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More recently, DBS has also been applied for lipidomics analysis, but this is an area that requires further research. The few works found in the literature on lipidomics of DBS samples performed the analysis in adult samples, leaving pediatric ages unmapped. The objective of this study was to assess the variability of the lipid profile (identified by high-resolution C18 RP-LC-MS\/MS) of DBS at pediatric age (0\u201310 days, 2\u201318 months, and 3\u201313 years) and to identify age-related variations. The results revealed that the lipidomic signature of the three age groups is significantly different, especially for a few species of neutral lipids and phosphatidylcholines. The main contributors to the differentiation of the groups correspond to 3 carnitine (Car), 2 cholesteryl ester (CE), 2 diacylglycerol (DG), 2 triacylglycerol (TG), 3 phosphatidylcholine (PC), 1 ether-linked PC, 1 phosphatidylethanolamine (PE), 1 ether-linked PE and 1 phosphatidylinositol (PI) species, all with statistically significant differences. Additionally, lipid species containing linoleic acid (C18:2) were shown to have significantly lower levels in the 0\u201310 days group with a gradual increase in the 2\u201318 month, reaching the highest concentrations in the 3\u201313 year group. The results of this study highlighted the adaptations of the lipid profile at different pediatric ages. These results may help improve understanding of the evolution of lipid metabolism throughout childhood and should be investigated further.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d2mo00206j","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T11:21:00Z","timestamp":1671189660000},"page":"229-237","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Lipid profile variability in children at different ages measured in dried blood spots"],"prefix":"10.1093","volume":"19","author":[{"given":"Helena Beatriz","family":"Ferreira","sequence":"first","affiliation":[{"name":"Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago Aveiro 3810-193, Portugal"},{"name":"CESAM, Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago Aveiro 3810-193, Portugal"}]},{"given":"T\u00e2nia","family":"Melo","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago Aveiro 3810-193, Portugal"},{"name":"CESAM, Centre for Environmental and Marine Studies, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago Aveiro 3810-193, Portugal"}]},{"given":"Hugo","family":"Rocha","sequence":"additional","affiliation":[{"name":"Newborn Screening, Metabolism and Genetics Unit, Human Genetics Department, National Institute of Health Doutor Ricardo Jorge Porto 4000-053, Portugal"},{"name":"Department of Pathological, Cytological and Thanatological Anatomy, School of Health, Polytechnic Institute of Porto Porto 4200-072, Portugal"}]},{"given":"Artur","family":"Paiva","sequence":"additional","affiliation":[{"name":"Unidade de Gest\u00e3o Operacional em Citometria, Centro Hospitalar e Universit\u00e1rio de Coimbra (CHUC) Portugal"},{"name":"Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra Coimbra, Portugal"},{"name":"Instituto Polit\u00e9cnico de Coimbra, ESTESC \u2013 Coimbra Health School, Ci\u00eancias Biom\u00e9dicas Laboratoriais Portugal"}]},{"given":"Pedro","family":"Domingues","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Campus Universit\u00e1rio de Santiago Aveiro 3810-193, Portugal"}]},{"given":"M. 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