{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:42:34Z","timestamp":1776789754535,"version":"3.51.2"},"reference-count":142,"publisher":"Royal Society of Chemistry (RSC)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Sci."],"DOI":"10.1039\/c2sc21112b","type":"journal-article","created":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T08:35:04Z","timestamp":1346315704000},"page":"103-117","source":"Crossref","is-referenced-by-count":136,"title":["Chloride, carboxylate and carbonate transport by ortho-phenylenediamine-based bisureas"],"prefix":"10.1039","volume":"4","author":[{"given":"Stephen J.","family":"Moore","sequence":"first","affiliation":[]},{"given":"Cally J. E.","family":"Haynes","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[]},{"given":"Jennifer L.","family":"Sutton","sequence":"additional","affiliation":[]},{"given":"Simon J.","family":"Brooks","sequence":"additional","affiliation":[]},{"given":"Mark E.","family":"Light","sequence":"additional","affiliation":[]},{"given":"Julie","family":"Herniman","sequence":"additional","affiliation":[]},{"given":"G. John","family":"Langley","sequence":"additional","affiliation":[]},{"given":"Vanessa","family":"Soto-Cerrato","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"P\u00e9rez-Tom\u00e1s","sequence":"additional","affiliation":[]},{"given":"Igor","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Paulo J.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"V\u00edtor","family":"F\u00e9lix","sequence":"additional","affiliation":[]},{"given":"Philip A.","family":"Gale","sequence":"additional","affiliation":[]}],"member":"292","published-online":{"date-parts":[[2013]]},"reference":[{"key":"C2SC21112B-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.ph.39.030177.000315","volume":"39","author":"Korenbrot","year":"1977","journal-title":"Annu. Rev. Physiol."},{"key":"C2SC21112B-(cit2)\/*[position()=1]","volume-title":"Ion Channels and Disease","author":"Ashcroft","year":"2000","unstructured":"F. M. Ashcroft , Ion Channels and Disease, Academic Press, San Diego, 2000"},{"key":"C2SC21112B-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1042\/BJ20081634","volume":"417","author":"Cordat","year":"2009","journal-title":"Biochem. J."},{"key":"C2SC21112B-(cit4a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0140-6736(08)61162-9","volume":"372","author":"Quinton","year":"2008","journal-title":"Lancet"},{"key":"C2SC21112B-(cit4b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1172\/JCI38662","volume":"119","author":"Garcia","year":"2009","journal-title":"J. Clin. Invest."},{"key":"C2SC21112B-(cit5a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1084\/jem.187.10.1583","volume":"187","author":"Altan","year":"1998","journal-title":"J. Exp. Med."},{"key":"C2SC21112B-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18364","DOI":"10.1074\/jbc.274.26.18364","volume":"274","author":"Chen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"C2SC21112B-(cit5c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/35014006","volume":"2","author":"Matsuyama","year":"2000","journal-title":"Nat. Cell Biol."},{"key":"C2SC21112B-(cit6a)\/*[position()=1]","volume-title":"Topics in Heterocyclic Chemistry","volume":"vol. 24","author":"Davis","year":"2010","unstructured":"J. T. Davis , in Topics in Heterocyclic Chemistry, ed. P. A. Gale and W. Dehaen, Springer-Verlag, Berlin Heidelberg, 2010, vol. 24, pp. 145\u2013176"},{"key":"C2SC21112B-(cit6b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"21455","DOI":"10.1074\/jbc.273.34.21455","volume":"273","author":"Sato","year":"1998","journal-title":"J. Biol. Chem."},{"key":"C2SC21112B-(cit6c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1002\/anie.200501740","volume":"44","author":"Sessler","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2SC21112B-(cit6d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1002\/anie.200300582","volume":"42","author":"F\u00fcrstner","year":"2003","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2SC21112B-(cit6e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1039\/b511847f","author":"Seganish","year":"2005","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit6f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/oxfordjournals.jbchem.a022147","volume":"124","author":"Konno","year":"1998","journal-title":"J. Biochem."},{"key":"C2SC21112B-(cit6g)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nchem.178","volume":"1","author":"Davis","year":"2009","journal-title":"Nat. Chem."},{"key":"C2SC21112B-(cit6h)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19512","DOI":"10.1073\/pnas.0709443104","volume":"104","author":"Nguyen","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C2SC21112B-(cit7a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1039\/b414589e","author":"McNally","year":"2005","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit7b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0010-8545(03)00020-1","volume":"240","author":"Davis","year":"2003","journal-title":"Coord. Chem. Rev."},{"key":"C2SC21112B-(cit7c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1016\/j.ccr.2006.05.008","volume":"250","author":"Davis","year":"2006","journal-title":"Coord. Chem. Rev."},{"key":"C2SC21112B-(cit7d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9599","DOI":"10.1002\/chem.200801163","volume":"14","author":"McNally","year":"2008","journal-title":"Chem.\u2013Eur. J."},{"key":"C2SC21112B-(cit8a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6321","DOI":"10.1039\/b814988g","author":"Tong","year":"2008","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit8b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3240","DOI":"10.1021\/ja9092693","volume":"132","author":"Gale","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit8c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1039\/b904089g","author":"Fisher","year":"2009","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1021\/ja809733c","volume":"131","author":"Berezin","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit9)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1039\/c2cc18148g","volume":"48","author":"Bahmanjah","year":"2012","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1021\/ja068067v","volume":"129","author":"Santacroce","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit10)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"4426","DOI":"10.1002\/anie.201200729","volume":"51","author":"Busschaert","year":"2012","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2SC21112B-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6252","DOI":"10.1039\/c0cc01684e","volume":"46","author":"Busschaert","year":"2010","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit12a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1378\/chest.06-2085","volume":"131","author":"Grasemann","year":"2007","journal-title":"Chest"},{"key":"C2SC21112B-(cit12b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1039\/b719482j","author":"Izzo","year":"2008","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit12c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13676","DOI":"10.1021\/ja902352g","volume":"131","author":"Li","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit13a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1021\/jm701122q","volume":"51","author":"Gleeson","year":"2008","journal-title":"J. Med. Chem."},{"key":"C2SC21112B-(cit13b)\/*[position()=1]","volume-title":"Drug-like Properties: Concepts, Structure Design and Methods","author":"Kerns","year":"2008","unstructured":"E. H. Kerns and L.Di, Drug-like Properties: Concepts, Structure Design and Methods, Academic Press, Amsterdam, 2008"},{"key":"C2SC21112B-(cit14a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(96)00423-1","volume":"23","author":"Lipinski","year":"1997","journal-title":"Adv. Drug Delivery Rev."},{"key":"C2SC21112B-(cit14b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1056-8719(00)00107-6","volume":"44","author":"Lipinski","year":"2000","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"C2SC21112B-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1039\/c2sc20551c","volume":"3","author":"Moore","year":"2012","journal-title":"Chem. Sci."},{"key":"C2SC21112B-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1039\/c2sc20041d","volume":"3","author":"Haynes","year":"2012","journal-title":"Chem. Sci."},{"key":"C2SC21112B-(cit17a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.1039\/b508144k","author":"Brooks","year":"2005","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit17b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1039\/B511963D","volume":"30","author":"Brooks","year":"2006","journal-title":"New J. Chem."},{"key":"C2SC21112B-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9635","DOI":"10.1016\/j.tet.2006.07.081","volume":"62","author":"Kim","year":"2006","journal-title":"Tetrahedron"},{"key":"C2SC21112B-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/10610270600879076","volume":"19","author":"Brooks","year":"2007","journal-title":"Supramol. Chem."},{"key":"C2SC21112B-(cit20a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1039\/c0cc00937g","volume":"46","author":"Jia","year":"2010","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit20b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1021\/ol102221x","volume":"12","author":"Jia","year":"2010","journal-title":"Org. Lett."},{"key":"C2SC21112B-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/anie.201004461","volume":"50","author":"Jia","year":"2011","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2SC21112B-(cit22a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.1039\/b610938a","author":"Brooks","year":"2006","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit22b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1002\/chem.200601647","volume":"13","author":"Brooks","year":"2007","journal-title":"Chem.\u2013Eur. J."},{"key":"C2SC21112B-(cit23a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6732","DOI":"10.1016\/j.tet.2007.04.086","volume":"63","author":"Yang","year":"2007","journal-title":"Tetrahedron"},{"key":"C2SC21112B-(cit23b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5343","DOI":"10.1016\/j.tetlet.2005.06.011","volume":"46","author":"Jose","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"C2SC21112B-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1039\/b504931h","volume":"3","author":"Amendola","year":"2005","journal-title":"Org. Biomol. Chem."},{"key":"C2SC21112B-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1016\/j.tet.2010.07.006","volume":"66","author":"Odago","year":"2010","journal-title":"Tetrahedron"},{"key":"C2SC21112B-(cit26a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1039\/b511932d","volume":"7","author":"Brooks","year":"2005","journal-title":"CrystEngComm"},{"key":"C2SC21112B-(cit26b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1039\/c2cc17699h","volume":"48","author":"Li","year":"2012","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/(SICI)1521-3765(19990301)5:3<937::AID-CHEM937>3.0.CO;2-0","volume":"5","author":"van Esch","year":"1999","journal-title":"Chem.\u2013Eur. J."},{"key":"C2SC21112B-(cit28a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0957-4166(01)00042-8","volume":"12","author":"Bied","year":"2001","journal-title":"Tetrahedron: Asymmetry"},{"key":"C2SC21112B-(cit28b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13624","DOI":"10.1021\/ja105337h","volume":"132","author":"Klauber","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit29a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1021\/ja02206a015","volume":"34","author":"Bogert","year":"1912","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit29b)\/*[position()=1]","first-page":"846","volume":"9","author":"Peyron","year":"1953","journal-title":"Bull. Soc. Chim."},{"key":"C2SC21112B-(cit29c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.cclet.2010.12.018","volume":"22","author":"Gavade","year":"2011","journal-title":"Chin. Chem. Lett."},{"key":"C2SC21112B-(cit30a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1039\/a806722h","author":"Scheele","year":"1998","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit30b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8831","DOI":"10.1021\/jo000520c","volume":"65","author":"Ge","year":"2000","journal-title":"J. Org. Chem."},{"key":"C2SC21112B-(cit31a)\/*[position()=1]","first-page":"1559","volume":"10","author":"Grammaticakis","year":"1959","journal-title":"Bull. Soc. Chim."},{"key":"C2SC21112B-(cit31b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/0031-9422(80)80165-8","volume":"19","author":"Iwamura","year":"1980","journal-title":"Phytochemistry"},{"key":"C2SC21112B-(cit32a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1248\/cpb.34.1950","volume":"34","author":"Miyahara","year":"1986","journal-title":"Chem. Pharm. Bull."},{"key":"C2SC21112B-(cit32b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1023\/A:1016503307552","volume":"38","author":"Artamkina","year":"2002","journal-title":"Russ. J. Org. Chem."},{"key":"C2SC21112B-(cit32c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1016\/S0040-4039(01)00716-X","volume":"42","author":"Artamkina","year":"2001","journal-title":"Tetrahedron Lett."},{"key":"C2SC21112B-(cit32d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1021\/ol802931m","volume":"11","author":"Kotecki","year":"2009","journal-title":"Org. Lett."},{"key":"C2SC21112B-(cit33a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1039\/C0SC00503G","volume":"2","author":"Andrews","year":"2011","journal-title":"Chem. Sci."},{"key":"C2SC21112B-(cit33b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/asia.200900230","volume":"5","author":"Gale","year":"2010","journal-title":"Chem.\u2013Asian J."},{"key":"C2SC21112B-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1039\/dt9930000311","author":"Hynes","year":"1993","journal-title":"J. Chem. Soc., Dalton Trans."},{"key":"C2SC21112B-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1039\/b817889e","volume":"7","author":"Barnard","year":"2009","journal-title":"Org. Biomol. Chem."},{"key":"C2SC21112B-(cit36a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1002\/chem.200401049","volume":"11","author":"Boiocchi","year":"2005","journal-title":"Chem.\u2013Eur. J."},{"key":"C2SC21112B-(cit36b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1021\/jo050528s","volume":"70","author":"Esteban-G\u00f3mez","year":"2005","journal-title":"J. Org. Chem."},{"key":"C2SC21112B-(cit36c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1021\/ar050195l","volume":"39","author":"Amendola","year":"2006","journal-title":"Acc. Chem. Res."},{"key":"C2SC21112B-(cit36d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1002\/ejoc.200600388","author":"Bonizzoni","year":"2006","journal-title":"Eur. J. Org. Chem."},{"key":"C2SC21112B-(cit36e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1039\/B618072H","author":"Garc\u00eda-Garrido","year":"2007","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0022-0728(97)00394-X","volume":"441","author":"Shao","year":"1998","journal-title":"J. Electroanal. Chem."},{"key":"C2SC21112B-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s13361-011-0311-9","volume":"23","author":"Kitova","year":"2012","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"C2SC21112B-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1007\/s13361-011-0305-7","volume":"23","author":"Jaquillard","year":"2012","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"C2SC21112B-(cit40a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1039\/b303359g","author":"Smith","year":"2003","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit40b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.1002\/anie.200351957","volume":"42","author":"Koulov","year":"2003","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2SC21112B-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1039\/c0ob00128g","volume":"8","author":"Yano","year":"2010","journal-title":"Org. Biomol. Chem."},{"key":"C2SC21112B-(cit42a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1021\/cr970010r","volume":"98","author":"Cleland","year":"1998","journal-title":"Chem. Rev."},{"key":"C2SC21112B-(cit42b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S8756-3282(02)00672-5","volume":"30","author":"Rousselle","year":"2002","journal-title":"Bone"},{"key":"C2SC21112B-(cit42c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/ng1176","volume":"34","author":"Bok","year":"2003","journal-title":"Nat. Genet."},{"key":"C2SC21112B-(cit42d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.yjmcc.2008.10.024","volume":"46","author":"Vaughan-Jones","year":"2009","journal-title":"J. Mol. Cell. Cardiol."},{"key":"C2SC21112B-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1039\/FT9918702995","volume":"87","author":"Marcus","year":"1991","journal-title":"J. Chem. Soc., Faraday Trans."},{"key":"C2SC21112B-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"14136","DOI":"10.1021\/ja205884y","volume":"133","author":"Busschaert","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1039\/b703259e","author":"Gale","year":"2007","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1021\/bi00509a019","volume":"20","author":"Clement","year":"1981","journal-title":"Biochemistry"},{"key":"C2SC21112B-(cit47a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1039\/B512651G","volume":"36","author":"Davis","year":"2007","journal-title":"Chem. Soc. Rev."},{"key":"C2SC21112B-(cit47b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1039\/B512423A","volume":"35","author":"Sisson","year":"2006","journal-title":"Chem. Soc. Rev."},{"key":"C2SC21112B-(cit47c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"17274","DOI":"10.1021\/ja8082363","volume":"130","author":"McNally","year":"2008","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit47d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1039\/b817245p","volume":"33","author":"Gokel","year":"2009","journal-title":"New J. Chem."},{"key":"C2SC21112B-(cit47e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1039\/b926164h","volume":"39","author":"Davis","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"C2SC21112B-(cit47f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1021\/ar100134p","volume":"44","author":"Gale","year":"2011","journal-title":"Acc. Chem. Res."},{"key":"C2SC21112B-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1042\/bj1860591","volume":"186","author":"Kirby","year":"1980","journal-title":"Biochem. J."},{"key":"C2SC21112B-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1021\/ja962694a","volume":"119","author":"Murillo","year":"1997","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit50a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1042\/bj0070471","volume":"7","author":"Hill","year":"1913","journal-title":"Biochem. J."},{"key":"C2SC21112B-(cit50b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/chir.20326","volume":"18","author":"Bhosale","year":"2006","journal-title":"Chirality"},{"key":"C2SC21112B-(cit51a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1021\/jm000942e","volume":"43","author":"Ertl","year":"2000","journal-title":"J. Med. Chem."},{"key":"C2SC21112B-(cit51b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1021\/ci990307l","volume":"39","author":"Wildman","year":"1999","journal-title":"J. Chem. Inf. Comput. Sci."},{"key":"C2SC21112B-(cit52a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/jo01097a026","volume":"23","author":"McDaniel","year":"1958","journal-title":"J. Org. Chem."},{"key":"C2SC21112B-(cit53a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/anie.200390178","volume":"42","author":"Sancen\u00f3n","year":"2003","journal-title":"Angew. Chem., Int. Ed."},{"key":"C2SC21112B-(cit53b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1039\/b515320d","author":"Costero","year":"2006","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit53c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.inoche.2006.02.024","volume":"9","author":"Kim","year":"2006","journal-title":"Inorg. Chem. Commun."},{"key":"C2SC21112B-(cit53d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7357","DOI":"10.1016\/j.tetlet.2006.08.010","volume":"47","author":"Yen","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"C2SC21112B-(cit53e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3592","DOI":"10.1039\/b710695e","volume":"5","author":"Tseng","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"C2SC21112B-(cit53f)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1039\/c1nj20339h","volume":"35","author":"Goswami","year":"2011","journal-title":"New J. Chem."},{"key":"C2SC21112B-(cit54a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1021\/ja00054a066","volume":"115","author":"Fan","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit54b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.1021\/ja00095a009","volume":"116","author":"Kelly","year":"1994","journal-title":"J. Am. Chem. Soc."},{"key":"C2SC21112B-(cit54c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1016\/0040-4039(96)00431-5","volume":"37","author":"Jeong","year":"1996","journal-title":"Tetrahedron Lett."},{"key":"C2SC21112B-(cit54d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1039\/b009041g","author":"Fitzmaurice","year":"2002","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"C2SC21112B-(cit55a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1089\/ars.2009.2444","volume":"11","author":"Foran","year":"2009","journal-title":"Antioxid. Redox Signaling"},{"key":"C2SC21112B-(cit55b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuint.2005.12.001","volume":"48","author":"Yi","year":"2006","journal-title":"Neurochem. Int."},{"key":"C2SC21112B-(cit55c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ana.410400512","volume":"40","author":"Masliah","year":"1996","journal-title":"Ann. Neurol."},{"key":"C2SC21112B-(cit55d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/00005072-199708000-00008","volume":"56","author":"Li","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"C2SC21112B-(cit55e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1093\/brain\/awf180","volume":"125","author":"Behrens","year":"2002","journal-title":"Brain"},{"key":"C2SC21112B-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1113\/jphysiol.2007.143222","volume":"586","author":"Clark","year":"2008","journal-title":"J. Physiol."},{"key":"C2SC21112B-(cit57)\/*[position()=1]","volume-title":"The Citric Acid Cycle","author":"Krebs","year":"1953","unstructured":"H. A. Krebs , The Citric Acid Cycle, Nobel Lecture, 1953"},{"key":"C2SC21112B-(cit58a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1021\/jm040835a","volume":"48","author":"Kazius","year":"2005","journal-title":"J. Med. Chem."},{"key":"C2SC21112B-(cit58b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0300-483X(99)00065-7","volume":"137","author":"Li","year":"1999","journal-title":"Toxicology"},{"key":"C2SC21112B-(cit58c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s002040050505","volume":"72","author":"Shinoda","year":"1998","journal-title":"Arch. Toxicol."},{"key":"C2SC21112B-(cit58d)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/10915810050202097","volume":"19","author":"Sajan","year":"2000","journal-title":"Int. J. Toxicol."},{"key":"C2SC21112B-(cit58e)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1006\/bbrc.1999.0525","volume":"257","author":"Ohkuma","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C2SC21112B-(cit59)\/*[position()=1]","first-page":"264","volume":"15","author":"McCarty","year":"2010","journal-title":"Alternative Med. Rev."},{"key":"C2SC21112B-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2500001","volume":"250","author":"Madshus","year":"1988","journal-title":"Biochem. J."},{"key":"C2SC21112B-(cit61)\/*[position()=1]","volume-title":"Lysosomes in Biology and Pathology","volume":"vol. 2","author":"Allison","year":"1969","unstructured":"A. C. Allison and M. R.Young, Lysosomes in Biology and Pathology, North-Holland Publishing Co., Amsterdam, 1969, vol. 2"},{"key":"C2SC21112B-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1038\/bjc.1996.254","volume":"73","author":"Yamagate","year":"1996","journal-title":"Br. J. Cancer"},{"key":"C2SC21112B-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/S0006-2952(03)00496-9","volume":"66","author":"P\u00e9rez-Tom\u00e1s","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"C2SC21112B-(cit63)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1039\/C1CC11300C","volume":"48","author":"Hern\u00e1ndez","year":"2012","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12017","DOI":"10.1039\/c1dt10213c","volume":"40","author":"Moore","year":"2011","journal-title":"Dalton Trans."},{"key":"C2SC21112B-(cit64)\/*[position()=2]","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1039\/C0CC04430J","volume":"47","author":"Moore","year":"2011","journal-title":"Chem. Commun."},{"key":"C2SC21112B-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1158\/0008-5472.CAN-06-4095","volume":"67","author":"De Milito","year":"2007","journal-title":"Cancer Res."},{"key":"C2SC21112B-(cit66)\/*[position()=1]","volume-title":"AMBER 12","author":"Case","year":"2012","unstructured":"D. A. Case , T. A.Darden, T. E.Cheatham, III, C. L.Simmerling, J.Wang, R. E.Duke, R.Luo, R. C.Walker, W.Zhang, K. M.Merz, B.Roberts, S.Hayik, A.Roitberg, G.Seabra, J.Swails, A. W.G\u00f6tz, I.Kolossv\u00e1ry, K. F.Wong, F.Paesani, J.Vanicek, R. M.Wolf, J.Liu, X.Wu, S. R.Brozell, T.Steinbrecher, H.Gohlke, Q.Cai, X.Ye, J.Wang, M.-J.Hsieh, G.Cui, D. R.Roe, D. H.Mathews, M. G.Seetin, R.Salomon-Ferrer, C.Sagui, V.Babin, T.Luchko, S.Gusarov, A.Kovalenko, and P. A.Kollman, AMBER 12, University of California, San Francisco, 2012"},{"key":"C2SC21112B-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"key":"C2SC21112B-(cit68a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"key":"C2SC21112B-(cit68b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/jcc.20145","volume":"26","author":"Wang","year":"2005","journal-title":"J. Comput. Chem."},{"key":"C2SC21112B-(cit69a)\/*[position()=1]","doi-asserted-by":"publisher","DOI":"10.1021\/jp3059992","author":"Skjevik","year":"2012","journal-title":"J. Phys. Chem. B"},{"key":"C2SC21112B-(cit69b)\/*[position()=1]","author":"Walker","year":"2012","unstructured":"R. C. Walker and B.Madej, private communication, 2012"},{"key":"C2SC21112B-(cit70)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9020","DOI":"10.1021\/jp8001614","volume":"112","author":"Joung","year":"2008","journal-title":"J. Phys. Chem. B"},{"key":"C2SC21112B-(cit71)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1016\/j.bbamem.2011.07.022","volume":"1808","author":"Ku\u010derka","year":"2011","journal-title":"Biochim. Biophys. Acta, Biomembr."},{"key":"C2SC21112B-(cit72)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1039\/C2SC00955B","volume":"3","author":"Coles","year":"2012","journal-title":"Chem. Sci."}],"container-title":["Chem. Sci."],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2013\/SC\/C2SC21112B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T15:11:16Z","timestamp":1713366676000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=C2SC21112B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":142,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.1039\/c2sc21112b","relation":{},"ISSN":["2041-6520","2041-6539"],"issn-type":[{"value":"2041-6520","type":"print"},{"value":"2041-6539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}