{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:55:10Z","timestamp":1791395710426,"version":"4.3.3"},"reference-count":44,"publisher":"Royal Society of Chemistry (RSC)","issue":"38","license":[{"start":{"date-parts":[[2027,9,3]],"date-time":"2027-09-03T00:00:00Z","timestamp":1819929600000},"content-version":"am","delay-in-days":610,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/100012556","name":"Sichuan Provincial Youth Science and Technology Foundation","doi-asserted-by":"publisher","award":["2024NSFSC0002"],"award-info":[{"award-number":["2024NSFSC0002"]}],"id":[{"id":"10.13039\/100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012556","name":"Sichuan Provincial Youth Science and Technology Foundation","doi-asserted-by":"publisher","award":["2025ZDZX0099"],"award-info":[{"award-number":["2025ZDZX0099"]}],"id":[{"id":"10.13039\/100012556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["ZYGD23037"],"award-info":[{"award-number":["ZYGD23037"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>\n                    An injectable, tissue-adhesive OP\/bECM@Z hydrogel combines bone-specific cues with sustained Zn\n                    <jats:sup>2+<\/jats:sup>\n                    release to promote bone regeneration\n                    <jats:italic>via<\/jats:italic>\n                    immunomodulation, vascular maturation, and Rap1-mediated angiogenesis\u2013osteogenesis coupling.\n                  <\/jats:p>","DOI":"10.1039\/d6tb01286h","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:22:36Z","timestamp":1788452556000},"page":"11923-11942","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A bioinspired adhesive hydrogel promotes bone regeneration through osteoimmunomodulation and angiogenic\u2013osteogenic coupling"],"prefix":"10.1039","volume":"14","author":[{"given":"Yan-Lin","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Ye","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Animal Laboratory Center, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Yu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hui","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian-Jin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long-Mei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Xue","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1063-857X","authenticated-orcid":false,"given":"Ting-Wu","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0760-0853","authenticated-orcid":false,"given":"Hui-Qi","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"9","key":"D6TB01286H\/cit1\/1","doi-asserted-by":"publisher","first-page":"e580","DOI":"10.1016\/S2666-7568(21)00172-0","volume":"2","author":"GBD 2019 Fracture Collaborators","year":"2021","unstructured":"GBD 2019 Fracture Collaborators , Global, regional, and national burden of bone fractures in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019,  The Lancet Healthy Longevity ,  2021 ,  2 ( 9 ),  e580e592 10.1016\/S2666-7568(21)00172-0"},{"issue":"3","key":"D6TB01286H\/cit2\/1","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1007\/s00590-017-2063-0","volume":"28","author":"Roddy","year":"2018","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"D6TB01286H\/cit3\/1","doi-asserted-by":"publisher","first-page":"121114","DOI":"10.1016\/j.biomaterials.2021.121114","volume":"277","author":"Newman","year":"2021","journal-title":"Biomaterials"},{"key":"D6TB01286H\/cit4\/1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.20517\/2347-9264.2024.153","volume":"12","author":"Patel","year":"2025","journal-title":"Plast. Aesthet. Res."},{"key":"D6TB01286H\/cit5\/1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.addr.2019.05.005","volume":"149\u2013150","author":"O'Brien","year":"2019","journal-title":"Adv. Drug Delivery Rev."},{"key":"D6TB01286H\/cit6\/1","doi-asserted-by":"publisher","first-page":"100121","DOI":"10.1016\/j.bmt.2025.100121","volume":"12","author":"Viraji","year":"2025","journal-title":"Biomed. Technol."},{"issue":"1","key":"D6TB01286H\/cit7\/1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41413-025-00417-0","volume":"13","author":"Li","year":"2025","journal-title":"Bone Res."},{"issue":"2","key":"D6TB01286H\/cit8\/1","doi-asserted-by":"publisher","first-page":"e2304641","DOI":"10.1002\/advs.202304641","volume":"11","author":"Wu","year":"2024","journal-title":"Adv. Sci."},{"issue":"1","key":"D6TB01286H\/cit9\/1","doi-asserted-by":"publisher","first-page":"113064","DOI":"10.1016\/j.yexcr.2022.113064","volume":"413","author":"Han","year":"2022","journal-title":"Exp. Cell Res."},{"issue":"10","key":"D6TB01286H\/cit10\/1","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.20517\/2347-9264.2025.09","volume":"12","author":"Vignolo","year":"2025","journal-title":"Plast. Aesthet. Res."},{"key":"D6TB01286H\/cit11\/1","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jconrel.2024.08.011","volume":"374","author":"Niu","year":"2024","journal-title":"J. Controlled Release"},{"issue":"26","key":"D6TB01286H\/cit12\/1","doi-asserted-by":"publisher","first-page":"e2400349","DOI":"10.1002\/advs.202400349","volume":"11","author":"Huang","year":"2024","journal-title":"Adv. Sci."},{"issue":"30","key":"D6TB01286H\/cit13\/1","doi-asserted-by":"publisher","first-page":"e2401919","DOI":"10.1002\/adhm.202401919","volume":"13","author":"Liu","year":"2024","journal-title":"Adv. Healthcare Mater."},{"key":"D6TB01286H\/cit14\/1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.bioactmat.2025.02.033","volume":"49","author":"Gai","year":"2025","journal-title":"Bioact. Mater."},{"key":"D6TB01286H\/cit15\/1","doi-asserted-by":"publisher","first-page":"119552","DOI":"10.1016\/j.biomaterials.2019.119552","volume":"227","author":"Qiu","year":"2020","journal-title":"Biomaterials"},{"issue":"23","key":"D6TB01286H\/cit16\/1","doi-asserted-by":"publisher","first-page":"3350","DOI":"10.1039\/c7cc00765e","volume":"53","author":"Pettignano","year":"2017","journal-title":"Chem. Commun."},{"key":"D6TB01286H\/cit17\/1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.bioactmat.2022.02.034","volume":"16","author":"Zou","year":"2022","journal-title":"Bioact. Mater."},{"issue":"34","key":"D6TB01286H\/cit18\/1","doi-asserted-by":"publisher","first-page":"6881","DOI":"10.1039\/d1tb00895a","volume":"9","author":"Dong","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"D6TB01286H\/cit19\/1","doi-asserted-by":"publisher","first-page":"100099","DOI":"10.1016\/j.bmt.2025.100099","volume":"11","author":"Cai","year":"2025","journal-title":"Biomed. Technol."},{"issue":"10","key":"D6TB01286H\/cit20\/1","doi-asserted-by":"publisher","first-page":"4014","DOI":"10.7150\/thno.97335","volume":"14","author":"Wu","year":"2024","journal-title":"Theranostics"},{"issue":"10","key":"D6TB01286H\/cit21\/1","doi-asserted-by":"publisher","first-page":"5630","DOI":"10.7150\/thno.130240","volume":"16","author":"Zhu","year":"2026","journal-title":"Theranostics"},{"key":"D6TB01286H\/cit22\/1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.bioactmat.2022.12.015","volume":"24","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"issue":"25","key":"D6TB01286H\/cit23\/1","doi-asserted-by":"publisher","first-page":"4725","DOI":"10.1039\/d2sm00410k","volume":"18","author":"Kamio","year":"2022","journal-title":"Soft Matter"},{"issue":"3","key":"D6TB01286H\/cit24\/1","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1021\/bm801197m","volume":"10","author":"Park","year":"2009","journal-title":"Biomacromolecules"},{"issue":"2","key":"D6TB01286H\/cit25\/1","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1021\/acsbiomaterials.9b01549","volume":"6","author":"Nishiguchi","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"9","key":"D6TB01286H\/cit26\/1","doi-asserted-by":"publisher","first-page":"577","DOI":"10.3390\/gels8090577","volume":"8","author":"Han","year":"2022","journal-title":"Gels"},{"key":"D6TB01286H\/cit27\/1","doi-asserted-by":"publisher","first-page":"119953","DOI":"10.1016\/j.carbpol.2022.119953","volume":"296","author":"Li","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"33","key":"D6TB01286H\/cit28\/1","doi-asserted-by":"publisher","first-page":"9058","DOI":"10.1016\/j.biomaterials.2014.07.036","volume":"35","author":"Kim","year":"2014","journal-title":"Biomaterials"},{"key":"D6TB01286H\/cit29\/1","doi-asserted-by":"publisher","first-page":"100698","DOI":"10.1016\/j.mtadv.2026.100698","volume":"29","author":"Zhu","year":"2026","journal-title":"Mater. Today Adv."},{"key":"D6TB01286H\/cit30\/1","doi-asserted-by":"publisher","first-page":"119833","DOI":"10.1016\/j.biomaterials.2020.119833","volume":"239","author":"Mahon","year":"2020","journal-title":"Biomaterials"},{"key":"D6TB01286H\/cit31\/1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.bioactmat.2021.07.030","volume":"9","author":"He","year":"2021","journal-title":"Bioact. Mater."},{"key":"D6TB01286H\/cit32\/1","doi-asserted-by":"publisher","first-page":"e658","DOI":"10.1002\/mco2.658","volume":"5","author":"Yan","year":"2024","journal-title":"MedComm"},{"issue":"11","key":"D6TB01286H\/cit33\/1","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1016\/j.yexcr.2013.03.026","volume":"319","author":"Baer","year":"2013","journal-title":"Exp. Cell Res."},{"key":"D6TB01286H\/cit34\/1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jot.2022.09.001","volume":"37","author":"Xu","year":"2022","journal-title":"J. Orthop. Translat."},{"key":"D6TB01286H\/cit35\/1","doi-asserted-by":"publisher","first-page":"121038","DOI":"10.1016\/j.biomaterials.2021.121038","volume":"276","author":"Qiao","year":"2021","journal-title":"Biomaterials"},{"key":"D6TB01286H\/cit36\/1","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.actbio.2022.10.024","volume":"154","author":"Toita","year":"2022","journal-title":"Acta Biomater."},{"issue":"9","key":"D6TB01286H\/cit37\/1","doi-asserted-by":"publisher","first-page":"e10733","DOI":"10.1002\/smll.202510733","volume":"22","author":"Yang","year":"2026","journal-title":"Small"},{"issue":"11","key":"D6TB01286H\/cit38\/1","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1016\/j.yexcr.2013.03.026","volume":"319","author":"Baer","year":"2013","journal-title":"Exp. Cell Res."},{"key":"D6TB01286H\/cit39\/1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.bone.2016.06.013","volume":"91","author":"Hu","year":"2016","journal-title":"Bone"},{"key":"D6TB01286H\/cit40\/1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.actbio.2021.10.044","volume":"138","author":"Huang","year":"2022","journal-title":"Acta Biomater."},{"issue":"46","key":"D6TB01286H\/cit41\/1","doi-asserted-by":"publisher","first-page":"2507840","DOI":"10.1002\/adfm.202507840","volume":"35","author":"Chen","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"D6TB01286H\/cit42\/1","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.1007\/s42765-025-00596-9","author":"Jiang","year":"2025","journal-title":"Adv. Fiber Mater."},{"issue":"1","key":"D6TB01286H\/cit43\/1","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1158\/1078-0432.CCR-09-1122","volume":"16","author":"Goto","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"D6TB01286H\/cit44\/1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.actbio.2021.10.044","volume":"138","author":"Huang","year":"2022","journal-title":"Acta Biomater."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/TB\/article-pdf\/doi\/10.1039\/D6TB01286H\/0\/D6TB01286H.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:17:39Z","timestamp":1791393459000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/TB\/article-lookup\/doi\/10.1039\/D6TB01286H"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":44,"journal-issue":{"issue":"38","published-print":{"date-parts":[[2026,10,7]]}},"URL":"https:\/\/doi.org\/10.1039\/d6tb01286h","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}