{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:43:39Z","timestamp":1792575819015,"version":"4.5.0"},"reference-count":35,"publisher":"Royal Society of Chemistry (RSC)","license":[{"start":{"date-parts":[[2027,10,13]],"date-time":"2027-10-13T00:00:00Z","timestamp":1823385600000},"content-version":"am","delay-in-days":650,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52373165"],"award-info":[{"award-number":["52373165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>\n                    Ciprofloxacin-loaded hybrid membrane vesicles (CIP@HMVs) exploit ciprofloxacin as a sonosensitizer and HMVs as a detoxified bacterial-targeting delivery system, achieving potent anti-biofilm efficacy both\n                    <jats:italic>in vitro<\/jats:italic>\n                    and\n                    <jats:italic>in vivo via<\/jats:italic>\n                    sonodynamic therapy.\n                  <\/jats:p>","DOI":"10.1039\/d6tb01238h","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:43:14Z","timestamp":1791859394000},"update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hybrid membrane vesicle-enabled sonodynamic therapy using ciprofloxacin for treating biofilm-associated infections"],"prefix":"10.1039","author":[{"given":"Xueyi","family":"Xiao","sequence":"first","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen Campus, Shenzhen, 518107, China"},{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Shenzhen Campus, Shenzhen, 518107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4952-4707","authenticated-orcid":false,"given":"Manzhen","family":"Yan","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen Campus, Shenzhen, 518107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen Campus, Shenzhen, 518107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingling","family":"Li","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen Campus, Shenzhen, 518107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxuan","family":"He","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen Campus, Shenzhen, 518107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Yuan","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen Campus, Shenzhen, 518107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyu","family":"Guo","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen Campus, Shenzhen, 518107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhong","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen Campus, Shenzhen, 518107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6993-3034","authenticated-orcid":false,"given":"Xin","family":"Ding","sequence":"additional","affiliation":[{"name":"Zhongshan School of Medicine, Sun Yat-sen University, Shenzhen Campus, Shenzhen, 518107, China"},{"name":"State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6TB01238H\/cit1\/1","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1016\/S0140-6736(24)01867-1","volume":"404","author":"Collaborators G B D A R","year":"2024","journal-title":"The Lancet"},{"key":"D6TB01238H\/cit2\/1","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/s41579-020-0385-2","volume":"18","author":"Rumbaugh","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"key":"D6TB01238H\/cit3\/1","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1093\/jac\/dkv077","volume":"70","author":"Cao","year":"2015","journal-title":"J. Antimicrob. Chemother."},{"key":"D6TB01238H\/cit4\/1","doi-asserted-by":"publisher","first-page":"306","DOI":"10.3390\/biom12020306","volume":"12","author":"Ram\u00edrez-Larrota","year":"2022","journal-title":"Biomolecules"},{"key":"D6TB01238H\/cit5\/1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3390\/antibiotics10020131","volume":"10","author":"Kranjec","year":"2021","journal-title":"Antibiotics"},{"key":"D6TB01238H\/cit6\/1","doi-asserted-by":"publisher","first-page":"223","DOI":"10.4161\/viru.23724","volume":"4","author":"Soto","year":"2013","journal-title":"Virulence"},{"key":"D6TB01238H\/cit7\/1","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1128\/AAC.45.4.999-1007.2001","volume":"45","author":"Lewis","year":"2001","journal-title":"Antimicrob. Agents Chemother."},{"key":"D6TB01238H\/cit8\/1","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1128\/MMBR.00013-14","volume":"78","author":"Lebeaux","year":"2014","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"D6TB01238H\/cit9\/1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1093\/femsre\/fux010","volume":"41","author":"Hall","year":"2017","journal-title":"FEMS Microbiol. Rev."},{"key":"D6TB01238H\/cit10\/1","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3389\/fmicb.2019.00913","volume":"10","author":"Ciofu","year":"2019","journal-title":"Front. Microbiol."},{"key":"D6TB01238H\/cit11\/1","doi-asserted-by":"publisher","first-page":"851784","DOI":"10.3389\/fcimb.2022.851784","volume":"12","author":"Th\u00f6ming","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D6TB01238H\/cit12\/1","doi-asserted-by":"publisher","first-page":"8097","DOI":"10.1002\/adma.201602012","volume":"28","author":"Qian","year":"2016","journal-title":"Adv. Mater."},{"key":"D6TB01238H\/cit13\/1","doi-asserted-by":"publisher","first-page":"202400181","DOI":"10.1002\/cbic.202400181","volume":"25","author":"Liu","year":"2024","journal-title":"ChemBioChem"},{"key":"D6TB01238H\/cit14\/1","doi-asserted-by":"publisher","first-page":"6257","DOI":"10.1021\/acs.nanolett.6b02547","volume":"16","author":"Deepagan","year":"2016","journal-title":"Nano Lett."},{"key":"D6TB01238H\/cit15\/1","doi-asserted-by":"publisher","first-page":"12001","DOI":"10.3390\/ijms241512001","volume":"24","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"D6TB01238H\/cit16\/1","doi-asserted-by":"publisher","first-page":"22266","DOI":"10.1039\/d5sc06387f","volume":"16","author":"Lee","year":"2025","journal-title":"Chem. Sci."},{"key":"D6TB01238H\/cit17\/1","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.saa.2010.11.051","volume":"78","author":"Liu","year":"2011","journal-title":"Spectrochim. Acta, Part A"},{"key":"D6TB01238H\/cit18\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ultsonch.2016.12.007","volume":"37","author":"Dong","year":"2017","journal-title":"Ultrason. Sonochem."},{"key":"D6TB01238H\/cit19\/1","doi-asserted-by":"publisher","first-page":"2403612","DOI":"10.1002\/adma.202403612","volume":"36","author":"Ding","year":"2024","journal-title":"Adv. Mater."},{"key":"D6TB01238H\/cit20\/1","doi-asserted-by":"publisher","first-page":"160962","DOI":"10.1016\/j.cej.2024.160962","volume":"508","author":"Cheng","year":"2025","journal-title":"Chem. Eng. J."},{"key":"D6TB01238H\/cit21\/1","doi-asserted-by":"publisher","first-page":"2402588","DOI":"10.1002\/adfm.202402588","volume":"34","author":"He","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D6TB01238H\/cit22\/1","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/nrmicro3525","volume":"13","author":"Schwechheimer","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"D6TB01238H\/cit23\/1","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.addr.2020.05.003","volume":"159","author":"Elsharkasy","year":"2020","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6TB01238H\/cit24\/1","doi-asserted-by":"publisher","first-page":"2103442","DOI":"10.1002\/adfm.202103442","volume":"31","author":"Wu","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"D6TB01238H\/cit25\/1","doi-asserted-by":"publisher","first-page":"2300473","DOI":"10.1002\/sstr.202300473","volume":"5","author":"Yu","year":"2024","journal-title":"Small Struct."},{"key":"D6TB01238H\/cit26\/1","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1021\/acssynbio.4c00622","volume":"14","author":"Chen","year":"2025","journal-title":"ACS Synth. Biol."},{"key":"D6TB01238H\/cit27\/1","doi-asserted-by":"publisher","first-page":"105591","DOI":"10.1016\/j.ultsonch.2021.105591","volume":"75","author":"Fan","year":"2021","journal-title":"Ultrason. Sonochem."},{"key":"D6TB01238H\/cit28\/1","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1016\/j.ultrasmedbio.2023.05.007","volume":"49","author":"Duan","year":"2023","journal-title":"Ultrasound Med. Biol."},{"key":"D6TB01238H\/cit29\/1","doi-asserted-by":"publisher","first-page":"115158","DOI":"10.1016\/j.addr.2023.115158","volume":"205","author":"Liu","year":"2024","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6TB01238H\/cit30\/1","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1186\/s12951-024-03025-2","volume":"22","author":"Luo","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"D6TB01238H\/cit31\/1","doi-asserted-by":"publisher","first-page":"10186","DOI":"10.1074\/jbc.M117.796632","volume":"293","author":"Tsukamoto","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"26","key":"D6TB01238H\/cit32\/1","doi-asserted-by":"crossref","first-page":"2201280","DOI":"10.1002\/smll.202201280","volume":"18","author":"Che","year":"2022","journal-title":"Small"},{"key":"D6TB01238H\/cit33\/1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1186\/s12951-024-03058-3","volume":"22","author":"Lan","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"D6TB01238H\/cit34\/1","doi-asserted-by":"publisher","first-page":"39805","DOI":"10.1021\/acsnano.5c12658","volume":"19","author":"Hoffman","year":"2025","journal-title":"ACS Nano"},{"key":"D6TB01238H\/cit35\/1","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.34133\/research.1207","volume":"9","author":"Li","year":"2026","journal-title":"Research"}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/TB\/article-pdf\/doi\/10.1039\/D6TB01238H\/0\/D6TB01238H.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:11:36Z","timestamp":1792573896000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/TB\/article-lookup\/doi\/10.1039\/D6TB01238H"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":35,"URL":"https:\/\/doi.org\/10.1039\/d6tb01238h","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}