{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:53:04Z","timestamp":1760550784840},"reference-count":83,"publisher":"The Royal Society of Chemistry","isbn-type":[{"value":"9781788014687","type":"print"},{"value":"9781788014687","type":"print"},{"value":"9781788017510","type":"electronic"},{"value":"9781788016490","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,18]]},"abstract":"<jats:p>The Henry (nitroaldol) reaction provides a useful method for C\u2013C bond formation between a nitroalkane and an aldehyde or a ketone to form a \u03b2-nitro alcohol. Noncovalent interactions can play important roles in this reaction, namely by orienting the reactant molecules, lowering the reaction barriers or even building suitable supramolecular catalysts. This chapter considers the influence of noncovalent interactions (mainly H-bonding) in the Henry reaction (excluding the aza-Henry reaction) and the product selectivity including diastereoselectivity (anti or syn) and enantioselectivity.<\/jats:p>","DOI":"10.1039\/9781788016490-00232","type":"book-chapter","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T12:00:07Z","timestamp":1551700807000},"page":"232-252","source":"Crossref","is-referenced-by-count":2,"title":["Noncovalent Interactions in the Nitroaldol (Henry) Reaction"],"prefix":"10.1039","author":[{"given":"Susanta","family":"Hazra","sequence":"first","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, Universidade de Lisboa Av. Rovisco Pais 1049-001 Lisbon Portugal h.susanta@gmail.com pombeiro@tecnico.ulisboa.pt"}]},{"given":"Armando J. L.","family":"Pombeiro","sequence":"additional","affiliation":[{"name":"Centro de Qu\u00edmica Estrutural, Instituto Superior T\u00e9cnico, Universidade de Lisboa Av. Rovisco Pais 1049-001 Lisbon Portugal h.susanta@gmail.com pombeiro@tecnico.ulisboa.pt"}]}],"member":"292","reference":[{"key":"2023051922293878500_BK9781788014687-00232-cit1","first-page":"1265","volume":"120","author":"Henry","year":"1895","journal-title":"C. R. Acad. Sci."},{"key":"2023051922293878500_BK9781788014687-00232-cit2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/cber.186900201222","volume":"2","author":"von Richter","year":"1869","journal-title":"Ber. Dtsch. Chem. 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