{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:58:54Z","timestamp":1770019134656,"version":"3.49.0"},"reference-count":76,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"am","delay-in-days":411,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/137844\/2018"],"award-info":[{"award-number":["SFRH\/BD\/137844\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2020.09087.BD"],"award-info":[{"award-number":["2020.09087.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04378\/2020"],"award-info":[{"award-number":["UIDP\/04378\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04378\/2020"],"award-info":[{"award-number":["UIDB\/04378\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2020.01423.CEECIND\/CP1596\/CT0003"],"award-info":[{"award-number":["2020.01423.CEECIND\/CP1596\/CT0003"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Mol. Syst. Des. Eng."],"abstract":"<jats:p>The emergence of multi-drug resistant bacteria in the past decades has become one of the major public health issues of our time.<\/jats:p>","DOI":"10.1039\/d2me00009a","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T15:41:53Z","timestamp":1645026113000},"page":"434-446","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Identification of novel candidates for inhibition of<i>LasR<\/i>, a quorum-sensing receptor of multidrug resistant<i>Pseudomonas aeruginosa<\/i>, through a specialized multi-level<i>in silico<\/i>approach"],"prefix":"10.1039","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0156-2545","authenticated-orcid":false,"given":"Rita P.","family":"Magalh\u00e3es","sequence":"first","affiliation":[{"name":"UCIBIO\/REQUIMTE, BioSIM \u2013 Departamento de Medicina, Faculdade de Medicina da Universidade Do Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Associate Laboratory i4HB \u2013 Institute for Health and Bioeconomy, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5137-0798","authenticated-orcid":false,"given":"Tatiana F.","family":"Vieira","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE, BioSIM \u2013 Departamento de Medicina, Faculdade de Medicina da Universidade Do Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Associate Laboratory i4HB \u2013 Institute for Health and Bioeconomy, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal"}]},{"given":"Andr\u00e9","family":"Melo","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-5284","authenticated-orcid":false,"given":"S\u00e9rgio F.","family":"Sousa","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE, BioSIM \u2013 Departamento de Medicina, Faculdade de Medicina da Universidade Do Porto, Alameda Prof. Hern\u00e2ni Monteiro, 4200-319 Porto, Portugal"},{"name":"Associate Laboratory i4HB \u2013 Institute for Health and Bioeconomy, Faculdade de Medicina, Universidade do Porto, 4200-319 Porto, Portugal"}]}],"member":"292","published-online":{"date-parts":[[2022]]},"reference":[{"key":"D2ME00009A\/cit1\/1","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nrd1008","volume":"2","author":"Davies","year":"2003","journal-title":"Nat. Rev. Drug Discovery"},{"key":"D2ME00009A\/cit2\/1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nrmicro821","volume":"2","author":"Hall-Stoodley","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"key":"D2ME00009A\/cit3\/1","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.1039\/c2ob25835h","volume":"10","author":"Worthington","year":"2012","journal-title":"Org. Biomol. Chem."},{"key":"D2ME00009A\/cit4\/1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1099\/jmm.0.47668-0","volume":"57","author":"Smith","year":"2008","journal-title":"J. Med. Microbiol."},{"key":"D2ME00009A\/cit5\/1","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1126\/science.257.5073.1064","volume":"257","author":"Neu","year":"1992","journal-title":"Science"},{"key":"D2ME00009A\/cit6\/1","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.2174\/092986706777935212","volume":"13","author":"Musk","year":"2006","journal-title":"Curr. Med. Chem."},{"key":"D2ME00009A\/cit7\/1","doi-asserted-by":"crossref","first-page":"e28737","DOI":"10.1371\/journal.pone.0028737","volume":"7","author":"Quave","year":"2012","journal-title":"PLoS One"},{"key":"D2ME00009A\/cit8\/1","first-page":"1","author":"Sheikh","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"D2ME00009A\/cit9\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ma11091705","volume":"11","author":"Kamaruzzaman","year":"2018","journal-title":"Materials"},{"key":"D2ME00009A\/cit10\/1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.jcma.2017.07.012","volume":"81","author":"Jamal","year":"2018","journal-title":"J. Chin. Med. Assoc."},{"key":"D2ME00009A\/cit11\/1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s13613-020-00775-4","volume":"10","author":"Luyt","year":"2020","journal-title":"Ann. Intensive Care"},{"key":"D2ME00009A\/cit13\/1","first-page":"67","volume":"322","author":"Irie","year":"2008","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"D2ME00009A\/cit14\/1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.bioeng.10.061807.160536","volume":"10","author":"Jayaraman","year":"2008","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"D2ME00009A\/cit15\/1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/cr100109t","volume":"111","author":"Galloway","year":"2011","journal-title":"Chem. Rev."},{"key":"D2ME00009A\/cit16\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2017.07.002","volume":"190","author":"Kariminik","year":"2017","journal-title":"Immunol. Lett."},{"key":"D2ME00009A\/cit17\/1","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1172\/JCI200320364","volume":"112","author":"Smith","year":"2003","journal-title":"J. Clin. Invest."},{"key":"D2ME00009A\/cit18\/1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s12223-018-0585-4","volume":"63","author":"Skariyachan","year":"2018","journal-title":"Folia Microbiol."},{"key":"D2ME00009A\/cit19\/1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/sj.clpt.6100235","volume":"82","author":"Lalonde","year":"2007","journal-title":"Clin. Pharmacol. Ther."},{"key":"D2ME00009A\/cit20\/1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1124\/pr.112.007336","volume":"66","author":"Sliwoski","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"D2ME00009A\/cit21\/1","first-page":"26","author":"Vieira","year":"2021","journal-title":"Molecules"},{"key":"D2ME00009A\/cit22\/1","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.3390\/molecules26092600","volume":"26","author":"Martins","year":"2021","journal-title":"Molecules"},{"key":"D2ME00009A\/cit23\/1","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.tibtech.2020.04.002","volume":"38","author":"Magalh\u00e3es","year":"2020","journal-title":"Trends Biotechnol."},{"key":"D2ME00009A\/cit24\/1","volume-title":"The Protein Data Bank","author":"Berman","unstructured":"Z. F. H. M.Berman , J.Westbrook , I. N. S. G.Gilliland , T. N.Bhat , H.Weissig and P. E.Bourne , The Protein Data Bank , rcsb.org"},{"key":"D2ME00009A\/cit26\/1","doi-asserted-by":"crossref","first-page":"13592","DOI":"10.1074\/jbc.M700556200","volume":"282","author":"Bottomley","year":"2007","journal-title":"J. Biol. Chem."},{"key":"D2ME00009A\/cit27\/1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.chembiol.2009.09.001","volume":"16","author":"Zou","year":"2009","journal-title":"Chem. Biol."},{"key":"D2ME00009A\/cit28\/1","doi-asserted-by":"crossref","first-page":"20765","DOI":"10.1073\/pnas.1314415110","volume":"110","author":"Fan","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2ME00009A\/cit29\/1","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.chembiol.2018.06.007","volume":"25","author":"O'Reilly","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"D2ME00009A\/cit30\/1","first-page":"1","author":"Mccready","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D2ME00009A\/cit31\/1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1021\/acschembio.8b00971","volume":"14","author":"Paczkowski","year":"2019","journal-title":"ACS Chem. Biol."},{"key":"D2ME00009A\/cit32\/1","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","volume":"30","author":"Morris","year":"2010","journal-title":"J. Comput. Chem."},{"key":"D2ME00009A\/cit33\/1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/prot.10465","volume":"52","author":"Verdonk","year":"2003","journal-title":"Proteins"},{"key":"D2ME00009A\/cit34\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","volume":"3","author":"Boyle","year":"2011","journal-title":"J. Cheminf."},{"issue":"2","key":"D2ME00009A\/cit35\/1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"D2ME00009A\/cit36\/1","doi-asserted-by":"crossref","first-page":"3594","DOI":"10.1016\/j.bmcl.2016.06.013","volume":"26","author":"Zhang","year":"2016","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D2ME00009A\/cit37\/1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13321-019-0362-7","volume":"11","author":"Bell","year":"2019","journal-title":"J. Cheminf."},{"key":"D2ME00009A\/cit38\/1","doi-asserted-by":"crossref","first-page":"D1100","DOI":"10.1093\/nar\/gkr777","volume":"40","author":"Gaulton","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"D2ME00009A\/cit39\/1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jmgm.2018.10.014","volume":"86","author":"Ahumedo Monterrosa","year":"2019","journal-title":"J. Mol. Graphics Modell."},{"key":"D2ME00009A\/cit40\/1","doi-asserted-by":"crossref","first-page":"111800","DOI":"10.1016\/j.ejmech.2019.111800","volume":"185","author":"Hossain","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"D2ME00009A\/cit41\/1","doi-asserted-by":"crossref","first-page":"7467","DOI":"10.1021\/jm901742e","volume":"53","author":"Lowery","year":"2010","journal-title":"J. Med. Chem."},{"key":"D2ME00009A\/cit42\/1","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1016\/j.bmc.2018.05.018","volume":"26","author":"Boursier","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"D2ME00009A\/cit43\/1","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ejmech.2009.11.004","volume":"45","author":"Ahumedo","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"D2ME00009A\/cit44\/1","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1128\/AAC.01283-08","volume":"53","author":"Yang","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"D2ME00009A\/cit45\/1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.micpath.2018.03.012","volume":"118","author":"Rajkumari","year":"2018","journal-title":"Microb. Pathog."},{"issue":"6","key":"D2ME00009A\/cit46\/1","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.3390\/ijms21062190","volume":"21","author":"Zhong","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"D2ME00009A\/cit47\/1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1021\/acsinfecdis.5b00112","volume":"2","author":"O'Reilly","year":"2016","journal-title":"ACS Infect. Dis."},{"key":"D2ME00009A\/cit48\/1","doi-asserted-by":"crossref","first-page":"5629","DOI":"10.1128\/AAC.00955-13","volume":"57","author":"Tan","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"D2ME00009A\/cit49\/1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s10822-012-9599-1","volume":"26","author":"Annapoorani","year":"2012","journal-title":"J. Comput.-Aided Mol. Des."},{"key":"D2ME00009A\/cit50\/1","doi-asserted-by":"crossref","first-page":"10385","DOI":"10.1021\/acs.jmedchem.8b00540","volume":"61","author":"Soukarieh","year":"2018","journal-title":"J. Med. Chem."},{"key":"D2ME00009A\/cit51\/1","doi-asserted-by":"crossref","first-page":"5500","DOI":"10.1016\/j.bmc.2011.07.044","volume":"19","author":"Malladi","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"D2ME00009A\/cit52\/1","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1016\/j.bmc.2011.06.071","volume":"19","author":"McInnis","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"D2ME00009A\/cit53\/1","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1021\/jm300687e","volume":"55","author":"Mysinger","year":"2012","journal-title":"J. Med. Chem."},{"key":"D2ME00009A\/cit54\/1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fchem.2020.00204","volume":"8","author":"Soukarieh","year":"2020","journal-title":"Front. Chem."},{"key":"D2ME00009A\/cit55\/1","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1021\/acs.jcim.6b00283","volume":"56","author":"Empereur-Mot","year":"2016","journal-title":"J. Chem. Inf. Model."},{"key":"D2ME00009A\/cit56\/1","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1021\/jm0608356","volume":"49","author":"Huang","year":"2006","journal-title":"J. Med. Chem."},{"key":"D2ME00009A\/cit57\/1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fchem.2018.00130","volume":"6","author":"Ortuso","year":"2018","journal-title":"Front. Chem."},{"key":"D2ME00009A\/cit58\/1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.drudis.2009.05.012","volume":"14","author":"Hibert","year":"2009","journal-title":"Drug Discovery Today"},{"key":"D2ME00009A\/cit60\/1","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1021\/acs.jcim.5b00203","volume":"55","author":"Chevillard","year":"2015","journal-title":"J. Chem. Inf. Model."},{"key":"D2ME00009A\/cit61\/1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/ci049714+","volume":"45","author":"Irwin","year":"2005","journal-title":"J. Chem. Inf. Model."},{"key":"D2ME00009A\/cit62\/1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1021\/ci500588j","volume":"55","author":"Sander","year":"2015","journal-title":"J. Chem. Inf. Model."},{"key":"D2ME00009A\/cit63\/1","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/jcc.20290","volume":"26","author":"Case","year":"2005","journal-title":"J. Comput. Chem."},{"key":"D2ME00009A\/cit64\/1","doi-asserted-by":"crossref","first-page":"3696","DOI":"10.1021\/acs.jctc.5b00255","volume":"11","author":"Maier","year":"2015","journal-title":"J. Chem. Theory Comput."},{"key":"D2ME00009A\/cit66\/1","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"key":"D2ME00009A\/cit67\/1","doi-asserted-by":"crossref","first-page":"10096","DOI":"10.1063\/1.1808117","volume":"121","author":"Price","year":"2004","journal-title":"J. Chem. Phys."},{"key":"D2ME00009A\/cit68\/1","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"key":"D2ME00009A\/cit69\/1","first-page":"11","author":"Vieira","year":"2022","journal-title":"Antibiotics"},{"key":"D2ME00009A\/cit70\/1","doi-asserted-by":"crossref","first-page":"17464","DOI":"10.1038\/s41598-019-53945-1","volume":"9","author":"Yoshino","year":"2019","journal-title":"Sci. Rep."},{"key":"D2ME00009A\/cit71\/1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/acschemneuro.1c00694","volume":"13","author":"Xue","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"D2ME00009A\/cit72\/1","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1021\/acs.jmedchem.1c01563","volume":"65","author":"Golovanov","year":"2022","journal-title":"J. Med. Chem."},{"key":"D2ME00009A\/cit73\/1","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1021\/acs.jmedchem.1c01423","volume":"65","author":"El Salamouni","year":"2022","journal-title":"J. Med. Chem."},{"key":"D2ME00009A\/cit74\/1","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1021\/jacs.1c10329","volume":"144","author":"Li","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"D2ME00009A\/cit75\/1","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","volume":"9","author":"Roe","year":"2013","journal-title":"J. Chem. Theory Comput."},{"key":"D2ME00009A\/cit76\/1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graphics"},{"key":"D2ME00009A\/cit77\/1","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1021\/ct300418h","volume":"8","author":"Miller","year":"2012","journal-title":"J. Chem. Theory Comput."},{"key":"D2ME00009A\/cit78\/1","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"D2ME00009A\/cit79\/1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discovery Today: Technol."},{"key":"D2ME00009A\/cit80\/1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1758-2946-1-8","volume":"1","author":"Ertl","year":"2009","journal-title":"J. Cheminf."}],"container-title":["Molecular Systems Design &amp; Engineering"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2022\/ME\/D2ME00009A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T23:43:17Z","timestamp":1713397397000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D2ME00009A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":76,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,10]]}},"URL":"https:\/\/doi.org\/10.1039\/d2me00009a","relation":{},"ISSN":["2058-9689"],"issn-type":[{"value":"2058-9689","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]}}}