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The obtained results highlight similarities as well as differences between the two isoforms. In addition, we investigated the molecular mechanism of hAQP3 pH gating in silico, which may disclose new pathways to AQP regulation by small molecule inhibitors, and therefore may be important for drug development.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/c6mb00013d","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T07:09:44Z","timestamp":1456902584000},"page":"1564-1573","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Exploring the gating mechanisms of aquaporin-3: new clues for the design of inhibitors?"],"prefix":"10.1093","volume":"12","author":[{"given":"A","family":"de Almeida","sequence":"first","affiliation":[{"name":"Dept. of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute of Pharmacy, University of Groningen a , A. 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Bioqu\u00edmica e Biologia Humana, Faculty of Pharmacy, Universidade de Lisboa c , 1649-003 Lisboa, Portugal"},{"name":"Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa b , 1649-003 Lisboa, Portugal \u00a0 gsoveral@ff.ulisboa.pt"}]},{"given":"H J","family":"Wijma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen d , Nijenborgh 4, 9747 AG Groningen The Netherlands"}]},{"given":"C","family":"Prista","sequence":"additional","affiliation":[{"name":"Research Center \u201cLinking Landscape, Environment, Agriculture and Food\u201d (LEAF), Instituto Superior de Agronomia, Universidade de Lisboa e , 1349-017 Lisboa, Portugal"}]},{"given":"G","family":"Soveral","sequence":"additional","affiliation":[{"name":"Dept. 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