{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:36:26Z","timestamp":1772966186841,"version":"3.50.1"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Iron oxide nanoparticles (ION) have been widely used in biomedical applications, for both diagnosis and therapy, due to their unique magnetic properties. They are intensively explored in neuromedicine mostly because of their ability to cross the blood brain barrier. Hence, their potential harmful effects on neuronal cells need to be carefully assessed. The objective of this study was to evaluate the toxicity of silica-coated ION (S-ION) (10\u2013200 \u03bcg ml\u22121) on human neuronal SHSY5Y cells. Alterations in the cell cycle, cell death by apoptosis or necrosis, and membrane integrity were assessed as cytotoxicity parameters. Genotoxicity was determined by a \u03b3H2AX assay, a micronucleus (MN) test, and a comet assay. Complementarily, possible effects on DNA damage repair were also analysed by means of a DNA repair competence assay. All analyses were performed in complete and serum-free cell culture media. Iron ion release from the nanoparticles was notable only in complete medium. Despite being effectively internalized by the neuronal cells, S-ION presented in general low cytotoxicity; positive results were only obtained in some assays at the highest concentrations and\/or the longest exposure time tested (24 h). Genotoxicity evaluations in serum-free medium were negative for all conditions assayed; in complete medium, dose and time-dependent increase in DNA damage not related to the production of double strand breaks or chromosome loss (according to the results of the \u03b3H2AX assay and MN test), was obtained. The presence of serum slightly influenced the behaviour of S-ION; further studies to investigate the formation of a protein corona and its role in nanoparticle toxicity are necessary.<\/jats:p>","DOI":"10.1039\/c5tx00206k","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T08:31:47Z","timestamp":1445589107000},"page":"235-247","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["<i>In vitro<\/i> toxicity evaluation of silica-coated iron oxide nanoparticles in human SHSY5Y neuronal cells"],"prefix":"10.1093","volume":"5","author":[{"given":"G\u00f6zde","family":"Kili\u00e7","sequence":"first","affiliation":[{"name":"DICOMOSA Group, Department of Psychology, Area of Psychobiology, Universidade da Coru\u00f1a, Research Services Building, Campus Elvi\u00f1a s\/n, 15071-A Coru\u00f1a, Spain. Fax: +34 981167172; Tel: +34 981167000"},{"name":"Department of Cell and Molecular Biology, University of A Coru\u00f1a, Faculty of Sciences, Campus A Zapateira s\/n, 15071-A Coru\u00f1a, Spain"}]},{"given":"Carla","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Portuguese National Institute of Health, Rua Alexandre Herculano 321, Porto 4000-055, Portugal"},{"name":"EPIUnit - Institute of Public Health, University of Porto, Rua das Taipas no. 135, Porto 4050-600, Portugal"}]},{"given":"Natalia","family":"Fern\u00e1ndez-Bert\u00f3lez","sequence":"additional","affiliation":[{"name":"DICOMOSA Group, Department of Psychology, Area of Psychobiology, Universidade da Coru\u00f1a, Research Services Building, Campus Elvi\u00f1a s\/n, 15071-A Coru\u00f1a, Spain. Fax: +34 981167172; Tel: +34 981167000"},{"name":"Department of Cell and Molecular Biology, University of A Coru\u00f1a, Faculty of Sciences, Campus A Zapateira s\/n, 15071-A Coru\u00f1a, Spain"}]},{"given":"Eduardo","family":"P\u00e1saro","sequence":"additional","affiliation":[{"name":"DICOMOSA Group, Department of Psychology, Area of Psychobiology, Universidade da Coru\u00f1a, Research Services Building, Campus Elvi\u00f1a s\/n, 15071-A Coru\u00f1a, Spain. Fax: +34 981167172; Tel: +34 981167000"}]},{"given":"Jo\u00e3o Paulo","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, Portuguese National Institute of Health, Rua Alexandre Herculano 321, Porto 4000-055, Portugal"},{"name":"EPIUnit - Institute of Public Health, University of Porto, Rua das Taipas no. 135, Porto 4050-600, Portugal"}]},{"given":"Blanca","family":"Laffon","sequence":"additional","affiliation":[{"name":"DICOMOSA Group, Department of Psychology, Area of Psychobiology, Universidade da Coru\u00f1a, Research Services Building, Campus Elvi\u00f1a s\/n, 15071-A Coru\u00f1a, Spain. Fax: +34 981167172; Tel: +34 981167000"}]},{"given":"Vanessa","family":"Valdiglesias","sequence":"additional","affiliation":[{"name":"DICOMOSA Group, Department of Psychology, Area of Psychobiology, Universidade da Coru\u00f1a, Research Services Building, Campus Elvi\u00f1a s\/n, 15071-A Coru\u00f1a, Spain. Fax: +34 981167172; Tel: +34 981167000"}]}],"member":"286","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"2024030719464278400_cit1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1039\/C4FD00132J","volume":"175","author":"Peng","year":"2014","journal-title":"Faraday Discuss."},{"key":"2024030719464278400_cit2","first-page":"2527","volume":"9","author":"Xue","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"2024030719464278400_cit3","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1039\/c3nr00119a","volume":"5","author":"Zhang","year":"2013","journal-title":"Nanoscale"},{"key":"2024030719464278400_cit4","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1007\/s11095-014-1561-6","volume":"32","author":"Dan","year":"2014","journal-title":"Pharm. 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