{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:17:34Z","timestamp":1787768254290,"version":"build-2784847793"},"reference-count":68,"publisher":"Royal Society of Chemistry (RSC)","issue":"33","license":[{"start":{"date-parts":[[2027,8,11]],"date-time":"2027-08-11T00:00:00Z","timestamp":1817942400000},"content-version":"am","delay-in-days":587,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071321"],"award-info":[{"award-number":["32071321"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473130"],"award-info":[{"award-number":["52473130"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015956","name":"Special Project for Research and Development in Key areas of Guangdong Province","doi-asserted-by":"publisher","award":["2023B0909020003"],"award-info":[{"award-number":["2023B0909020003"]}],"id":[{"id":"10.13039\/501100015956","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["J. Mater. Chem. B"],"abstract":"<jats:p>This study reports an acellular cartilage matrix microgel assembly. After injection, SIM recruits microfracture-derived BMSCs, while Cur released from ZIF-8 inhibits pyroptosis, synergistically promoting hyaline cartilage regeneration.<\/jats:p>","DOI":"10.1039\/d6tb01437b","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T07:04:06Z","timestamp":1786431846000},"page":"10445-10463","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acellular matrix microgel assembly integrated with curcumin-loaded ZIF-8 nanoparticles and simvastatin promotes microfracture-based articular cartilage repair\n                    <i>via<\/i>\n                    pyroptosis inhibition, endogenous BMSC recruitment, and hyaline chondrogenic differentiation"],"prefix":"10.1039","volume":"14","author":[{"given":"Junlin","family":"Chen","sequence":"first","affiliation":[{"name":"School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), Guangzhou, 510006, China"},{"name":"Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510641, China"},{"name":"Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7658-4370","authenticated-orcid":false,"given":"Qingtao","family":"Li","sequence":"additional","affiliation":[{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), Guangzhou, 510006, China"},{"name":"Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510641, China"},{"name":"Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510641, China"},{"name":"School of Medicine, South China University of Technology, Guangzhou, 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuhan","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), Guangzhou, 510006, China"},{"name":"Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), Guangzhou, 510006, China"},{"name":"Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zibo","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), Guangzhou, 510006, China"},{"name":"Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510641, China"},{"name":"Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8794-3436","authenticated-orcid":false,"given":"Hua","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China"},{"name":"National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), Guangzhou, 510006, China"},{"name":"Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou, 510641, China"},{"name":"Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510641, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"292","published-online":{"date-parts":[[2026]]},"reference":[{"key":"D6TB01437B\/cit1\/1","doi-asserted-by":"publisher","first-page":"123084","DOI":"10.1016\/j.biomaterials.2025.123084","volume":"317","author":"Liu","year":"2025","journal-title":"Biomaterials"},{"key":"D6TB01437B\/cit2\/1","doi-asserted-by":"publisher","first-page":"202403079","DOI":"10.1002\/adhm.202403079","author":"Cao","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"D6TB01437B\/cit3\/1","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.bioactmat.2020.09.030","volume":"6","author":"Wei","year":"2021","journal-title":"Bioact. Mater."},{"key":"D6TB01437B\/cit4\/1","doi-asserted-by":"publisher","first-page":"121216","DOI":"10.1016\/j.biomaterials.2021.121216","volume":"279","author":"Liu","year":"2021","journal-title":"Biomaterials"},{"key":"D6TB01437B\/cit5\/1","doi-asserted-by":"publisher","first-page":"101735","DOI":"10.1016\/j.mtbio.2025.101735","author":"Tavares","year":"2025","journal-title":"Mater. Today Bio"},{"key":"D6TB01437B\/cit6\/1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1021\/acs.accounts.6b00544","volume":"50","author":"Plamper","year":"2017","journal-title":"Acc. Chem. Res."},{"key":"D6TB01437B\/cit7\/1","doi-asserted-by":"publisher","first-page":"25099","DOI":"10.1021\/acsami.8b06648","volume":"10","author":"Cai","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6TB01437B\/cit8\/1","doi-asserted-by":"publisher","first-page":"6265","DOI":"10.1039\/d3tb00346a","volume":"11","author":"Zheng","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"D6TB01437B\/cit9\/1","doi-asserted-by":"publisher","first-page":"2200304","DOI":"10.1002\/adem.202200304","volume":"24","author":"Liu","year":"2022","journal-title":"Adv. Eng. Mater."},{"key":"D6TB01437B\/cit10\/1","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1038\/s41584-025-01236-7","volume":"21","author":"Pueyo Moliner","year":"2025","journal-title":"Nat. Rev. Rheumatol."},{"key":"D6TB01437B\/cit11\/1","doi-asserted-by":"publisher","first-page":"2212325","DOI":"10.1002\/adfm.202212325","volume":"33","author":"Arin","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"D6TB01437B\/cit12\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.biomaterials.2016.04.018","volume":"98","author":"Huang","year":"2016","journal-title":"Biomaterials"},{"key":"D6TB01437B\/cit13\/1","doi-asserted-by":"publisher","first-page":"2001008","DOI":"10.1002\/adhm.202001008","volume":"9","author":"Zhou","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"D6TB01437B\/cit14\/1","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.actbio.2024.03.025","volume":"179","author":"Yan","year":"2024","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit15\/1","doi-asserted-by":"publisher","first-page":"035007","DOI":"10.1088\/1758-5090\/ab7e74","volume":"12","author":"Wen","year":"2020","journal-title":"Biofabrication"},{"key":"D6TB01437B\/cit16\/1","doi-asserted-by":"publisher","first-page":"5773","DOI":"10.1016\/j.celbio.2025.100220","volume":"25","author":"Malda","year":"2004","journal-title":"Biomaterials"},{"key":"D6TB01437B\/cit17\/1","doi-asserted-by":"publisher","first-page":"100234","DOI":"10.1016\/j.mtbio.2022.100234","volume":"14","author":"Wang","year":"2022","journal-title":"Mater. Today Bio"},{"key":"D6TB01437B\/cit18\/1","doi-asserted-by":"publisher","first-page":"24415","DOI":"10.1021\/acsami.6b06825","volume":"8","author":"Chen","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6TB01437B\/cit19\/1","doi-asserted-by":"publisher","first-page":"1903279","DOI":"10.1002\/adfm.201903279","volume":"29","author":"Zhang","year":"2019","journal-title":"Adv. Funct. Mater."},{"key":"D6TB01437B\/cit20\/1","doi-asserted-by":"publisher","first-page":"100962","DOI":"10.1016\/j.mtbio.2024.100962","volume":"25","author":"Wu","year":"2024","journal-title":"Mater. Today Bio"},{"key":"D6TB01437B\/cit21\/1","doi-asserted-by":"publisher","first-page":"2400223","DOI":"10.1002\/smtd.202400223","volume":"8","author":"Xu","year":"2024","journal-title":"Small Methods"},{"key":"D6TB01437B\/cit22\/1","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1016\/s0140-6736(16)31658-0","volume":"388","author":"Mumme","year":"2016","journal-title":"Lancet"},{"key":"D6TB01437B\/cit23\/1","doi-asserted-by":"publisher","first-page":"6131","DOI":"10.1021\/acsnano.3c01789","volume":"17","author":"Lu","year":"2023","journal-title":"ACS Nano"},{"key":"D6TB01437B\/cit24\/1","doi-asserted-by":"publisher","first-page":"10667","DOI":"10.1021\/acsnano.4c00780","volume":"18","author":"Zhou","year":"2024","journal-title":"ACS Nano"},{"key":"D6TB01437B\/cit25\/1","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.apsb.2021.02.006","volume":"11","author":"Burdette","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"D6TB01437B\/cit26\/1","doi-asserted-by":"publisher","first-page":"17184","DOI":"10.1021\/acsami.9b01218","volume":"11","author":"Sarkar","year":"2019","journal-title":"ACS Appl.\nMater. Interfaces"},{"key":"D6TB01437B\/cit27\/1","doi-asserted-by":"publisher","first-page":"167364","DOI":"10.1016\/j.cej.2025.167364","volume":"522","author":"Shao","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"10","key":"D6TB01437B\/cit28\/1","doi-asserted-by":"publisher","first-page":"12089","DOI":"10.1021\/acsami.2c00997","volume":"14","author":"Xia","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6TB01437B\/cit29\/1","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.biomaterials.2016.09.002","volume":"108","author":"Man","year":"2016","journal-title":"Biomaterials"},{"key":"D6TB01437B\/cit30\/1","doi-asserted-by":"publisher","first-page":"133495","DOI":"10.1016\/j.ijbiomac.2024.133495","volume":"274","author":"Shi","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"D6TB01437B\/cit31\/1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.actbio.2023.09.008","volume":"171","author":"Thomas","year":"2023","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit32\/1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.actbio.2017.12.043","volume":"69","author":"Yang","year":"2018","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit33\/1","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/s41584-019-0255-1","volume":"15","author":"Kwon","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"D6TB01437B\/cit34\/1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.bioactmat.2024.12.021","volume":"46","author":"Shanto","year":"2024","journal-title":"Bioact. Mater."},{"key":"D6TB01437B\/cit35\/1","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.actbio.2018.09.038","volume":"80","author":"Liang","year":"2018","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit36\/1","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.actbio.2019.09.017","volume":"99","author":"Levinson","year":"2019","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit37\/1","doi-asserted-by":"publisher","first-page":"157687","DOI":"10.1016\/j.cej.2024.157687","volume":"501","author":"Wang","year":"2024","journal-title":"Chem. Eng. J."},{"key":"D6TB01437B\/cit38\/1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.bioactmat.2024.10.013","volume":"44","author":"Chen","year":"2025","journal-title":"Bioact. Mater."},{"key":"D6TB01437B\/cit39\/1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.actbio.2018.01.039","volume":"69","author":"Yang","year":"2018","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit40\/1","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1186\/s12951-024-02712-0","volume":"22","author":"Chen","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"D6TB01437B\/cit41\/1","doi-asserted-by":"publisher","first-page":"102103","DOI":"10.1016\/j.mtbio.2025.102103","volume":"33","author":"Kuang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"D6TB01437B\/cit42\/1","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.actbio.2022.06.040","volume":"149","author":"Xie","year":"2022","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit43\/1","doi-asserted-by":"publisher","first-page":"2008451","DOI":"10.1002\/adma.202008451","volume":"33","author":"Maih\u00f6fer","year":"2021","journal-title":"Adv. Mater."},{"key":"D6TB01437B\/cit44\/1","doi-asserted-by":"publisher","first-page":"250394","DOI":"10.1002\/adfm.202503948","volume":"8","author":"Niu","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"D6TB01437B\/cit45\/1","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.bioactmat.2022.06.015","volume":"20","author":"Guo","year":"2022","journal-title":"Bioact. Mater."},{"key":"D6TB01437B\/cit46\/1","doi-asserted-by":"publisher","first-page":"119409","DOI":"10.1016\/j.biomaterials.2019.119409","volume":"220","author":"Tee","year":"2019","journal-title":"Biomaterials"},{"key":"D6TB01437B\/cit47\/1","doi-asserted-by":"publisher","first-page":"150447","DOI":"10.1016\/j.ijbiomac.2026.150447","volume":"344","author":"Yao","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"key":"D6TB01437B\/cit48\/1","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1186\/s12951-021-01086-x","volume":"19","author":"Li","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"D6TB01437B\/cit49\/1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.actbio.2020.07.008","volume":"114","author":"Yang","year":"2020","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit50\/1","doi-asserted-by":"publisher","first-page":"2505544","DOI":"10.1002\/adma.202505544","volume":"37","author":"Zhang","year":"2025","journal-title":"Adv. Mater."},{"key":"D6TB01437B\/cit51\/1","doi-asserted-by":"publisher","first-page":"2405979","DOI":"10.1002\/smll.202405979","volume":"20","author":"Hao","year":"2024","journal-title":"Small"},{"key":"D6TB01437B\/cit52\/1","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.bioactmat.2021.07.004","volume":"9","author":"Zhu","year":"2021","journal-title":"Bioact. Mater."},{"key":"D6TB01437B\/cit53\/1","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.actbio.2021.07.003","volume":"131","author":"Middendorf","year":"2021","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit54\/1","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.bioactmat.2023.03.008","volume":"26","author":"Zhou","year":"2023","journal-title":"Bioact. Mater."},{"key":"D6TB01437B\/cit55\/1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.actbio.2020.10.025","volume":"118","author":"Weizel","year":"2020","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit56\/1","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.actbio.2023.08.060","volume":"170","author":"Cui","year":"2023","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit57\/1","doi-asserted-by":"publisher","first-page":"2501496","DOI":"10.1002\/adhm.202501496","volume":"14","author":"Chen","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"D6TB01437B\/cit58\/1","doi-asserted-by":"publisher","first-page":"2405601","DOI":"10.1002\/adfm.202405601","volume":"34","author":"Pan","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"D6TB01437B\/cit59\/1","doi-asserted-by":"publisher","first-page":"37301","DOI":"10.1021\/acsami.2c06865","volume":"14","author":"Sharma","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D6TB01437B\/cit60\/1","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.actbio.2021.07.038","volume":"134","author":"Tao","year":"2021","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit61\/1","doi-asserted-by":"publisher","first-page":"100489","DOI":"10.1016\/j.mtbio.2022.100489","volume":"17","author":"Hua","year":"2022","journal-title":"Mater. Today Bio"},{"key":"D6TB01437B\/cit62\/1","doi-asserted-by":"publisher","first-page":"2102395","DOI":"10.1002\/adhm.202102395","volume":"11","author":"Feng","year":"2021","journal-title":"Adv. Healthcare Mater."},{"key":"D6TB01437B\/cit63\/1","doi-asserted-by":"publisher","first-page":"147940","DOI":"10.1016\/j.ijbiomac.2025.147940","volume":"330","author":"Zeng","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"D6TB01437B\/cit64\/1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.actbio.2019.12.029","volume":"103","author":"Hussein","year":"2020","journal-title":"Acta Biomater."},{"key":"D6TB01437B\/cit65\/1","doi-asserted-by":"publisher","first-page":"9853","DOI":"10.1021\/acs.nanolett.1c01920","volume":"21","author":"Predeina","year":"2021","journal-title":"Nano Lett."},{"key":"D6TB01437B\/cit66\/1","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.bioactmat.2023.05.001","volume":"8","author":"Jin","year":"2023","journal-title":"Bioact. Mater."},{"key":"D6TB01437B\/cit67\/1","doi-asserted-by":"publisher","first-page":"100530","DOI":"10.1016\/j.mtbio.2022.100530","volume":"18","author":"Wang","year":"2022","journal-title":"Mater. Today Bio"},{"key":"D6TB01437B\/cit68\/1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.actbio.2020.06.046","volume":"113","author":"Feng","year":"2020","journal-title":"Acta Biomater."}],"container-title":["Journal of Materials Chemistry B"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/TB\/article-pdf\/doi\/10.1039\/D6TB01437B\/0\/D6TB01437B.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:20:47Z","timestamp":1787764847000},"score":1,"resource":{"primary":{"URL":"http:\/\/pubs.rsc.org\/TB\/article-lookup\/doi\/10.1039\/D6TB01437B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":68,"journal-issue":{"issue":"33","published-print":{"date-parts":[[2026,8,26]]}},"URL":"https:\/\/doi.org\/10.1039\/d6tb01437b","relation":{},"ISSN":["2050-750X","2050-7518"],"issn-type":[{"value":"2050-750X","type":"print"},{"value":"2050-7518","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]}}}