},{"key":"D6TB01047D\/cit28\/1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12929-017-0345-9","volume":"24","author":"Tian","year":"2017","journal-title":"J. Biomed. Sci."},{"key":"D6TB01047D\/cit29\/1","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.2147\/IJN.S132434","volume":"12","author":"Feng","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"D6TB01047D\/cit30\/1","doi-asserted-by":"crossref","first-page":"113634","DOI":"10.1016\/j.foodres.2023.113634","volume":"174","author":"Zhu","year":"2023","journal-title":"Food Res. Int."},{"key":"D6TB01047D\/cit31\/1","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2147\/IJN.S126154","volume":"12","author":"Chan","year":"2017","journal-title":"Int. J. Nanomed."},{"key":"D6TB01047D\/cit32\/1","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1039\/C7CS00827A","volume":"47","author":"Makam","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"D6TB01047D\/cit33\/1","doi-asserted-by":"crossref","first-page":"33618","DOI":"10.1021\/acsami.5c05882","volume":"17","author":"Guo","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6TB01047D\/cit34\/1","doi-asserted-by":"crossref","first-page":"101689","DOI":"10.1016\/j.mtbio.2025.101689","volume":"32","author":"Hou","year":"2025","journal-title":"Mater. Today Bio"},{"key":"D6TB01047D\/cit35\/1","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1002\/med.21669","volume":"40","author":"Zhang","year":"2020","journal-title":"Med. Res. Rev."},{"key":"D6TB01047D\/cit36\/1","doi-asserted-by":"crossref","first-page":"20240388","DOI":"10.1002\/EXP.20240388","volume":"5","author":"Shi","year":"2025","journal-title":"Exploration"},{"key":"D6TB01047D\/cit37\/1","doi-asserted-by":"crossref","first-page":"20230174","DOI":"10.1002\/EXP.20230174","volume":"5","author":"Yang","year":"2025","journal-title":"Exploration"},{"key":"D6TB01047D\/cit38\/1","doi-asserted-by":"crossref","first-page":"683935","DOI":"10.3389\/fphar.2021.683935","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Pharmacol."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/TB\/article-pdf\/doi\/10.1039\/D6TB01047D\/0\/D6TB01047D.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:17:17Z","timestamp":1787159837000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/TB\/article-lookup\/doi\/10.1039\/D6TB01047D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":38,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2026,8,19]]}},"URL":"https:\/\/doi.org\/10.1039\/d6tb01047d","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}