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Marine toxins, in particular, due to their wide chemical diversity, offer a new range of possibilities, a few of which have already been translated into approved drugs. Glycera alba and Hediste diversicolor are sympatric Polychaeta with distinct ecology and behavior suspected to secrete toxins that evolved to interact with distinct molecular targets, thus with differential selectivity and potential applications in drug discovery. Comparative transcriptomics revealed that while G. alba's venom apparatus is localized in the proboscis and neurotoxins are secreted to overtake prey, H. diversicolor secretes fewer and less specific toxins that are seemingly a defense. Human interactome-directed analysis unraveled novel toxins and other bioactives with potential biomedical applications, like proteins from G. alba's venom that can regulate apoptosis, whereas H. diversicolor yielded proteins that may control inflammation and cell proliferation in humans. Omics and bioinformatics appear to be powerful tools for marine bioprospecting and drug discovery, enabling molecular mining through transcriptomes of non-model organisms and link their ecology and physiology with protein's specificity and bioreactivity. Interactome-directed analysis against the human proteome seems an efficient alternative to the design of synthetic drugs.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d2mo00138a","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T10:00:57Z","timestamp":1656064857000},"page":"731-744","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A drug discovery approach based on comparative transcriptomics between two toxin-secreting marine annelids:\n                    <i>Glycera alba<\/i>\n                    and\n                    <i>Hediste diversicolor<\/i>"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7628-8747","authenticated-orcid":false,"given":"In\u00eas","family":"Moutinho Cabral","sequence":"first","affiliation":[{"name":"UCIBIO \u2013 Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University of Lisbon b , 2829-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB \u2013 Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon a , 2829-516 Caparica, Portugal \u00a0 imf.cabral@campus.fct.unl.pt \u00a0 pmcosta@fct.unl.pt \u00a0 +351 212 948 300 ext. 11107"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1632-634X","authenticated-orcid":false,"given":"Carolina","family":"Madeira","sequence":"additional","affiliation":[{"name":"UCIBIO \u2013 Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University of Lisbon b , 2829-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB \u2013 Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon a , 2829-516 Caparica, Portugal \u00a0 imf.cabral@campus.fct.unl.pt \u00a0 pmcosta@fct.unl.pt \u00a0 +351 212 948 300 ext. 11107"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6974-4209","authenticated-orcid":false,"given":"Ana R","family":"Grosso","sequence":"additional","affiliation":[{"name":"UCIBIO \u2013 Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University of Lisbon b , 2829-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB \u2013 Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon a , 2829-516 Caparica, Portugal \u00a0 imf.cabral@campus.fct.unl.pt \u00a0 pmcosta@fct.unl.pt \u00a0 +351 212 948 300 ext. 11107"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9072-3522","authenticated-orcid":false,"given":"Pedro M","family":"Costa","sequence":"additional","affiliation":[{"name":"UCIBIO \u2013 Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, NOVA University of Lisbon b , 2829-516 Caparica, Portugal"},{"name":"Associate Laboratory i4HB \u2013 Institute for Health and Bioeconomy, NOVA School of Science and Technology, NOVA University of Lisbon a , 2829-516 Caparica, Portugal \u00a0 imf.cabral@campus.fct.unl.pt \u00a0 pmcosta@fct.unl.pt \u00a0 +351 212 948 300 ext. 11107"}]}],"member":"286","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"key":"2026010813073590800_cit1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nrd2487","article-title":"Drug development from marine natural products","volume":"8","author":"Molinski","year":"2009","journal-title":"Nat. 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