{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:39:50Z","timestamp":1770885590480,"version":"3.50.1"},"reference-count":55,"publisher":"Royal Society of Chemistry (RSC)","issue":"27","license":[{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"am","delay-in-days":520,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/146809\/2019"],"award-info":[{"award-number":["SFRH\/BD\/146809\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00313\/2020"],"award-info":[{"award-number":["UIDB\/00313\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04564\/2020"],"award-info":[{"award-number":["UIDB\/04564\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/00313\/2020"],"award-info":[{"award-number":["UIDP\/00313\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04564\/2020"],"award-info":[{"award-number":["UIDP\/04564\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["CrystEngComm"],"abstract":"<jats:p>Nateglinide is a prolific polymorph former. Cryo-milling and quench cooling were explored as alternatives to stabilize its co-amorphous systems with ranolazine and tryptophan, and their molecular dynamics of relaxation investigated.<\/jats:p>","DOI":"10.1039\/d4ce00195h","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T10:55:29Z","timestamp":1717498529000},"page":"3653-3664","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Avoiding pits on the energy landscape \u2013 alternative strategies for stabilizing nateglinide co-amorphous systems"],"prefix":"10.1039","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-2251","authenticated-orcid":false,"given":"Joana F. C.","family":"Silva","sequence":"first","affiliation":[{"name":"CQC-IMS, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7897-3254","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Jasiurkowska-Delaporte","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, PL-31342 Krak\u00f3w, Poland"}]},{"given":"Pedro S.","family":"Pereira Silva","sequence":"additional","affiliation":[{"name":"CFisUC, Departamento de F\u00edsica, Faculdade de Ci\u00eancias e Tecnologia, Universidade de Coimbra, 3000-370 Coimbra, Portugal"}]},{"given":"Manuela Ramos","family":"Silva","sequence":"additional","affiliation":[{"name":"CFisUC, Departamento de F\u00edsica, Faculdade de Ci\u00eancias e Tecnologia, Universidade de Coimbra, 3000-370 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5515-7721","authenticated-orcid":false,"given":"M. Ermelinda S.","family":"Eus\u00e9bio","sequence":"additional","affiliation":[{"name":"CQC-IMS, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5782-8819","authenticated-orcid":false,"given":"M\u00e1rio T. S.","family":"Rosado","sequence":"additional","affiliation":[{"name":"CQC-IMS, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4CE00195H\/cit1\/1","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1021\/mp800092t","volume":"5","author":"Willart","year":"2008","journal-title":"Mol. Pharmaceutics"},{"key":"D4CE00195H\/cit2\/1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/pharmaceutics13030389","volume":"13","author":"Liu","year":"2021","journal-title":"Pharmaceutics"},{"key":"D4CE00195H\/cit3\/1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3390\/pharmaceutics2020224","volume":"2","author":"Graeser","year":"2010","journal-title":"Pharmaceutics"},{"key":"D4CE00195H\/cit4\/1","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1021\/mp049938f","volume":"1","author":"Gupta","year":"2004","journal-title":"Mol. Pharmaceutics"},{"key":"D4CE00195H\/cit5\/1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1208\/s12249-022-02261-5","volume":"23","author":"Wang","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"D4CE00195H\/cit6\/1","doi-asserted-by":"crossref","first-page":"122645","DOI":"10.1016\/j.ijpharm.2023.122645","volume":"634","author":"Huang","year":"2023","journal-title":"Int. J. Pharm."},{"key":"D4CE00195H\/cit7\/1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ijpharm.2014.10.021","volume":"477","author":"Mart\u00ednez","year":"2014","journal-title":"Int. J. Pharm."},{"key":"D4CE00195H\/cit8\/1","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1021\/acs.molpharmaceut.5b00334","volume":"12","author":"Knapik","year":"2015","journal-title":"Mol. Pharmaceutics"},{"key":"D4CE00195H\/cit9\/1","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1039\/C8RA09710K","volume":"9","author":"Zhang","year":"2019","journal-title":"RSC Adv."},{"key":"D4CE00195H\/cit10\/1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejps.2014.05.015","volume":"62","author":"Dengale","year":"2014","journal-title":"Eur. J. Pharm. Sci."},{"key":"D4CE00195H\/cit11\/1","first-page":"105636","author":"Chambers","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"D4CE00195H\/cit12\/1","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1021\/acs.jchemed.3c00036","volume":"100","author":"Silva","year":"2023","journal-title":"J. Chem. Educ."},{"key":"D4CE00195H\/cit13\/1","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.3390\/biomedicines10092055","volume":"10","author":"Bhalani","year":"2022","journal-title":"Biomedicines"},{"key":"D4CE00195H\/cit14\/1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1208\/s12249-021-02137-0","volume":"23","author":"Shi","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"D4CE00195H\/cit15\/1","doi-asserted-by":"crossref","first-page":"6679","DOI":"10.1021\/acs.cgd.3c00565","volume":"23","author":"Silva","year":"2023","journal-title":"Cryst. Growth Des."},{"key":"D4CE00195H\/cit16\/1","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.drudis.2011.11.007","volume":"17","author":"Di","year":"2012","journal-title":"Drug Discovery Today"},{"key":"D4CE00195H\/cit17\/1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1016212804288","volume":"12","author":"Amidon","year":"1995","journal-title":"Pharm. Res."},{"key":"D4CE00195H\/cit18\/1","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1080\/03639045.2020.1820035","volume":"46","author":"Bazeed","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"D4CE00195H\/cit19\/1","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1039\/C9CE01504C","volume":"22","author":"Sarmah","year":"2020","journal-title":"CrystEngComm"},{"key":"D4CE00195H\/cit20\/1","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.xphs.2018.11.033","volume":"108","author":"Bruni","year":"2019","journal-title":"J. Pharm. Sci."},{"key":"D4CE00195H\/cit21\/1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.5530\/ijper.51.4.85","volume":"51","author":"Swain","year":"2017","journal-title":"Indian J. Pharm. Educ. Res."},{"key":"D4CE00195H\/cit22\/1","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1007\/s10973-015-4714-x","volume":"123","author":"Ikeda","year":"2016","journal-title":"J. Therm. Anal. Calorim."},{"key":"D4CE00195H\/cit23\/1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ijpharm.2013.06.084","volume":"454","author":"Maggi","year":"2013","journal-title":"Int. J. Pharm."},{"key":"D4CE00195H\/cit24\/1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.ijpharm.2013.06.085","volume":"454","author":"Maggi","year":"2013","journal-title":"Int. J. Pharm."},{"key":"D4CE00195H\/cit25\/1","doi-asserted-by":"crossref","first-page":"806966","DOI":"10.3389\/fmolb.2022.806966","volume":"9","author":"Ren","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"D4CE00195H\/cit26\/1","doi-asserted-by":"crossref","first-page":"e003196","DOI":"10.1161\/JAHA.116.003196","volume":"5","author":"Rayner-Hartley","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"D4CE00195H\/cit27\/1","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.jacc.2013.02.011","volume":"61","author":"Kosiborod","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"D4CE00195H\/cit28\/1","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1021\/acs.molpharmaceut.5b00295","volume":"12","author":"Jensen","year":"2015","journal-title":"Mol. Pharmaceutics"},{"key":"D4CE00195H\/cit29\/1","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1021\/acs.molpharmaceut.7b00803","volume":"14","author":"Walker","year":"2017","journal-title":"Mol. Pharmaceutics"},{"key":"D4CE00195H\/cit30\/1","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1021\/acs.molpharmaceut.7b00217","volume":"14","author":"Pang","year":"2017","journal-title":"Mol. Pharmaceutics"},{"key":"D4CE00195H\/cit31\/1","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ijpharm.2018.12.036","volume":"557","author":"Kasten","year":"2019","journal-title":"Int. J. Pharm."},{"key":"D4CE00195H\/cit32\/1","doi-asserted-by":"crossref","first-page":"4247","DOI":"10.1021\/acs.molpharmaceut.8b00650","volume":"15","author":"Kissi","year":"2018","journal-title":"Mol. Pharmaceutics"},{"key":"D4CE00195H\/cit33\/1","doi-asserted-by":"crossref","first-page":"121552","DOI":"10.1016\/j.ijpharm.2022.121552","volume":"616","author":"Holzapfel","year":"2022","journal-title":"Int. J. Pharm."},{"key":"D4CE00195H\/cit34\/1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ejpb.2016.06.020","volume":"107","author":"Jensen","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"D4CE00195H\/cit35\/1","volume-title":"Marvin (version 21.17.0)","year":"2021","unstructured":"Marvin (version 21.17.0) ,  ChemAxon ,  2021 ,  http:\/\/www.chemaxon.com"},{"key":"D4CE00195H\/cit36\/1","first-page":"2817","volume":"65","author":"Gang","year":"2007","journal-title":"Acta Chim. Sin."},{"key":"D4CE00195H\/cit37\/1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jpba.2009.06.017","volume":"50","author":"Bruni","year":"2009","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D4CE00195H\/cit38\/1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0040-6031(99)00009-X","volume":"331","author":"Sabbah","year":"1999","journal-title":"Thermochim. Acta"},{"key":"D4CE00195H\/cit39\/1","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1351\/pac200678071455","volume":"78","author":"Gatta","year":"2006","journal-title":"Pure Appl. Chem."},{"key":"D4CE00195H\/cit40\/1","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1021\/acs.macromol.8b02697","volume":"52","author":"Szymoniak","year":"2019","journal-title":"Macromolecules"},{"key":"D4CE00195H\/cit41\/1","doi-asserted-by":"crossref","first-page":"37289","DOI":"10.1021\/acsami.7b10572","volume":"9","author":"Madkour","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"D4CE00195H\/cit42\/1","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jpba.2009.11.019","volume":"51","author":"Bruni","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D4CE00195H\/cit43\/1","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.jpba.2010.12.003","volume":"54","author":"Bruni","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"D4CE00195H\/cit45\/1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1007\/s11095-010-0129-3","volume":"27","author":"Trasi","year":"2010","journal-title":"Pharm. Res."},{"key":"D4CE00195H\/cit46\/1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1208\/s12249-012-9801-8","volume":"13","author":"Trasi","year":"2012","journal-title":"AAPS PharmSciTech"},{"key":"D4CE00195H\/cit47\/1","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1023\/A:1021453810624","volume":"19","author":"Kakumanu","year":"2002","journal-title":"Pharm. Res."},{"key":"D4CE00195H\/cit48\/1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/bph.12150","volume":"169","author":"Peters","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"D4CE00195H\/cit49\/1","doi-asserted-by":"crossref","first-page":"144","DOI":"10.59566\/IJBS.2012.8144","volume":"8","author":"El-Wasseef","year":"2012","journal-title":"Int. J. Biomed. Sci."},{"key":"D4CE00195H\/cit50\/1","doi-asserted-by":"crossref","first-page":"140654","DOI":"10.1016\/j.cplett.2023.140654","volume":"826","author":"Quintano","year":"2023","journal-title":"Chem. Phys. Lett."},{"key":"D4CE00195H\/cit51\/1","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1021\/acs.molpharmaceut.8b00174","volume":"15","author":"Ueda","year":"2018","journal-title":"Mol. Pharmaceutics"},{"key":"D4CE00195H\/cit52\/1","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1021\/mp300487u","volume":"10","author":"Bhardwaj","year":"2013","journal-title":"Mol. Pharmaceutics"},{"key":"D4CE00195H\/cit53\/1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jpha.2014.09.003","volume":"6","author":"Sailaja","year":"2016","journal-title":"J. Pharm. Anal."},{"key":"D4CE00195H\/cit54\/1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1209\/epl\/i1997-00518-y","volume":"40","author":"Kudlik","year":"1997","journal-title":"Europhys. Lett."},{"key":"D4CE00195H\/cit55\/1","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1063\/1.1674335","volume":"53","author":"Johari","year":"2003","journal-title":"J. Chem. Phys."},{"key":"D4CE00195H\/cit56\/1","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jfoodeng.2018.08.036","volume":"243","author":"Morrow","year":"2019","journal-title":"J. Food Eng."}],"container-title":["CrystEngComm"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/CE\/D4CE00195H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T06:39:58Z","timestamp":1720420798000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D4CE00195H"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":55,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2024,7,8]]}},"URL":"https:\/\/doi.org\/10.1039\/d4ce00195h","relation":{},"ISSN":["1466-8033"],"issn-type":[{"value":"1466-8033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}