{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T17:40:08Z","timestamp":1751737208332,"version":"3.41.0"},"reference-count":113,"publisher":"The Royal Society of Chemistry","isbn-type":[{"type":"print","value":"9781788011136"},{"type":"print","value":"9781788011136"},{"type":"electronic","value":"9781788014663"},{"type":"electronic","value":"9781788013536"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,10]]},"abstract":"<jats:p>The design of systems that are able to deliver drugs in a controlled manner to specific organs, tissues and\/or cells targets has been a major goal, as well as a huge challenge, in the field of nanomedicine. Besides the possibility of passive and active targeting, stimuli-responsive nanomedicines can effectively release drugs after being exposed to specific microenvironmental conditions, resulting from natural or pathological processes. In particular, thermo-responsive nanomedicines, systems that release the drug when triggered by variations in microenvironmental temperature, have been shown to be promising for the treatment of multiple medical conditions, including inflammation and cancer. Since inflammatory and cancerous tissues present temperature values above those considered physiological, several nanomedicines have been developed by using thermo-responsive polymers that can be engineered in order to release their cargo in response to mild temperature changes. In such a way, these systems may increase the drug concentration at the desired site, while healthy tissues are minimally affected. This chapter discusses the use of thermo-responsive nanomedicines for the delivery of drugs in the specific context of the gastrointestinal tract. In particular, the importance of nanotechnology in the development of thermo-responsive formulations for the treatment of inflammatory bowel diseases and gastrointestinal cancers is addressed.<\/jats:p>","DOI":"10.1039\/9781788013536-00083","type":"book-chapter","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T14:00:19Z","timestamp":1531144819000},"page":"83-108","source":"Crossref","is-referenced-by-count":2,"title":["Thermo-responsive Nanomedicines for Drug Delivery in the Gastrointestinal Tract"],"prefix":"10.1039","author":[{"given":"Andreia","family":"Almeida","sequence":"first","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto Rua Alfredo Allen, 208 4200-393 Porto Portugal bruno.sarmento@ineb.up.pt"},{"name":"Instituto de Engenharia Biom\u00e9dica (INEB), Universidade do Porto Rua Alfredo Allen, 208 4200-393 Porto Portugal"},{"name":"Instituto Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Universidade do Porto Rua de Jorge Viterbo Ferreira 228 4050-313 Porto Portugal"}]},{"given":"Helena","family":"Macedo","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto Rua Alfredo Allen, 208 4200-393 Porto Portugal bruno.sarmento@ineb.up.pt"},{"name":"Instituto de Engenharia Biom\u00e9dica (INEB), Universidade do Porto Rua Alfredo Allen, 208 4200-393 Porto Portugal"},{"name":"Instituto Ci\u00eancias Biom\u00e9dicas Abel Salazar (ICBAS), Universidade do Porto Rua de Jorge Viterbo Ferreira 228 4050-313 Porto Portugal"}]},{"given":"Jos\u00e9 das","family":"Neves","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto Rua Alfredo Allen, 208 4200-393 Porto Portugal bruno.sarmento@ineb.up.pt"},{"name":"Instituto de Engenharia Biom\u00e9dica (INEB), Universidade do Porto Rua Alfredo Allen, 208 4200-393 Porto Portugal"}]},{"given":"Bruno","family":"Sarmento","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), Universidade do Porto Rua Alfredo Allen, 208 4200-393 Porto Portugal bruno.sarmento@ineb.up.pt"},{"name":"Instituto de Engenharia Biom\u00e9dica (INEB), Universidade do Porto Rua Alfredo Allen, 208 4200-393 Porto Portugal"},{"name":"CESPU, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade Rua Central de Gandra 1317 4585-116 Gandra Portugal"}]}],"member":"292","reference":[{"key":"2023051921391784300_BK9781788011136-00083-cit1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.drudis.2007.09.003","volume":"13","author":"Reichert","year":"2008","journal-title":"Drug Discovery Today"},{"key":"2023051921391784300_BK9781788011136-00083-cit2","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.drudis.2010.08.006","volume":"15","author":"Misra","year":"2010","journal-title":"Drug Discovery Today"},{"volume-title":"Media Centre: Cancer","year":"2017","key":"2023051921391784300_BK9781788011136-00083-cit3"},{"key":"2023051921391784300_BK9781788011136-00083-cit4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1046\/j.1365-2796.2000.00742.x","volume":"248","author":"Kuper","year":"2000","journal-title":"J. Intern. Med."},{"volume-title":"Cancer Facts & Figures 2016","year":"2016","key":"2023051921391784300_BK9781788011136-00083-cit5"},{"key":"2023051921391784300_BK9781788011136-00083-cit6","first-page":"159","volume":"5","author":"Kapse-Mistry","year":"2014","journal-title":"Front. Pharmacol."},{"key":"2023051921391784300_BK9781788011136-00083-cit7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/10611860701794353","volume":"16","author":"Parveen","year":"2008","journal-title":"J. Drug Targeting"},{"key":"2023051921391784300_BK9781788011136-00083-cit8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1124\/jpet.105.088146","volume":"315","author":"Lamprecht","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2023051921391784300_BK9781788011136-00083-cit9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijpharm.2006.01.032","volume":"316","author":"Meissner","year":"2006","journal-title":"Int. J. Pharm."},{"key":"2023051921391784300_BK9781788011136-00083-cit10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.colsurfb.2011.10.003","volume":"99","author":"Ayano","year":"2012","journal-title":"Colloids Surf., B"},{"key":"2023051921391784300_BK9781788011136-00083-cit11","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/00004424-200210000-00008","volume":"37","author":"Hilger","year":"2002","journal-title":"Invest. Radiol."},{"key":"2023051921391784300_BK9781788011136-00083-cit12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.carbpol.2016.08.031","volume":"154","author":"Abreu","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"2023051921391784300_BK9781788011136-00083-cit13","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.biomaterials.2006.11.039","volume":"28","author":"Seow","year":"2007","journal-title":"Biomaterials"},{"key":"2023051921391784300_BK9781788011136-00083-cit14","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1021\/mp100021c","volume":"7","author":"Akimoto","year":"2010","journal-title":"Mol. Pharmaceutics"},{"key":"2023051921391784300_BK9781788011136-00083-cit15","doi-asserted-by":"crossref","first-page":"3832","DOI":"10.1016\/j.biomaterials.2011.01.075","volume":"32","author":"Li","year":"2011","journal-title":"Biomaterials"},{"key":"2023051921391784300_BK9781788011136-00083-cit16","first-page":"6950","volume":"60","author":"Kong","year":"2000","journal-title":"Cancer Res."},{"key":"2023051921391784300_BK9781788011136-00083-cit17","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.biomaterials.2010.10.050","volume":"32","author":"Kono","year":"2011","journal-title":"Biomaterials"},{"key":"2023051921391784300_BK9781788011136-00083-cit18","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1021\/bm1004993","volume":"11","author":"Ta","year":"2010","journal-title":"Biomacromolecules"},{"key":"2023051921391784300_BK9781788011136-00083-cit19","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1021\/mp9000926","volume":"6","author":"Tirosh","year":"2009","journal-title":"Mol. Pharmaceutics"},{"key":"2023051921391784300_BK9781788011136-00083-cit20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0378-5173(03)00290-4","volume":"261","author":"Wells","year":"2003","journal-title":"Int. J. Pharm."},{"key":"2023051921391784300_BK9781788011136-00083-cit21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0065-2571(00)00013-3","volume":"41","author":"Maeda","year":"2001","journal-title":"Adv. Enzyme Regul."},{"key":"2023051921391784300_BK9781788011136-00083-cit22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0168-3659(99)00248-5","volume":"65","author":"Maeda","year":"2000","journal-title":"J. Controlled Release"},{"key":"2023051921391784300_BK9781788011136-00083-cit23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1126\/science.432641","volume":"204","author":"Weinstein","year":"1979","journal-title":"Science"},{"key":"2023051921391784300_BK9781788011136-00083-cit24","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nmat3776","volume":"12","author":"Mura","year":"2013","journal-title":"Nat. Mater."},{"key":"2023051921391784300_BK9781788011136-00083-cit25","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/j.addr.2006.09.020","volume":"58","author":"Schmaljohann","year":"2006","journal-title":"Adv. Drug Delivery Rev."},{"key":"2023051921391784300_BK9781788011136-00083-cit26","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0167-7799(02)01962-5","volume":"20","author":"Jeong","year":"2002","journal-title":"Trends Biotechnol."},{"key":"2023051921391784300_BK9781788011136-00083-cit27","doi-asserted-by":"crossref","first-page":"4130","DOI":"10.1021\/ma002082h","volume":"34","author":"Kujawa","year":"2001","journal-title":"Macromolecules"},{"key":"2023051921391784300_BK9781788011136-00083-cit28","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jcis.2011.04.006","volume":"360","author":"Rejinold","year":"2011","journal-title":"J. Colloid Interface Sci."},{"key":"2023051921391784300_BK9781788011136-00083-cit29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijbiomac.2014.11.044","volume":"74","author":"Rejinold","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"volume-title":"Molecular Mechanisms of Bacterial Infection via the Gut","year":"2009","key":"2023051921391784300_BK9781788011136-00083-cit30"},{"volume-title":"Colloquium Series on Integrated Systems Physiology: From Molecule to Function","year":"2011","key":"2023051921391784300_BK9781788011136-00083-cit31"},{"key":"2023051921391784300_BK9781788011136-00083-cit32","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.biomaterials.2015.03.054","volume":"56","author":"Pereira","year":"2015","journal-title":"Biomaterials"},{"key":"2023051921391784300_BK9781788011136-00083-cit33","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0016-5085(99)70193-9","volume":"116","author":"Montgomery","year":"1999","journal-title":"Gastroenterology"},{"volume-title":"Gastrointestinal and Oesophageal Pathology","year":"1995","key":"2023051921391784300_BK9781788011136-00083-cit34"},{"key":"2023051921391784300_BK9781788011136-00083-cit35","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/bdd.699","volume":"31","author":"Weiss","year":"2010","journal-title":"Biopharm. Drug Dispos."},{"key":"2023051921391784300_BK9781788011136-00083-cit36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1023\/A:1011948703571","volume":"15","author":"Larhed","year":"1998","journal-title":"Pharm. Res."},{"key":"2023051921391784300_BK9781788011136-00083-cit37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nri2707","volume":"10","author":"Abreu","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"2023051921391784300_BK9781788011136-00083-cit38","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1461-5347(99)00142-X","volume":"2","author":"Daugherty","year":"1999","journal-title":"Pharm. Sci. Technol. Today"},{"key":"2023051921391784300_BK9781788011136-00083-cit39","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0169-409X(00)00131-9","volume":"46","author":"Jain","year":"2001","journal-title":"Adv. Drug Delivery Rev."},{"key":"2023051921391784300_BK9781788011136-00083-cit40","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1126\/science.1095833","volume":"303","author":"Allen","year":"2004","journal-title":"Science"},{"key":"2023051921391784300_BK9781788011136-00083-cit41","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0163-7827(03)00032-8","volume":"42","author":"Sapra","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"2023051921391784300_BK9781788011136-00083-cit42","doi-asserted-by":"crossref","first-page":"395","DOI":"10.3322\/caac.21199","volume":"63","author":"Thakor","year":"2013","journal-title":"Ca-Cancer J. Clin."},{"key":"2023051921391784300_BK9781788011136-00083-cit43","first-page":"193","volume":"6","author":"Maeda","year":"1988","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"2023051921391784300_BK9781788011136-00083-cit44","first-page":"G484","volume":"302","author":"Ingersoll","year":"2012","journal-title":"Am. J. Physiol.: Gastrointest. Liver Physiol."},{"key":"2023051921391784300_BK9781788011136-00083-cit45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrgastro.2015.37","volume":"12","author":"Lamprecht","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"2023051921391784300_BK9781788011136-00083-cit46","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1515\/ejnm-2013-0004","volume":"5","author":"Ali","year":"2013","journal-title":"Eur. J. Nanomed."},{"key":"2023051921391784300_BK9781788011136-00083-cit47","doi-asserted-by":"crossref","first-page":"8858","DOI":"10.1016\/j.biomaterials.2012.08.043","volume":"33","author":"Du","year":"2012","journal-title":"Biomaterials"},{"key":"2023051921391784300_BK9781788011136-00083-cit48","first-page":"6942","volume":"60","author":"Sugano","year":"2000","journal-title":"Cancer Res."},{"key":"2023051921391784300_BK9781788011136-00083-cit49","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0022-3565(25)12359-8","volume":"276","author":"Rosebrough","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2023051921391784300_BK9781788011136-00083-cit50","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1158\/0008-5472.CAN-06-1185","volume":"67","author":"Tada","year":"2007","journal-title":"Cancer Res."},{"key":"2023051921391784300_BK9781788011136-00083-cit51","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1039\/b307878g","author":"Pan","year":"2003","journal-title":"Chem. Commun."},{"key":"2023051921391784300_BK9781788011136-00083-cit52","first-page":"1210","volume":"46","author":"Rossin","year":"2005","journal-title":"J. Nucl. Med."},{"key":"2023051921391784300_BK9781788011136-00083-cit53","doi-asserted-by":"crossref","first-page":"283","DOI":"10.2174\/1389201033489685","volume":"4","author":"Mehvar","year":"2003","journal-title":"Curr. Pharm. Biotechnol."},{"key":"2023051921391784300_BK9781788011136-00083-cit54","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/jbm.820250909","volume":"25","author":"Mazid","year":"1991","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"2023051921391784300_BK9781788011136-00083-cit55","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1517\/17425247.3.3.311","volume":"3","author":"Farokhzad","year":"2006","journal-title":"Expert Opin. Drug Delivery"},{"key":"2023051921391784300_BK9781788011136-00083-cit56","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S1389-0352(99)00004-5","volume":"74","author":"Brody","year":"2000","journal-title":"Rev. Mol. Biotechnol."},{"key":"2023051921391784300_BK9781788011136-00083-cit57","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ejpb.2008.09.028","volume":"71","author":"Andrews","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"2023051921391784300_BK9781788011136-00083-cit58","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.jconrel.2012.02.006","volume":"160","author":"Devriendt","year":"2012","journal-title":"J. Controlled Release"},{"key":"2023051921391784300_BK9781788011136-00083-cit59","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1128\/IAI.01388-12","volume":"81","author":"Charania","year":"2013","journal-title":"Infect. Immun."},{"key":"2023051921391784300_BK9781788011136-00083-cit60","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jconrel.2012.06.003","volume":"162","author":"Cook","year":"2012","journal-title":"J. Controlled Release"},{"key":"2023051921391784300_BK9781788011136-00083-cit61","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/(SICI)1099-1492(199912)12:8<495::AID-NBM594>3.0.CO;2-K","volume":"12","author":"Ojugo","year":"1999","journal-title":"NMR Biomed."},{"key":"2023051921391784300_BK9781788011136-00083-cit62","first-page":"4373","volume":"49","author":"Tannock","year":"1989","journal-title":"Cancer Res."},{"key":"2023051921391784300_BK9781788011136-00083-cit63","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1517\/17425247.2012.730517","volume":"9","author":"Xiao","year":"2012","journal-title":"Expert Opin. Drug Delivery"},{"key":"2023051921391784300_BK9781788011136-00083-cit64","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jconrel.2010.08.027","volume":"148","author":"Danhier","year":"2010","journal-title":"J. Controlled Release"},{"key":"2023051921391784300_BK9781788011136-00083-cit65","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s005950300055","volume":"33","author":"Yahara","year":"2003","journal-title":"Surg. Today"},{"key":"2023051921391784300_BK9781788011136-00083-cit66","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1040-8428(01)00179-2","volume":"43","author":"Hildebrandt","year":"2002","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"2023051921391784300_BK9781788011136-00083-cit67","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/02656730500271668","volume":"21","author":"Dewhirst","year":"2005","journal-title":"Int. J. Hyperthermia"},{"key":"2023051921391784300_BK9781788011136-00083-cit68","doi-asserted-by":"crossref","first-page":"7096","DOI":"10.1016\/j.biomaterials.2010.05.045","volume":"31","author":"Kono","year":"2010","journal-title":"Biomaterials"},{"key":"2023051921391784300_BK9781788011136-00083-cit69","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1016\/j.biomaterials.2009.03.048","volume":"30","author":"Peng","year":"2009","journal-title":"Biomaterials"},{"key":"2023051921391784300_BK9781788011136-00083-cit70","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1734-1140(11)70575-8","volume":"63","author":"Pithadia","year":"2011","journal-title":"Pharmacol. Rep."},{"key":"2023051921391784300_BK9781788011136-00083-cit71","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","volume":"347","author":"Podolsky","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"2023051921391784300_BK9781788011136-00083-cit72","doi-asserted-by":"crossref","first-page":"825463","DOI":"10.1155\/2014\/825463","volume":"2014","author":"Vural","year":"2014","journal-title":"Scientifica"},{"key":"2023051921391784300_BK9781788011136-00083-cit73","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"2023051921391784300_BK9781788011136-00083-cit74","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.med.51.1.289","volume":"51","author":"Papadakis","year":"2000","journal-title":"Annu. Rev. Med."},{"key":"2023051921391784300_BK9781788011136-00083-cit75","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/08916931003674709","volume":"43","author":"Melgar","year":"2010","journal-title":"Autoimmunity"},{"key":"2023051921391784300_BK9781788011136-00083-cit76","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jconrel.2015.05.003","volume":"209","author":"Fernandes","year":"2015","journal-title":"J. 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