{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:16:42Z","timestamp":1773947802914,"version":"3.50.1"},"reference-count":38,"publisher":"Royal Society of Chemistry (RSC)","issue":"9","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100010434","name":"'la Caixa' Foundation","doi-asserted-by":"publisher","award":["HR21-848"],"award-info":[{"award-number":["HR21-848"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["CIRCNA\/BRB\/0281\/2019"],"award-info":[{"award-number":["CIRCNA\/BRB\/0281\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SRFH\/BD\/147354\/2019"],"award-info":[{"award-number":["SRFH\/BD\/147354\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["10.54499\/UIDP\/50006\/2020"],"award-info":[{"award-number":["10.54499\/UIDP\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["10.54499\/UIDB\/50006\/2020"],"award-info":[{"award-number":["10.54499\/UIDB\/50006\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["10.54499\/LA\/P\/0008\/2020"],"award-info":[{"award-number":["10.54499\/LA\/P\/0008\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["rsc.org"],"crossmark-restriction":true},"short-container-title":["RSC Adv."],"abstract":"<jats:p>Greener, simpler and higher yield methods are greatly desirable for the production of acridines, given their relevance in the therapeutic field. Herein, we report an improved multi-step synthesis of antiplasmodial acridines.<\/jats:p>","DOI":"10.1039\/d4ra00091a","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T09:27:16Z","timestamp":1708334836000},"page":"6253-6261","update-policy":"https:\/\/doi.org\/10.1039\/rsc_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Improved synthesis of antiplasmodial 4-aminoacridines and 4,9-diaminoacridines"],"prefix":"10.1039","volume":"14","author":[{"given":"M\u00e9lanie","family":"Fonte","sequence":"first","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade do Porto, Portugal"}]},{"given":"C\u00e1tia","family":"Teixeira","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade do Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-4724","authenticated-orcid":false,"given":"Paula","family":"Gomes","sequence":"additional","affiliation":[{"name":"LAQV-REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias, Universidade do Porto, Portugal"}]}],"member":"292","published-online":{"date-parts":[[2024]]},"reference":[{"key":"D4RA00091A\/cit1\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/9780470186596.ch2","volume-title":"Chemistry of Heterocyclic Compounds","author":"Raulins","year":"1973","unstructured":"N. R.Raulins ,  Acridines , in  Chemistry of Heterocyclic Compounds , ed.  R. M. Acheson ,  John Wiley & Sons, Inc. , 2nd edn,  1973 , ch. 1,  pp. 9\u2013108"},{"key":"D4RA00091A\/cit2\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9780470186596","volume-title":"Chemistry of Heterocyclic Compounds","author":"Acheson","year":"1973","unstructured":"R. M.Acheson ,  Nomenclature and Numbering System , in  Chemistry of Heterocyclic Compounds , ed.  R. M. Acheson ,  John Wiley & Sons, Inc. , 2nd edn,  1973 , vol. 9,  pp. 1\u20138"},{"key":"D4RA00091A\/cit3\/1","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1039\/C8MD00384J","volume":"9","author":"Prasher","year":"2018","journal-title":"MedChemComm"},{"key":"D4RA00091A\/cit4\/1","doi-asserted-by":"crossref","first-page":"15776","DOI":"10.1039\/C7RA01026E","volume":"7","author":"Gensicka-Kowalewska","year":"2017","journal-title":"RSC Adv."},{"key":"D4RA00091A\/cit5\/1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/B978-0-08-102083-8.00003-0","volume-title":"Key Heterocycle Cores for Designing Multitargeting Molecules","author":"Kumar","year":"2018","unstructured":"R.Kumar ,  S.Sharma  and  D.Prasad ,  Acridones: A Relatively Lesser Explored Heterocycle for Multifactorial Diseases , in  Key Heterocycle Cores for Designing Multitargeting Molecules , ed.  O. Silakari ,  Elsevier , 1st edn,  2018 , ch. 3,  pp. 53\u2013132"},{"key":"D4RA00091A\/cit6\/1","first-page":"3","volume":"69","author":"Kumar","year":"2012","journal-title":"Acta Pol. Pharm."},{"key":"D4RA00091A\/cit7\/1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jlac.18842240102","volume":"224","author":"Bernthsen","year":"1884","journal-title":"Justus Liebigs Ann. Chem."},{"key":"D4RA00091A\/cit8\/1","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-3-319-63953-6_3","volume-title":"Biomedical Applications of Acridines: Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases","volume":"72","author":"Je\u017eek","year":"2017","unstructured":"J.Je\u017eek ,  J.Hlav\u00e1\u010dek  and  J.\u0160ebest\u00edk ,  Syntheses , in  Biomedical Applications of Acridines: Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases , ed.  J. Je\u017eek ,  J. Hlav\u00e1\u010dek  and  J. \u0160ebest\u00edk ,  Springer International Publishing ,  Cham ,  2017 ,  vol. 72 ,  pp. 9\u201345"},{"key":"D4RA00091A\/cit9\/1","first-page":"287","volume-title":"Advances in Heterocyclic Chemistry","volume":"115","author":"Schmidt","year":"2015","unstructured":"A.Schmidt  and  M.Liu ,  Recent Advances in the Chemistry of Acridines , in  Advances in Heterocyclic Chemistry , ed.  E. F. V. Scriven  and  C. A. Ramsden ,  Academic Press ,  2015 , ch. 4,  vol. 115 ,  pp. 287\u2013353"},{"key":"D4RA00091A\/cit10\/1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1055\/s-2003-44379","author":"Chiron","year":"2004","journal-title":"Synthesis"},{"key":"D4RA00091A\/cit11\/1","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.1002\/ejoc.201101017","author":"Zawada","year":"2011","journal-title":"Eur. J. Org Chem."},{"key":"D4RA00091A\/cit12\/1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jat.4072","volume":"41","author":"Kozurkova","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"D4RA00091A\/cit13\/1","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3390\/molecules26030600","volume":"26","author":"Fonte","year":"2021","journal-title":"Molecules"},{"key":"D4RA00091A\/cit14\/1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/cmdc.201300459","volume":"9","author":"Gomes","year":"2014","journal-title":"ChemMedChem"},{"key":"D4RA00091A\/cit15\/1","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/j.tetlet.2019.03.052","volume":"60","author":"Fonte","year":"2019","journal-title":"Tetrahedron Lett."},{"key":"D4RA00091A\/cit16\/1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/cmdc.202000740","volume":"16","author":"Fonte","year":"2021","journal-title":"ChemMedChem"},{"key":"D4RA00091A\/cit17\/1","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.bmcl.2012.12.032","volume":"23","author":"P\u00e9rez","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"D4RA00091A\/cit18\/1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bmc.2005.08.017","volume":"14","author":"Anderson","year":"2006","journal-title":"Bioorg. Med. Chem."},{"key":"D4RA00091A\/cit19\/1","doi-asserted-by":"crossref","first-page":"e202202351","DOI":"10.1002\/slct.202202351","volume":"7","author":"Young Kim","year":"2022","journal-title":"ChemistrySelect"},{"key":"D4RA00091A\/cit20\/1","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1016\/j.tet.2014.03.045","volume":"70","author":"Jeon","year":"2014","journal-title":"Tetrahedron"},{"key":"D4RA00091A\/cit21\/1","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1016\/j.tetlet.2004.06.034","volume":"45","author":"Boechat","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"D4RA00091A\/cit22\/1","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1021\/acs.joc.7b02993","volume":"83","author":"Prasanth","year":"2018","journal-title":"J. Org. Chem."},{"key":"D4RA00091A\/cit23\/1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/BF02711452","volume":"118","author":"Saeed","year":"2006","journal-title":"J. Chem. Sci."},{"key":"D4RA00091A\/cit24\/1","first-page":"1","volume-title":"Alternative Energy Sources for Green Chemistry","author":"de la Hoz","year":"2016","unstructured":"A.de la Hoz ,  A.D\u00edaz-Ortiz  and  P.Prieto ,  Microwave-Assisted Green Organic Synthesis , in  Alternative Energy Sources for Green Chemistry , ed.  G. Stefanidis  and  A. Stankiewicz ,  The Royal Society of Chemistry , 23rd edn,  2016 , ch. 1,  pp. 1\u201333"},{"key":"D4RA00091A\/cit25\/1","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.tet.2012.11.083","volume":"69","author":"Staderini","year":"2013","journal-title":"Tetrahedron"},{"key":"D4RA00091A\/cit26\/1","doi-asserted-by":"crossref","first-page":"7549","DOI":"10.1021\/jo00103a067","volume":"59","author":"Meyer","year":"1994","journal-title":"J. Org. Chem."},{"key":"D4RA00091A\/cit27\/1","first-page":"5575","volume":"22","author":"Setamdideh","year":"2010","journal-title":"Asian J. Chem."},{"key":"D4RA00091A\/cit28\/1","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1039\/c2ra20371e","volume":"2","author":"Kadam","year":"2012","journal-title":"RSC Adv."},{"key":"D4RA00091A\/cit29\/1","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1039\/C4OB00945B","volume":"12","author":"MacNair","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"D4RA00091A\/cit30\/1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1080\/00304948.2014.884374","volume":"46","author":"Ficker","year":"2014","journal-title":"Org. Prep. Proced. Int."},{"key":"D4RA00091A\/cit31\/1","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1039\/P19790002409","author":"Hanaya","year":"1979","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"D4RA00091A\/cit32\/1","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1055\/s-2006-949639","volume":"2006","author":"Bailey","year":"2006","journal-title":"Synlett"},{"key":"D4RA00091A\/cit33\/1","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/cmdc.201200257","volume":"7","author":"P\u00e9rez","year":"2012","journal-title":"ChemMedChem"},{"key":"D4RA00091A\/cit34\/1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1021\/jm301654b","volume":"56","author":"P\u00e9rez","year":"2013","journal-title":"J. Med. Chem."},{"key":"D4RA00091A\/cit35\/1","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.ejmech.2012.05.022","volume":"54","author":"P\u00e9rez","year":"2012","journal-title":"Eur. J. Med. Chem."},{"key":"D4RA00091A\/cit36\/1","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1039\/c2md20113e","volume":"3","author":"P\u00e9rez","year":"2012","journal-title":"MedChemComm"},{"key":"D4RA00091A\/cit37\/1","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1002\/cmdc.201600477","volume":"11","author":"Gomes","year":"2016","journal-title":"ChemMedChem"},{"key":"D4RA00091A\/cit38\/1","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/cmdc.201500164","volume":"10","author":"Gomes","year":"2015","journal-title":"ChemMedChem"}],"container-title":["RSC Advances"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.rsc.org\/en\/content\/articlepdf\/2024\/RA\/D4RA00091A","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T17:01:29Z","timestamp":1738602089000},"score":1,"resource":{"primary":{"URL":"https:\/\/xlink.rsc.org\/?DOI=D4RA00091A"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,2,14]]}},"URL":"https:\/\/doi.org\/10.1039\/d4ra00091a","relation":{},"ISSN":["2046-2069"],"issn-type":[{"value":"2046-2069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}