{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T05:17:37Z","timestamp":1770355057366,"version":"3.49.0"},"reference-count":121,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The development of therapeutic approaches combining efficacy and safety represents an important goal in intestinal inflammation research. Recently, evidence has supported dietary polyphenols as useful tools in the treatment and prevention of chronic inflammatory diseases, but the mechanisms of action are still poorly understood. We here reveal molecular mechanisms underlying the anti-inflammatory action of a non-alcoholic polyphenol red wine extract (RWE), operating at complementary levels via the Janus kinase\/signal transducer and activator of transcription (JAK\/STAT) and Nuclear factor-erythroid 2-related factor-2 (Nrf2) pathways. RWE significantly reduced the nuclear levels of phosphorylated STAT1 and also the cellular levels of phosphorylated JAK1 induced by cytokines, suppressing the JAK\/STAT inflammatory signalling cascade. In turn, RWE increased the Nrf2 nuclear level, activating the Nrf2 pathway, leading not only to an up-regulation of the heme oxygenase-1 (HO-1) expression but also to an increase of the glutamate\u2013cysteine ligase subunit catalytic (GCLc) gene expression, enhancing the GSH synthesis, thereby counteracting GSH depletion that occurs under inflammatory conditions. Overall, data indicate that the anti-inflammatory action of RWE is exerted at complementary levels, via suppression of the JAK\/STAT inflammatory pathway and positive modulation of the activity of Nrf2. These results point to the potential use of the RWE as an efficient, readily available and inexpensive therapeutic strategy in the context of gastrointestinal inflammation.<\/jats:p>","DOI":"10.1039\/c5tx00214a","type":"journal-article","created":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T09:03:09Z","timestamp":1444035789000},"page":"53-65","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation <i>via<\/i> opposite modulation of JAK\/STAT and Nrf2 pathways"],"prefix":"10.1093","volume":"5","author":[{"given":"Carla","family":"Nunes","sequence":"first","affiliation":[{"name":"Center for Neurosciences and Cell Biology and Faculty of Pharmacy, University of Coimbra, Health Sciences Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Nat\u00e9rcia","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, University of Porto, Portugal"}]},{"given":"Diana","family":"Serra","sequence":"additional","affiliation":[{"name":"Center for Neurosciences and Cell Biology and Faculty of Pharmacy, University of Coimbra, Health Sciences Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"given":"V\u00edctor","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, University of Porto, Portugal"}]},{"given":"Leonor","family":"Almeida","sequence":"additional","affiliation":[{"name":"Center for Neurosciences and Cell Biology and Faculty of Pharmacy, University of Coimbra, Health Sciences Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]},{"given":"Jo\u00e3o","family":"Laranjinha","sequence":"additional","affiliation":[{"name":"Center for Neurosciences and Cell Biology and Faculty of Pharmacy, University of Coimbra, Health Sciences Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal"}]}],"member":"286","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"2024030719462268200_cit1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00054725-200305000-00006","volume":"9","author":"Cross","year":"2003","journal-title":"Inflammatory Bowel Dis."},{"key":"2024030719462268200_cit2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"2024030719462268200_cit3","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature10209","volume":"474","author":"Khor","year":"2011","journal-title":"Nature"},{"key":"2024030719462268200_cit4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/MOG.0b013e328353e61e","volume":"28","author":"Scharl","year":"2012","journal-title":"Curr. Opin. Gastroenterol."},{"key":"2024030719462268200_cit5","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2165\/00002018-200023050-00006","volume":"23","author":"Stein","year":"2000","journal-title":"Drug Saf."},{"key":"2024030719462268200_cit6","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1517\/14740331003639412","volume":"9","author":"Rosenberg","year":"2010","journal-title":"Expert Opin. Drug Saf."},{"key":"2024030719462268200_cit7","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.3748\/wjg.v10.i16.2311","volume":"10","author":"Xu","year":"2004","journal-title":"World J. Gastroenterol."},{"key":"2024030719462268200_cit8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.mrfmmm.2005.04.022","volume":"591","author":"Dolara","year":"2005","journal-title":"Mutat. Res."},{"key":"2024030719462268200_cit9","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.freeradbiomed.2007.06.007","volume":"43","author":"Gago","year":"2007","journal-title":"Free Radical Biol. Med."},{"key":"2024030719462268200_cit10","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1039\/C4FO00097H","volume":"5","author":"Janega","year":"2014","journal-title":"Food Funct."},{"key":"2024030719462268200_cit11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1039\/C2FO30233K","volume":"4","author":"Nunes","year":"2013","journal-title":"Food Funct."},{"key":"2024030719462268200_cit12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2013.06.007","volume":"76","author":"Coskun","year":"2013","journal-title":"Pharmacol. Res."},{"key":"2024030719462268200_cit13","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.1074\/jbc.275.9.6462","volume":"275","author":"Huang","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2024030719462268200_cit14","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.cellsig.2006.09.003","volume":"19","author":"Kim","year":"2007","journal-title":"Cell. Signalling"},{"key":"2024030719462268200_cit15","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.bcp.2012.11.016","volume":"85","author":"Bryan","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"2024030719462268200_cit16","doi-asserted-by":"crossref","first-page":"10074","DOI":"10.3390\/molecules190710074","volume":"19","author":"Keum","year":"2014","journal-title":"Molecules"},{"key":"2024030719462268200_cit17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/mc.20465","volume":"48","author":"Li","year":"2009","journal-title":"Mol. Carcinog."},{"key":"2024030719462268200_cit18","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mrfmmm.2009.09.007","volume":"690","author":"Kim","year":"2010","journal-title":"Mutat. Res."},{"key":"2024030719462268200_cit19","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.foodchem.2010.10.016","volume":"125","author":"Fernandes","year":"2011","journal-title":"Food Chem."},{"key":"2024030719462268200_cit20","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1080\/11358120109487653","volume":"3","author":"Mateus","year":"2001","journal-title":"Cienc. Tecnol. Aliment."},{"key":"2024030719462268200_cit21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.5344\/ajev.1999.50.3.285","volume":"50","author":"Pe\u00f1a-Neira","year":"1999","journal-title":"Am. J. Enol. Vitic."},{"key":"2024030719462268200_cit22","first-page":"627","author":"Rib\u00e9reau-Gayon","year":"1966","journal-title":"Chim. Anal."},{"key":"2024030719462268200_cit23","doi-asserted-by":"crossref","first-page":"5736","DOI":"10.1021\/jf010827s","volume":"49","author":"Arnous","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"2024030719462268200_cit24","first-page":"1936","volume":"48","author":"Chantret","year":"1988","journal-title":"Cancer Res."},{"key":"2024030719462268200_cit25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","volume":"89","author":"Denizot","year":"1986","journal-title":"J. Immunol. Methods"},{"key":"2024030719462268200_cit26","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","volume":"74","author":"Hissin","year":"1976","journal-title":"Anal. Biochem."},{"key":"2024030719462268200_cit27","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.semcdb.2008.08.010","volume":"19","author":"Schindler","year":"2008","journal-title":"Semin. Cell Dev. Biol."},{"key":"2024030719462268200_cit28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nm0196-87","volume":"2","author":"Willis","year":"1996","journal-title":"Nat. Med."},{"issue":"Suppl 1","key":"2024030719462268200_cit29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1365-2036.2004.01992.x","volume":"20","author":"Naito","year":"2004","journal-title":"Aliment. Pharmacol. Ther."},{"key":"2024030719462268200_cit30","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1007\/s10753-012-9431-z","volume":"35","author":"Yalniz","year":"2012","journal-title":"Inflammation"},{"key":"2024030719462268200_cit31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1080\/01926230701311344","volume":"35","author":"Aleksunes","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"2024030719462268200_cit32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1146\/annurev.pharmtox.43.100901.140229","volume":"43","author":"Nguyen","year":"2003","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"2024030719462268200_cit33","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0167-4781(00)00238-4","volume":"1517","author":"Chan","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"2024030719462268200_cit34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1042\/bj20020320","volume":"365","author":"Chanas","year":"2002","journal-title":"Biochem. J."},{"key":"2024030719462268200_cit35","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.3390\/md12074214","volume":"12","author":"Zheng","year":"2014","journal-title":"Mar. Drugs"},{"key":"2024030719462268200_cit36","doi-asserted-by":"crossref","first-page":"705","DOI":"10.3109\/15412555.2014.898040","volume":"11","author":"Santus","year":"2014","journal-title":"COPD"},{"key":"2024030719462268200_cit37","doi-asserted-by":"crossref","first-page":"4628","DOI":"10.1073\/pnas.0511304103","volume":"103","author":"Tirouvanziam","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2024030719462268200_cit38","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2147\/COPD.S49307","volume":"8","author":"De Backer","year":"2013","journal-title":"Int. J. Chronic Obstruct. Pulm. Dis."},{"key":"2024030719462268200_cit39","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/00365513.2012.734859","volume":"73","author":"Uraz","year":"2013","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"2024030719462268200_cit40","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1017\/S0031182009991090","volume":"137","author":"Jeong","year":"2010","journal-title":"Parasitology"},{"key":"2024030719462268200_cit41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/011542650802300149","volume":"23","author":"Clarke","year":"2008","journal-title":"Nutr. Clin. Pract."},{"key":"2024030719462268200_cit42","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/01.mcg.0000155570.19340.61","volume":"39","author":"Kong","year":"2005","journal-title":"J. Clin. Gastroenterol."},{"key":"2024030719462268200_cit43","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gut.2006.094599","volume":"56","author":"Shapiro","year":"2007","journal-title":"Gut"},{"key":"2024030719462268200_cit44","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.nutres.2012.09.013","volume":"32","author":"Hur","year":"2012","journal-title":"Nutr. Res."},{"key":"2024030719462268200_cit45","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.2174\/092986711797535263","volume":"18","author":"Biasi","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"2024030719462268200_cit46","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1039\/C4FO00124A","volume":"5","author":"Rocha","year":"2014","journal-title":"Food Funct."},{"key":"2024030719462268200_cit47","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.mam.2010.09.006","volume":"31","author":"Fraga","year":"2010","journal-title":"Mol. Aspects Med."},{"key":"2024030719462268200_cit48","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.bcp.2006.07.004","volume":"72","author":"Rahman","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"2024030719462268200_cit49","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1365-2249.2005.02844.x","volume":"141","author":"Kim","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"2024030719462268200_cit50","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1055\/s-2006-931597","volume":"72","author":"Netsch","year":"2006","journal-title":"Planta Med."},{"key":"2024030719462268200_cit51","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1124\/mol.65.1.111","volume":"65","author":"Tedeschi","year":"2004","journal-title":"Mol. Pharmacol."},{"key":"2024030719462268200_cit52","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.fct.2009.02.015","volume":"47","author":"Romier-Crouzet","year":"2009","journal-title":"Food Chem. Toxicol."},{"key":"2024030719462268200_cit53","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.phymed.2014.12.002","volume":"22","author":"Jeong","year":"2015","journal-title":"Phytomedicine"},{"key":"2024030719462268200_cit54","doi-asserted-by":"crossref","first-page":"5979","DOI":"10.1021\/jf400342g","volume":"61","author":"Carey","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"2024030719462268200_cit55","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.foodchem.2012.02.017","volume":"133","author":"Hole","year":"2012","journal-title":"Food Chem."},{"key":"2024030719462268200_cit56","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.phymed.2011.12.001","volume":"19","author":"Herranz-Lopez","year":"2012","journal-title":"Phytomedicine"},{"key":"2024030719462268200_cit57","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0003-9861(02)00561-1","volume":"408","author":"Rossetto","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"2024030719462268200_cit58","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1177\/1060028013512790","volume":"47","author":"Vyas","year":"2013","journal-title":"Ann. Pharmacother."},{"key":"2024030719462268200_cit59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12876-015-0239-9","volume":"15","author":"Panes","year":"2015","journal-title":"BMC Gastroenterol."},{"key":"2024030719462268200_cit60","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1056\/NEJMoa1112168","volume":"367","author":"Sandborn","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"2024030719462268200_cit61","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.immunol.15.1.563","volume":"15","author":"Bach","year":"1997","journal-title":"Annu. Rev. Immunol."},{"key":"2024030719462268200_cit62","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1126\/science.1496401","volume":"257","author":"Schindler","year":"1992","journal-title":"Science"},{"key":"2024030719462268200_cit63","doi-asserted-by":"crossref","first-page":"8638","DOI":"10.1073\/pnas.151239498","volume":"98","author":"Ganster","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2024030719462268200_cit64","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1124\/jpet.103.054460","volume":"307","author":"Tedeschi","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2024030719462268200_cit65","doi-asserted-by":"crossref","first-page":"6474","DOI":"10.1021\/jf2008925","volume":"59","author":"Andujar","year":"2011","journal-title":"J. Agric. Food Chem."},{"key":"2024030719462268200_cit66","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.4049\/jimmunol.166.7.4481","volume":"166","author":"Suk","year":"2001","journal-title":"J. Immunol."},{"key":"2024030719462268200_cit67","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1074\/jbc.M307774200","volume":"279","author":"Sironi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2024030719462268200_cit68","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1074\/jbc.M302637200","volume":"279","author":"Townsend","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2024030719462268200_cit69","doi-asserted-by":"crossref","first-page":"6821","DOI":"10.1128\/MCB.25.15.6821-6833.2005","volume":"25","author":"Kim","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"2024030719462268200_cit70","doi-asserted-by":"crossref","first-page":"13153","DOI":"10.1074\/jbc.M007646200","volume":"276","author":"Suk","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2024030719462268200_cit71","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.jnutbio.2010.01.011","volume":"22","author":"Kao","year":"2011","journal-title":"J. Nutr. Biochem."},{"key":"2024030719462268200_cit72","doi-asserted-by":"crossref","first-page":"6072","DOI":"10.4049\/jimmunol.171.11.6072","volume":"171","author":"Kim","year":"2003","journal-title":"J. Immunol."},{"key":"2024030719462268200_cit73","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.jaci.2004.06.042","volume":"114","author":"Chen","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"2024030719462268200_cit74","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1074\/jbc.R300030200","volume":"279","author":"Wormald","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2024030719462268200_cit75","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.2741\/3051","volume":"13","author":"Xu","year":"2008","journal-title":"Front. Biosci."},{"key":"2024030719462268200_cit76","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0891-5849(02)00853-5","volume":"33","author":"Pavlick","year":"2002","journal-title":"Free Radical Biol. Med."},{"key":"2024030719462268200_cit77","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.disamonth.2006.05.005","volume":"52","author":"Karp","year":"2006","journal-title":"DM, Dis. \u2013 Mon."},{"key":"2024030719462268200_cit78","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3164\/jcbn.10-41","volume":"48","author":"Tanida","year":"2011","journal-title":"J. Clin. Biochem. Nutr."},{"key":"2024030719462268200_cit79","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.fct.2014.04.032","volume":"69","author":"Arab","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"2024030719462268200_cit80","first-page":"407","volume":"76","author":"Tkachev","year":"2011","journal-title":"Biochemistry"},{"key":"2024030719462268200_cit81","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/j.freeradbiomed.2008.02.006","volume":"44","author":"Patel","year":"2008","journal-title":"Free Radical Biol. Med."},{"key":"2024030719462268200_cit82","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.fct.2010.10.002","volume":"49","author":"Hwang","year":"2011","journal-title":"Food Chem. Toxicol."},{"key":"2024030719462268200_cit83","doi-asserted-by":"crossref","first-page":"e0126457","DOI":"10.1371\/journal.pone.0126457","volume":"10","author":"Chen","year":"2015","journal-title":"PLoS One"},{"key":"2024030719462268200_cit84","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1053\/j.gastro.2009.03.033","volume":"137","author":"Theiss","year":"2009","journal-title":"Gastroenterology"},{"key":"2024030719462268200_cit85","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1053\/j.gastro.2011.06.074","volume":"141","author":"Choi","year":"2011","journal-title":"Gastroenterology"},{"key":"2024030719462268200_cit86","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/path.1408","volume":"201","author":"Kruidenier","year":"2003","journal-title":"J. Pathol."},{"key":"2024030719462268200_cit87","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11010-009-0284-1","volume":"337","author":"Khodagholi","year":"2010","journal-title":"Mol. Cell. Biochem."},{"key":"2024030719462268200_cit88","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.lfs.2010.06.014","volume":"87","author":"Sahin","year":"2010","journal-title":"Life Sci."},{"key":"2024030719462268200_cit89","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.redox.2013.10.007","volume":"1","author":"Aminzadeh","year":"2013","journal-title":"Redox Biol."},{"key":"2024030719462268200_cit90","doi-asserted-by":"crossref","first-page":"770","DOI":"10.2174\/156652411798062395","volume":"11","author":"Speciale","year":"2011","journal-title":"Curr. Mol. Med."},{"key":"2024030719462268200_cit91","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.arr.2007.08.004","volume":"7","author":"Mattson","year":"2008","journal-title":"Ageing Res. Rev."},{"key":"2024030719462268200_cit92","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1016\/j.freeradbiomed.2011.09.033","volume":"51","author":"Erlank","year":"2011","journal-title":"Free Radical Biol. Med."},{"key":"2024030719462268200_cit93","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1021\/tx060157q","volume":"19","author":"Lee-Hilz","year":"2006","journal-title":"Chem. Res. Toxicol."},{"key":"2024030719462268200_cit94","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.redox.2014.11.012","volume":"4","author":"Sirota","year":"2015","journal-title":"Redox Biol."},{"key":"2024030719462268200_cit95","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/emm.2007.30","volume":"39","author":"Pae","year":"2007","journal-title":"Exp. Mol. Med."},{"key":"2024030719462268200_cit96","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/S0006-2952(03)00422-2","volume":"66","author":"Lin","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"2024030719462268200_cit97","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1124\/jpet.300.1.188","volume":"300","author":"Haider","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2024030719462268200_cit98","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.ijsu.2013.10.007","volume":"11","author":"Chen","year":"2013","journal-title":"Int. J. Surg."},{"key":"2024030719462268200_cit99","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1073\/pnas.61.2.748","volume":"61","author":"Tenhunen","year":"1968","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2024030719462268200_cit100","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s10620-010-1484-y","volume":"56","author":"Takagi","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"2024030719462268200_cit101","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1097\/01.MIB.0000440817.84251.98","volume":"20","author":"Lenicek","year":"2014","journal-title":"Inflammatory Bowel Dis."},{"key":"2024030719462268200_cit102","first-page":"F563","volume":"290","author":"Kirkby","year":"2006","journal-title":"Am. J. Physiol.: Renal, Fluid Electrolyte Physiol."},{"key":"2024030719462268200_cit103","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3389\/fphar.2014.00196","volume":"5","author":"Aquilano","year":"2014","journal-title":"Front. Pharmacol."},{"key":"2024030719462268200_cit104","doi-asserted-by":"crossref","first-page":"105","DOI":"10.2147\/IJGM.S15618","volume":"4","author":"Ghezzi","year":"2011","journal-title":"Int. J. Gen. Med."},{"key":"2024030719462268200_cit105","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/gut.42.4.485","volume":"42","author":"Sido","year":"1998","journal-title":"Gut"},{"key":"2024030719462268200_cit106","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.mcn.2011.06.009","volume":"48","author":"Nunes","year":"2011","journal-title":"Mol. Cell. Neurosci."},{"key":"2024030719462268200_cit107","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-1-4615-4811-9_21","volume":"457","author":"Hall","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"2024030719462268200_cit108","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.bbamcr.2012.06.019","volume":"1823","author":"Circu","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"2024030719462268200_cit109","first-page":"989","volume":"7","author":"Ek","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"2024030719462268200_cit110","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1023\/A:1005565708038","volume":"45","author":"Nieto","year":"2000","journal-title":"Dig. Dis. Sci."},{"key":"2024030719462268200_cit111","doi-asserted-by":"crossref","first-page":"e97193","DOI":"10.1371\/journal.pone.0097193","volume":"9","author":"Arab","year":"2014","journal-title":"PLoS One"},{"key":"2024030719462268200_cit112","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1196\/annals.1299.082","volume":"1010","author":"D'Alessio","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2024030719462268200_cit113","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1089\/ars.2012.4553","volume":"17","author":"Franco","year":"2012","journal-title":"Antioxid. Redox Signaling"},{"key":"2024030719462268200_cit114","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1096\/fasebj.12.6.479","volume":"12","author":"Ghibelli","year":"1998","journal-title":"FASEB J."},{"key":"2024030719462268200_cit115","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jep.2011.12.043","volume":"140","author":"Lyu","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"2024030719462268200_cit116","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1089\/ars.2010.3216","volume":"13","author":"Wakabayashi","year":"2010","journal-title":"Antioxid. Redox Signalling"},{"key":"2024030719462268200_cit117","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","volume":"76","author":"Li","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"2024030719462268200_cit118","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI25790","volume":"116","author":"Thimmulappa","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2024030719462268200_cit119","doi-asserted-by":"crossref","first-page":"11580","DOI":"10.1158\/0008-5472.CAN-06-3562","volume":"66","author":"Khor","year":"2006","journal-title":"Cancer Res."},{"key":"2024030719462268200_cit120","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbamcr.2008.01.002","volume":"1783","author":"Liu","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"2024030719462268200_cit121","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cellsig.2011.01.014","volume":"23","author":"Yu","year":"2011","journal-title":"Cell. Signalling"}],"container-title":["Toxicology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/toxres\/article-pdf\/5\/1\/53\/29582701\/c5tx00214a.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/toxres\/article-pdf\/5\/1\/53\/29582701\/c5tx00214a.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T19:47:16Z","timestamp":1709840836000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/toxres\/article\/5\/1\/53\/5545515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,19]]},"references-count":121,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1,21]]}},"URL":"https:\/\/doi.org\/10.1039\/c5tx00214a","relation":{},"ISSN":["2045-4538"],"issn-type":[{"value":"2045-4538","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2016,1]]},"published":{"date-parts":[[2015,10,19]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"The accepted version of this article will be made freely available after a 12 month embargo period","name":"copyright_licence","label":"OPEN ACCESS","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 1 July 2015; Accepted 1 October 2015; Accepted Manuscript published 5 October 2015; Advance Article published 19 October 2015; Version of Record published 21 December 2015","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}