{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:47:35Z","timestamp":1777492055603,"version":"3.51.4"},"reference-count":70,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Soc. Rev."],"published-print":{"date-parts":[[2012]]},"DOI":"10.1039\/c2cs15317c","type":"journal-article","created":{"date-parts":[[2012,2,20]],"date-time":"2012-02-20T14:36:21Z","timestamp":1329748581000},"page":"3571","source":"Crossref","is-referenced-by-count":506,"title":["Developing drug molecules for therapy with carbon monoxide"],"prefix":"10.1039","volume":"41","author":[{"given":"Carlos C.","family":"Rom\u00e3o","sequence":"first","affiliation":[]},{"given":"Walter A.","family":"Bl\u00e4ttler","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o D.","family":"Seixas","sequence":"additional","affiliation":[]},{"given":"Gon\u00e7alo J. L.","family":"Bernardes","sequence":"additional","affiliation":[]}],"member":"292","reference":[{"key":"c2cs15317c-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/164580a0","volume":"164","author":"Sj\u00f6strand","year":"1949","journal-title":"Nature"},{"key":"c2cs15317c-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.61.2.748","volume":"61","author":"Tenhunen","year":"1968","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"c2cs15317c-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/bies.20005","volume":"26","author":"Ryter","year":"2004","journal-title":"BioEssays"},{"key":"c2cs15317c-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1517\/13543784.14.11.1305","volume":"14","author":"Motterlini","year":"2005","journal-title":"Expert Opin. Invest. Drugs"},{"key":"c2cs15317c-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/nrd3228","volume":"9","author":"Motterlini","year":"2010","journal-title":"Nat. Rev. Drug Discovery"},{"key":"c2cs15317c-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/pr.57.4.3","volume":"57","author":"Wu","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"c2cs15317c-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1039\/c0cc01887b","volume":"46","author":"Crespy","year":"2010","journal-title":"Chem. Commun."},{"key":"c2cs15317c-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"925","DOI":"10.4187\/002013209793800394","volume":"54","author":"Otterbein","year":"2009","journal-title":"Respir. Care"},{"key":"c2cs15317c-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0300-483X(02)00387-6","volume":"180","author":"Omaye","year":"2002","journal-title":"Toxicology"},{"key":"c2cs15317c-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00011-006-0084-y","volume":"55","author":"Mannaioni","year":"2006","journal-title":"Inflammation Res."},{"key":"c2cs15317c-(cit11)\/*[position()=1]","first-page":"1289","volume":"46","author":"Goldbaum","year":"1975","journal-title":"Aviat., Space Environ. Med."},{"key":"c2cs15317c-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1002\/anie.200301634","volume":"42","author":"Johnson","year":"2003","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2cs15317c-(cit13)\/*[position()=1]","first-page":"L1029","volume":"279","author":"Otterbein","year":"2000","journal-title":"Am. J. Physiol.: Lung Cell. Mol. Physiol."},{"key":"c2cs15317c-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1126\/science.7678352","volume":"259","author":"Verma","year":"1993","journal-title":"Science"},{"key":"c2cs15317c-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scitranslmed.3000721","volume":"2","author":"Szabo","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"c2cs15317c-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1128\/MMBR.68.3.453-473.2004","volume":"68","author":"Roberts","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"c2cs15317c-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.freeradbiomed.2008.05.013","volume":"45","author":"Piantadosi","year":"2008","journal-title":"Free Radical Biol. Med."},{"key":"c2cs15317c-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1039\/B707077M","volume":"38","author":"Hartinger","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"c2cs15317c-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1096\/fj.04-2169fje","volume":"19","author":"Motterlini","year":"2005","journal-title":"FASEB J."},{"key":"c2cs15317c-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1039\/c0ob00099j","volume":"8","author":"Pitchumony","year":"2010","journal-title":"Org. Biomol. Chem."},{"key":"c2cs15317c-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18114","DOI":"10.1021\/ja208652n","volume":"133","author":"Friis","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"c2cs15317c-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1124\/jpet.302.1.26","volume":"302","author":"Kitazawa","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"c2cs15317c-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/ejic.200800909","author":"Alberto","year":"2009","journal-title":"Eur. J. Inorg. Chem."},{"key":"c2cs15317c-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.1021\/ic100458j","volume":"49","author":"Zobi","year":"2010","journal-title":"Inorg. Chem."},{"key":"c2cs15317c-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1039\/C1DT10649J","volume":"41","author":"Zobi","year":"2012","journal-title":"Dalton Trans."},{"key":"c2cs15317c-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ica.2011.02.068","volume":"374","author":"Schatzschneider","year":"2011","journal-title":"Inorg. Chim. Acta"},{"key":"c2cs15317c-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1161\/hh0202.104530","volume":"90","author":"Motterlini","year":"2002","journal-title":"Circ. Res."},{"key":"c2cs15317c-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1523-1755.2004.00409.x","volume":"65","author":"Arregui","year":"2004","journal-title":"Kidney Int."},{"key":"c2cs15317c-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jinorgbio.2010.10.006","volume":"105","author":"Kretschmer","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"c2cs15317c-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1021\/ic1024197","volume":"50","author":"D\u00f6rdelmann","year":"2011","journal-title":"Inorg. Chem."},{"key":"c2cs15317c-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1002\/anie.201000097","volume":"49","author":"Meister","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2cs15317c-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1021\/ic2000848","volume":"50","author":"Gonzalez","year":"2011","journal-title":"Inorg. Chem."},{"key":"c2cs15317c-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1021\/ic200676s","volume":"50","author":"Jackson","year":"2011","journal-title":"Inorg. Chem."},{"key":"c2cs15317c-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1021\/ic980233f","volume":"37","author":"Darensbourg","year":"1998","journal-title":"Inorg. Chem."},{"key":"c2cs15317c-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1021\/cr00057a005","volume":"83","author":"Howell","year":"1983","journal-title":"Chem. Rev."},{"key":"c2cs15317c-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1002\/anie.201190036","volume":"50","author":"Romanski","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2cs15317c-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1021\/ja108820s","volume":"133","author":"Santos-Silva","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"c2cs15317c-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1161\/01.RES.0000084381.86567.08","volume":"93","author":"Clark","year":"2003","journal-title":"Circ. Res."},{"key":"c2cs15317c-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.1039\/c0dt01809k","volume":"40","author":"Atkin","year":"2011","journal-title":"Dalton Trans."},{"key":"c2cs15317c-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1039\/b704832g","author":"Scapens","year":"2007","journal-title":"Dalton Trans."},{"key":"c2cs15317c-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1021\/ic902147n","volume":"49","author":"Rimmer","year":"2010","journal-title":"Inorg. Chem."},{"key":"c2cs15317c-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3361","DOI":"10.2174\/092986711796504583","volume":"18","author":"Santos-Silva","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"c2cs15317c-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1161\/ATVBAHA.111.229039","volume":"31","author":"Marazioti","year":"2011","journal-title":"Arterioscler., Thromb., Vasc. Biol."},{"key":"c2cs15317c-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.1039\/b822157j","author":"Zhang","year":"2009","journal-title":"Dalton Trans."},{"key":"c2cs15317c-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1039\/b904627p","author":"Atkin","year":"2009","journal-title":"Dalton Trans."},{"key":"c2cs15317c-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.1039\/c0dt00203h","volume":"39","author":"Hewison","year":"2010","journal-title":"Dalton Trans."},{"key":"c2cs15317c-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1039\/b707377a","author":"Fairlamb","year":"2007","journal-title":"Dalton Trans."},{"key":"c2cs15317c-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1039\/c1dt10125k","volume":"40","author":"Crook","year":"2011","journal-title":"Dalton Trans."},{"key":"c2cs15317c-(cit53)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05571-11","author":"Pena","year":"2012","journal-title":"Antimicrob. Agents Chemoter."},{"key":"c2cs15317c-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1039\/b514859f","volume":"35","author":"Storr","year":"2006","journal-title":"Chem. Soc. Rev."},{"key":"c2cs15317c-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1126\/science.1083004","volume":"300","author":"Thompson","year":"2003","journal-title":"Science"},{"key":"c2cs15317c-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/(SICI)1521-3773(19980703)37:12<1634::AID-ANIE1634>3.0.CO;2-C","volume":"37","author":"Severin","year":"1998","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2cs15317c-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1289\/ehp.0800035","volume":"117","author":"Burton","year":"2008","journal-title":"Environ. Health Perspect."},{"key":"c2cs15317c-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1002\/anie.200906079","volume":"49","author":"Liu","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"c2cs15317c-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1595\/147106705X82874","volume":"50","author":"Chatterjee","year":"2006","journal-title":"Platinum Met. Rev."},{"key":"c2cs15317c-(cit61)\/*[position()=1]","first-page":"727","volume":"39","author":"Turnlund","year":"2002","journal-title":"Met. Ions Biol. Syst."},{"key":"c2cs15317c-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jn\/137.1.37","volume":"137","author":"Novotny","year":"2007","journal-title":"J. Nutr."},{"key":"c2cs15317c-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S1359-6446(05)03541-5","volume":"10","author":"Brewer","year":"2005","journal-title":"Drug Discovery Today"},{"key":"c2cs15317c-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18273","DOI":"10.1021\/ja1075025","volume":"132","author":"Hasegawa","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"c2cs15317c-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1084\/jem.20031003","volume":"198","author":"Zuckerbraun","year":"2003","journal-title":"J. Exp. Med."},{"key":"c2cs15317c-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/sj.bjp.0706241","volume":"145","author":"Sawle","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"c2cs15317c-(cit68)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.4049\/jimmunol.1002433","volume":"186","author":"Sheikh","year":"2011","journal-title":"J. Immunol."},{"key":"c2cs15317c-(cit69)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1084\/jem.20051047","volume":"202","author":"Hegazi","year":"2005","journal-title":"J. Exp. Med."},{"key":"c2cs15317c-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/gut.2008.155481","volume":"58","author":"De Backer","year":"2009","journal-title":"Gut"},{"key":"c2cs15317c-(cit71)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1136\/ard.2007.082412","volume":"67","author":"Ferr\u00e1ndiz","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"c2cs15317c-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejphar.2010.02.028","volume":"634","author":"Maicas","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"c2cs15317c-(cit73)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1365-2249.2010.04303.x","volume":"163","author":"Fagone","year":"2011","journal-title":"Clin. Exp. Immunol."},{"key":"c2cs15317c-(cit74)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1582-4934.2006.tb00426.x","volume":"10","author":"Nakao","year":"2006","journal-title":"J. Cell. Mol. Med."},{"key":"c2cs15317c-(cit75)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1161\/CIRCULATIONAHA.109.887695","volume":"121","author":"Wegiel","year":"2010","journal-title":"Circulation"},{"key":"c2cs15317c-(cit76)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1084\/jem.20052267","volume":"203","author":"Zuckerbraun","year":"2006","journal-title":"J. Exp. Med."}],"container-title":["Chemical Society Reviews"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2012\/CS\/C2CS15317C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T09:53:06Z","timestamp":1713347586000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=c2cs15317c"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1039\/c2cs15317c","relation":{},"ISSN":["0306-0012","1460-4744"],"issn-type":[{"value":"0306-0012","type":"print"},{"value":"1460-4744","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}