{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:34:53Z","timestamp":1768588493838,"version":"3.49.0"},"reference-count":67,"publisher":"Royal Society of Chemistry (RSC)","issue":"24","funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["SFRH\/BD\/9123\/2011"],"award-info":[{"award-number":["SFRH\/BD\/9123\/2011"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>Behavior of insulin-loaded biopolymer-based nanoparticles upon passage through the gastrointestinal tract. Intestinal pH triggered insulin release from nanoparticles, allowing its permeability through cell-based engineered intestinal models.<\/p>","DOI":"10.1039\/c5ra26224k","type":"journal-article","created":{"date-parts":[[2016,2,9]],"date-time":"2016-02-09T15:44:54Z","timestamp":1455032694000},"page":"20155-20165","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of the in vitro gastrointestinal passage of biopolymer-based nanoparticles on insulin absorption"],"prefix":"10.1039","volume":"6","author":[{"given":"Marlene","family":"Lopes","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy"},{"name":"University of Coimbra"},{"name":"3000-548 Coimbra"},{"name":"Portugal"},{"name":"CNC \u2013 Center for Neuroscience and Cell Biology"}]},{"given":"Amelie","family":"Derenne","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy"},{"name":"University of Coimbra"},{"name":"3000-548 Coimbra"},{"name":"Portugal"},{"name":"Faculty of Medicine"}]},{"given":"Carla","family":"Pereira","sequence":"additional","affiliation":[{"name":"I3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"},{"name":"University of Porto"},{"name":"4150-180 Porto"},{"name":"Portugal"}]},{"given":"Francisco","family":"Veiga","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy"},{"name":"University of Coimbra"},{"name":"3000-548 Coimbra"},{"name":"Portugal"},{"name":"CNC \u2013 Center for Neuroscience and Cell Biology"}]},{"given":"Raquel","family":"Sei\u00e7a","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology"},{"name":"IBILI \u2013 Institute for Biomedical Imaging and Life Sciences"},{"name":"Faculty of Medicine"},{"name":"3000-548 Coimbra"},{"name":"Portugal"}]},{"given":"Bruno","family":"Sarmento","sequence":"additional","affiliation":[{"name":"I3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"},{"name":"University of Porto"},{"name":"4150-180 Porto"},{"name":"Portugal"},{"name":"CESPU"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-8944","authenticated-orcid":false,"given":"Ant\u00f3nio","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy"},{"name":"University of Coimbra"},{"name":"3000-548 Coimbra"},{"name":"Portugal"},{"name":"I3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C5RA26224K-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0169-409X(98)00075-1","volume":"35","author":"Carino","year":"1999","journal-title":"Adv. Drug Delivery Rev."},{"key":"C5RA26224K-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.ejps.2010.08.009","volume":"41","author":"Woitiski","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"C5RA26224K-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijpharm.2011.04.003","volume":"412","author":"Woitiski","year":"2011","journal-title":"Int. J. Pharm."},{"key":"C5RA26224K-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.1002\/jps.21347","volume":"97","author":"Reis","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"C5RA26224K-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijpharm.2007.09.009","volume":"350","author":"Stops","year":"2008","journal-title":"Int. J. Pharm."},{"key":"C5RA26224K-(cit6)\/*[position()=1]","first-page":"477","volume":"12","author":"Abbaspour","year":"2013","journal-title":"Trop. J. Pharm. Res."},{"key":"C5RA26224K-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/bm900035u","volume":"10","author":"Cui","year":"2009","journal-title":"Biomacromolecules"},{"key":"C5RA26224K-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9678","DOI":"10.1016\/j.biomaterials.2013.08.048","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"C5RA26224K-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1016\/j.biomaterials.2014.04.104","volume":"35","author":"Shrestha","year":"2014","journal-title":"Biomaterials"},{"key":"C5RA26224K-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2006.04.017","volume":"114","author":"George","year":"2006","journal-title":"J. Controlled Release"},{"key":"C5RA26224K-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/bit.10606","volume":"82","author":"Kamiya","year":"2003","journal-title":"Biotechnol. Bioeng."},{"key":"C5RA26224K-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ejps.2006.12.007","volume":"30","author":"Reis","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"C5RA26224K-(cit13)\/*[position()=1]","volume-title":"Chapter fifteen \u2013 Chitosan-Coated Solid Lipid Nanoparticles for Insulin Delivery","author":"Fonte","year":"2012","unstructured":"P. Fonte , F.Andrade, F.Ara\u00fajo, C.Andrade, J. d.Neves and B.Sarmento, in Chapter fifteen \u2013 Chitosan-Coated Solid Lipid Nanoparticles for Insulin Delivery, ed. D. Nejat, Academic Press, 2012, pp. 295\u2013314"},{"key":"C5RA26224K-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"8712","DOI":"10.1016\/j.biomaterials.2011.07.086","volume":"32","author":"Sonaje","year":"2011","journal-title":"Biomaterials"},{"key":"C5RA26224K-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.carbpol.2005.09.023","volume":"63","author":"Qin","year":"2006","journal-title":"Carbohydr. Polym."},{"key":"C5RA26224K-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.carbpol.2009.03.031","volume":"78","author":"Fan","year":"2009","journal-title":"Carbohydr. Polym."},{"key":"C5RA26224K-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ijbiomac.2005.02.006","volume":"35","author":"Borchard","year":"2005","journal-title":"Int. J. Biol. Macromol."},{"key":"C5RA26224K-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2217\/nnm.09.110","volume":"5","author":"Roger","year":"2010","journal-title":"Nanomedicine"},{"key":"C5RA26224K-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12989-015-0085-5","volume":"12","author":"Hinkley","year":"2015","journal-title":"Part. Fibre Toxicol."},{"key":"C5RA26224K-(cit20)\/*[position()=1]","first-page":"5865","volume":"10","author":"Lopes","year":"2015","journal-title":"Int. J. Nanomed."},{"key":"C5RA26224K-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1166\/jcc.2013.1025","volume":"1","author":"Lopes","year":"2013","journal-title":"J. Chitin Chitosan Sci."},{"key":"C5RA26224K-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0378-5173(01)00646-9","volume":"220","author":"V\u00e1zquez","year":"2001","journal-title":"Int. J. Pharm."},{"key":"C5RA26224K-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1002\/bmc.616","volume":"20","author":"Sarmento","year":"2006","journal-title":"Biomed. Chromatogr."},{"key":"C5RA26224K-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ejpb.2005.03.002","volume":"60","author":"Vertzoni","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"C5RA26224K-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ijpharm.2008.05.012","volume":"364","author":"McConnell","year":"2008","journal-title":"Int. J. Pharm."},{"key":"C5RA26224K-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ejps.2008.11.015","volume":"36","author":"Gaumet","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"C5RA26224K-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s13346-011-0023-5","volume":"1","author":"Fonte","year":"2011","journal-title":"Drug Delivery Transl. Res."},{"key":"C5RA26224K-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.carbpol.2010.12.042","volume":"84","author":"Sarmento","year":"2011","journal-title":"Carbohydr. Polym."},{"key":"C5RA26224K-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ddtec.2005.05.019","volume":"2","author":"Florence","year":"2005","journal-title":"Drug Discovery Today: Technol."},{"key":"C5RA26224K-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0169-409X(98)00037-4","volume":"34","author":"Norris","year":"1998","journal-title":"Adv. Drug Delivery Rev."},{"key":"C5RA26224K-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.addr.2008.11.002","volume":"61","author":"Lai","year":"2009","journal-title":"Adv. Drug Delivery Rev."},{"key":"C5RA26224K-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.carbpol.2013.06.063","volume":"98","author":"Santos","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"C5RA26224K-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1517\/17425240903579971","volume":"7","author":"Caldorera-Moore","year":"2010","journal-title":"Expert Opin. Drug Delivery"},{"key":"C5RA26224K-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"11613","DOI":"10.1073\/pnas.0801763105","volume":"105","author":"Gratton","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"C5RA26224K-(cit35)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s12274-011-0184-z","volume":"5","author":"Verma","year":"2012","journal-title":"Nano Res."},{"key":"C5RA26224K-(cit36)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijpharm.2009.10.008","volume":"390","author":"Gaumet","year":"2010","journal-title":"Int. J. Pharm."},{"key":"C5RA26224K-(cit37)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0378-5173(95)04353-5","volume":"132","author":"Hillery","year":"1996","journal-title":"Int. J. Pharm."},{"key":"C5RA26224K-(cit38)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1016\/j.biomaterials.2004.07.050","volume":"26","author":"Win","year":"2005","journal-title":"Biomaterials"},{"key":"C5RA26224K-(cit39)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ejps.2005.04.015","volume":"25","author":"des Rieux","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"C5RA26224K-(cit40)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1016\/j.carres.2005.08.011","volume":"340","author":"Mimmo","year":"2005","journal-title":"Carbohydr. Res."},{"key":"C5RA26224K-(cit41)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carbpol.2006.02.008","volume":"66","author":"Sarmento","year":"2006","journal-title":"Carbohydr. Polym."},{"key":"C5RA26224K-(cit42)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1023\/A:1012029517394","volume":"14","author":"Florence","year":"1997","journal-title":"Pharm. Res."},{"key":"C5RA26224K-(cit43)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.foodhyd.2011.05.011","volume":"26","author":"Lesmes","year":"2012","journal-title":"Food Hydrocolloids"},{"key":"C5RA26224K-(cit44)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1016\/S0032-3861(97)00597-1","volume":"39","author":"Wang","year":"1998","journal-title":"Polym. J."},{"key":"C5RA26224K-(cit45)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1016\/j.actbio.2009.03.007","volume":"5","author":"Woitiski","year":"2009","journal-title":"Acta Biomater."},{"key":"C5RA26224K-(cit46)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jconrel.2006.12.023","volume":"118","author":"des Rieux","year":"2007","journal-title":"J. Controlled Release"},{"key":"C5RA26224K-(cit47)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0927-7765(02)00053-X","volume":"27","author":"Garcia-Fuentes","year":"2003","journal-title":"Colloids Surf., B"},{"key":"C5RA26224K-(cit48)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3109\/03639049609065908","volume":"22","author":"Chien","year":"1996","journal-title":"Drug Dev. Ind. Pharm."},{"key":"C5RA26224K-(cit49)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1208\/s12249-010-9561-2","volume":"12","author":"Chaudhury","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"C5RA26224K-(cit50)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3109\/10717544.2013.819611","volume":"20","author":"Gupta","year":"2013","journal-title":"Drug Delivery"},{"key":"C5RA26224K-(cit51)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9199","DOI":"10.1016\/j.biomaterials.2014.07.026","volume":"35","author":"Ara\u00fajo","year":"2014","journal-title":"Biomaterials"},{"key":"C5RA26224K-(cit52)\/*[position()=1]","first-page":"3525","volume":"19","author":"Zhang","year":"2008","journal-title":"J. Mater. Sci.: Mater. Med."},{"key":"C5RA26224K-(cit53)\/*[position()=1]","first-page":"2205","volume":"18","author":"Liu","year":"2007","journal-title":"J. Mater. Sci.: Mater. Med."},{"key":"C5RA26224K-(cit54)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"221","DOI":"10.59566\/IJBS.2008.4221","volume":"4","author":"Li","year":"2008","journal-title":"Int. J. Biomed. Sci."},{"key":"C5RA26224K-(cit55)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1208\/s12249-010-9380-5","volume":"11","author":"Nagarwal","year":"2010","journal-title":"AAPS PharmSciTech"},{"key":"C5RA26224K-(cit56)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0168-3659(87)90034-4","volume":"5","author":"Ritger","year":"1987","journal-title":"J. Controlled Release"},{"key":"C5RA26224K-(cit57)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijpharm.2013.10.003","volume":"458","author":"Ara\u00fajo","year":"2013","journal-title":"Int. J. Pharm."},{"key":"C5RA26224K-(cit58)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1517\/17425255.2012.673586","volume":"8","author":"Sarmento","year":"2012","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"C5RA26224K-(cit59)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.ejpb.2012.10.003","volume":"83","author":"Antunes","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"C5RA26224K-(cit60)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"9826","DOI":"10.1016\/j.biomaterials.2011.08.087","volume":"32","author":"Chen","year":"2011","journal-title":"Biomaterials"},{"key":"C5RA26224K-(cit61)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S1359-6446(01)01962-6","volume":"6","author":"Pillai","year":"2001","journal-title":"Drug Discovery Today"},{"key":"C5RA26224K-(cit62)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.addr.2012.10.010","volume":"65","author":"Chen","year":"2013","journal-title":"Adv. Drug Delivery Rev."},{"key":"C5RA26224K-(cit63)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6254","DOI":"10.1016\/j.biomaterials.2012.05.013","volume":"33","author":"Hsu","year":"2012","journal-title":"Biomaterials"},{"key":"C5RA26224K-(cit64)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1021\/mp200572t","volume":"9","author":"Sonaje","year":"2012","journal-title":"Mol. Pharm."},{"key":"C5RA26224K-(cit65)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.1016\/j.ces.2009.04.050","volume":"64","author":"Peppas","year":"2009","journal-title":"Chem. Eng. Sci."},{"key":"C5RA26224K-(cit66)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1021\/js960110x","volume":"85","author":"Walter","year":"1996","journal-title":"J. Pharm. Sci."},{"key":"C5RA26224K-(cit67)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ijbiomac.2015.03.066","volume":"78","author":"Dinarvand","year":"2015","journal-title":"Int. J. Biol. Macromol."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/RA\/C5RA26224K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T07:56:41Z","timestamp":1718351801000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=C5RA26224K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":67,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c5ra26224k","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Ant\u00f3nio Ribeiro (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-1399-8944","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 8 December 2015; Accepted 6 February 2016; Accepted Manuscript published 9 February 2016; Version of Record published 18 February 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}