{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T06:34:38Z","timestamp":1775802878102,"version":"3.50.1"},"reference-count":71,"publisher":"Royal Society of Chemistry (RSC)","issue":"17","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":219,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"funder":[{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["760891"],"award-info":[{"award-number":["760891"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Food Funct."],"abstract":"<jats:p>Sesquiterpene lactones (STLs) from chicory root extract may inhibit SARS-CoV-2 Mpro and PLpro.<\/jats:p>","DOI":"10.1039\/d2fo00933a","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T12:02:07Z","timestamp":1659960127000},"page":"8977-8988","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Targeting proteases involved in the viral replication of SARS-CoV-2 by sesquiterpene lactones from chicory (<i>Cichorium intybus<\/i> L.)"],"prefix":"10.1039","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-1026","authenticated-orcid":false,"given":"Mar\u00eda \u00c1ngeles","family":"\u00c1vila-G\u00e1lvez","sequence":"first","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica (iBET), Av. Rep\u00fablica, Qta. Marqu\u00eas, 2780-157 Oeiras, Portugal"},{"name":"NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal"}]},{"given":"Carlos","family":"Rafael-Pita","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica (iBET), Av. Rep\u00fablica, Qta. Marqu\u00eas, 2780-157 Oeiras, Portugal"},{"name":"NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal"}]},{"given":"Naiara","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica (iBET), Av. Rep\u00fablica, Qta. Marqu\u00eas, 2780-157 Oeiras, Portugal"}]},{"given":"Jo\u00e3o","family":"Baixinho","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica (iBET), Av. Rep\u00fablica, Qta. Marqu\u00eas, 2780-157 Oeiras, Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa, Av. da Rep\u00fablica, 2780-157 Oeiras, Portugal"}]},{"given":"Jos\u00e9 D.","family":"Anast\u00e1cio","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica (iBET), Av. Rep\u00fablica, Qta. Marqu\u00eas, 2780-157 Oeiras, Portugal"},{"name":"NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-4192","authenticated-orcid":false,"given":"Katarina","family":"Cankar","sequence":"additional","affiliation":[{"name":"Wageningen University and Research, Wageningen Plant Research, BU Bioscience, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands"}]},{"given":"Dirk","family":"Bosch","sequence":"additional","affiliation":[{"name":"Wageningen University and Research, Wageningen Plant Research, BU Bioscience, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands"}]},{"given":"Cl\u00e1udia","family":"Nunes dos Santos","sequence":"additional","affiliation":[{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica (iBET), Av. Rep\u00fablica, Qta. Marqu\u00eas, 2780-157 Oeiras, Portugal"},{"name":"NOVA Medical School|Faculdade de Ci\u00eancias M\u00e9dicas, NMS|FCM, Universidade Nova de Lisboa, Lisboa, Portugal"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2FO00933A\/cit1\/1","doi-asserted-by":"crossref","first-page":"105924","DOI":"10.1016\/j.ijantimicag.2020.105924","volume":"55","author":"Lai","year":"2020","journal-title":"Int. J. Antimicrob. Agents"},{"key":"D2FO00933A\/cit2\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00408-021-00423-z","volume":"199","author":"Sykes","year":"2021","journal-title":"Lung"},{"key":"D2FO00933A\/cit3\/1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MOP.0000000000001097","volume":"34","author":"Irwin","year":"2022","journal-title":"Curr. Opin. Pediatr."},{"key":"D2FO00933A\/cit4\/1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0065-3527(06)66005-3","volume":"66","author":"Masters","year":"2006","journal-title":"Adv. Virus Res."},{"key":"D2FO00933A\/cit5\/1","first-page":"1","author":"Bai","year":"2021","journal-title":"Sci. China: Life Sci."},{"key":"D2FO00933A\/cit6\/1","doi-asserted-by":"crossref","first-page":"166725","DOI":"10.1016\/j.jmb.2020.11.024","volume":"433","author":"Arya","year":"2021","journal-title":"J. Mol. Biol."},{"key":"D2FO00933A\/cit7\/1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s43856-022-00072-0","volume":"2","author":"Borges","year":"2022","journal-title":"Commun. Med."},{"key":"D2FO00933A\/cit8\/1","doi-asserted-by":"crossref","first-page":"876212","DOI":"10.3389\/fchem.2022.876212","volume":"10","author":"Calleja","year":"2022","journal-title":"Front. Chem."},{"key":"D2FO00933A\/cit9\/1","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1016\/j.csbj.2022.03.009","volume":"20","author":"Antonopoulou","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"D2FO00933A\/cit10\/1","doi-asserted-by":"crossref","first-page":"822785","DOI":"10.3389\/fchem.2022.822785","volume":"10","author":"Jiang","year":"2022","journal-title":"Front. Chem."},{"key":"D2FO00933A\/cit11\/1","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.chembiol.2004.08.011","volume":"11","author":"Blanchard","year":"2004","journal-title":"Chem. Biol."},{"key":"D2FO00933A\/cit12\/1","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1126\/science.abl4784","volume":"374","author":"Owen","year":"2021","journal-title":"Science"},{"key":"D2FO00933A\/cit13\/1","doi-asserted-by":"crossref","first-page":"6055","DOI":"10.1038\/s41467-021-26239-2","volume":"12","author":"Boras","year":"2021","journal-title":"Nat. Commun."},{"key":"D2FO00933A\/cit14\/1","unstructured":"Coronavirus (COVID-19) | Drugs. Available online:  https:\/\/www.fda.gov\/drugs\/emergency-preparedness-drugs\/coronavirus-covid-19-drugs"},{"key":"D2FO00933A\/cit15\/1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/s41422-020-0356-z","volume":"30","author":"Ma","year":"2020","journal-title":"Cell Res."},{"key":"D2FO00933A\/cit16\/1","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1038\/s41467-020-18096-2","volume":"11","author":"Vuong","year":"2020","journal-title":"Nat. Commun."},{"key":"D2FO00933A\/cit17\/1","doi-asserted-by":"crossref","first-page":"607278","DOI":"10.1093\/ecam\/neh081","volume":"2","author":"Chen","year":"2005","journal-title":"Evidence-Based Complementary Altern. Med."},{"key":"D2FO00933A\/cit18\/1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.antiviral.2005.07.002","volume":"68","author":"Lin","year":"2005","journal-title":"Antiviral Res."},{"key":"D2FO00933A\/cit19\/1","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41467-021-21060-3","volume":"12","author":"Osipiuk","year":"2021","journal-title":"Nat. Commun."},{"key":"D2FO00933A\/cit20\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.antiviral.2014.12.015","volume":"115","author":"B\u00e1ez-Santos","year":"2015","journal-title":"Antiviral Res."},{"key":"D2FO00933A\/cit21\/1","doi-asserted-by":"crossref","first-page":"877813","DOI":"10.3389\/fmicb.2022.877813","volume":"13","author":"Kulandaisamy","year":"2022","journal-title":"Front. Microbiol."},{"key":"D2FO00933A\/cit22\/1","doi-asserted-by":"crossref","first-page":"7561","DOI":"10.1021\/acs.jmedchem.2c00303","volume":"65","author":"Tan","year":"2022","journal-title":"J. Med. Chem."},{"key":"D2FO00933A\/cit23\/1","doi-asserted-by":"crossref","first-page":"991","DOI":"10.3390\/pharmaceutics13070991","volume":"13","author":"Matos","year":"2021","journal-title":"Pharmaceutics"},{"key":"D2FO00933A\/cit24\/1","doi-asserted-by":"crossref","first-page":"12780","DOI":"10.3390\/ijms140612780","volume":"14","author":"Chadwick","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"D2FO00933A\/cit25\/1","doi-asserted-by":"crossref","first-page":"127676","DOI":"10.1016\/j.foodchem.2020.127676","volume":"336","author":"Perovi\u0107","year":"2021","journal-title":"Food Chem."},{"key":"D2FO00933A\/cit26\/1","first-page":"1","volume":"12","author":"Matos","year":"2020","journal-title":"Nutrients"},{"key":"D2FO00933A\/cit27\/1","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3390\/ph14090941","volume":"14","author":"H\u00e4kkinen","year":"2021","journal-title":"Pharmaceutics"},{"key":"D2FO00933A\/cit28\/1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.fitote.2015.05.004","volume":"104","author":"Liu","year":"2015","journal-title":"Fitoterapia"},{"key":"D2FO00933A\/cit29\/1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.fitote.2016.09.023","volume":"115","author":"Yan","year":"2016","journal-title":"Fitoterapia"},{"key":"D2FO00933A\/cit30\/1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12906-016-1528-8","volume":"17","author":"Wang","year":"2017","journal-title":"BMC Complementary Altern. Med."},{"key":"D2FO00933A\/cit31\/1","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.3390\/molecules26092583","volume":"26","author":"Baixinho","year":"2021","journal-title":"Molecules"},{"key":"D2FO00933A\/cit32\/1","doi-asserted-by":"crossref","first-page":"P17","DOI":"10.1186\/1758-2946-4-S1-P17","volume":"4","author":"Kiss","year":"2012","journal-title":"J. Cheminf."},{"key":"D2FO00933A\/cit33\/1","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1038\/s41467-020-16954-7","volume":"11","author":"Kneller","year":"2020","journal-title":"Nat. Commun."},{"key":"D2FO00933A\/cit34\/1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discovery Today: Technol."},{"key":"D2FO00933A\/cit35\/1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.3390\/foods10071503","volume":"10","author":"Guijarro-Real","year":"2021","journal-title":"Foods"},{"key":"D2FO00933A\/cit36\/1","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3390\/ph14080742","volume":"14","author":"Nawrot-Hadzik","year":"2021","journal-title":"Pharmaceuticals"},{"key":"D2FO00933A\/cit37\/1","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.3390\/molecules26051409","volume":"26","author":"Sardanelli","year":"2021","journal-title":"Molecules"},{"key":"D2FO00933A\/cit38\/1","doi-asserted-by":"crossref","first-page":"638187","DOI":"10.3389\/fchem.2021.638187","volume":"9","author":"Tito","year":"2021","journal-title":"Front. Chem."},{"key":"D2FO00933A\/cit39\/1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1002\/pca.3088","volume":"33","author":"Dogan","year":"2022","journal-title":"Phytochem. Anal."},{"key":"D2FO00933A\/cit40\/1","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.3390\/molecules26154405","volume":"26","author":"Kim","year":"2021","journal-title":"Molecules"},{"key":"D2FO00933A\/cit41\/1","first-page":"e14101","author":"Xu","year":"2022","journal-title":"J. Food Biochem."},{"key":"D2FO00933A\/cit42\/1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fmolb.2020.00174","volume":"7","author":"Bosken","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"D2FO00933A\/cit43\/1","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.3390\/molecules26216744","volume":"26","author":"Montone","year":"2021","journal-title":"Molecules"},{"key":"D2FO00933A\/cit44\/1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1126\/science.abb3405","volume":"368","author":"Zhang","year":"2020","journal-title":"Science"},{"key":"D2FO00933A\/cit45\/1","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1042\/BCJ20200029","volume":"477","author":"Krichel","year":"2020","journal-title":"Biochem. J."},{"key":"D2FO00933A\/cit46\/1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.4155\/fmc-2021-0269","volume":"14","author":"Zhang","year":"2022","journal-title":"Future Med. Chem."},{"key":"D2FO00933A\/cit47\/1","doi-asserted-by":"crossref","first-page":"130152","DOI":"10.1016\/j.molstruc.2021.130152","volume":"1234","author":"Mandal","year":"2021","journal-title":"J. Mol. Struct."},{"key":"D2FO00933A\/cit48\/1","doi-asserted-by":"crossref","first-page":"622898","DOI":"10.3389\/fchem.2021.622898","volume":"9","author":"Mengist","year":"2021","journal-title":"Front. Chem."},{"key":"D2FO00933A\/cit49\/1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.12688\/f1000research.22457.2","volume":"9","author":"Chen","year":"2020","journal-title":"F1000Research"},{"key":"D2FO00933A\/cit50\/1","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1039\/D0SC04641H","volume":"11","author":"Nguyen","year":"2020","journal-title":"Chem. Sci."},{"key":"D2FO00933A\/cit51\/1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s42003-022-03090-9","volume":"5","author":"Narayanan","year":"2022","journal-title":"Commun. Biol."},{"key":"D2FO00933A\/cit52\/1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3109\/10408444.2013.813905","volume":"43","author":"Amorim","year":"2013","journal-title":"Crit. Rev. Toxicol."},{"key":"D2FO00933A\/cit53\/1","first-page":"3099","volume":"39","author":"Joshi","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"D2FO00933A\/cit54\/1","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3390\/molecules27031142","volume":"27","author":"Pa\u00e7o","year":"2022","journal-title":"Molecules"},{"key":"D2FO00933A\/cit55\/1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1039\/C2MD20172K","volume":"4","author":"Woods","year":"2013","journal-title":"MedChemComm"},{"key":"D2FO00933A\/cit56\/1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s11030-021-10220-8","volume":"26","author":"Rao","year":"2022","journal-title":"Mol. Divers."},{"key":"D2FO00933A\/cit57\/1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41586-020-2601-5","volume":"587","author":"Shin","year":"2020","journal-title":"Nature"},{"key":"D2FO00933A\/cit58\/1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbrc.2020.11.083","volume":"538","author":"Li","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"D2FO00933A\/cit59\/1","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","volume":"45","author":"Veber","year":"2002","journal-title":"J. Med. Chem."},{"key":"D2FO00933A\/cit60\/1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3390\/ph15020129","volume":"15","author":"Badraoui","year":"2022","journal-title":"Pharmaceuticals"},{"key":"D2FO00933A\/cit61\/1","doi-asserted-by":"crossref","first-page":"780257","DOI":"10.3389\/fpls.2022.780257","volume":"13","author":"Farmanpour-Kalalagh","year":"2022","journal-title":"Front. Plant Sci."},{"key":"D2FO00933A\/cit62\/1","doi-asserted-by":"crossref","first-page":"106216","DOI":"10.1016\/j.ijantimicag.2020.106216","volume":"57","author":"Li","year":"2021","journal-title":"Int. J. Antimicrob. Agents"},{"key":"D2FO00933A\/cit63\/1","doi-asserted-by":"crossref","first-page":"2524","DOI":"10.1021\/acsinfecdis.0c00522","volume":"6","author":"Cao","year":"2020","journal-title":"ACS Infect. Dis."},{"key":"D2FO00933A\/cit64\/1","doi-asserted-by":"crossref","first-page":"38128","DOI":"10.1039\/D0RA04876C","volume":"10","author":"Ebada","year":"2020","journal-title":"RSC Adv."},{"key":"D2FO00933A\/cit65\/1","doi-asserted-by":"crossref","first-page":"19790","DOI":"10.1039\/D0RA04199H","volume":"10","author":"Sayed","year":"2020","journal-title":"RSC Adv."},{"key":"D2FO00933A\/cit66\/1","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1016\/j.bmc.2012.07.038","volume":"20","author":"Park","year":"2012","journal-title":"Bioorg. Med. Chem."},{"key":"D2FO00933A\/cit67\/1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13578-021-00564-x","volume":"11","author":"Chen","year":"2021","journal-title":"Cell Biosci."},{"key":"D2FO00933A\/cit68\/1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1021\/acscentsci.0c00272","volume":"6","author":"Liu","year":"2020","journal-title":"ACS Cent. Sci."},{"key":"D2FO00933A\/cit69\/1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/cbic.202000047","volume":"21","author":"Morse","year":"2020","journal-title":"ChemBioChem"},{"key":"D2FO00933A\/cit70\/1","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1021\/acs.jproteome.0c00430","volume":"19","author":"Luan","year":"2020","journal-title":"J. Proteome Res."},{"key":"D2FO00933A\/cit71\/1","doi-asserted-by":"crossref","first-page":"129433","DOI":"10.1016\/j.molstruc.2020.129433","volume":"1228","author":"Sepay","year":"2021","journal-title":"J. Mol. Struct."}],"container-title":["Food &amp; Function"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/FO\/D2FO00933A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T19:18:28Z","timestamp":1713381508000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D2FO00933A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":71,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2022,8,30]]}},"URL":"https:\/\/doi.org\/10.1039\/d2fo00933a","relation":{},"ISSN":["2042-6496","2042-650X"],"issn-type":[{"value":"2042-6496","type":"print"},{"value":"2042-650X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}