{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:18:59Z","timestamp":1775024339535,"version":"3.50.1"},"reference-count":66,"publisher":"Royal Society of Chemistry (RSC)","issue":"115","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>Delivery of a curcumin supramolecular complex from pH-responsive gum arabic-based hydrogels.<\/p>","DOI":"10.1039\/c5ra14331d","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T10:30:16Z","timestamp":1444991416000},"page":"94519-94533","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Synthesis and controlled curcumin supramolecular complex release from pH-sensitive modified gum-arabic-based hydrogels"],"prefix":"10.1039","volume":"5","author":[{"given":"Adriana P.","family":"Gerola","sequence":"first","affiliation":[{"name":"CQC"},{"name":"Department of Chemistry"},{"name":"University of Coimbra"},{"name":"3004-535 Coimbra"},{"name":"Portugal"}]},{"given":"Danielle C.","family":"Silva","sequence":"additional","affiliation":[{"name":"CQC"},{"name":"Department of Chemistry"},{"name":"University of Coimbra"},{"name":"3004-535 Coimbra"},{"name":"Portugal"}]},{"given":"Sandra","family":"Jesus","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy"},{"name":"University of Coimbra"},{"name":"Coimbra"},{"name":"Portugal"},{"name":"CNC"}]},{"given":"Rui A.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Life Sciences"},{"name":"University of Coimbra"},{"name":"3004-535 Coimbra"},{"name":"Portugal"}]},{"given":"Adley F.","family":"Rubira","sequence":"additional","affiliation":[{"name":"Grupo de Materiais Polim\u00e9ricos e Comp\u00f3sitos"},{"name":"GMPC"},{"name":"Chemistry Department"},{"name":"Maring\u00e1 State University"},{"name":"87020-900 Maring\u00e1"}]},{"given":"Edvani C.","family":"Muniz","sequence":"additional","affiliation":[{"name":"Grupo de Materiais Polim\u00e9ricos e Comp\u00f3sitos"},{"name":"GMPC"},{"name":"Chemistry Department"},{"name":"Maring\u00e1 State University"},{"name":"87020-900 Maring\u00e1"}]},{"given":"Olga","family":"Borges","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy"},{"name":"University of Coimbra"},{"name":"Coimbra"},{"name":"Portugal"},{"name":"CNC"}]},{"given":"Artur J. M.","family":"Valente","sequence":"additional","affiliation":[{"name":"CQC"},{"name":"Department of Chemistry"},{"name":"University of Coimbra"},{"name":"3004-535 Coimbra"},{"name":"Portugal"}]}],"member":"292","published-online":{"date-parts":[[2015]]},"reference":[{"key":"C5RA14331D-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.saa.2011.04.016","volume":"79","author":"Patra","year":"2011","journal-title":"Spectrochim. Acta, Part A"},{"key":"C5RA14331D-(cit2)\/*[position()=1]","first-page":"2084","volume":"19","author":"Jitoe-Masuda","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"C5RA14331D-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/mp700113r","volume":"4","author":"Anand","year":"2007","journal-title":"Mol. Pharmaceutics"},{"key":"C5RA14331D-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-0-387-46401-5_1","volume":"595","author":"Aggarwal","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"C5RA14331D-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1590\/S0074-02762001000500026","volume":"96","author":"Ara\u00fajo","year":"2001","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"C5RA14331D-(cit6)\/*[position()=1]","first-page":"4","volume":"2","author":"Jangle","year":"2010","journal-title":"Pravara Med. Rev."},{"key":"C5RA14331D-(cit7)\/*[position()=1]","volume-title":"Advances in Cancer Therapy","author":"Pongrakhananon","year":"2011","unstructured":"V.\n            Pongrakhananon\n           and Y.Rojanasakul, in Advances in Cancer Therapy, ed. H. Gali-Muhtasib, INTECH Open Access Publisher, 2011"},{"key":"C5RA14331D-(cit8)\/*[position()=1]","first-page":"636053","volume":"2013","author":"Zhang","year":"2013","journal-title":"J. Evidence-Based Complementary Altern. Med."},{"key":"C5RA14331D-(cit9)\/*[position()=1]","volume-title":"The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease","author":"Hsu","year":"2007","unstructured":"C.-H.\n            Hsu\n           and A.-L.Cheng, in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, ed. B. B. Aggarwal, Y.-J. Surh and S. Shishodia, Springer Science+Business Media, LLC, New York, 2007"},{"key":"C5RA14331D-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1517\/13543784.2012.693479","volume":"21","author":"Darvesh","year":"2012","journal-title":"Expert Opin. Invest. Drugs"},{"key":"C5RA14331D-(cit11)\/*[position()=1]","volume-title":"The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease","author":"Bright","year":"2007","unstructured":"J. J.\n            Bright\n          , in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, ed. B. B. Aggarwal, Y.-J. Surh and S. Shishodia, Springer Science+Business Media, LLC, New York, 2007"},{"key":"C5RA14331D-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-0-387-46401-5_8","volume":"595","author":"Cole","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"C5RA14331D-(cit13)\/*[position()=1]","volume-title":"Profiles of drug substances, excipients, and related methodology","volume":"vol. 39","author":"Lestari","year":"2014","unstructured":"M. L.\n            Lestari\n           and G.Indrayanto, Profiles of drug substances, excipients, and related methodology, Academic Press, San Diego, 2014, vol. 39, pp. 113\u2013204"},{"key":"C5RA14331D-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ijpharm.2013.12.007","volume":"461","author":"Hasan","year":"2014","journal-title":"Int. J. Pharm."},{"key":"C5RA14331D-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ijpharm.2012.12.032","volume":"443","author":"Liu","year":"2013","journal-title":"Int. J. Pharm."},{"key":"C5RA14331D-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3654","DOI":"10.1021\/jf400002x","volume":"61","author":"Xiao","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"C5RA14331D-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.carbpol.2012.02.036","volume":"93","author":"Da-Lozzo","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"C5RA14331D-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.1021\/mp400309s","volume":"10","author":"Harada","year":"2013","journal-title":"Mol. Pharmaceutics"},{"key":"C5RA14331D-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1208\/s12249-009-9264-8","volume":"10","author":"Yadav","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"C5RA14331D-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1016\/j.biomaterials.2013.12.090","volume":"35","author":"Naksuriya","year":"2014","journal-title":"Biomaterials"},{"key":"C5RA14331D-(cit21)\/*[position()=1]","first-page":"1","volume":"2011","author":"Wang","year":"2011","journal-title":"J. Nanomater."},{"key":"C5RA14331D-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10940","DOI":"10.1021\/cr500081p","volume":"114","author":"Crini","year":"2014","journal-title":"Chem. Rev."},{"key":"C5RA14331D-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1021\/cr960371r","volume":"97","author":"Connors","year":"1997","journal-title":"Chem. Rev."},{"key":"C5RA14331D-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1002\/jps.23077","volume":"101","author":"Loftsson","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"C5RA14331D-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00396-013-3124-5","volume":"292","author":"Medronho","year":"2014","journal-title":"Colloid Polym. Sci."},{"key":"C5RA14331D-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ijpharm.2012.06.055","volume":"453","author":"Kurkov","year":"2013","journal-title":"Int. J. Pharm."},{"key":"C5RA14331D-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cis.2013.08.001","volume":"205","author":"Valente","year":"2014","journal-title":"Adv. Colloid Interface Sci."},{"key":"C5RA14331D-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1016\/j.bmc.2006.01.052","volume":"14","author":"Castronuovo","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"C5RA14331D-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1039\/C3TB21016B","volume":"2","author":"Vashist","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"C5RA14331D-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.jconrel.2007.01.004","volume":"119","author":"Coviello","year":"2007","journal-title":"J. Controlled Release"},{"key":"C5RA14331D-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/j.polymer.2006.01.058","volume":"47","author":"Reis","year":"2006","journal-title":"Polymer"},{"key":"C5RA14331D-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.foodchem.2013.12.067","volume":"153","author":"Mangolim","year":"2014","journal-title":"Food Chem."},{"key":"C5RA14331D-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ijpharm.2007.12.006","volume":"355","author":"Maior","year":"2008","journal-title":"Int. J. Pharm."},{"key":"C5RA14331D-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0378-5173(83)90064-9","volume":"15","author":"Korsmeyer","year":"1983","journal-title":"Int. J. Pharm."},{"key":"C5RA14331D-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"13780","DOI":"10.1021\/la2026285","volume":"27","author":"Costa","year":"2011","journal-title":"Langmuir"},{"key":"C5RA14331D-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1021\/ie50262a025","volume":"23","author":"Hixson","year":"1931","journal-title":"Ind. Eng. Chem."},{"key":"C5RA14331D-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1080\/09593330.2011.650219","volume":"33","author":"Asci","year":"2012","journal-title":"Environ. Technol."},{"key":"C5RA14331D-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.molstruc.2008.05.024","volume":"892","author":"Benassi","year":"2008","journal-title":"J. Mol. Struct."},{"key":"C5RA14331D-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.saa.2012.11.048","volume":"104","author":"Dutta","year":"2013","journal-title":"Spectrochim. Acta, Part A"},{"key":"C5RA14331D-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vibspec.2012.05.002","volume":"62","author":"Mohan","year":"2012","journal-title":"Vib. Spectrosc."},{"key":"C5RA14331D-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.colsurfb.2010.03.039","volume":"79","author":"Yallapu","year":"2010","journal-title":"Colloids Surf., B"},{"key":"C5RA14331D-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.addr.2007.05.012","volume":"59","author":"Brewster","year":"2007","journal-title":"Adv. Drug Delivery Rev."},{"key":"C5RA14331D-(cit43)\/*[position()=1]","first-page":"171","volume":"2","author":"Singh","year":"2010","journal-title":"J. Pharm. Sci. Technol."},{"key":"C5RA14331D-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF00706472","volume":"15","author":"Li","year":"1993","journal-title":"J. Inclusion Phenom. Mol. Recognit. Chem."},{"key":"C5RA14331D-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10094","DOI":"10.1021\/jp034127x","volume":"107","author":"Funasaki","year":"2003","journal-title":"J. Phys. Chem. B"},{"key":"C5RA14331D-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1021\/cr970019t","volume":"98","author":"Schneider","year":"1998","journal-title":"Chem. Rev."},{"key":"C5RA14331D-(cit47)\/*[position()=1]","first-page":"513","volume":"55","author":"Fathy","year":"2000","journal-title":"Pharmazie"},{"key":"C5RA14331D-(cit48)\/*[position()=1]","volume-title":"Magnetic Resonance Spectroscopy","author":"Pessine","year":"2012","unstructured":"F. B. T.\n            Pessine\n          , A.Calderini and G. L.Alexandrino, in Magnetic Resonance Spectroscopy, ed. D. Kim, InTech, 2012, pp. 237\u2013264"},{"key":"C5RA14331D-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.foodchem.2014.05.094","volume":"165","author":"Jahed","year":"2014","journal-title":"Food Chem."},{"key":"C5RA14331D-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s10847-013-0322-1","volume":"78","author":"Patro","year":"2014","journal-title":"J. Inclusion Phenom. Macrocyclic Chem."},{"key":"C5RA14331D-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.jphotochem.2005.04.002","volume":"173","author":"Baglole","year":"2005","journal-title":"J. Photochem. Photobiol., A"},{"key":"C5RA14331D-(cit52)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1021\/jf0111965","volume":"50","author":"Tang","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"C5RA14331D-(cit53)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5242","DOI":"10.1016\/j.chroma.2009.05.017","volume":"1216","author":"Chalumot","year":"2009","journal-title":"J. Chromatogr. A"},{"key":"C5RA14331D-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1021\/ja01176a030","volume":"71","author":"Benesi","year":"1949","journal-title":"J. Am. Chem. Soc."},{"key":"C5RA14331D-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tca.2012.04.029","volume":"541","author":"Bai","year":"2012","journal-title":"Thermochim. Acta"},{"key":"C5RA14331D-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1002\/mabi.201000084","volume":"10","author":"Yallapu","year":"2010","journal-title":"Macromol. Biosci."},{"key":"C5RA14331D-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0168-3659(03)00129-9","volume":"89","author":"Juang","year":"2003","journal-title":"J. Controlled Release"},{"key":"C5RA14331D-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.colsurfa.2011.03.046","volume":"391","author":"Costa","year":"2011","journal-title":"Colloids Surf., A"},{"key":"C5RA14331D-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.colsurfb.2014.07.014","volume":"122","author":"Sitta","year":"2014","journal-title":"Colloids Surf., B"},{"key":"C5RA14331D-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.jhazmat.2005.12.043","volume":"136","author":"Ho","year":"2006","journal-title":"J. Hazard. Mater."},{"key":"C5RA14331D-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/10717540490884804","volume":"11","author":"Ekici","year":"2004","journal-title":"Drug Delivery"},{"key":"C5RA14331D-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.carbpol.2015.03.052","volume":"128","author":"Montiel-Herrera","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"C5RA14331D-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"18C501","DOI":"10.1063\/1.4895539","volume":"141","author":"Hazra","year":"2014","journal-title":"J. Chem. Phys."},{"key":"C5RA14331D-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0169-409X(96)00427-9","volume":"23","author":"Gan","year":"1997","journal-title":"Adv. Drug Delivery Rev."},{"key":"C5RA14331D-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10565-005-0085-6","volume":"21","author":"Sambuy","year":"2005","journal-title":"Cell Biol. Toxicol."},{"key":"C5RA14331D-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s00204-010-0513-0","volume":"84","author":"Puerto","year":"2010","journal-title":"Arch. Toxicol."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2015\/RA\/C5RA14331D","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T12:26:39Z","timestamp":1713356799000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=C5RA14331D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"references-count":66,"journal-issue":{"issue":"115","published-print":{"date-parts":[[2015]]}},"URL":"https:\/\/doi.org\/10.1039\/c5ra14331d","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C5RA14331D","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 23 July 2015; Accepted 15 October 2015;  Accepted Manuscript published 16 October 2015;  Version of Record published 3 November 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}