{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:11:36Z","timestamp":1764493896207},"reference-count":34,"publisher":"Royal Society of Chemistry (RSC)","issue":"55","content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>Novel 6-methyl-3-carboxamidocoumarins were synthesized by an effective three step synthetic strategy and screened towards MAO, AChE and BuChE enzymes.<\/p>","DOI":"10.1039\/c6ra05262b","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T09:35:04Z","timestamp":1463045704000},"page":"49764-49768","update-policy":"http:\/\/dx.doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Exploring coumarin potentialities: development of new enzymatic inhibitors based on the 6-methyl-3-carboxamidocoumarin scaffold"],"prefix":"10.1039","volume":"6","author":[{"given":"A.","family":"Fonseca","sequence":"first","affiliation":[{"name":"CIQUP\/Departamento de Qu\u00edmica e Bioqu\u00edmica"},{"name":"Faculdade de Ci\u00eancias"},{"name":"Universidade do Porto"},{"name":"Porto"},{"name":"Portugal"}]},{"given":"M. J.","family":"Matos","sequence":"additional","affiliation":[{"name":"CIQUP\/Departamento de Qu\u00edmica e Bioqu\u00edmica"},{"name":"Faculdade de Ci\u00eancias"},{"name":"Universidade do Porto"},{"name":"Porto"},{"name":"Portugal"}]},{"given":"J.","family":"Reis","sequence":"additional","affiliation":[{"name":"CIQUP\/Departamento de Qu\u00edmica e Bioqu\u00edmica"},{"name":"Faculdade de Ci\u00eancias"},{"name":"Universidade do Porto"},{"name":"Porto"},{"name":"Portugal"}]},{"given":"Y.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Laboratorio de S\u00edntesis Org\u00e1nica"},{"name":"Instituto de Qu\u00edmica de Recursos Naturales Universidad de Talca"},{"name":"Talca"},{"name":"Chile"}]},{"given":"M.","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Laboratorio de S\u00edntesis Org\u00e1nica"},{"name":"Instituto de Qu\u00edmica de Recursos Naturales Universidad de Talca"},{"name":"Talca"},{"name":"Chile"}]},{"given":"L.","family":"Santana","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica"},{"name":"Faculdade de Farmacia"},{"name":"Universidade de Santiago de Compostela"},{"name":"Santiago de Compostela"},{"name":"Spain"}]},{"given":"E.","family":"Uriarte","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica"},{"name":"Faculdade de Farmacia"},{"name":"Universidade de Santiago de Compostela"},{"name":"Santiago de Compostela"},{"name":"Spain"}]},{"given":"F.","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP\/Departamento de Qu\u00edmica e Bioqu\u00edmica"},{"name":"Faculdade de Ci\u00eancias"},{"name":"Universidade do Porto"},{"name":"Porto"},{"name":"Portugal"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6RA05262B-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.disamonth.2010.06.001","volume":"56","author":"Castellani","year":"2010","journal-title":"Dis.-Mon."},{"key":"C6RA05262B-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","volume":"5","author":"de Lau","year":"2006","journal-title":"Lancet Neurol."},{"key":"C6RA05262B-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.amjmed.2006.08.036","volume":"120","author":"Farlow","year":"2007","journal-title":"Am. J. Med."},{"key":"C6RA05262B-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/0006-2952(68)90066-X","volume":"17","author":"Johnson","year":"1968","journal-title":"Biochem. Pharmacol."},{"key":"C6RA05262B-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrn1883","volume":"7","author":"Youdim","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"C6RA05262B-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"432","DOI":"10.2174\/1568026614666141229124141","volume":"15","author":"Gaspar","year":"2015","journal-title":"Curr. Top. Med. Chem."},{"key":"C6RA05262B-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0161-813X(03)00106-2","volume":"25","author":"Riederer","year":"2004","journal-title":"Neurotoxicology"},{"key":"C6RA05262B-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1038\/jcbfm.2010.49","volume":"30","author":"Jain","year":"2010","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"C6RA05262B-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrn3453","volume":"14","author":"Rouault","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"C6RA05262B-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"26072","DOI":"10.1074\/jbc.M115.669291","volume":"290","author":"Itakura","year":"2015","journal-title":"J. Biol. Chem."},{"key":"C6RA05262B-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0047-6374(01)00309-8","volume":"122","author":"Talesa","year":"2001","journal-title":"Mech. Ageing Dev."},{"key":"C6RA05262B-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ejmech.2013.07.045","volume":"68","author":"Khoobi","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"C6RA05262B-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1017\/S1461145705005833","volume":"9","author":"Lane","year":"2006","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"C6RA05262B-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejmech.2013.09.050","volume":"70","author":"Singh","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"C6RA05262B-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"887","DOI":"10.2174\/0929867053507315","volume":"12","author":"Borges","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"C6RA05262B-(cit16)\/*[position()=1]","first-page":"23","volume":"4","author":"Borges","year":"2009","journal-title":"Front. Med. Chem."},{"key":"C6RA05262B-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.2174\/092986710790936284","volume":"17","author":"Riveiro","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"C6RA05262B-(cit18)\/*[position()=1]","first-page":"1140","volume":"8","author":"Matos","year":"2012","journal-title":"Med. Chem."},{"key":"C6RA05262B-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/cmdc.201100538","volume":"7","author":"Vi\u00f1a","year":"2012","journal-title":"ChemMedChem"},{"key":"C6RA05262B-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1016\/j.bmcl.2011.05.074","volume":"21","author":"Matos","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C6RA05262B-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4846","DOI":"10.1016\/j.ejmech.2011.07.017","volume":"46","author":"Secci","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"C6RA05262B-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/jphp.12028","volume":"65","author":"Vazquez-Rodriguez","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"C6RA05262B-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.2174\/092986711803414395","volume":"18","author":"Kostova","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"C6RA05262B-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"371","DOI":"10.4155\/fmc.14.9","volume":"6","author":"Matos","year":"2014","journal-title":"Future Med. Chem."},{"key":"C6RA05262B-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1016\/j.bmcl.2009.04.085","volume":"19","author":"Matos","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C6RA05262B-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1016\/j.bmcl.2009.07.039","volume":"19","author":"Matos","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C6RA05262B-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.3390\/molecules18021394","volume":"18","author":"Matos","year":"2013","journal-title":"Molecules"},{"key":"C6RA05262B-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7127","DOI":"10.1021\/jm200716y","volume":"54","author":"Matos","year":"2011","journal-title":"J. Med. Chem."},{"key":"C6RA05262B-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1039\/C1MD00221J","volume":"3","author":"Vi\u00f1a","year":"2012","journal-title":"Med. Chem. Commun."},{"key":"C6RA05262B-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/cmdc.201300533","volume":"9","author":"Matos","year":"2014","journal-title":"ChemMedChem"},{"key":"C6RA05262B-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1016\/j.bmcl.2010.06.048","volume":"20","author":"Chimenti","year":"2010","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"C6RA05262B-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1248\/cpb.53.750","volume":"53","author":"Murata","year":"2005","journal-title":"Chem. Pharm. Bull."},{"key":"C6RA05262B-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.bbrc.2006.03.190","volume":"344","author":"Y\u00e1\u00f1ez","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"C6RA05262B-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"12072","DOI":"10.3390\/molecules171012072","volume":"17","author":"Torre","year":"2012","journal-title":"Molecules"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/RA\/C6RA05262B","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T22:00:52Z","timestamp":1713391252000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=C6RA05262B"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":34,"journal-issue":{"issue":"55","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6ra05262b","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C6RA05262B","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 28 February 2016; Accepted 11 May 2016;  Accepted Manuscript published 12 May 2016;  Version of Record published 20 May 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}