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From the different types of cancer, pancreatic cancer (PaC) has one of the lowest survival rates, with a survival rate of about 20% after the first year of diagnosis and about 8% after 5 years. The lack of highly sensitive and specific biomarkers, together with the absence of symptoms in the early stages, determines a late diagnosis, which is associated with a decrease in the effectiveness of medical intervention, regardless of its nature \u2013 surgery and\/or chemotherapy. This review provides an updated overview of recent studies combining multi-OMICs approaches (e.g., proteomics, metabolomics) with analytical tools, highlighting the synergy between high-throughput molecular data generation and precise analytical tools such as LC\u2013MS, GC\u2013MS and MALDI-TOF MS. This combination significantly improves the detection, quantification and identification of biomolecules in complex biological systems and represents the latest advances in understanding PaC management and the search for effective diagnostic tools. Large-scale data analysis coupled with bioinformatics tools enables the identification of specific genetic mutations, gene expression patterns, pathways, networks, protein modifications and metabolic signatures associated with PaC pathogenesis, progression and treatment response through the integration of multi-OMICs data.<\/jats:p>\n                  <jats:p\/>","DOI":"10.1039\/d4mo00187g","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T09:24:52Z","timestamp":1734945892000},"page":"108-121","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Integrating OMICS-based platforms and analytical tools for diagnosis and management of pancreatic cancer: a review"],"prefix":"10.1093","volume":"21","author":[{"given":"Patr\u00edcia","family":"Sousa","sequence":"first","affiliation":[{"name":"CQM \u2013 Centro de Qu\u00edmica da Madeira, Universidade da Madeira a , Campus da Penteada, 9020-105 Funchal Portugal \u00a0 rmp@staff.uma.pt \u00a0 (+351) 291705149 \u00a0 (+351) 291705254"}]},{"given":"Laurentina","family":"Silva","sequence":"additional","affiliation":[{"name":"Hospital Dr N\u00e9lio Mendon\u00e7a, SESARAM, EPERAM \u2013 Servi\u00e7o de Sa\u00fade da Regi\u00e3o Aut\u00f3noma da Madeira b , Avenida Lu\u00eds de Cam\u00f5es, 9004-514 Funchal Portugal"}]},{"given":"Jos\u00e9 S","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias Exatas e Engenharia, Universidade da Madeira c , Campus da Penteada, 9020-105 Funchal Portugal"},{"name":"CQM \u2013 Centro de Qu\u00edmica da Madeira, Universidade da Madeira a , Campus da Penteada, 9020-105 Funchal Portugal \u00a0 rmp@staff.uma.pt \u00a0 (+351) 291705149 \u00a0 (+351) 291705254"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7395-5700","authenticated-orcid":false,"given":"Paula","family":"Guedes de Pinho","sequence":"additional","affiliation":[{"name":"UCIBIO \u2013 Applied Molecular Biosciences Unit, Lab. of Toxicology, Faculty of Pharmacy, University of Porto e , 4050-313 Porto, Portugal"},{"name":"Associate Laboratory i4HB \u2013 Institute for Health and Bioeconomy, University of Porto d , 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7223-1022","authenticated-orcid":false,"given":"Rosa","family":"Perestrelo","sequence":"additional","affiliation":[{"name":"CQM \u2013 Centro de Qu\u00edmica da Madeira, Universidade da Madeira a , Campus da Penteada, 9020-105 Funchal Portugal \u00a0 rmp@staff.uma.pt \u00a0 (+351) 291705149 \u00a0 (+351) 291705254"}]}],"member":"286","published-online":{"date-parts":[[2024,12,23]]},"reference":[{"key":"2026010813053543400_cit1","volume-title":"Global cancer burden growing, amidst mounting need for services","author":"World Health Organization (WHO)","year":"2024"},{"issue":"3","key":"2026010813053543400_cit2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: Globocan estimates of incidence and mortality worldwide for 36 Cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"Ca-Cancer J. 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