{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:34:57Z","timestamp":1775090097490,"version":"3.50.1"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","issue":"16","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":186,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100006111","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","doi-asserted-by":"publisher","award":["CEECIND\/00259\/2017"],"award-info":[{"award-number":["CEECIND\/00259\/2017"]}],"id":[{"id":"10.13039\/501100006111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006111","name":"Minist\u00e9rio da Ci\u00eancia, Tecnologia e Ensino Superior","doi-asserted-by":"publisher","award":["DL57\/2016"],"award-info":[{"award-number":["DL57\/2016"]}],"id":[{"id":"10.13039\/501100006111","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["CEECIND\/00259\/2017"],"award-info":[{"award-number":["CEECIND\/00259\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/00256\/2015"],"award-info":[{"award-number":["IF\/00256\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["DL57\/2016"],"award-info":[{"award-number":["DL57\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["Grant agreement No 764920 MSCA-EJD PhotoBioCat"],"award-info":[{"award-number":["Grant agreement No 764920 MSCA-EJD PhotoBioCat"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Green Chem."],"abstract":"<jats:p>Biotransformation of testosterone into 15\u03b2-hydroxytestosterone by the cyanobacterium <jats:italic>Synechocystis<\/jats:italic> expressing the heterologous monooxygenase CYP110D1. The reaction is sustained by reducing equivalents and oxygen provided by oxygenic photosynthesis.<\/jats:p>","DOI":"10.1039\/d1gc04714k","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T13:34:07Z","timestamp":1657114447000},"page":"6156-6167","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Light-driven hydroxylation of testosterone by <i>Synechocystis<\/i> sp. PCC 6803 expressing the heterologous CYP450 monooxygenase CYP110D1"],"prefix":"10.1039","volume":"24","author":[{"given":"Francesco","family":"Mascia","sequence":"first","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"IBMC \u2013 Instituto de Biologia Celular e Molecular, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"},{"name":"CNRS, Institut des Sciences Mol\u00e9culaires de Marseille, UMR7313, Aix Marseille Universit\u00e9, Avenue Escadrille Normandie Niemen 52, 13013 Marseille, France"}]},{"given":"Sara B.","family":"Pereira","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"IBMC \u2013 Instituto de Biologia Celular e Molecular, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"}]},{"given":"Catarina C.","family":"Pacheco","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"IBMC \u2013 Instituto de Biologia Celular e Molecular, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0938-152X","authenticated-orcid":false,"given":"Paulo","family":"Oliveira","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"IBMC \u2013 Instituto de Biologia Celular e Molecular, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Jennifer","family":"Solarczek","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Biotechnologie & Bioinformatik, Technische Universit\u00e4t Braunschweig, Spielmannstr. 7, 38106 Braunschweig, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6670-0574","authenticated-orcid":false,"given":"Anett","family":"Schallmey","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Biochemie, Biotechnologie & Bioinformatik, Technische Universit\u00e4t Braunschweig, Spielmannstr. 7, 38106 Braunschweig, Germany"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2853-3525","authenticated-orcid":false,"given":"Robert","family":"Kourist","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biotechnology, Graz University of Technology, NAWI Graz, BioTechMed, Petersgasse 14, 8010 Graz, Austria"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6855-7292","authenticated-orcid":false,"given":"V\u00e9ronique","family":"Alphand","sequence":"additional","affiliation":[{"name":"CNRS, Institut des Sciences Mol\u00e9culaires de Marseille, UMR7313, Aix Marseille Universit\u00e9, Avenue Escadrille Normandie Niemen 52, 13013 Marseille, France"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4396-2122","authenticated-orcid":false,"given":"Paula","family":"Tamagnini","sequence":"additional","affiliation":[{"name":"i3S \u2013 Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"IBMC \u2013 Instituto de Biologia Celular e Molecular, Universidade do Porto, R. Alfredo Allen 208, 4200-135 Porto, Portugal"},{"name":"Departamento de Biologia, Faculdade de Ci\u00eancias, Universidade do Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D1GC04714K\/cit1\/1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3390\/catal7080240","volume":"7","author":"B\u00f6hmer","year":"2017","journal-title":"Catalysts"},{"key":"D1GC04714K\/cit2\/1","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/bit.27006","volume":"116","author":"Hoschek","year":"2019","journal-title":"Biotechnol. Bioeng."},{"key":"D1GC04714K\/cit3\/1","doi-asserted-by":"crossref","first-page":"1800724","DOI":"10.1002\/biot.201800724","volume":"14","author":"Hoschek","year":"2019","journal-title":"Biotechnol. J."},{"key":"D1GC04714K\/cit4\/1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1021\/acscatal.1c04555","volume":"12","author":"Erdem","year":"2022","journal-title":"ACS Catal."},{"key":"D1GC04714K\/cit5\/1","doi-asserted-by":"crossref","first-page":"11864","DOI":"10.1021\/acscatal.0c02601","volume":"10","author":"Assil-Companioni","year":"2020","journal-title":"ACS Catal."},{"key":"D1GC04714K\/cit6\/1","doi-asserted-by":"crossref","first-page":"5582","DOI":"10.1002\/anie.201601200","volume":"55","author":"Koninger","year":"2016","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1GC04714K\/cit7\/1","doi-asserted-by":"crossref","first-page":"100008","DOI":"10.1016\/j.engmic.2021.100008","volume":"2","author":"Jurka\u0161","year":"2022","journal-title":"Eng. Microbiol."},{"key":"D1GC04714K\/cit8\/1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1002\/cctc.201901592","volume":"12","author":"B\u00fcchsensch\u00fctz","year":"2020","journal-title":"ChemCatChem"},{"key":"D1GC04714K\/cit9\/1","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1039\/b203844g","author":"Nakamura","year":"2002","journal-title":"Chem. Commun."},{"key":"D1GC04714K\/cit10\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbiotec.2018.11.002","volume":"289","author":"Sengupta","year":"2019","journal-title":"J. Biotechnol."},{"key":"D1GC04714K\/cit11\/1","doi-asserted-by":"crossref","first-page":"36640","DOI":"10.1038\/srep36640","volume":"6","author":"Englund","year":"2016","journal-title":"Sci. Rep."},{"key":"D1GC04714K\/cit12\/1","doi-asserted-by":"crossref","first-page":"ysy014","DOI":"10.1093\/synbio\/ysy014","volume":"3","author":"Ferreira","year":"2018","journal-title":"Synth. Biol."},{"key":"D1GC04714K\/cit13\/1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1754-1611-7-10","volume":"7","author":"Huang","year":"2013","journal-title":"J. Biol. Eng."},{"key":"D1GC04714K\/cit14\/1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1515\/9783110550603-006","volume-title":"The Autotrophic Biorefinery","author":"Pacheco","year":"2021","unstructured":"C. C.Pacheco ,  E. A.Ferreira ,  P.Oliveira  and  P.Tamagnini ,  Synthetic biology of cyanobacteria , in  The Autotrophic Biorefinery , ed.  R. Kourist  and  S. Schmidt ,  De Gruyter ,  2021 , ch. 6, pp.  131\u2013172"},{"key":"D1GC04714K\/cit15\/1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/S0021-9258(17)49939-X","volume":"295","author":"Li","year":"2020","journal-title":"J. Biol. Chem."},{"key":"D1GC04714K\/cit16\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cbic.201900760","volume":"21","author":"Bracco","year":"2020","journal-title":"ChemBioChem"},{"key":"D1GC04714K\/cit17\/1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11120-017-0364-0","volume":"134","author":"Mellor","year":"2017","journal-title":"Photosynth. Res."},{"key":"D1GC04714K\/cit18\/1","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3390\/life4040666","volume":"4","author":"Cassier-Chauvat","year":"2014","journal-title":"Life"},{"key":"D1GC04714K\/cit19\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ymben.2015.10.009","volume":"33","author":"Wlodarczyk","year":"2016","journal-title":"Metab. Eng."},{"key":"D1GC04714K\/cit20\/1","doi-asserted-by":"crossref","first-page":"15146","DOI":"10.1002\/anie.201706886","volume":"56","author":"Hoschek","year":"2017","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1GC04714K\/cit21\/1","unstructured":"The Business Research Company, Corticosteroids Global Market Report 2021: COVID 19 Implications And Growth To 2030,  https:\/\/www.thebusinessresearchcompany.com\/report\/corticosteroids-therapy-market-global-report-2020-2030-covid-19-implications-and-growth"},{"key":"D1GC04714K\/cit23\/1","doi-asserted-by":"crossref","first-page":"R201","DOI":"10.1530\/EJE-19-0071","volume":"180","author":"Nieschlag","year":"2019","journal-title":"Eur. J. Endocrinol."},{"key":"D1GC04714K\/cit24\/1","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0039-128X(95)00196-W","volume":"61","author":"\u010cern\u00fd","year":"1996","journal-title":"Steroids"},{"key":"D1GC04714K\/cit25\/1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3109\/03602532.2015.1011658","volume":"47","author":"Niwa","year":"2015","journal-title":"Drug Metab. Rev."},{"key":"D1GC04714K\/cit26\/1","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1007\/s00253-018-9239-3","volume":"102","author":"Szaleniec","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"D1GC04714K\/cit27\/1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1271\/bbb.70.307","volume":"70","author":"Agematu","year":"2006","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"D1GC04714K\/cit28\/1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/dnares\/dsr042","volume":"19","author":"Kanesaki","year":"2012","journal-title":"DNA Res."},{"key":"D1GC04714K\/cit29\/1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/dnares\/dss024","volume":"19","author":"Trautmann","year":"2012","journal-title":"DNA Res."},{"key":"D1GC04714K\/cit30\/1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1128\/br.35.2.171-205.1971","volume":"35","author":"Stanier","year":"1971","journal-title":"Bacteriol. Rev."},{"key":"D1GC04714K\/cit31\/1","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s00253-010-2965-9","volume":"89","author":"Schallmey","year":"2011","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"D1GC04714K\/cit32\/1","doi-asserted-by":"crossref","first-page":"D666","DOI":"10.1093\/nar\/gks1119","volume":"41","author":"Silva-Rocha","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"D1GC04714K\/cit33\/1","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1021\/acssynbio.1c00605","volume":"11","author":"Opel","year":"2022","journal-title":"ACS Synth. Biol."},{"key":"D1GC04714K\/cit34\/1","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1128\/jb.173.9.2761-2767.1991","volume":"173","author":"Anderson","year":"1991","journal-title":"J. Bacteriol."},{"key":"D1GC04714K\/cit35\/1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/dnares\/dsv024","volume":"22","author":"Pinto","year":"2015","journal-title":"DNA Res."},{"key":"D1GC04714K\/cit36\/1","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"D1GC04714K\/cit37\/1","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1002\/adsc.202000251","volume":"362","author":"Fessner","year":"2020","journal-title":"Adv. Synth. Catal."},{"key":"D1GC04714K\/cit38\/1","doi-asserted-by":"crossref","first-page":"6066","DOI":"10.1016\/S0021-9258(19)39292-0","volume":"265","author":"Peterson","year":"1990","journal-title":"J. Biol. Chem."},{"key":"D1GC04714K\/cit39\/1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1039\/B918763B","volume":"39","author":"Anastas","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"D1GC04714K\/cit40\/1","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1093\/nar\/gkq164","volume":"38","author":"Huang","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"D1GC04714K\/cit41\/1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/mrc.1767","volume":"44","author":"Jacobsen","year":"2006","journal-title":"Magn. Reson. Chem."},{"key":"D1GC04714K\/cit42\/1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.steroids.2011.06.010","volume":"76","author":"Peart","year":"2011","journal-title":"Steroids"},{"key":"D1GC04714K\/cit43\/1","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1021\/cr0307143","volume":"105","author":"Denisov","year":"2005","journal-title":"Chem. Rev."},{"key":"D1GC04714K\/cit44\/1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.3389\/fmicb.2016.00966","volume":"7","author":"Damrow","year":"2016","journal-title":"Front. Microbiol."},{"key":"D1GC04714K\/cit45\/1","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1073\/pnas.1221194110","volume":"110","author":"Allahverdiyeva","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D1GC04714K\/cit46\/1","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1128\/AEM.70.4.2137-2145.2004","volume":"70","author":"Lindberg","year":"2004","journal-title":"Appl. Environ. Microbiol."},{"key":"D1GC04714K\/cit47\/1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ymben.2016.08.002","volume":"38","author":"Zhou","year":"2016","journal-title":"Metab. Eng."},{"key":"D1GC04714K\/cit48\/1","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.bbabio.2006.11.019","volume":"1767","author":"Murata","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"D1GC04714K\/cit49\/1","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.1038\/s41598-020-62681-w","volume":"10","author":"Dienst","year":"2020","journal-title":"Sci. Rep."},{"key":"D1GC04714K\/cit50\/1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jbiotec.2007.06.007","volume":"131","author":"Ruijssenaars","year":"2007","journal-title":"J. Biotechnol."},{"key":"D1GC04714K\/cit51\/1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1002\/cbic.200900706","volume":"11","author":"Zehentgruber","year":"2010","journal-title":"ChemBioChem"},{"key":"D1GC04714K\/cit52\/1","doi-asserted-by":"crossref","first-page":"649000","DOI":"10.3389\/fchem.2021.649000","volume":"9","author":"Zhang","year":"2021","journal-title":"Front. Chem."},{"key":"D1GC04714K\/cit53\/1","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1002\/cssc.202100832","volume":"14","author":"Hobisch","year":"2021","journal-title":"ChemSusChem"},{"key":"D1GC04714K\/cit54\/1","doi-asserted-by":"crossref","first-page":"101510","DOI":"10.1016\/j.algal.2019.101510","volume":"41","author":"Lindblad","year":"2019","journal-title":"Algal Res."},{"key":"D1GC04714K\/cit55\/1","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/anie.199502591","volume":"34","author":"Trost","year":"1995","journal-title":"Angew. Chem., Int. Ed."},{"key":"D1GC04714K\/cit56\/1","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1021\/acschembio.6b00190","volume":"11","author":"Mellor","year":"2016","journal-title":"ACS Chem. Biol."}],"container-title":["Green Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/GC\/D1GC04714K","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T19:10:45Z","timestamp":1713381045000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D1GC04714K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":55,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2022,8,15]]}},"URL":"https:\/\/doi.org\/10.1039\/d1gc04714k","relation":{},"ISSN":["1463-9262","1463-9270"],"issn-type":[{"value":"1463-9262","type":"print"},{"value":"1463-9270","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}