{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:07:28Z","timestamp":1790168848785,"version":"4.1.0"},"reference-count":53,"publisher":"Royal Society of Chemistry (RSC)","issue":"36","license":[{"start":{"date-parts":[[2027,9,3]],"date-time":"2027-09-03T00:00:00Z","timestamp":1819929600000},"content-version":"am","delay-in-days":610,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["2026C04011"],"award-info":[{"award-number":["2026C04011"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003786","name":"Hangzhou Science and Technology Bureau","doi-asserted-by":"publisher","award":["2025SZRJJ1679"],"award-info":[{"award-number":["2025SZRJJ1679"]}],"id":[{"id":"10.13039\/501100003786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFA0914200"],"award-info":[{"award-number":["2023YFA0914200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>\n                    Curved microneedles are optimized\n                    <jats:italic>via<\/jats:italic>\n                    finite element simulation to achieve conformal corneal contact and uniform drug delivery. Loaded with AmB-PLA NPs, they show potent anti-\n                    <jats:italic>C. albicans<\/jats:italic>\n                    efficacy and accelerates corneal healing in fungal keratitis.\n                  <\/jats:p>","DOI":"10.1039\/d6tb01241h","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:35:14Z","timestamp":1788424514000},"page":"11248-11262","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized curved-backing microneedles with amphotericin B-loaded nanoparticles for fungal keratitis treatment"],"prefix":"10.1039","volume":"14","author":[{"given":"Shulin","family":"Shen","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China"},{"name":"Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China"},{"name":"Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China"},{"name":"Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiqun","family":"Wan","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China"},{"name":"Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Weng","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China"},{"name":"Institute of Laser Advanced Manufacturing, Zhejiang University of Technology, Hangzhou 310023, P. R. China"},{"name":"College of Mechanical Engineering, Zhejiang University of Technology, Hangzhou 310023, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghui","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China"},{"name":"Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1007-1852","authenticated-orcid":false,"given":"Yuanbin","family":"She","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3632-8537","authenticated-orcid":false,"given":"Laurent","family":"David","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Lyon 1, INSA Lyon, Universit\u00e9 Jean Monnet, CNRS, UMR 5223, Ing\u00e9nierie des Mat\u00e9riaux Polym\u00e8res, F-69622 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School, Shanghai 200011, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0398-1505","authenticated-orcid":false,"given":"Qinying","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China"},{"name":"Research Institute of Pharmaceutical Particle Technology, Zhejiang University of Technology, Hangzhou 310014, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6TB01241H\/cit1\/1","doi-asserted-by":"crossref","first-page":"25637","DOI":"10.1021\/acsami.3c19482","volume":"16","author":"Mahfufah","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6TB01241H\/cit2\/1","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.jtos.2021.08.007","volume":"28","author":"Stapleton","year":"2023","journal-title":"Ocul. Surf."},{"key":"D6TB01241H\/cit3\/1","doi-asserted-by":"crossref","first-page":"e2104657","DOI":"10.1002\/smll.202104657","volume":"18","author":"Shi","year":"2022","journal-title":"Small"},{"key":"D6TB01241H\/cit4\/1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1038\/s41586-023-06710-4","volume":"623","author":"Maji","year":"2023","journal-title":"Nature"},{"key":"D6TB01241H\/cit5\/1","doi-asserted-by":"crossref","first-page":"18729","DOI":"10.1021\/acsnano.2c07444","volume":"16","author":"Ye","year":"2022","journal-title":"ACS Nano"},{"key":"D6TB01241H\/cit6\/1","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/S1473-3099(20)30448-5","volume":"21","author":"Brown","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"D6TB01241H\/cit7\/1","doi-asserted-by":"crossref","first-page":"212771","DOI":"10.1016\/j.bioadv.2022.212771","volume":"136","author":"Gu","year":"2022","journal-title":"Biomater. Adv."},{"key":"D6TB01241H\/cit8\/1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00253-025-13529-8","volume":"109","author":"Zhang","year":"2025","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"D6TB01241H\/cit9\/1","doi-asserted-by":"crossref","first-page":"118762","DOI":"10.1016\/j.carbpol.2021.118762","volume":"275","author":"Shi","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"D6TB01241H\/cit10\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jconrel.2024.05.031","volume":"371","author":"Ahmed","year":"2024","journal-title":"J. Controlled Release"},{"key":"D6TB01241H\/cit11\/1","doi-asserted-by":"crossref","first-page":"167859","DOI":"10.1016\/j.cej.2025.167859","volume":"522","author":"Yuan","year":"2025","journal-title":"Chem. Eng. J."},{"key":"D6TB01241H\/cit12\/1","doi-asserted-by":"crossref","first-page":"e2414548","DOI":"10.1002\/advs.202414548","volume":"12","author":"Jiang","year":"2025","journal-title":"Adv. Sci."},{"key":"D6TB01241H\/cit13\/1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/s44222-023-00141-6","volume":"2","author":"Zheng","year":"2024","journal-title":"Nat. Rev. Bioeng."},{"key":"D6TB01241H\/cit14\/1","doi-asserted-by":"crossref","first-page":"37065","DOI":"10.1021\/acsnano.5c10610","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"D6TB01241H\/cit15\/1","doi-asserted-by":"crossref","first-page":"e2102327","DOI":"10.1002\/advs.202102327","volume":"8","author":"Cui","year":"2021","journal-title":"Adv. Sci."},{"key":"D6TB01241H\/cit16\/1","doi-asserted-by":"crossref","first-page":"118808","DOI":"10.1016\/j.ijpharm.2019.118808","volume":"572","author":"Roy","year":"2019","journal-title":"Int. J. Pharm."},{"key":"D6TB01241H\/cit17\/1","doi-asserted-by":"crossref","first-page":"eadv1661","DOI":"10.1126\/sciadv.adv1661","volume":"11","author":"Wang","year":"2025","journal-title":"Sci. Adv."},{"key":"D6TB01241H\/cit18\/1","doi-asserted-by":"crossref","first-page":"100762","DOI":"10.1016\/j.preteyeres.2019.05.003","volume":"73","author":"Al-Aqaba","year":"2019","journal-title":"Prog. Retinal Eye Res."},{"key":"D6TB01241H\/cit19\/1","doi-asserted-by":"crossref","first-page":"100987","DOI":"10.1016\/j.preteyeres.2021.100987","volume":"87","author":"Catal\u00e0","year":"2022","journal-title":"Prog. Retinal Eye Res."},{"key":"D6TB01241H\/cit20\/1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jtos.2020.10.006","volume":"19","author":"Kamil","year":"2021","journal-title":"Ocul. Surf."},{"key":"D6TB01241H\/cit21\/1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jtos.2023.08.001","volume":"30","author":"Kaur","year":"2023","journal-title":"Ocul. Surf."},{"key":"D6TB01241H\/cit22\/1","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3390\/pharmaceutics14081625","volume":"14","author":"Yan","year":"2022","journal-title":"Pharmaceutics"},{"key":"D6TB01241H\/cit23\/1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.ajo.2007.02.016","volume":"143","author":"Sun","year":"2007","journal-title":"Am. J. Ophthalmol."},{"key":"D6TB01241H\/cit24\/1","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3390\/jof10100689","volume":"10","author":"Lamas-Francis","year":"2024","journal-title":"J. Fungi"},{"key":"D6TB01241H\/cit25\/1","doi-asserted-by":"crossref","first-page":"771763","DOI":"10.3389\/fbioe.2021.771763","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D6TB01241H\/cit26\/1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.actbio.2013.09.025","volume":"10","author":"Thomasy","year":"2014","journal-title":"Acta Biomater."},{"key":"D6TB01241H\/cit27\/1","doi-asserted-by":"crossref","first-page":"e2500833","DOI":"10.1002\/advs.202500833","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."},{"key":"D6TB01241H\/cit28\/1","doi-asserted-by":"crossref","first-page":"882392","DOI":"10.3389\/fbioe.2022.882392","volume":"10","author":"Song","year":"2022","journal-title":"Front. Bioeng.\nBiotechnol."},{"key":"D6TB01241H\/cit29\/1","doi-asserted-by":"crossref","first-page":"126418","DOI":"10.1016\/j.ijpharm.2025.126418","volume":"688","author":"Shen","year":"2026","journal-title":"Int. J. Pharm."},{"key":"D6TB01241H\/cit30\/1","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1038\/s41467-018-06981-w","volume":"9","author":"Than","year":"2018","journal-title":"Nat. Commun."},{"key":"D6TB01241H\/cit31\/1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0168-3659(97)00106-5","volume":"50","author":"Zambaux","year":"1998","journal-title":"J. Controlled Release"},{"key":"D6TB01241H\/cit32\/1","doi-asserted-by":"crossref","first-page":"33793","DOI":"10.1021\/acsomega.2c02141","volume":"7","author":"Ekinci","year":"2022","journal-title":"ACS Omega"},{"key":"D6TB01241H\/cit33\/1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3390\/nano13010155","volume":"13","author":"Uroro","year":"2022","journal-title":"Nanomaterials"},{"key":"D6TB01241H\/cit34\/1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.jconrel.2012.05.037","volume":"161","author":"Van de Ven","year":"2012","journal-title":"J. Controlled Release"},{"key":"D6TB01241H\/cit35\/1","doi-asserted-by":"crossref","first-page":"111279","DOI":"10.1016\/j.msec.2020.111279","volume":"117","author":"Singh","year":"2020","journal-title":"Mater. Sci. Eng., C"},{"key":"D6TB01241H\/cit36\/1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.colsurfb.2015.07.032","volume":"139","author":"Butani","year":"2016","journal-title":"Colloids Surf., B"},{"key":"D6TB01241H\/cit37\/1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0168-3659(02)00347-4","volume":"87","author":"Adams","year":"2003","journal-title":"J. Controlled Release"},{"key":"D6TB01241H\/cit38\/1","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.3390\/pharmaceutics17091100","volume":"17","author":"Jin","year":"2025","journal-title":"Pharmaceutics"},{"key":"D6TB01241H\/cit39\/1","doi-asserted-by":"crossref","first-page":"e2002287","DOI":"10.1002\/adhm.202002287","volume":"10","author":"Park","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"D6TB01241H\/cit40\/1","doi-asserted-by":"crossref","first-page":"1123393","DOI":"10.3389\/fcimb.2023.1123393","volume":"13","author":"Lu","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"D6TB01241H\/cit41\/1","doi-asserted-by":"crossref","first-page":"948","DOI":"10.3389\/fbioe.2020.00948","volume":"8","author":"He","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"D6TB01241H\/cit42\/1","doi-asserted-by":"crossref","first-page":"869429","DOI":"10.3389\/fmed.2022.869429","volume":"9","author":"Zhao","year":"2022","journal-title":"Front. Med."},{"key":"D6TB01241H\/cit43\/1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.carbpol.2018.08.142","volume":"202","author":"V\u00e1squez Marcano","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"D6TB01241H\/cit44\/1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s13346-021-00974-x","volume":"12","author":"Durgun","year":"2022","journal-title":"Drug Delivery Transl. Res."},{"key":"D6TB01241H\/cit45\/1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.jare.2024.07.020","volume":"72","author":"Liu","year":"2025","journal-title":"J. Adv. Res."},{"key":"D6TB01241H\/cit46\/1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/jps.23439","volume":"102","author":"Olatunji","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"D6TB01241H\/cit47\/1","doi-asserted-by":"crossref","first-page":"12983","DOI":"10.1038\/s41598-020-69909-9","volume":"10","author":"Pitre, Jr.","year":"2020","journal-title":"Sci. Rep."},{"key":"D6TB01241H\/cit48\/1","first-page":"133","volume":"50","author":"Hatami-Marbini","year":"2013","journal-title":"Biorheology"},{"key":"D6TB01241H\/cit49\/1","doi-asserted-by":"crossref","first-page":"103701","DOI":"10.1016\/j.ijengsci.2022.103701","volume":"176","author":"Xiao","year":"2022","journal-title":"Int. J. Eng. Sci."},{"key":"D6TB01241H\/cit50\/1","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/j.survophthal.2018.05.004","volume":"63","author":"Ma","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"D6TB01241H\/cit51\/1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.actbio.2018.06.005","volume":"75","author":"Cui","year":"2018","journal-title":"Acta Biomater."},{"key":"D6TB01241H\/cit52\/1","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1080\/17425247.2024.2420750","volume":"21","author":"Kailasam","year":"2024","journal-title":"Expert Opin. Drug Delivery"},{"key":"D6TB01241H\/cit53\/1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.ijbiomac.2020.02.166","volume":"152","author":"Richter","year":"2020","journal-title":"Int. J. Biol. Macromol."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/TB\/article-pdf\/doi\/10.1039\/D6TB01241H\/0\/D6TB01241H.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:46:32Z","timestamp":1790167592000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/TB\/article-lookup\/doi\/10.1039\/D6TB01241H"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":53,"journal-issue":{"issue":"36","published-print":{"date-parts":[[2026,9,23]]}},"URL":"https:\/\/doi.org\/10.1039\/d6tb01241h","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}