{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T13:39:47Z","timestamp":1777297187289,"version":"3.51.4"},"reference-count":62,"publisher":"Royal Society of Chemistry (RSC)","issue":"17","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"am","delay-in-days":449,"URL":"http:\/\/rsc.li\/journals-terms-of-use"}],"funder":[{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2021-123059OB-I00"],"award-info":[{"award-number":["PID2021-123059OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"Agencia Estatal de Investigaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020-116460RB-I00"],"award-info":[{"award-number":["PID2020-116460RB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007757","name":"Agencia Canaria de Investigaci\u00f3n, Innovaci\u00f3n y Sociedad de la Informaci\u00f3n","doi-asserted-by":"publisher","award":["TESIS2020010055"],"award-info":[{"award-number":["TESIS2020010055"]}],"id":[{"id":"10.13039\/501100007757","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002704","name":"Fundaci\u00f3n Cient\u00edfica Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer","doi-asserted-by":"publisher","award":["PRDTF233958GONZ"],"award-info":[{"award-number":["PRDTF233958GONZ"]}],"id":[{"id":"10.13039\/501100002704","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["Org. Biomol. Chem."],"abstract":"<jats:p>Coumarin\u2013azasugar\u2013benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity <jats:italic>in vitro<\/jats:italic> and no neurotoxicity.<\/jats:p>","DOI":"10.1039\/d4ob00312h","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T11:01:05Z","timestamp":1711364465000},"page":"3425-3438","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Coumarin\u2013azasugar\u2013benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth"],"prefix":"10.1039","volume":"22","author":[{"given":"I. Caroline","family":"Vaaland Holmgard","sequence":"first","affiliation":[{"name":"Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway"}]},{"given":"Aday","family":"Gonz\u00e1lez-Bakker","sequence":"additional","affiliation":[{"name":"BioLab, Instituto Universitario de Bio-Org\u00e1nica \u201cAntonio Gonz\u00e1lez\u201d (IUBO-AG), Universidad de La Laguna, c\/Astrof\u00edsico Francisco S\u00e1nchez 2, La Laguna, E-38206, Spain"}]},{"given":"Eleonora","family":"Poeta","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy"}]},{"given":"Adri\u00e1n","family":"Puerta","sequence":"additional","affiliation":[{"name":"BioLab, Instituto Universitario de Bio-Org\u00e1nica \u201cAntonio Gonz\u00e1lez\u201d (IUBO-AG), Universidad de La Laguna, c\/Astrof\u00edsico Francisco S\u00e1nchez 2, La Laguna, E-38206, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1840-616X","authenticated-orcid":false,"given":"Miguel X.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Engineering and Chemical Sciences, Karlstad University, Karlstad, Sweden"}]},{"given":"Barbara","family":"Monti","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1499-0650","authenticated-orcid":false,"given":"Jos\u00e9 G.","family":"Fern\u00e1ndez-Bola\u00f1os","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Qu\u00edmica, Universidad de Sevilla, Seville, Spain"}]},{"given":"Jos\u00e9 M.","family":"Padr\u00f3n","sequence":"additional","affiliation":[{"name":"BioLab, Instituto Universitario de Bio-Org\u00e1nica \u201cAntonio Gonz\u00e1lez\u201d (IUBO-AG), Universidad de La Laguna, c\/Astrof\u00edsico Francisco S\u00e1nchez 2, La Laguna, E-38206, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2896-6993","authenticated-orcid":false,"given":"\u00d3scar","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Facultad de Qu\u00edmica, Universidad de Sevilla, Seville, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5809-7368","authenticated-orcid":false,"given":"Emil","family":"Lindb\u00e4ck","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Bioscience and Environmental Engineering, Faculty of Science and Technology, University of Stavanger, Stavanger, Norway"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4OB00312H\/cit1\/1","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","volume":"430","author":"Matttson","year":"2004","journal-title":"Nature"},{"key":"D4OB00312H\/cit2\/1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"D4OB00312H\/cit3\/1","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1021\/acs.chemrev.8b00138","volume":"119","author":"Savelieff","year":"2019","journal-title":"Chem. Rev."},{"key":"D4OB00312H\/cit4\/1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2174\/157015906776359577","volume":"4","author":"Niikura","year":"2006","journal-title":"Curr. Neuropharmacol."},{"key":"D4OB00312H\/cit5\/1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13024-021-00460-5","volume":"16","author":"Xia","year":"2021","journal-title":"Mol. Neurodegener."},{"key":"D4OB00312H\/cit6\/1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nm0796-783","volume":"2","author":"Alonso","year":"1996","journal-title":"Nat. Med."},{"key":"D4OB00312H\/cit7\/1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/ageing\/afl027","volume":"35","author":"Tabet","year":"2006","journal-title":"Age Ageing"},{"key":"D4OB00312H\/cit8\/1","first-page":"211","volume":"3","author":"Hansen","year":"2008","journal-title":"Clin. Interventions Aging"},{"key":"D4OB00312H\/cit9\/1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1080\/14756360701421294","volume":"22","author":"Wiesner","year":"2007","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D4OB00312H\/cit10\/1","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1126\/science.1678899","volume":"253","author":"Sussman","year":"1991","journal-title":"Science"},{"key":"D4OB00312H\/cit11\/1","doi-asserted-by":"crossref","first-page":"10447","DOI":"10.1021\/bi0101392","volume":"40","author":"De Ferrari","year":"2001","journal-title":"Biochemistry"},{"key":"D4OB00312H\/cit12\/1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(00)80108-7","volume":"16","author":"Inestrosa","year":"1996","journal-title":"Neuron"},{"key":"D4OB00312H\/cit13\/1","first-page":"1","volume":"1","author":"Walker","year":"2020","journal-title":"Free Neuropathol."},{"key":"D4OB00312H\/cit14\/1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0006-2952(02)01514-9","volume":"65","author":"Bartolini","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"D4OB00312H\/cit15\/1","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1021\/jm0340602","volume":"46","author":"Piazzi","year":"2003","journal-title":"J. Med. Chem."},{"key":"D4OB00312H\/cit16\/1","doi-asserted-by":"crossref","first-page":"4970","DOI":"10.1016\/j.ejmech.2011.08.002","volume":"46","author":"Tang","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"D4OB00312H\/cit17\/1","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.neuropharm.2011.10.007","volume":"62","author":"Minarini","year":"2012","journal-title":"Neuropharmacology"},{"key":"D4OB00312H\/cit18\/1","doi-asserted-by":"crossref","first-page":"117419","DOI":"10.1016\/j.bmc.2023.117419","volume":"91","author":"Uliassi","year":"2023","journal-title":"Bioorg. Med. Chem."},{"key":"D4OB00312H\/cit19\/1","author":"The United States Food and Drug Administration","unstructured":"The United States Food and Drug Administration ,  https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-grants-accelerated-approval-alzheimers-disease-treatment"},{"key":"D4OB00312H\/cit20\/1","author":"The United States Food and Drug Administration","unstructured":"The United States Food and Drug Administration ,  https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-grants-accelerated-approval-alzheimers-drug"},{"key":"D4OB00312H\/cit21\/1","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1038\/s41591-021-01477-5","volume":"27","author":"Perlmutter","year":"2021","journal-title":"Nat. Med."},{"key":"D4OB00312H\/cit22\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJMoa2212948","volume":"388","author":"van Dyck","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"D4OB00312H\/cit23\/1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.bbcan.2017.07.001","volume":"1868","author":"Guo","year":"2017","journal-title":"Biochim. Biophys. Acta, Rev. Cancer"},{"key":"D4OB00312H\/cit24\/1","doi-asserted-by":"crossref","first-page":"7173","DOI":"10.1007\/s12035-019-1591-5","volume":"56","author":"Nudelman","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"D4OB00312H\/cit25\/1","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.pharmthera.2018.10.002","volume":"194","author":"Friedman","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"D4OB00312H\/cit26\/1","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/1759-7714.12249","volume":"6","author":"Xi","year":"2015","journal-title":"Thorac. Cancer"},{"key":"D4OB00312H\/cit27\/1","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.bbadis.2015.04.003","volume":"1852","author":"P\u00e9rez-Aguilar","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"D4OB00312H\/cit28\/1","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1016\/j.bmcl.2015.04.017","volume":"25","author":"Nguyen","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4OB00312H\/cit29\/1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejmech.2014.03.015","volume":"78","author":"Saeed","year":"2014","journal-title":"Eur. J. Med. Chem."},{"key":"D4OB00312H\/cit30a\/1","first-page":"58","volume":"6","author":"Zovko","year":"2009","journal-title":"WSEAS Trans. Biol. Biomed."},{"key":"D4OB00312H\/cit30b\/1","doi-asserted-by":"crossref","first-page":"3830","DOI":"10.3390\/ijms22083830","volume":"22","author":"Hud\u00e1\u010dov\u00e1","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"D4OB00312H\/cit31\/1","first-page":"187","volume":"66","author":"St\u00fctz","year":"2011","journal-title":"Adv. Carbohydr. Chem."},{"key":"D4OB00312H\/cit32\/1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2174\/1568026033452438","volume":"3","author":"Asano","year":"2003","journal-title":"Curr. Top. Med. Chem."},{"key":"D4OB00312H\/cit33\/1","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/B978-044451967-2\/00100-8","volume-title":"Comprehensive Glycoscience","volume":"1","author":"Bols","year":"2007","unstructured":"M.Bols ,  \u00d3.L\u00f3pez  and  F.Ortega-Caballero ,  Glycosidase inhibitors: structure, activity, synthesis, and medical relevance , in  Comprehensive Glycoscience , ed.  J. P. Kamerling ,  Elsevier ,  2007 , vol.  1 ,  pp. 815\u2013884"},{"key":"D4OB00312H\/cit34\/1","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1002\/ejoc.201900605","author":"Dehoux-Baudoin","year":"2019","journal-title":"Eur. J. Org. Chem."},{"key":"D4OB00312H\/cit35\/1","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.bmcl.2014.12.071","volume":"25","author":"Decroocq","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4OB00312H\/cit36\/1","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1073\/pnas.90.19.9031","volume":"90","author":"Harel","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"D4OB00312H\/cit37\/1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejmech.2016.07.021","volume":"123","author":"Olsen","year":"2016","journal-title":"Eur. J. Med. Chem."},{"key":"D4OB00312H\/cit38\/1","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1039\/D0OB02588G","volume":"19","author":"Oliveira de Santana","year":"2021","journal-title":"Org. Biomol. Chem."},{"key":"D4OB00312H\/cit39\/1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1080\/14756366.2022.2150762","volume":"38","author":"Vaaland","year":"2023","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D4OB00312H\/cit40\/1","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1080\/14756366.2022.2117912","volume":"37","author":"Evangelista","year":"2022","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D4OB00312H\/cit41\/1","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1080\/14756366.2020.1847101","volume":"36","author":"Ahuja-Casar\u00edn","year":"2021","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"D4OB00312H\/cit42\/1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0969-2126(99)80040-9","volume":"7","author":"Kryger","year":"1999","journal-title":"Structure"},{"key":"D4OB00312H\/cit43\/1","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1002\/1521-3773(20010917)40:18<3447::AID-ANIE3447>3.0.CO;2-8","volume":"40","author":"Jensen","year":"2001","journal-title":"Angew. Chem., Int. Ed."},{"key":"D4OB00312H\/cit44\/1","doi-asserted-by":"crossref","first-page":"14140","DOI":"10.1002\/slct.201903607","volume":"4","author":"Hasan","year":"2019","journal-title":"ChemistrySelect"},{"key":"D4OB00312H\/cit45\/1","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.biochi.2010.02.033","volume":"92","author":"Kancheva","year":"2010","journal-title":"Biochimie"},{"key":"D4OB00312H\/cit46\/1","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.2174\/092986711803414395","volume":"18","author":"Kostova","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"D4OB00312H\/cit47\/1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3390\/biology11020212","volume":"11","author":"Pritam","year":"2022","journal-title":"Biology"},{"key":"D4OB00312H\/cit48\/1","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.3390\/antiox11061128","volume":"11","author":"Luo","year":"2022","journal-title":"Antioxidants"},{"key":"D4OB00312H\/cit49\/1","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0968-0896(00)00291-1","volume":"9","author":"Jakobsen","year":"2001","journal-title":"Bioorg. Med. Chem."},{"key":"D4OB00312H\/cit50\/1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tet.2006.10.075","volume":"63","author":"Kosiova","year":"2007","journal-title":"Tetrahedron"},{"key":"D4OB00312H\/cit51\/1","doi-asserted-by":"crossref","first-page":"758","DOI":"10.3390\/molecules21060758","volume":"21","author":"Tian","year":"2016","journal-title":"Molecules"},{"key":"D4OB00312H\/cit52\/1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"D4OB00312H\/cit53\/1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0009-2797(99)00014-9","volume":"119\u2013120","author":"Saxena","year":"1999","journal-title":"Chem.-Biol. Interact."},{"key":"D4OB00312H\/cit54\/1","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1046\/j.1432-1033.2003.03837.x","volume":"270","author":"Saxena","year":"2003","journal-title":"Eur. J. Biochem."},{"key":"D4OB00312H\/cit55\/1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ejmech.2017.03.062","volume":"132","author":"Li","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"D4OB00312H\/cit56\/1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/bj1370143","volume":"137","author":"Cornish-Bowden","year":"1974","journal-title":"Biochem. J."},{"key":"D4OB00312H\/cit57\/1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/105172399242573","volume":"9","author":"Moorad","year":"1999","journal-title":"Toxicol. Methods"},{"key":"D4OB00312H\/cit58\/1","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1046\/j.1471-4159.1997.68020750.x","volume":"68","author":"Nardi","year":"1997","journal-title":"J. Neurochem."},{"key":"D4OB00312H\/cit59\/1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1021\/acschemneuro.5b00329","volume":"7","author":"Huang","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"D4OB00312H\/cit60\/1","doi-asserted-by":"crossref","first-page":"8511","DOI":"10.3390\/molecules27238511","volume":"27","author":"Skrzypek","year":"2022","journal-title":"Molecules"},{"key":"D4OB00312H\/cit61\/1","doi-asserted-by":"crossref","first-page":"115390","DOI":"10.1016\/j.ejmech.2023.115390","volume":"255","author":"Padilla-P\u00e9rez","year":"2023","journal-title":"Eur. J. Med. Chem."}],"container-title":["Organic &amp; Biomolecular Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/OB\/D4OB00312H","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T10:12:48Z","timestamp":1714558368000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D4OB00312H"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":62,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2024,5,1]]}},"URL":"https:\/\/doi.org\/10.1039\/d4ob00312h","relation":{},"ISSN":["1477-0520","1477-0539"],"issn-type":[{"value":"1477-0520","type":"print"},{"value":"1477-0539","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}