{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T23:00:29Z","timestamp":1769554829123,"version":"3.49.0"},"reference-count":42,"publisher":"Royal Society of Chemistry (RSC)","issue":"11","funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Phys. Chem. Chem. Phys."],"abstract":"<p>The kinetics of transthyretin aggregation from acid-unfolded monomers to amyloid fibrils was studied by several biophysical techniques and may be described as a two-step process with transient accumulation of oligomeric species.<\/p>","DOI":"10.1039\/c4cp04549a","type":"journal-article","created":{"date-parts":[[2015,2,4]],"date-time":"2015-02-04T09:00:40Z","timestamp":1423040440000},"page":"7255-7263","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model"],"prefix":"10.1039","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0564-8415","authenticated-orcid":false,"given":"Tiago Q.","family":"Faria","sequence":"first","affiliation":[{"name":"Center for Neuroscience and Cell Biology"},{"name":"University of Coimbra"},{"name":"Coimbra"},{"name":"Portugal"}]},{"given":"Zaida L.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology"},{"name":"University of Coimbra"},{"name":"Coimbra"},{"name":"Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-0134","authenticated-orcid":false,"given":"Pedro F.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Chemistry Department"},{"name":"University of Coimbra"},{"name":"Coimbra"},{"name":"Portugal"}]},{"given":"Catarina S. H.","family":"Jesus","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology"},{"name":"University of Coimbra"},{"name":"Coimbra"},{"name":"Portugal"},{"name":"Chemistry Department"}]},{"given":"Pedro","family":"Castanheira","sequence":"additional","affiliation":[{"name":"Biocant \u2013 Biotechnology Innovation Center"},{"name":"Parque Tecnol\u00f3gico de Cantanhede"},{"name":"Cantanhede"},{"name":"Portugal"}]},{"given":"Rui M. M.","family":"Brito","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology"},{"name":"University of Coimbra"},{"name":"Coimbra"},{"name":"Portugal"},{"name":"Chemistry Department"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C4CP04549A-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.bbapap.2008.10.016","volume":"1794","author":"Morris","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"C4CP04549A-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1016\/j.bpj.2008.12.3903","volume":"96","author":"Bernacki","year":"2009","journal-title":"Biophys. J."},{"key":"C4CP04549A-(cit3)\/*[position()=1]","first-page":"349","volume":"3","author":"Brito","year":"2003","journal-title":"Curr. Med. Chem.: Immunol., Endocr. Metab. Agents"},{"key":"C4CP04549A-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","volume":"75","author":"Chiti","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"C4CP04549A-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.molcel.2011.05.012","volume":"43","author":"Eichner","year":"2011","journal-title":"Mol. Cell"},{"key":"C4CP04549A-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0065-3233(08)60320-4","volume":"50","author":"Sunde","year":"1997","journal-title":"Adv. Protein Chem."},{"key":"C4CP04549A-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1006\/jmbi.2000.3908","volume":"300","author":"Serpell","year":"2000","journal-title":"J. Mol. Biol."},{"key":"C4CP04549A-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/10.3.355","volume":"10","author":"Puchtler","year":"1962","journal-title":"J. Histochem. Cytochem."},{"key":"C4CP04549A-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/pro.5560020312","volume":"2","author":"LeVine III","year":"1993","journal-title":"Protein Sci."},{"key":"C4CP04549A-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.jmb.2005.06.040","volume":"351","author":"Gosal","year":"2005","journal-title":"J. Mol. Biol."},{"key":"C4CP04549A-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1146\/annurev-biochem-090908-120656","volume":"80","author":"Toyama","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"C4CP04549A-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.2174\/092986712800269317","volume":"19","author":"Ando","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"C4CP04549A-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1073\/pnas.87.7.2843","volume":"87","author":"Westermark","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4CP04549A-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1172\/JCI111390","volume":"74","author":"Saraiva","year":"1984","journal-title":"J. Clin. Invest."},{"key":"C4CP04549A-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0166-2236(89)90162-8","volume":"12","author":"Benson","year":"1989","journal-title":"Trends Neurosci."},{"key":"C4CP04549A-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1056\/NEJM199702133360703","volume":"336","author":"Jacobson","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"C4CP04549A-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/01.LAB.0000059937.11023.1F","volume":"83","author":"Sekijima","year":"2003","journal-title":"Lab. Invest."},{"key":"C4CP04549A-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/13506120500352404","volume":"12","author":"Mitsuhashi","year":"2005","journal-title":"Amyloid"},{"key":"C4CP04549A-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3109\/13506120308998998","volume":"10","author":"Connors","year":"2003","journal-title":"Amyloid"},{"key":"C4CP04549A-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/PL00000791","volume":"58","author":"Hamilton","year":"2001","journal-title":"Cell. Mol. Life Sci."},{"key":"C4CP04549A-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0022-2836(78)90368-6","volume":"121","author":"Blake","year":"1978","journal-title":"J. Mol. Biol."},{"key":"C4CP04549A-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1016\/S0021-9258(18)53792-3","volume":"268","author":"Hamilton","year":"1993","journal-title":"J. Biol. Chem."},{"key":"C4CP04549A-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6796","DOI":"10.1016\/S0021-9258(19)42128-5","volume":"249","author":"Kanda","year":"1974","journal-title":"J. Biol. Chem."},{"key":"C4CP04549A-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6470","DOI":"10.1021\/bi952501g","volume":"35","author":"Lai","year":"1996","journal-title":"Biochemistry"},{"key":"C4CP04549A-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"32943","DOI":"10.1074\/jbc.274.46.32943","volume":"274","author":"Quintas","year":"1999","journal-title":"J. Biol. Chem."},{"key":"C4CP04549A-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"27207","DOI":"10.1074\/jbc.M101024200","volume":"276","author":"Quintas","year":"2001","journal-title":"J. Biol. Chem."},{"key":"C4CP04549A-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"16427","DOI":"10.1073\/pnas.202495199","volume":"99","author":"Hammarstr\u00f6m","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4CP04549A-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1529\/biophysj.104.049700","volume":"88","author":"Lindgren","year":"2005","journal-title":"Biophys. J."},{"key":"C4CP04549A-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jmb.2011.12.060","volume":"421","author":"Johnson","year":"2012","journal-title":"J. Mol. Biol."},{"key":"C4CP04549A-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7365","DOI":"10.1021\/bi049621l","volume":"43","author":"Hurshman","year":"2004","journal-title":"Biochemistry"},{"key":"C4CP04549A-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.bbrc.2008.10.121","volume":"377","author":"S\u00f6rgjerd","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C4CP04549A-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"30585","DOI":"10.1074\/jbc.M112.375345","volume":"287","author":"Crespo","year":"2012","journal-title":"J. Biol. Chem."},{"key":"C4CP04549A-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbapap.2005.06.005","volume":"1751","author":"Kelly","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"C4CP04549A-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"48680","DOI":"10.1074\/jbc.M408806200","volume":"279","author":"Faria","year":"2004","journal-title":"J. Biol. Chem."},{"key":"C4CP04549A-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0014-5793(97)01398-7","volume":"418","author":"Quintas","year":"1997","journal-title":"FEBS Lett."},{"key":"C4CP04549A-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1006\/jmbi.1995.0604","volume":"254","author":"Serpell","year":"1995","journal-title":"J. Mol. Biol."},{"key":"C4CP04549A-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0006-291X(02)00465-5","volume":"294","author":"Andersson","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C4CP04549A-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"e44992","DOI":"10.1371\/journal.pone.0044992","volume":"7","author":"Pires","year":"2012","journal-title":"PLoS One"},{"key":"C4CP04549A-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1073\/pnas.0400062101","volume":"101","author":"Reixach","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C4CP04549A-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1016\/S0021-9258(18)93118-2","volume":"244","author":"Raz","year":"1969","journal-title":"J. Biol. Chem."},{"key":"C4CP04549A-(cit41)\/*[position()=1]","first-page":"301","volume":"55","author":"Bax","year":"1983","journal-title":"J. Magn. Reson."},{"key":"C4CP04549A-(cit42)\/*[position()=1]","first-page":"393","volume":"85","author":"Marion","year":"1969","journal-title":"J. Magn. Reson."}],"container-title":["Physical Chemistry Chemical Physics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/CP\/C4CP04549A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T17:03:14Z","timestamp":1713373394000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=C4CP04549A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c4cp04549a","relation":{},"ISSN":["1463-9076","1463-9084"],"issn-type":[{"value":"1463-9076","type":"print"},{"value":"1463-9084","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C4CP04549A","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Tiago Q. Faria (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-0564-8415","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Pedro F. Cruz (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-3578-0134","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Pedro F. Cruz (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/J-8776-2014","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The PCCP Owner Societies have an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 8 October 2014; Accepted 29 January 2015; Accepted Manuscript published 4 February 2015; Advance Article published 19 February 2015; Version of Record published 4 March 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}