{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:04:20Z","timestamp":1740164660621,"version":"3.37.3"},"reference-count":28,"publisher":"Royal Society of Chemistry (RSC)","issue":"107","funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["OE\/AGR\/UI0690\/2014"],"award-info":[{"award-number":["OE\/AGR\/UI0690\/2014"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<p>New 7\/9-terpenylpurines were synthesized and evaluated as cytotoxics. Those derived from the natural compounds <italic>trans<\/italic>-communic and cupressic acids, showed GI<sub>50<\/sub> at the \u03bcM level.<\/p>","DOI":"10.1039\/c6ra24254e","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T09:04:59Z","timestamp":1477386299000},"page":"105412-105420","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis and cytotoxic evaluation of new terpenylpurines"],"prefix":"10.1039","volume":"6","author":[{"given":"Elena","family":"Valles","sequence":"first","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas"},{"name":"Secci\u00f3n de Qu\u00edmica Farmac\u00e9utica"},{"name":"Facultad de Farmacia"},{"name":"CIETUS-IBSAL"},{"name":"Universidad de Salamanca"}]},{"given":"Pablo A.","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas"},{"name":"Secci\u00f3n de Qu\u00edmica Farmac\u00e9utica"},{"name":"Facultad de Farmacia"},{"name":"CIETUS-IBSAL"},{"name":"Universidad de Salamanca"}]},{"given":"Jos\u00e9 Ma","family":"Miguel del Corral","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas"},{"name":"Secci\u00f3n de Qu\u00edmica Farmac\u00e9utica"},{"name":"Facultad de Farmacia"},{"name":"CIETUS-IBSAL"},{"name":"Universidad de Salamanca"}]},{"given":"Marta","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas"},{"name":"Secci\u00f3n de Qu\u00edmica Farmac\u00e9utica"},{"name":"Facultad de Farmacia"},{"name":"CIETUS-IBSAL"},{"name":"Universidad de Salamanca"}]},{"given":"Isabel C. F. R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO)"},{"name":"Escola Superior Agr\u00e1ria"},{"name":"Instituto Polit\u00e9cnico de Bragan\u00e7a"},{"name":"5300-253 Bragan\u00e7a"},{"name":"Portugal"}]},{"given":"Ricardo C.","family":"Calhelha","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o de Montanha (CIMO)"},{"name":"Escola Superior Agr\u00e1ria"},{"name":"Instituto Polit\u00e9cnico de Bragan\u00e7a"},{"name":"5300-253 Bragan\u00e7a"},{"name":"Portugal"}]},{"given":"Arturo","family":"San Feliciano","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas"},{"name":"Secci\u00f3n de Qu\u00edmica Farmac\u00e9utica"},{"name":"Facultad de Farmacia"},{"name":"CIETUS-IBSAL"},{"name":"Universidad de Salamanca"}]},{"given":"Ma \u00c1ngeles","family":"Castro","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias Farmac\u00e9uticas"},{"name":"Secci\u00f3n de Qu\u00edmica Farmac\u00e9utica"},{"name":"Facultad de Farmacia"},{"name":"CIETUS-IBSAL"},{"name":"Universidad de Salamanca"}]}],"member":"292","published-online":{"date-parts":[[2016]]},"reference":[{"key":"C6RA24254E-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/cbdv.200490033","volume":"1","author":"Rosemeyer","year":"2004","journal-title":"Chem. Biodiversity"},{"key":"C6RA24254E-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3987","DOI":"10.1016\/j.bmc.2005.12.060","volume":"14","author":"Legraverend","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"C6RA24254E-(cit3a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11101-012-9236-6","volume":"12","author":"Gundersen","year":"2013","journal-title":"Phytochem. Rev."},{"key":"C6RA24254E-(cit3b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3390\/md7040833","volume":"7","author":"Gordaliza","year":"2009","journal-title":"Mar. Drugs"},{"key":"C6RA24254E-(cit4)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1039\/C2NP00090C","volume":"29","author":"Blunt","year":"2013","journal-title":"Nat. Prod. Rep."},{"key":"C6RA24254E-(cit5a)\/*[position()=1]","volume-title":"Plant Bioactives and Drug Discovery. Principles, Practice and Perspectives","author":"San Feliciano","year":"2012","unstructured":"A.\n              San Feliciano\n            , M. A.Castro, J. L.L\u00f3pez-P\u00e9rez and E.del Olmo, The importance of structural manipulation of natural compounds in drug discovery and development, in Plant Bioactives and Drug Discovery. Principles, Practice and Perspectives, ed. C. Cechinel-Filho, John Wiley & Sons, New Jersey, 2012, pp. 127\u2013160"},{"key":"C6RA24254E-(cit5b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.toxicon.2004.05.008","volume":"44","author":"Gordaliza","year":"2004","journal-title":"Toxicon"},{"key":"C6RA24254E-(cit5c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/jm901373w","volume":"53","author":"Castro","year":"2010","journal-title":"J. Med. Chem."},{"key":"C6RA24254E-(cit6a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ejmech.2013.06.018","volume":"67","author":"Castro","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"C6RA24254E-(cit6b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5760","DOI":"10.1016\/j.bmc.2007.06.005","volume":"15","author":"Miguel del Corral","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"C6RA24254E-(cit6c)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.tetlet.2011.11.080","volume":"53","author":"Castro","year":"2012","journal-title":"Tetrahedron Lett."},{"key":"C6RA24254E-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.3390\/12071376","volume":"12","author":"Motti","year":"2007","journal-title":"Molecules"},{"key":"C6RA24254E-(cit8)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ejmech.2012.10.026","volume":"58","author":"Castro","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"C6RA24254E-(cit9)\/*[position()=1]","volume-title":"Purines in Comprehensive Heterocyclic Chemistry","volume":"vol. 5","author":"Shaw","year":"1984","unstructured":"G.\n            Shaw\n          , Purines in Comprehensive Heterocyclic Chemistry, ed. A. R. Katritzky and C. W. Rees, Pergamon, Oxford, 1984, vol. 5"},{"key":"C6RA24254E-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"4061","DOI":"10.1016\/0040-4039(92)88100-J","volume":"33","author":"Rao","year":"1992","journal-title":"Tetrahedron Lett."},{"key":"C6RA24254E-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1248\/cpb.29.1475","volume":"29","author":"Hashimoto","year":"1981","journal-title":"Chem. Pharm. Bull."},{"key":"C6RA24254E-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"7289","DOI":"10.1016\/S0040-4020(99)00355-5","volume":"55","author":"Barrero","year":"1999","journal-title":"Tetrahedron"},{"key":"C6RA24254E-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6925","DOI":"10.1016\/S0040-4020(02)00752-4","volume":"58","author":"Lambertin","year":"2002","journal-title":"Tetrahedron"},{"key":"C6RA24254E-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1021\/jm0508078","volume":"49","author":"He","year":"2006","journal-title":"J. Med. Chem."},{"key":"C6RA24254E-(cit15)\/*[position()=1]","volume-title":"Carbon-13NMR spectroscopy","author":"Breitmaier","year":"1987","unstructured":"E.\n            Breitmaier\n           and W.Voelter, Carbon-13NMR spectroscopy, VCH, Weinheim, Germany, 3rd edn, 1987, ch. 5"},{"key":"C6RA24254E-(cit16a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1016\/S0040-4020(01)88116-3","volume":"42","author":"Kjellberg","year":"1986","journal-title":"Tetrahedron"},{"key":"C6RA24254E-(cit16b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0066-4103(04)54005-X","volume":"54","author":"Marek","year":"2004","journal-title":"Annu. Rep. NMR Spectrosc."},{"key":"C6RA24254E-(cit17a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nprot.2006.179","volume":"1","author":"Vichai","year":"2006","journal-title":"Nat. Protoc."},{"key":"C6RA24254E-(cit17b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1016\/j.jff.2013.07.019","volume":"5","author":"Barros","year":"2013","journal-title":"J. Funct. Foods"},{"key":"C6RA24254E-(cit18a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.3390\/molecules17021448","volume":"17","author":"Barrero","year":"2012","journal-title":"Molecules"},{"key":"C6RA24254E-(cit18b)\/*[position()=1]","first-page":"1015","volume":"70","author":"de Pascual-Teresa","year":"1974","journal-title":"An. Quim."},{"key":"C6RA24254E-(cit19a)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0031-9422(00)91235-4","volume":"13","author":"Caputo","year":"1974","journal-title":"Phytochemistry"},{"key":"C6RA24254E-(cit19b)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1590\/S0103-50532002000200020","volume":"13","author":"Rodrigues-Filho","year":"2002","journal-title":"J. Braz. Chem. Soc."}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2016\/RA\/C6RA24254E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T22:32:28Z","timestamp":1713393148000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=C6RA24254E"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":28,"journal-issue":{"issue":"107","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.1039\/c6ra24254e","relation":{},"ISSN":["2046-2069"],"issn-type":[{"type":"electronic","value":"2046-2069"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"Supplementary Information","URL":"https:\/\/doi.org\/10.1039\/C6RA24254E","name":"related_data","group":{"name":"related_data","label":"RELATED DATA"}},{"value":"Isabel C. F. R. Ferreira (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/E-8500-2013","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"The Royal Society of Chemistry has an exclusive publication licence for this journal","name":"copyright_licence","group":{"name":"copyright_licensing","label":"COPYRIGHT AND LICENSING"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 29 September 2016; Accepted 21 October 2016;  Accepted Manuscript published 25 October 2016;  Version of Record published 4 November 2016","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}