{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T14:57:03Z","timestamp":1772117823073,"version":"3.50.1"},"reference-count":34,"publisher":"Royal Society of Chemistry (RSC)","issue":"6","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"am","delay-in-days":507,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["POCI-01-0145-FEDER-007274"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007274"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","award":["UID\/AGR\/00690\/2013"],"award-info":[{"award-number":["UID\/AGR\/00690\/2013"]}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<p><italic>Melissa officinalis<\/italic>is a plant from the family Lamiaceae, native in Europe particularly in the Mediterranean region.<\/p>","DOI":"10.1039\/c8fo00446c","type":"journal-article","created":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T12:04:00Z","timestamp":1527077040000},"page":"3134-3142","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["<i>Melissa officinalis<\/i>L. ethanolic extract inhibits the growth of a lung cancer cell line by interfering with the cell cycle and inducing apoptosis"],"prefix":"10.1039","volume":"9","author":[{"given":"D. B.","family":"Magalh\u00e3es","sequence":"first","affiliation":[{"name":"Department of Biological Sciences"},{"name":"FFUP \u2013 Faculty of Pharmacy"},{"name":"University of Porto"},{"name":"4050-313 Porto"},{"name":"Portugal"}]},{"given":"I.","family":"Castro","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"},{"name":"Universidade do Porto"},{"name":"4200-135 Porto"},{"name":"Portugal"},{"name":"Cancer Drug Resistance Group"}]},{"given":"V.","family":"Lopes-Rodrigues","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"},{"name":"Universidade do Porto"},{"name":"4200-135 Porto"},{"name":"Portugal"},{"name":"Cancer Drug Resistance Group"}]},{"given":"J. M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"},{"name":"Universidade do Porto"},{"name":"4200-135 Porto"},{"name":"Portugal"},{"name":"Cancer Drug Resistance Group"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-5189","authenticated-orcid":false,"given":"L.","family":"Barros","sequence":"additional","affiliation":[{"name":"CIMO \u2013 Centro de Investiga\u00e7\u00e3o de Montanha"},{"name":"Instituto Polit\u00e9cnico de Bragan\u00e7a"},{"name":"Campus de Santa Apol\u00f3nia"},{"name":"Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4910-4882","authenticated-orcid":false,"given":"I. C. F. R.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"CIMO \u2013 Centro de Investiga\u00e7\u00e3o de Montanha"},{"name":"Instituto Polit\u00e9cnico de Bragan\u00e7a"},{"name":"Campus de Santa Apol\u00f3nia"},{"name":"Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4613-1917","authenticated-orcid":false,"given":"C. P. R.","family":"Xavier","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade"},{"name":"Universidade do Porto"},{"name":"4200-135 Porto"},{"name":"Portugal"},{"name":"Cancer Drug Resistance Group"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7801-4643","authenticated-orcid":false,"given":"M. H.","family":"Vasconcelos","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences"},{"name":"FFUP \u2013 Faculty of Pharmacy"},{"name":"University of Porto"},{"name":"4050-313 Porto"},{"name":"Portugal"}]}],"member":"292","published-online":{"date-parts":[[2018]]},"reference":[{"issue":"3","key":"C8FO00446C-(cit1)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","volume":"79","author":"Newman","year":"2016","journal-title":"J. Nat. Prod."},{"issue":"6","key":"C8FO00446C-(cit2)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1016\/j.bbagen.2013.02.008","volume":"1830","author":"Cragg","year":"2013","journal-title":"Biochim. Biophys. Acta, Gen. Subj."},{"issue":"Suppl 1","key":"C8FO00446C-(cit3)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"S181","DOI":"10.4103\/0975-7406.155895","volume":"7","author":"Rajesh","year":"2015","journal-title":"J. Pharm. BioAllied Sci."},{"issue":"1","key":"C8FO00446C-(cit4)\/*[position()=1]","first-page":"92","volume":"10","author":"Aliya","year":"2016","journal-title":"Curr. Trends Biotechnol. Pharm."},{"issue":"3","key":"C8FO00446C-(cit5)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1586\/ecp.11.7","volume":"4","author":"Montero","year":"2011","journal-title":"Expert Rev. Clin. Pharmacol."},{"issue":"5","key":"C8FO00446C-(cit6)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/CAD.0000000000000063","volume":"25","author":"Wani","year":"2014","journal-title":"Anti-Cancer Drugs"},{"issue":"5","key":"C8FO00446C-(cit7)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1211\/0022357023321","volume":"56","author":"Sousa","year":"2004","journal-title":"J. Pharm. Pharmacol."},{"issue":"25","key":"C8FO00446C-(cit8)\/*[position()=1]","first-page":"2753","volume":"4","author":"Moradkhani","year":"2010","journal-title":"J. Med. Plants Res."},{"issue":"9","key":"C8FO00446C-(cit9)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1021\/jf030698a","volume":"52","author":"Mimica-Dukic","year":"2004","journal-title":"J. Agric. Food Chem."},{"issue":"14","key":"C8FO00446C-(cit10)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.7314\/APJCP.2015.16.14.5703","volume":"16","author":"Jahanban-Esfahlan","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"4","key":"C8FO00446C-(cit11)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s11130-011-0256-y","volume":"66","author":"Encalada","year":"2011","journal-title":"Plant Foods Hum. Nutr."},{"issue":"6","key":"C8FO00446C-(cit12)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.7314\/APJCP.2012.13.6.2765","volume":"13","author":"Saraydin","year":"2012","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"6","key":"C8FO00446C-(cit13)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.fct.2012.03.057","volume":"50","author":"Dias","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"C8FO00446C-(cit14)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodchem.2012.07.107","volume":"136","author":"Barros","year":"2013","journal-title":"Food Chem."},{"key":"C8FO00446C-(cit15)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.indcrop.2016.04.065","volume":"89","author":"Bessada","year":"2016","journal-title":"Ind. Crops Prod."},{"issue":"13","key":"C8FO00446C-(cit16)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","volume":"82","author":"Skehan","year":"1990","journal-title":"JNCI, J. Natl. Cancer Inst."},{"issue":"5","key":"C8FO00446C-(cit17)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3390\/molecules21050595","volume":"21","author":"Pereira","year":"2016","journal-title":"Molecules"},{"key":"C8FO00446C-(cit18)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.indcrop.2014.05.009","volume":"59","author":"Lima","year":"2014","journal-title":"Ind. Crops Prod."},{"key":"C8FO00446C-(cit19)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.fct.2016.02.005","volume":"90","author":"Reis","year":"2016","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"C8FO00446C-(cit20)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-3835(99)00441-3","volume":"152","author":"Vasconcelos","year":"2000","journal-title":"Cancer Lett."},{"issue":"1","key":"C8FO00446C-(cit21)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"issue":"2","key":"C8FO00446C-(cit22)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0003-2697(79)90222-7","volume":"100","author":"Peterson","year":"1979","journal-title":"Anal. Biochem."},{"key":"C8FO00446C-(cit23)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/1471-2407-9-387","volume":"9","author":"Preto","year":"2009","journal-title":"BMC Cancer"},{"issue":"2","key":"C8FO00446C-(cit24)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1590\/S0100-40422007000200026","volume":"30","author":"Gobbo-Neto","year":"2007","journal-title":"Quim. Nova"},{"key":"C8FO00446C-(cit25)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.foodchem.2017.07.113","volume":"240","author":"Pereira","year":"2018","journal-title":"Food Chem."},{"issue":"7","key":"C8FO00446C-(cit26)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1039\/C5FO00309A","volume":"6","author":"Carocho","year":"2015","journal-title":"Food Funct."},{"key":"C8FO00446C-(cit27)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chroma.2013.02.075","volume":"1288","author":"Miron","year":"2013","journal-title":"J. Chromatogr., A"},{"issue":"3","key":"C8FO00446C-(cit28)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cell.2009.04.037","volume":"137","author":"Vousden","year":"2009","journal-title":"Cell"},{"issue":"Pt 24","key":"C8FO00446C-(cit29)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1242\/jcs.03293","volume":"119","author":"Vousden","year":"2006","journal-title":"J. Cell Sci."},{"issue":"3","key":"C8FO00446C-(cit30)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00709-013-0548-1","volume":"251","author":"Wawryk-Gawda","year":"2014","journal-title":"Protoplasma"},{"issue":"4","key":"C8FO00446C-(cit31)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00204-015-1459-z","volume":"89","author":"Speidel","year":"2015","journal-title":"Arch. Toxicol."},{"key":"C8FO00446C-(cit32)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.cellbio.15.1.269","volume":"15","author":"Budihardjo","year":"1999","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"Pt 1","key":"C8FO00446C-(cit33)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem. J."},{"issue":"2","key":"C8FO00446C-(cit34)\/*[position()=1]","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/sj.cdd.4400476","volume":"6","author":"Porter","year":"1999","journal-title":"Cell Death Differ."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2018\/FO\/C8FO00446C","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T20:21:56Z","timestamp":1713385316000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=C8FO00446C"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1039\/c8fo00446c","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"This document is Similarity Check deposited","name":"similarity_check","explanation":{"URL":"https:\/\/www.crossref.org\/services\/similarity-check\/"},"group":{"name":"similarity_check","label":"SIMILARITY CHECK"}},{"value":"L. Barros (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-9050-5189","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"L. Barros (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/J-3600-2013","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"I. C. F. R. Ferreira (ORCID)","URL":"http:\/\/orcid.org\/0000-0003-4910-4882","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"I. C. F. R. Ferreira (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/E-8500-2013","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"C. P. R. Xavier (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-4613-1917","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"C. P. R. Xavier (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/C-7442-2015","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"M. H. Vasconcelos (ORCID)","URL":"http:\/\/orcid.org\/0000-0002-7801-4643","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"M. H. Vasconcelos (ResearcherID)","URL":"http:\/\/www.researcherid.com\/rid\/J-9547-2013","name":"identifier","group":{"name":"author_identifiers","label":"IDENTIFIERS"}},{"value":"Single-blind","order":2,"name":"peer_review_method","group":{"name":"peer_review_method","label":"PEER REVIEW METHOD"}},{"value":"Received 9 March 2018; Accepted 23 April 2018; Advance Article published 23 May 2018; Version of Record published 20 June 2018","order":1,"name":"history","group":{"name":"publication_history","label":"PUBLICATION HISTORY"}}]}}