{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T04:49:03Z","timestamp":1767156543623,"version":"build-2238731810"},"reference-count":20,"publisher":"Royal Society of Chemistry (RSC)","issue":"5","license":[{"start":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T00:00:00Z","timestamp":1712880000000},"content-version":"vor","delay-in-days":102,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2021.06305.BD"],"award-info":[{"award-number":["2021.06305.BD"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["DL57\/2016\/CP1370\/CT0041"],"award-info":[{"award-number":["DL57\/2016\/CP1370\/CT0041"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PD\/BD\/143160\/2019"],"award-info":[{"award-number":["PD\/BD\/143160\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/00313\/2020"],"award-info":[{"award-number":["UIDB\/00313\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/00313\/2020"],"award-info":[{"award-number":["UIDP\/00313\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/QUI\/50006\/2020"],"award-info":[{"award-number":["UIDP\/QUI\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Med. Chem."],"abstract":"<jats:p>Structural modulation of a lead p53-activating anticancer molecule was performed, leading to the synthesis of new bioactive molecules. Activity against human colorectal cancer cells with different p53 status provided in-depth SAR data.<\/jats:p>","DOI":"10.1039\/d4md00076e","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T03:22:05Z","timestamp":1712892125000},"page":"1652-1663","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chiral hydroxymethyl-1\n                    <i>H<\/i>\n                    ,3\n                    <i>H<\/i>\n                    -pyrrolo[1,2-\n                    <i>c<\/i>\n                    ]thiazoles: the search for selective p53-activating agents for colorectal cancer therapy"],"prefix":"10.1039","volume":"15","author":[{"given":"Mees M.","family":"Hendrikx","sequence":"first","affiliation":[{"name":"University of Coimbra, Coimbra Chemistry Centre \u2013 Institute of Molecular Sciences and Department of Chemistry, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6512-2485","authenticated-orcid":false,"given":"Adelino M. R.","family":"Pereira","sequence":"additional","affiliation":[{"name":"University of Coimbra, Coimbra Chemistry Centre \u2013 Institute of Molecular Sciences and Department of Chemistry, 3004-535 Coimbra, Portugal"}]},{"given":"Ana B.","family":"Pereira","sequence":"additional","affiliation":[{"name":"University of Coimbra, Coimbra Chemistry Centre \u2013 Institute of Molecular Sciences and Department of Chemistry, 3004-535 Coimbra, Portugal"}]},{"given":"Carla S. C.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5185-3930","authenticated-orcid":false,"given":"Jo\u00e3o L. P.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"University of Coimbra, Coimbra Chemistry Centre \u2013 Institute of Molecular Sciences and Department of Chemistry, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8860-0470","authenticated-orcid":false,"given":"Maria I. L.","family":"Soares","sequence":"additional","affiliation":[{"name":"University of Coimbra, Coimbra Chemistry Centre \u2013 Institute of Molecular Sciences and Department of Chemistry, 3004-535 Coimbra, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9531-4939","authenticated-orcid":false,"given":"Luc\u00edlia","family":"Saraiva","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE, Laborat\u00f3rio de Microbiologia, Departamento de Ci\u00eancias Biol\u00f3gicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3256-4954","authenticated-orcid":false,"given":"Teresa M. V. D.","family":"Pinho e Melo","sequence":"additional","affiliation":[{"name":"University of Coimbra, Coimbra Chemistry Centre \u2013 Institute of Molecular Sciences and Department of Chemistry, 3004-535 Coimbra, Portugal"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4MD00076E\/cit1\/1","doi-asserted-by":"crossref","first-page":"e000285","DOI":"10.1136\/esmoopen-2017-000285","volume":"3","author":"Prager","year":"2018","journal-title":"ESMO Open"},{"key":"D4MD00076E\/cit2\/1","volume-title":"WHO report on cancer: setting priorities, investing wisely and providing care for all","year":"2020","unstructured":"WHO report on cancer: setting priorities, investing wisely and providing care for all ,  World Health Organization ,  Geneva ,  2020"},{"key":"D4MD00076E\/cit3\/1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"Sung","year":"2021","journal-title":"Ca-Cancer J. Clin."},{"key":"D4MD00076E\/cit4\/1","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/S0140-6736(19)32319-0","volume":"394","author":"Dekker","year":"2019","journal-title":"Lancet"},{"key":"D4MD00076E\/cit5\/1","doi-asserted-by":"crossref","first-page":"108982","DOI":"10.1016\/j.celrep.2021.108982","volume":"35","author":"Ramos","year":"2021","journal-title":"Cell Rep."},{"key":"D4MD00076E\/cit6\/1","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1016\/S0040-4020(00)00243-X","volume":"56","author":"Pinho e Melo","year":"2000","journal-title":"Tetrahedron"},{"key":"D4MD00076E\/cit7\/1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1021\/ja00496a026","volume":"101","author":"Szil\u00e1gyi","year":"1979","journal-title":"J. Am. Chem. Soc."},{"key":"D4MD00076E\/cit8\/1","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/jlac.198719870850","author":"Gy\u00f6rgyde\u00e1k","year":"1987","journal-title":"Liebigs Ann. Chem."},{"key":"D4MD00076E\/cit9\/1","doi-asserted-by":"crossref","first-page":"5093","DOI":"10.1016\/S0040-4020(02)00463-5","volume":"58","author":"Pinho e Melo","year":"2002","journal-title":"Tetrahedron"},{"key":"D4MD00076E\/cit10\/1","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ejmech.2012.11.036","volume":"60","author":"Soares","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"D4MD00076E\/cit11\/1","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.1016\/j.ejmech.2010.07.029","volume":"45","author":"Soares","year":"2010","journal-title":"Eur. J. Med. Chem."},{"key":"D4MD00076E\/cit12\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.aihch.2020.10.003","volume-title":"Applications of Heterocycles in the Design of Drugs and Agricultural Products","volume":"134","author":"Regueiro-Ren","year":"2021","unstructured":"A.Regueiro-Ren , in  Applications of Heterocycles in the Design of Drugs and Agricultural Products , ed.  N. A. Meanwell  and  M. L. Lolli ,  2021 ,  vol. 134 ,  pp. 1\u201330"},{"key":"D4MD00076E\/cit13\/1","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1016\/j.tetlet.2004.03.111","volume":"45","author":"Pinho e Melo","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"D4MD00076E\/cit14\/1","doi-asserted-by":"crossref","first-page":"4045","DOI":"10.1021\/jo010807p","volume":"67","author":"Pinho e Melo","year":"2002","journal-title":"J. Org. Chem."},{"key":"D4MD00076E\/cit15\/1","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1021\/jo050480i","volume":"70","author":"Pinho e Melo","year":"2005","journal-title":"J. Org. Chem."},{"key":"D4MD00076E\/cit16\/1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejmech.2014.04.008","volume":"79","author":"Santos","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"D4MD00076E\/cit17\/1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/molecules26020383","volume":"26","author":"Yang","year":"2021","journal-title":"Molecules"},{"key":"D4MD00076E\/cit18\/1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1021\/jo01359a023","volume":"22","author":"Schmolka","year":"1957","journal-title":"J. Org. Chem."},{"key":"D4MD00076E\/cit19\/1","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1016\/j.tetlet.2004.06.034","volume":"45","author":"Boechat","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"D4MD00076E\/cit20\/1","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1111\/bph.15506","volume":"178","author":"Raimundo","year":"2021","journal-title":"Br. J. Pharmacol."}],"updated-by":[{"DOI":"10.1039\/d5md90004b","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T00:00:00Z","timestamp":1738540800000}}],"container-title":["RSC Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/MD\/D4MD00076E","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T10:17:15Z","timestamp":1716373035000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D4MD00076E"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5,22]]}},"URL":"https:\/\/doi.org\/10.1039\/d4md00076e","relation":{},"ISSN":["2632-8682"],"issn-type":[{"value":"2632-8682","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}