{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:34:17Z","timestamp":1770824057540,"version":"3.50.1"},"reference-count":237,"publisher":"Portland Press Ltd.","issue":"3","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":3711,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/2.5\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,6,15]]},"abstract":"<jats:p>RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are constitutively enhanced by point mutation, amplification or rearrangement of the corresponding genes. The ALK (anaplastic lymphoma kinase) RTK was originally identified as a member of the insulin receptor subfamily of RTKs that acquires transforming capability when truncated and fused to NPM (nucleophosmin) in the t(2;5) chromosomal rearrangement associated with ALCL (anaplastic large cell lymphoma). To date, many chromosomal rearrangements leading to enhanced ALK activity have been described and are implicated in a number of cancer types. Recent reports of the EML4 (echinoderm microtubule-associated protein like 4)\u2013ALK oncoprotein in NSCLC (non-small cell lung cancer), together with the identification of activating point mutations in neuroblastoma, have highlighted ALK as a significant player and target for drug development in cancer. In the present review we address the role of ALK in development and disease and discuss implications for the future.<\/jats:p>","DOI":"10.1042\/bj20090387","type":"journal-article","created":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T16:00:11Z","timestamp":1243440011000},"page":"345-361","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":353,"title":["Anaplastic lymphoma kinase: signalling in development and disease"],"prefix":"10.1042","volume":"420","author":[{"given":"Ruth\u00a0H.","family":"Palmer","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Building 6L, Ume\u00e5 University, Ume\u00e5 901 87, Sweden"}]},{"given":"Emma","family":"Vernersson","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Building 6L, Ume\u00e5 University, Ume\u00e5 901 87, Sweden"}]},{"given":"Caroline","family":"Grabbe","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Building 6L, Ume\u00e5 University, Ume\u00e5 901 87, Sweden"}]},{"given":"Bengt","family":"Hallberg","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Building 6L, Ume\u00e5 University, Ume\u00e5 901 87, Sweden"}]}],"member":"288","published-online":{"date-parts":[[2009,5,27]]},"reference":[{"key":"2021112215083418800_B1","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.8122112","article-title":"Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma","volume":"263","author":"Morris","year":"1994","journal-title":"Science"},{"key":"2021112215083418800_B2","first-page":"1567","article-title":"Hyperphosphorylation of a novel 80\u00a0kDa protein-tyrosine kinase similar to Ltk in a human Ki-1 lymphoma cell line, AMS3","volume":"9","author":"Shiota","year":"1994","journal-title":"Oncogene"},{"key":"2021112215083418800_B3","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/sj.onc.1200849","article-title":"Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system","volume":"14","author":"Iwahara","year":"1997","journal-title":"Oncogene"},{"key":"2021112215083418800_B4","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1038\/sj.onc.1201062","article-title":"ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)","volume":"14","author":"Morris","year":"1997","journal-title":"Oncogene"},{"key":"2021112215083418800_B5","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.1365-2443.2001.00440.x","article-title":"Identification and characterization of DAlk: a novel Drosophila melanogaster RTK which drives ERK activation In vivo","volume":"6","author":"Loren","year":"2001","journal-title":"Genes Cells"},{"key":"2021112215083418800_B6","doi-asserted-by":"crossref","first-page":"16772","DOI":"10.1074\/jbc.M010660200","article-title":"Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin","volume":"276","author":"Stoica","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B7","doi-asserted-by":"crossref","first-page":"6334","DOI":"10.1073\/pnas.92.14.6334","article-title":"Three-dimensional structure of a cysteine-rich repeat from the low-density lipoprotein receptor","volume":"92","author":"Daly","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112215083418800_B8","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/41798","article-title":"Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module","volume":"388","author":"Fass","year":"1997","journal-title":"Nature"},{"key":"2021112215083418800_B9","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0968-0004(93)90049-S","article-title":"An adhesive domain detected in functionally diverse receptors","volume":"18","author":"Beckmann","year":"1993","journal-title":"Trends Biochem. Sci."},{"key":"2021112215083418800_B10","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/sj.embor.embor897","article-title":"A crucial role for the Anaplastic lymphoma kinase receptor tyrosine kinase in gut development in Drosophila melanogaster","volume":"4","author":"Loren","year":"2003","journal-title":"EMBO Rep."},{"key":"2021112215083418800_B11","doi-asserted-by":"crossref","first-page":"6951","DOI":"10.1128\/MCB.18.12.6951","article-title":"Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-\u03b3 to mediate its mitogenicity","volume":"18","author":"Bai","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"2021112215083418800_B12","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.1021\/bi0472954","article-title":"Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity","volume":"44","author":"Donella-Deana","year":"2005","journal-title":"Biochemistry"},{"key":"2021112215083418800_B13","doi-asserted-by":"crossref","first-page":"3743","DOI":"10.1074\/jbc.M706067200","article-title":"Characterization of some molecular mechanisms governing autoactivation of the catalytic domain of the anaplastic lymphoma kinase","volume":"283","author":"Tartari","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B14","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/nature01950","article-title":"Jeb signals through the Alk receptor tyrosine kinase to drive visceral muscle fusion","volume":"425","author":"Englund","year":"2003","journal-title":"Nature"},{"key":"2021112215083418800_B15","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature01916","article-title":"Jelly belly protein activates the receptor tyrosine kinase Alk to specify visceral muscle pioneers","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"2021112215083418800_B16","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1242\/dev.00972","article-title":"Myoblast determination in the somatic and visceral mesoderm depends on Notch signalling as well as on milliways [mili(Alk)] as receptor for Jeb signalling","volume":"131","author":"Stute","year":"2004","journal-title":"Development"},{"key":"2021112215083418800_B17","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0925-4773(01)00567-6","article-title":"The formation of syncytia within the visceral musculature of the Drosophila midgut is dependent on duf, sns and mbc","volume":"110","author":"Klapper","year":"2002","journal-title":"Mech. Dev."},{"key":"2021112215083418800_B18","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1242\/dev.128.17.3331","article-title":"A distinct set of founders and fusion-competent myoblasts make visceral muscles in the Drosophila embryo","volume":"128","author":"Martin","year":"2001","journal-title":"Development"},{"key":"2021112215083418800_B19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0092-8674(01)00540-2","article-title":"Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation","volume":"107","author":"Weiss","year":"2001","journal-title":"Cell"},{"key":"2021112215083418800_B20","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.bbrc.2006.10.117","article-title":"The bHLH transcription factor Hand is regulated by Alk in the Drosophila embryonic gut","volume":"351","author":"Varshney","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021112215083418800_B21","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1432-0436.2006.00148.x","article-title":"Drosophila anaplastic lymphoma kinase regulates Dpp signalling in the developing embryonic gut","volume":"75","author":"Shirinian","year":"2007","journal-title":"Differentiation"},{"key":"2021112215083418800_B22","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.cell.2007.02.024","article-title":"Anterograde Jelly belly and Alk receptor tyrosine kinase signaling mediates retinal axon targeting in Drosophila","volume":"128","author":"Bazigou","year":"2007","journal-title":"Cell"},{"key":"2021112215083418800_B23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature02647","article-title":"An SCF-like ubiquitin ligase complex that controls presynaptic differentiation","volume":"430","author":"Liao","year":"2004","journal-title":"Nature"},{"key":"2021112215083418800_B24","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.cub.2008.06.060","article-title":"C elegans anaplastic lymphoma kinase ortholog SCD-2 controls dauer formation by modulating TGF-\u03b2 signaling","volume":"18","author":"Reiner","year":"2008","journal-title":"Curr. Biol."},{"key":"2021112215083418800_B25","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0092-8674(02)00748-1","article-title":"HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans","volume":"109","author":"Ishihara","year":"2002","journal-title":"Cell"},{"key":"2021112215083418800_B26","doi-asserted-by":"crossref","first-page":"e1000026","DOI":"10.1371\/journal.pgen.1000026","article-title":"Leukocyte tyrosine kinase functions in pigment cell development","volume":"4","author":"Lopes","year":"2008","journal-title":"PLoS Genet."},{"key":"2021112215083418800_B27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.modgep.2005.11.006","article-title":"Characterization of the expression of the ALK receptor tyrosine kinase in mice","volume":"6","author":"Vernersson","year":"2006","journal-title":"Gene Expr. Patterns"},{"key":"2021112215083418800_B28","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/cne.20887","article-title":"Anaplastic lymphoma kinase is dynamically expressed on subsets of motor neurons and in the peripheral nervous system","volume":"495","author":"Hurley","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"2021112215083418800_B29","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1460-9568.2008.06593.x","article-title":"ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction","volume":"29","author":"Degoutin","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"2021112215083418800_B30","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1182\/blood.V89.4.1394","article-title":"Detection of anaplastic lymphoma kinase (ALK) and nucleolar protein nucleophosmin (NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1","volume":"89","author":"Pulford","year":"1997","journal-title":"Blood"},{"key":"2021112215083418800_B31","doi-asserted-by":"crossref","first-page":"9526","DOI":"10.1074\/jbc.M007333200","article-title":"Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway","volume":"276","author":"Souttou","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B32","doi-asserted-by":"crossref","first-page":"26039","DOI":"10.1074\/jbc.M501972200","article-title":"Activation and inhibition of anaplastic lymphoma kinase receptor tyrosine kinase by monoclonal antibodies and absence of agonist activity of pleiotrophin","volume":"280","author":"Moog-Lutz","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B33","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1242\/jcs.01183","article-title":"ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth","volume":"117","author":"Motegi","year":"2004","journal-title":"J. Cell Sci."},{"key":"2021112215083418800_B34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jez.b.21146","article-title":"The ligand Jelly Belly (Jeb) activates the Drosophila Alk RTK to drive PC12 cell differentiation, but is unable to activate the Mouse ALK RTK","volume":"308","author":"Yang","year":"2007","journal-title":"J. Exp. Zool. B Mol. Dev. Evol."},{"key":"2021112215083418800_B35","doi-asserted-by":"crossref","first-page":"5811","DOI":"10.1242\/jcs.02695","article-title":"Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells","volume":"118","author":"Gouzi","year":"2005","journal-title":"J. Cell Sci."},{"key":"2021112215083418800_B36","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.febslet.2007.01.039","article-title":"ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation","volume":"581","author":"Degoutin","year":"2007","journal-title":"FEBS Lett."},{"key":"2021112215083418800_B37","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1038\/sj.onc.1210095","article-title":"Identification of multiple SNT-binding sites on NPM-ALK oncoprotein and their involvement in cell transformation","volume":"26","author":"Chikamori","year":"2007","journal-title":"Oncogene"},{"key":"2021112215083418800_B38","doi-asserted-by":"crossref","first-page":"22231","DOI":"10.1074\/jbc.M111145200","article-title":"A ligand-inducible epidermal growth factor receptor\/anaplastic lymphoma kinase chimera promotes mitogenesis and transforming properties in 3T3 cells","volume":"277","author":"Piccinini","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B39","doi-asserted-by":"crossref","first-page":"16721","DOI":"10.1016\/S0021-9258(17)44817-4","article-title":"Molecular cloning of the 18-kDa growth-associated protein of developing brain","volume":"265","author":"Merenmies","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B40","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0006-291X(05)81048-4","article-title":"Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues","volume":"173","author":"Tezuka","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021112215083418800_B41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0006-291X(05)81267-7","article-title":"Mitogenic properties of a new endothelial cell growth factor related to pleiotrophin","volume":"180","author":"Courty","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021112215083418800_B42","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/0006-291X(90)90753-A","article-title":"Heparin-binding neurotrophic factor (HBNF) and MK, members of a new family of homologous, developmentally regulated proteins","volume":"172","author":"Kovesdi","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021112215083418800_B43","doi-asserted-by":"crossref","first-page":"10765","DOI":"10.1016\/S0021-9258(18)87013-2","article-title":"A retinoic acid-responsive gene, MK, found in the teratocarcinoma system. Heterogeneity of the transcript and the nature of the translation product","volume":"265","author":"Tomomura","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B44","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/j.1432-1033.1989.tb15267.x","article-title":"Identification of a new heparin-binding protein localized within chick basement membranes","volume":"186","author":"Vigny","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"2021112215083418800_B45","doi-asserted-by":"crossref","first-page":"35990","DOI":"10.1074\/jbc.M205749200","article-title":"Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types","volume":"277","author":"Stoica","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B46","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0304-3835(03)00450-6","article-title":"Midkine and pleiotrophin in neural development and cancer","volume":"204","author":"Kadomatsu","year":"2004","journal-title":"Cancer Lett."},{"key":"2021112215083418800_B47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/oxfordjournals.jbchem.a003231","article-title":"Midkine and pleiotrophin: two related proteins involved in development, survival, inflammation and tumorigenesis","volume":"132","author":"Muramatsu","year":"2002","journal-title":"J. Biochem. (Tokyo)"},{"key":"2021112215083418800_B48","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1073\/pnas.020487997","article-title":"Pleiotrophin signals increased tyrosine phosphorylation of \u03b2-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase \u03b2\/\u03b6","volume":"97","author":"Meng","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112215083418800_B49","doi-asserted-by":"crossref","first-page":"21446","DOI":"10.1074\/jbc.271.35.21446","article-title":"6B4 proteoglycan\/phosphacan, an extracellular variant of receptor-like protein-tyrosine phosphatase \u03b6\/RPTP\u03b2, binds pleiotrophin\/heparin-binding growth-associated molecule (HB-GAM)","volume":"271","author":"Maeda","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B50","first-page":"197","article-title":"Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine","volume":"121","author":"Nakanishi","year":"1997","journal-title":"J. Biochem."},{"key":"2021112215083418800_B51","doi-asserted-by":"crossref","first-page":"12999","DOI":"10.1016\/S0021-9258(18)99975-8","article-title":"Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3)","volume":"269","author":"Raulo","year":"1994","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B52","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1006\/bbrc.2000.2549","article-title":"LDL receptor-related protein as a component of the midkine receptor","volume":"270","author":"Muramatsu","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021112215083418800_B53","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.1242\/jcs.01423","article-title":"\u03b14\u03b21- and \u03b16\u03b21-integrins are functional receptors for midkine, a heparin-binding growth factor","volume":"117","author":"Muramatsu","year":"2004","journal-title":"J. Cell Sci."},{"key":"2021112215083418800_B54","doi-asserted-by":"crossref","first-page":"35862","DOI":"10.1074\/jbc.M203963200","article-title":"Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase","volume":"277","author":"Bowden","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B55","doi-asserted-by":"crossref","first-page":"14153","DOI":"10.1074\/jbc.M112354200","article-title":"Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth","volume":"277","author":"Powers","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B56","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1038\/sj.onc.1209840","article-title":"Recruitment of insulin receptor substrate-1 and activation of NF-\u03baB essential for midkine growth signaling through anaplastic lymphoma kinase","volume":"26","author":"Kuo","year":"2007","journal-title":"Oncogene"},{"key":"2021112215083418800_B57","doi-asserted-by":"crossref","first-page":"26953","DOI":"10.1074\/jbc.M502614200","article-title":"Differential induction of glioblastoma migration and growth by two forms of pleiotrophin","volume":"280","author":"Lu","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B58","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/ijc.10435","article-title":"Expression and functional analysis of the anaplastic lymphoma kinase (ALK) gene in tumor cell lines","volume":"100","author":"Dirks","year":"2002","journal-title":"Int. J. Cancer"},{"key":"2021112215083418800_B59","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.cellsig.2007.07.011","article-title":"In contrast to agonist monoclonal antibodies, both C-terminal truncated form and full length form of Pleiotrophin failed to activate vertebrate ALK (anaplastic lymphoma kinase)?","volume":"19","author":"Mathivet","year":"2007","journal-title":"Cell. Signalling"},{"key":"2021112215083418800_B60","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1128\/MCB.01515-05","article-title":"Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage","volume":"26","author":"Mourali","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"2021112215083418800_B61","doi-asserted-by":"crossref","first-page":"28683","DOI":"10.1074\/jbc.M704505200","article-title":"Anaplastic lymphoma kinase is activated through the pleiotrophin\/receptor protein-tyrosine phosphatase \u03b2\/\u03b6 signaling pathway: an alternative mechanism of receptor tyrosine kinase activation","volume":"282","author":"Perez-Pinera","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B62","first-page":"1","article-title":"Characterization of bovine heparin-binding neurotrophic factor (HBNF): assignment of disulfide bonds","volume":"28","author":"Fabri","year":"1992","journal-title":"Biochem. Int."},{"key":"2021112215083418800_B63","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1006\/bbrc.1994.2300","article-title":"Localization of heparin-binding, neurite outgrowth and antigenic regions in midkine molecule","volume":"203","author":"Muramatsu","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021112215083418800_B64","doi-asserted-by":"crossref","first-page":"13564","DOI":"10.1074\/jbc.275.18.13564","article-title":"Heparin-binding growth-associated molecule contains two heparin-binding \u03b2-sheet domains that are homologous to the thrombospondin type\u00a0I repeat","volume":"275","author":"Kilpelainen","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s00427-005-0025-8","article-title":"Miple1 and miple2 encode a family of MK\/PTN homologues in Drosophila melanogaster","volume":"216","author":"Englund","year":"2006","journal-title":"Dev. Genes Evol."},{"key":"2021112215083418800_B66","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jcp.10472","article-title":"Anaplastic lymphoma kinase proteins in growth control and cancer","volume":"199","author":"Pulford","year":"2004","journal-title":"J. Cell Physiol."},{"key":"2021112215083418800_B67","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/sj.npp.1301446","article-title":"Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications","volume":"33","author":"Bilsland","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"2021112215083418800_B68","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1046\/j.1365-2443.1998.00231.x","article-title":"Disruption of the midkine gene (Mdk) resulted in altered expression of a calcium binding protein in the hippocampus of infant mice and their abnormal behaviour","volume":"3","author":"Nakamura","year":"1998","journal-title":"Genes Cells"},{"key":"2021112215083418800_B69","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1440-169x.2000.00497.x","article-title":"Distinct expression of midkine and pleiotrophin in the spinal cord and placental tissues during early mouse development","volume":"42","author":"Fan","year":"2000","journal-title":"Dev. Growth Differ."},{"key":"2021112215083418800_B70","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0304-3940(94)90762-5","article-title":"Localization of pleiotrophin and midkine in the postnatal developing cerebellum","volume":"178","author":"Matsumoto","year":"1994","journal-title":"Neurosci. Lett."},{"key":"2021112215083418800_B71","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1242\/dev.121.1.37","article-title":"Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis","volume":"121","author":"Mitsiadis","year":"1995","journal-title":"Development"},{"key":"2021112215083418800_B72","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/BF00185989","article-title":"Cellular distribution of the new growth factor pleiotrophin (HB-GAM) mRNA in developing and adult rat tissues","volume":"186","author":"Vanderwinden","year":"1992","journal-title":"Anat. Embryol."},{"key":"2021112215083418800_B73","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.bbrc.2005.05.160","article-title":"Midkine regulates pleiotrophin organ-specific gene expression: evidence for transcriptional regulation and functional redundancy within the pleiotrophin\/midkine developmental gene family","volume":"333","author":"Herradon","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021112215083418800_B74","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/j.1365-2443.2006.01028.x","article-title":"Female infertility in mice deficient in midkine and pleiotrophin, which form a distinct family of growth factors","volume":"11","author":"Muramatsu","year":"2006","journal-title":"Genes Cells"},{"key":"2021112215083418800_B75","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/labinvest.3700428","article-title":"Mice doubly deficient in the midkine and pleiotrophin genes exhibit deficits in the expression of \u03b2-tectorin gene and in auditory response","volume":"86","author":"Zou","year":"2006","journal-title":"Lab. Invest."},{"key":"2021112215083418800_B76","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1002\/j.1460-2075.1990.tb07399.x","article-title":"The ltk receptor tyrosine kinase is expressed in pre-B lymphocytes and cerebral neurons and uses a non-AUG translational initiator","volume":"9","author":"Bernards","year":"1990","journal-title":"EMBO J."},{"key":"2021112215083418800_B77","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1097\/WNR.0b013e3283186bf8","article-title":"Expression of a chimeric CSF1R-LTK mediates ligand-dependent neurite outgrowth","volume":"19","author":"Yamada","year":"2008","journal-title":"NeuroRep."},{"key":"2021112215083418800_B78","first-page":"2776","article-title":"Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors","volume":"59","author":"Griffin","year":"1999","journal-title":"Cancer Res."},{"key":"2021112215083418800_B79","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature05945","article-title":"Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer","volume":"448","author":"Soda","year":"2007","journal-title":"Nature"},{"key":"2021112215083418800_B80","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.cell.2007.11.025","article-title":"Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer","volume":"131","author":"Rikova","year":"2007","journal-title":"Cell"},{"key":"2021112215083418800_B81","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/S0046-8177(96)90167-7","article-title":"Detection of the t(2;5)(p23;q35) chromosomal translocation in large B-cell lymphomas other than anaplastic large cell lymphoma","volume":"27","author":"Arber","year":"1996","journal-title":"Hum. Pathol."},{"key":"2021112215083418800_B82","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00109-007-0159-4","article-title":"Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma","volume":"85","author":"Du","year":"2007","journal-title":"J. Mol. Med."},{"key":"2021112215083418800_B83","doi-asserted-by":"crossref","first-page":"7104","DOI":"10.3748\/wjg.v12.i44.7104","article-title":"Identification of squamous cell carcinoma associated proteins by proteomics and loss of \u03b2 tropomyosin expression in esophageal cancer","volume":"12","author":"Jazii","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"2021112215083418800_B84","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bbrc.2007.04.137","article-title":"Anaplastic lymphoma kinase is expressed in different subtypes of human breast cancer","volume":"358","author":"Perez-Pinera","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021112215083418800_B85","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1182\/blood.V89.5.1483","article-title":"A new subtype of large B-cell lymphoma expressing the ALK kinase and lacking the 2; 5 translocation","volume":"89","author":"Delsol","year":"1997","journal-title":"Blood"},{"key":"2021112215083418800_B86","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/01.MP.0000026615.04130.1F","article-title":"Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases","volume":"15","author":"Cessna","year":"2002","journal-title":"Mod. Pathol."},{"key":"2021112215083418800_B87","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1046\/j.1365-2559.2002.01534.x","article-title":"ALK protein expression in rhabdomyosarcomas","volume":"41","author":"Pillay","year":"2002","journal-title":"Histopathology"},{"key":"2021112215083418800_B88","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0002-9440(10)65042-0","article-title":"Expression of the ALK tyrosine kinase gene in neuroblastoma","volume":"156","author":"Lamant","year":"2000","journal-title":"Am. J. Pathol."},{"key":"2021112215083418800_B89","doi-asserted-by":"crossref","first-page":"5823","DOI":"10.1038\/sj.onc.1205735","article-title":"Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines","volume":"21","author":"Miyake","year":"2002","journal-title":"Oncogene"},{"key":"2021112215083418800_B90","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0002-9440(10)62966-5","article-title":"Biological role of anaplastic lymphoma kinase in neuroblastoma","volume":"167","author":"Osajima-Hakomori","year":"2005","journal-title":"Am. J. Pathol."},{"key":"2021112215083418800_B91","article-title":"ALK expression in rhabdomyosarcomas: correlation with histologic subtype and fusion status","author":"Corao","year":"2008","journal-title":"Pediatr. Dev. Pathol."},{"key":"2021112215083418800_B92","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.humpath.2003.12.004","article-title":"Expression of anaplastic lymphoma kinase in soft tissue tumors: an immunohistochemical and molecular study of 249 cases","volume":"35","author":"Li","year":"2004","journal-title":"Hum. Pathol."},{"key":"2021112215083418800_B93","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/BJ20081834","article-title":"High incidence of DNA mutations and gene amplifications of the ALK gene in advanced sporadic neuroblastoma tumours","volume":"416","author":"Caren","year":"2008","journal-title":"Biochem. J."},{"key":"2021112215083418800_B94","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nature07399","article-title":"Oncogenic mutations of ALK kinase in neuroblastoma","volume":"455","author":"Chen","year":"2008","journal-title":"Nature"},{"key":"2021112215083418800_B95","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nature07397","article-title":"Activating mutations in ALK provide a therapeutic target in neuroblastoma","volume":"455","author":"George","year":"2008","journal-title":"Nature"},{"key":"2021112215083418800_B96","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature07398","article-title":"Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma","volume":"455","author":"Janoueix-Lerosey","year":"2008","journal-title":"Nature"},{"key":"2021112215083418800_B97","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nature07261","article-title":"Identification of ALK as a major familial neuroblastoma predisposition gene","volume":"455","author":"Mosse","year":"2008","journal-title":"Nature"},{"key":"2021112215083418800_B98","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1182\/blood.V66.4.848.848","article-title":"The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells","volume":"66","author":"Stein","year":"1985","journal-title":"Blood"},{"key":"2021112215083418800_B99","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1182\/blood.V96.12.3681","article-title":"CD30+ anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features","volume":"96","author":"Stein","year":"2000","journal-title":"Blood"},{"key":"2021112215083418800_B100","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1182\/blood-2007-04-060715","article-title":"Pathobiology of ALK+ anaplastic large-cell lymphoma","volume":"110","author":"Amin","year":"2007","journal-title":"Blood"},{"key":"2021112215083418800_B101","article-title":"WHO Classification of Tumours of Haematopoietic and Lymphiod Tissues","author":"Swerdlow","year":"2008"},{"key":"2021112215083418800_B102","doi-asserted-by":"crossref","first-page":"5496","DOI":"10.1182\/blood-2008-01-134270","article-title":"ALK anaplastic large-cell lymphoma is clinically and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project","volume":"111","author":"Savage","year":"2008","journal-title":"Blood"},{"key":"2021112215083418800_B103","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1182\/blood.V93.11.3913","article-title":"Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma","volume":"93","author":"Gascoyne","year":"1999","journal-title":"Blood"},{"key":"2021112215083418800_B104","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1182\/blood.V86.5.1954.bloodjournal8651954","article-title":"Anaplastic large cell lymphomas expressing the novel chimeric protein p80NPM\/ALK: a distinct clinicopathologic entity","volume":"86","author":"Shiota","year":"1995","journal-title":"Blood"},{"key":"2021112215083418800_B105","first-page":"2697","article-title":"ALK+ lymphoma: clinico-pathological findings and outcome","volume":"93","author":"Falini","year":"1999","journal-title":"Blood"},{"key":"2021112215083418800_B106","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1023\/A:1008352726155","article-title":"Relapses of childhood anaplastic large-cell lymphoma: treatment results in a series of 41 children\u2013a report from the French Society of Pediatric Oncology","volume":"11","author":"Brugieres","year":"2000","journal-title":"Ann. Oncol."},{"key":"2021112215083418800_B107","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1182\/blood.V99.12.4540","article-title":"Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma","volume":"99","author":"ten\u00a0Berge","year":"2002","journal-title":"Blood"},{"key":"2021112215083418800_B108","first-page":"3692","article-title":"Differential expression and clinical significance of tyrosine-phosphorylated STAT3 in ALK+ and ALK- anaplastic large cell lymphoma","volume":"9","author":"Khoury","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"2021112215083418800_B109","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1200\/JCO.2004.10.172","article-title":"Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma","volume":"22","author":"Schlette","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"2021112215083418800_B110","first-page":"2213","article-title":"Prognostic significance of MUC-1 expression in systemic anaplastic large cell lymphoma","volume":"9","author":"Rassidakis","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"2021112215083418800_B111","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1146\/annurev.physiol.70.113006.100659","article-title":"Structure and function of the cell surface (tethered) mucins","volume":"70","author":"Hattrup","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"2021112215083418800_B112","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1046\/j.1365-2141.1998.01097.x","article-title":"Detection of the t(2;5)-associated NPM\/ALK fusion cDNA in peripheral blood cells of healthy individuals","volume":"103","author":"Trumper","year":"1998","journal-title":"Br. J. Haematol."},{"key":"2021112215083418800_B113","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1016\/S0002-9440(10)64690-1","article-title":"The NPM-ALK and the ATIC-ALK fusion genes can be detected in non-neoplastic cells","volume":"158","author":"Maes","year":"2001","journal-title":"Am. J. Pathol."},{"key":"2021112215083418800_B114","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/jb\/mvm222","article-title":"The structure and functions of NPM1\/Nucleophsmin\/B23, a multifunctional nucleolar acidic protein","volume":"143","author":"Okuwaki","year":"2008","journal-title":"J. Biochem."},{"key":"2021112215083418800_B115","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1073\/pnas.93.9.4181","article-title":"Characterization of the transforming activity of p80, a hyperphosphorylated protein in a Ki-1 lymphoma cell line with chromosomal translocation t(2;5)","volume":"93","author":"Fujimoto","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112215083418800_B116","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1128\/MCB.17.4.2312","article-title":"Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis","volume":"17","author":"Bischof","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"2021112215083418800_B117","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/gcc.10033","article-title":"Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor","volume":"34","author":"Cools","year":"2002","journal-title":"Genes Chromosomes Cancer"},{"key":"2021112215083418800_B118","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/S0002-9440(10)62574-6","article-title":"Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas: identification of a new TFG-ALK(XL) chimeric gene with transforming activity","volume":"160","author":"Hernandez","year":"2002","journal-title":"Am. J. Pathol."},{"key":"2021112215083418800_B119","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1182\/blood.V94.9.3265","article-title":"TRK-fused gene (TFG) is a new partner of ALK in anaplastic large cell lymphoma producing two structurally different TFG-ALK translocations","volume":"94","author":"Hernandez","year":"1999","journal-title":"Blood"},{"key":"2021112215083418800_B120","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/labinvest.3780249","article-title":"Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma","volume":"81","author":"Tort","year":"2001","journal-title":"Lab. Invest."},{"key":"2021112215083418800_B121","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1182\/blood.V93.9.3088.409k30_3088_3095","article-title":"A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation","volume":"93","author":"Lamant","year":"1999","journal-title":"Blood"},{"key":"2021112215083418800_B122","first-page":"3614","article-title":"Complex variant translocation t(1;2) with TPM3-ALK fusion due to cryptic ALK gene rearrangement in anaplastic large-cell lymphoma","volume":"94","author":"Siebert","year":"1999","journal-title":"Blood"},{"key":"2021112215083418800_B123","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1182\/blood.V98.4.1209","article-title":"Unusual childhood extramedullary hematologic malignancy with natural killer cell properties that contains tropomyosin 4\u2013anaplastic lymphoma kinase gene fusion","volume":"98","author":"Meech","year":"2001","journal-title":"Blood"},{"key":"2021112215083418800_B124","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1182\/blood.V95.6.2144","article-title":"Inv(2)(p23q35) in anaplastic large-cell lymphoma induces constitutive anaplastic lymphoma kinase (ALK) tyrosine kinase activation by fusion to ATIC, an enzyme involved in purine nucleotide biosynthesis","volume":"95","author":"Ma","year":"2000","journal-title":"Blood"},{"key":"2021112215083418800_B125","first-page":"793","article-title":"A new variant anaplastic lymphoma kinase (ALK)-fusion protein (ATIC-ALK) in a case of ALK-positive anaplastic large cell lymphoma","volume":"60","author":"Trinei","year":"2000","journal-title":"Cancer Res."},{"key":"2021112215083418800_B126","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0002-9440(10)64945-0","article-title":"ATIC-ALK: a novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35)","volume":"156","author":"Colleoni","year":"2000","journal-title":"Am. J. Pathol."},{"key":"2021112215083418800_B127","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/gcc.10232","article-title":"Non-muscle myosin heavy chain (MYH9): a new partner fused to ALK in anaplastic large cell lymphoma","volume":"37","author":"Lamant","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"2021112215083418800_B128","doi-asserted-by":"crossref","first-page":"3204","DOI":"10.1182\/blood.V95.10.3204","article-title":"Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like)","volume":"95","author":"Touriol","year":"2000","journal-title":"Blood"},{"key":"2021112215083418800_B129","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-4615-5381-6_43","article-title":"Structure and functional relationships in human pur H","volume":"431","author":"Beardsley","year":"1998","journal-title":"Adv. Exp. Med. Biol."},{"key":"2021112215083418800_B130","doi-asserted-by":"crossref","first-page":"4319","DOI":"10.1182\/blood.V96.13.4319","article-title":"Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase\/Akt antiapoptotic signaling pathway","volume":"96","author":"Bai","year":"2000","journal-title":"Blood"},{"key":"2021112215083418800_B131","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mrfmmm.2004.09.011","article-title":"Truncated ALK derived from chromosomal translocation t(2;5)(p23;q35) binds to the SH3 domain of p85-PI3K","volume":"570","author":"Polgar","year":"2005","journal-title":"Mutat. Res."},{"key":"2021112215083418800_B132","first-page":"2194","article-title":"Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin\/anaplastic lymphoma kinase-mediated lymphomagenesis","volume":"61","author":"Slupianek","year":"2001","journal-title":"Cancer Res."},{"key":"2021112215083418800_B133","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1182\/blood-2003-03-0820","article-title":"NPM-ALK fusion kinase of anaplastic large-cell lymphoma regulates survival and proliferative signaling through modulation of FOXO3a","volume":"103","author":"Gu","year":"2004","journal-title":"Blood"},{"key":"2021112215083418800_B134","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1182\/blood-2004-06-2125","article-title":"Inhibition of Akt increases p27Kip1 levels and induces cell cycle arrest in anaplastic large cell lymphoma","volume":"105","author":"Rassidakis","year":"2005","journal-title":"Blood"},{"key":"2021112215083418800_B135","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1158\/0008-5472.CAN-05-3018","article-title":"Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma","volume":"66","author":"Vega","year":"2006","journal-title":"Cancer Res."},{"key":"2021112215083418800_B136","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.1038\/sj.onc.1210346","article-title":"Oncogenic tyrosine kinase NPM\/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway","volume":"26","author":"Marzec","year":"2007","journal-title":"Oncogene"},{"key":"2021112215083418800_B137","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1038\/sj.onc.1207398","article-title":"Identification of NPM\u2013ALK interacting proteins by tandem mass spectrometry","volume":"23","author":"Crockett","year":"2004","journal-title":"Oncogene"},{"key":"2021112215083418800_B138","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/sj.onc.1209843","article-title":"Oncogenic tyrosine kinase NPM\/ALK induces activation of the MEK\/ERK signaling pathway independently of c-Raf","volume":"26","author":"Marzec","year":"2007","journal-title":"Oncogene"},{"key":"2021112215083418800_B139","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1038\/sj.onc.1207703","article-title":"Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma","volume":"23","author":"Amin","year":"2004","journal-title":"Oncogene"},{"key":"2021112215083418800_B140","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/sj.onc.1205152","article-title":"Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death","volume":"21","author":"Zamo","year":"2002","journal-title":"Oncogene"},{"key":"2021112215083418800_B141","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.168.1.466","article-title":"Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T\/null-cell lymphoma","volume":"168","author":"Zhang","year":"2002","journal-title":"J. Immunol."},{"key":"2021112215083418800_B142","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1073\/pnas.0609412103","article-title":"Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK","volume":"104","author":"Galkin","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112215083418800_B143","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1038\/labinvest.3700348","article-title":"Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3","volume":"85","author":"Marzec","year":"2005","journal-title":"Lab. Invest."},{"key":"2021112215083418800_B144","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1182\/blood-2005-08-3254","article-title":"Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells","volume":"107","author":"Wan","year":"2006","journal-title":"Blood"},{"key":"2021112215083418800_B145","doi-asserted-by":"crossref","first-page":"5399","DOI":"10.1038\/sj.onc.1206849","article-title":"Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma","volume":"22","author":"Amin","year":"2003","journal-title":"Oncogene"},{"key":"2021112215083418800_B146","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2141.2006.06259.x","article-title":"JSI-124 (cucurbitacin I) inhibits Janus kinase-3\/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells","volume":"135","author":"Shi","year":"2006","journal-title":"Br. J. Haematol."},{"key":"2021112215083418800_B147","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.humpath.2005.07.011","article-title":"Jak3 activation is significantly associated with ALK expression in anaplastic large cell lymphoma","volume":"36","author":"Lai","year":"2005","journal-title":"Hum. Pathol."},{"key":"2021112215083418800_B148","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1182\/blood-2006-04-020305","article-title":"Autocrine release of interleukin-9 promotes Jak3-dependent survival of ALK+ anaplastic large-cell lymphoma cells","volume":"108","author":"Qiu","year":"2006","journal-title":"Blood"},{"key":"2021112215083418800_B149","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1182\/blood-2006-04-017434","article-title":"Loss of SHP1 enhances JAK3\/STAT3 signaling and decreases proteosome degradation of JAK3 and NPM-ALK in ALK+ anaplastic large-cell lymphoma","volume":"108","author":"Han","year":"2006","journal-title":"Blood"},{"key":"2021112215083418800_B150","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm1249","article-title":"Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target","volume":"11","author":"Chiarle","year":"2005","journal-title":"Nat. Med."},{"key":"2021112215083418800_B151","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1182\/blood-2004-03-1151","article-title":"Methylation of SHP1 gene and loss of SHP1 protein expression are frequent in systemic anaplastic large cell lymphoma","volume":"104","author":"Khoury","year":"2004","journal-title":"Blood"},{"key":"2021112215083418800_B152","first-page":"6517","article-title":"Role of signal transducer and activator of transcription 5 in nucleophosmin\/anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells","volume":"61","author":"Nieborowska-Skorska","year":"2001","journal-title":"Cancer Res."},{"key":"2021112215083418800_B153","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/nm1659","article-title":"STAT5A is epigenetically silenced by the tyrosine kinase NPM1-ALK and acts as a tumor suppressor by reciprocally inhibiting NPM1-ALK expression","volume":"13","author":"Zhang","year":"2007","journal-title":"Nat. Med."},{"key":"2021112215083418800_B154","doi-asserted-by":"crossref","first-page":"8899","DOI":"10.1158\/0008-5472.CAN-08-2568","article-title":"The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation","volume":"68","author":"Ambrogio","year":"2008","journal-title":"Cancer Res."},{"key":"2021112215083418800_B155","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1038\/sj.onc.1210921","article-title":"Activation of Rac1 and the exchange factor Vav3 are involved in NPM-ALK signaling in anaplastic large cell lymphomas","volume":"27","author":"Colomba","year":"2008","journal-title":"Oncogene"},{"key":"2021112215083418800_B156","doi-asserted-by":"crossref","first-page":"4278","DOI":"10.1158\/0008-5472.CAN-06-4350","article-title":"The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration","volume":"67","author":"Voena","year":"2007","journal-title":"Cancer Res."},{"key":"2021112215083418800_B157","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1182\/blood-2003-04-1038","article-title":"Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity","volume":"103","author":"Cussac","year":"2004","journal-title":"Blood"},{"key":"2021112215083418800_B158","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2005.04.034","article-title":"NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry","volume":"122","author":"Bassermann","year":"2005","journal-title":"Cell"},{"key":"2021112215083418800_B159","doi-asserted-by":"crossref","first-page":"30028","DOI":"10.1074\/jbc.M300883200","article-title":"Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA)","volume":"278","author":"Ouyang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B160","doi-asserted-by":"crossref","first-page":"7750","DOI":"10.1038\/sj.onc.1207048","article-title":"Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase","volume":"22","author":"Turner","year":"2003","journal-title":"Oncogene"},{"key":"2021112215083418800_B161","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1182\/blood-2006-11-059451","article-title":"NPM\u2013ALK oncogenic kinase promotes cell cycle progression through activation of JNK\/cJun signaling in anaplastic large cell lymphoma","volume":"110","author":"Leventaki","year":"2007","journal-title":"Blood"},{"key":"2021112215083418800_B162","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1158\/0008-5472.CAN-08-1808","article-title":"Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma","volume":"69","author":"Singh","year":"2009","journal-title":"Cancer Res."},{"key":"2021112215083418800_B163","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1182\/blood-2008-06-161018","article-title":"The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase\/IMP cyclohydrolase (ATIC) is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL","volume":"113","author":"Boccalatte","year":"2008","journal-title":"Blood"},{"key":"2021112215083418800_B164","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1172\/JCI29401","article-title":"Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and BCL2A1 as critical target genes","volume":"116","author":"Piva","year":"2006","journal-title":"J. Clin. Invest."},{"key":"2021112215083418800_B165","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1182\/blood-2006-06-028969","article-title":"Gene-expression profiling of systemic anaplastic large-cell lymphoma reveals differences based on ALK status and two distinct morphologic ALK+ subtypes","volume":"109","author":"Lamant","year":"2007","journal-title":"Blood"},{"key":"2021112215083418800_B166","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nbt1046","article-title":"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells","volume":"23","author":"Rush","year":"2005","journal-title":"Nat. Biotechnol."},{"key":"2021112215083418800_B167","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.exphem.2007.04.011","article-title":"Global proteome profiling of NPM\/ALK-positive anaplastic large cell lymphoma","volume":"35","author":"Sjostrom","year":"2007","journal-title":"Exp. Haematol."},{"key":"2021112215083418800_B168","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2353\/ajpath.2009.080521","article-title":"Proteome-wide identification of novel binding partners to the oncogenic fusion gene protein, NPM-ALK, using tandem affinity purification and mass spectrometry","volume":"174","author":"Wu","year":"2009","journal-title":"Am. J. Pathol."},{"key":"2021112215083418800_B169","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.1038\/sj.onc.1207813","article-title":"Differential effects of X-ALK fusion proteins on proliferation, transformation, and invasion properties of NIH3T3 cells","volume":"23","author":"Armstrong","year":"2004","journal-title":"Oncogene"},{"key":"2021112215083418800_B170","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.humpath.2008.06.009","article-title":"Hyperactivated STAT3 in ALK-positive diffuse large B-cell lymphoma with clathrin-ALK fusion","volume":"40","author":"Momose","year":"2009","journal-title":"Hum. Pathol."},{"key":"2021112215083418800_B171","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/jcp.2007.049387","article-title":"Inflammatory myofibroblastic tumours: where are we now?","volume":"61","author":"Gleason","year":"2008","journal-title":"J. Clin. Pathol."},{"key":"2021112215083418800_B172","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0096-5588(20)30758-3","article-title":"Postinflammatory tumors of the lung; report of four cases simulating xanthoma, fibroma, or plasma cell tumor","volume":"28","author":"Umiker","year":"1954","journal-title":"J. Thorac. Surg."},{"key":"2021112215083418800_B173","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/00000478-199508000-00001","article-title":"Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases","volume":"19","author":"Coffin","year":"1995","journal-title":"Am. J. Surg. Pathol."},{"key":"2021112215083418800_B174","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0002-9440(10)64550-6","article-title":"TPM3\u2013ALK and TPM4\u2013ALK oncogenes in inflammatory myofibroblastic tumors","volume":"157","author":"Lawrence","year":"2000","journal-title":"Am. J. Pathol."},{"key":"2021112215083418800_B175","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/gcc.10267","article-title":"ALK\u2013ATIC fusion in urinary bladder inflammatory myofibroblastic tumor","volume":"38","author":"Debiec-Rychter","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"2021112215083418800_B176","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cancergencyto.2007.04.004","article-title":"RANBP2 and CLTC are involved in ALK rearrangements in inflammatory myofibroblastic tumors","volume":"176","author":"Patel","year":"2007","journal-title":"Cancer Genet. Cytogenet."},{"key":"2021112215083418800_B177","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0002-9440(10)61711-7","article-title":"Fusion of the ALK gene to the clathrin heavy chain gene, CLTC, in inflammatory myofibroblastic tumor","volume":"159","author":"Bridge","year":"2001","journal-title":"Am. J. Pathol."},{"key":"2021112215083418800_B178","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1097\/01.LAB.0000088856.49388.EA","article-title":"Identification of CARS-ALK fusion in primary and metastatic lesions of an inflammatory myofibroblastic tumor","volume":"83","author":"Debelenko","year":"2003","journal-title":"Lab. Invest."},{"key":"2021112215083418800_B179","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/gcc.10177","article-title":"Fusion of ALK to the Ran-binding protein 2 (RANBP2) gene in inflammatory myofibroblastic tumor","volume":"37","author":"Ma","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"2021112215083418800_B180","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/ijc.21490","article-title":"Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor","volume":"118","author":"Panagopoulos","year":"2006","journal-title":"Int. J. Cancer"},{"key":"2021112215083418800_B181","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/modpathol.3880352","article-title":"ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor","volume":"14","author":"Coffin","year":"2001","journal-title":"Mod. Pathol."},{"key":"2021112215083418800_B182","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1097\/00000478-200111000-00003","article-title":"Anaplastic lymphoma kinase (ALK) expression in the inflammatory myofibroblastic tumor: a comparative immunohistochemical study","volume":"25","author":"Cook","year":"2001","journal-title":"Am. J. Surg. Pathol."},{"key":"2021112215083418800_B183","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/01.pas.0000213393.57322.c7","article-title":"Inflammatory myofibroblastic tumor: comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases","volume":"31","author":"Coffin","year":"2007","journal-title":"Am. J. Surg. Pathol."},{"key":"2021112215083418800_B184","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/pbc.20294","article-title":"Pediatric inflammatory myofibroblastic tumor: anaplastic lymphoma kinase (ALK) expression and prognosis","volume":"45","author":"Chun","year":"2005","journal-title":"Ped. Blood Cancer"},{"key":"2021112215083418800_B185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/cncr.20288","article-title":"Annual report to the nation on the status of cancer, 1975\u20132001, with a special feature regarding survival","volume":"101","author":"Jemal","year":"2004","journal-title":"Cancer"},{"key":"2021112215083418800_B186","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1200\/JCO.2005.05.2308","article-title":"Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world","volume":"24","author":"Kamangar","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"2021112215083418800_B187","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1593\/neo.07878","article-title":"EML4\u2013ALK fusion lung cancer: a rare acquired event","volume":"10","author":"Perner","year":"2008","journal-title":"Neoplasia"},{"key":"2021112215083418800_B188","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/JTO.0b013e31815e8b60","article-title":"EML4\u2013ALK fusion is linked to histological characteristics in a subset of lung cancers","volume":"3","author":"Inamura","year":"2008","journal-title":"J. Thorac. Oncol."},{"key":"2021112215083418800_B189","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/sj.bjc.6604341","article-title":"EML4-ALK fusion transcript is not found in gastrointestinal and breast cancers","volume":"98","author":"Fukuyoshi","year":"2008","journal-title":"Br. J. Cancer"},{"key":"2021112215083418800_B190","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.lungcan.2007.12.013","article-title":"EML4\u2013ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas","volume":"61","author":"Shinmura","year":"2008","journal-title":"Lung Cancer"},{"key":"2021112215083418800_B191","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1158\/1078-0432.CCR-08-0168","article-title":"EML4\u2013ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer","volume":"14","author":"Koivunen","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"2021112215083418800_B192","doi-asserted-by":"crossref","DOI":"10.1002\/cncr.24181","article-title":"The EML4\u2013ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS, Cancer","author":"Wong","year":"2009"},{"key":"2021112215083418800_B193","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2353\/ajpath.2009.080755","article-title":"EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues","volume":"174","author":"Martelli","year":"2009","journal-title":"Am. J. Pathol."},{"key":"2021112215083418800_B194","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.1099314","article-title":"EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy","volume":"304","author":"Paez","year":"2004","journal-title":"Science"},{"key":"2021112215083418800_B195","doi-asserted-by":"crossref","first-page":"19893","DOI":"10.1073\/pnas.0805381105","article-title":"A mouse model for EML4-ALK-positive lung cancer","volume":"105","author":"Soda","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112215083418800_B196","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1158\/0008-5472.CAN-06-4443","article-title":"An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms","volume":"67","author":"Zou","year":"2007","journal-title":"Cancer Res."},{"key":"2021112215083418800_B197","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1158\/1535-7163.MCT-07-0365","article-title":"Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma","volume":"6","author":"Christensen","year":"2007","journal-title":"Mol. Cancer Ther."},{"key":"2021112215083418800_B198","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1158\/0008-5472.CAN-07-6186","article-title":"Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors","volume":"68","author":"McDermott","year":"2008","journal-title":"Cancer Res."},{"key":"2021112215083418800_B199","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/modpathol.3800742","article-title":"ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature","volume":"20","author":"Reichard","year":"2007","journal-title":"Mod. Pathol."},{"key":"2021112215083418800_B200","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.humpath.2006.12.019","article-title":"Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma with a complex karyotype and cryptic 3\u2032 ALK gene insertion to chromosome 4 q22\u201324","volume":"38","author":"Stachurski","year":"2007","journal-title":"Hum. Pathol."},{"key":"2021112215083418800_B201","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/hon.841","article-title":"ALK-positive diffuse large B-cell lymphoma: report of three cases","volume":"26","author":"Lee","year":"2008","journal-title":"Hematol. Oncol."},{"key":"2021112215083418800_B202","first-page":"89","article-title":"[Cytomorphology and molecular characterization of CLTC-ALK rearrangement in 2 cases of ALK-positive diffuse large B-cell lymphoma with extensive bone marrow involvement]","volume":"28","author":"Choung","year":"2008","journal-title":"Korean J. Lab. Med."},{"key":"2021112215083418800_B203","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1182\/blood-2003-04-1095","article-title":"ALK-positive plasmablastic B-cell lymphoma with expression of the NPM-ALK fusion transcript: report of 2 cases","volume":"102","author":"Onciu","year":"2003","journal-title":"Blood"},{"key":"2021112215083418800_B204","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/00000478-200311000-00012","article-title":"A case of a diffuse large B-cell lymphoma of plasmablastic type\u00a0associated with the t(2;5)(p23;q35) chromosome translocation","volume":"27","author":"Adam","year":"2003","journal-title":"Am. J. Surg. Pathol."},{"key":"2021112215083418800_B205","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1593\/neo.81040","article-title":"Enhanced antitumorigenic effects in glioblastoma on double targeting of pleiotrophin and its receptor ALK","volume":"11","author":"Grzelinski","year":"2009","journal-title":"Neoplasia"},{"key":"2021112215083418800_B206","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/1097-0142(19940901)74:5<1584::AID-CNCR2820740514>3.0.CO;2-V","article-title":"Midkine and pleiotrophin expression in normal and malignant breast tissue","volume":"74","author":"Garver","year":"1994","journal-title":"Cancer"},{"key":"2021112215083418800_B207","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/BF00666163","article-title":"The potential role of the heparin-binding growth factor pleiotrophin in breast cancer","volume":"31","author":"Riegel","year":"1994","journal-title":"Breast Cancer Res. Treatment"},{"key":"2021112215083418800_B208","doi-asserted-by":"crossref","first-page":"16733","DOI":"10.1074\/jbc.272.27.16733","article-title":"Human breast cancer growth inhibited In vivo by a dominant negative pleiotrophin mutant","volume":"272","author":"Zhang","year":"1997","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B209","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(07)60983-0","article-title":"Neuroblastoma","volume":"369","author":"Maris","year":"2007","journal-title":"Lancet"},{"key":"2021112215083418800_B210","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrc1014","article-title":"Neuroblastoma: biological insights into a clinical enigma","volume":"3","author":"Brodeur","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"2021112215083418800_B211","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1182\/blood.V90.8.2901","article-title":"Retrovirus-mediated gene transfer of NPM\u2013ALK causes lymphoid malignancy in mice","volume":"90","author":"Kuefer","year":"1997","journal-title":"Blood"},{"key":"2021112215083418800_B212","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/sj.onc.1206076","article-title":"Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice","volume":"22","author":"Lange","year":"2003","journal-title":"Oncogene"},{"key":"2021112215083418800_B213","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1182\/blood-2002-05-1343","article-title":"NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors","volume":"101","author":"Chiarle","year":"2003","journal-title":"Blood"},{"key":"2021112215083418800_B214","first-page":"3191","article-title":"Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas","volume":"25","author":"Jager","year":"2005","journal-title":"Anticancer Res."},{"key":"2021112215083418800_B215","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/sj.leu.2403797","article-title":"What have we learnt from mouse models of NPM-ALK-induced lymphomagenesis?","volume":"19","author":"Turner","year":"2005","journal-title":"Leukemia"},{"key":"2021112215083418800_B216","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm0596-561","article-title":"Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells","volume":"2","author":"Druker","year":"1996","journal-title":"Nat. Med."},{"key":"2021112215083418800_B217","doi-asserted-by":"crossref","first-page":"4808","DOI":"10.1182\/blood-2008-07-077958","article-title":"Translation of the Philadelphia chromosome into therapy for CML","volume":"112","author":"Druker","year":"2008","journal-title":"Blood"},{"key":"2021112215083418800_B218","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-3565(24)38879-2","article-title":"Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors","volume":"295","author":"Buchdunger","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2021112215083418800_B219","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1073\/pnas.92.7.2558","article-title":"Selective inhibition of the platelet-derived growth factor signal transduction pathway by a protein-tyrosine kinase inhibitor of the 2-phenylaminopyrimidine class","volume":"92","author":"Buchdunger","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112215083418800_B220","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1126\/science.279.5350.577","article-title":"Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors","volume":"279","author":"Hirota","year":"1998","journal-title":"Science"},{"key":"2021112215083418800_B221","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1056\/NEJMoa020461","article-title":"Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors","volume":"347","author":"Demetri","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"2021112215083418800_B222","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/S0140-6736(01)06535-7","article-title":"Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study","volume":"358","author":"van\u00a0Oosterom","year":"2001","journal-title":"Lancet"},{"key":"2021112215083418800_B223","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1056\/NEJM200104053441404","article-title":"Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor","volume":"344","author":"Joensuu","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"2021112215083418800_B224","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1124\/jpet.105.084145","article-title":"Role of tyrosine kinase inhibitors in cancer therapy","volume":"315","author":"Arora","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2021112215083418800_B225","doi-asserted-by":"crossref","first-page":"571","DOI":"10.7164\/antibiotics.42.571","article-title":"UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities","volume":"42","author":"Takahashi","year":"1989","journal-title":"J. Antibiotics"},{"key":"2021112215083418800_B226","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.1074\/jbc.275.8.5600","article-title":"The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01","volume":"275","author":"Graves","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2021112215083418800_B227","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1200\/JCO.2001.19.8.2319","article-title":"Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms","volume":"19","author":"Sausville","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"2021112215083418800_B228","first-page":"988","article-title":"An enzyme-linked immunosorbent assay to screen for inhibitors of the oncogenic anaplastic lymphoma kinase","volume":"90","author":"Gunby","year":"2005","journal-title":"Haematologica"},{"key":"2021112215083418800_B229","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1021\/jm050824x","article-title":"Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase","volume":"49","author":"Li","year":"2006","journal-title":"J. Med. Chem."},{"key":"2021112215083418800_B230","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/med.20109","article-title":"Development of anaplastic lymphoma kinase (ALK) small-molecule inhibitors for cancer therapy","volume":"28","author":"Li","year":"2008","journal-title":"Med. Res. Rev."},{"key":"2021112215083418800_B231","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/ijc.21276","article-title":"Ribozyme-targeting reveals the rate-limiting role of pleiotrophin in glioblastoma","volume":"117","author":"Grzelinski","year":"2005","journal-title":"Int. J. Cancer"},{"key":"2021112215083418800_B232","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0301-472X(02)01084-6","article-title":"Hammerhead ribozyme-mediated cleavage of the fusion transcript NPM-ALK associated with anaplastic large-cell lymphoma","volume":"31","author":"Hubinger","year":"2003","journal-title":"Exp. Hematol."},{"key":"2021112215083418800_B233","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1182\/blood-2005-05-2125","article-title":"Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas","volume":"107","author":"Piva","year":"2006","journal-title":"Blood"},{"key":"2021112215083418800_B234","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nm1769","article-title":"The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination","volume":"14","author":"Chiarle","year":"2008","journal-title":"Nat. Med."},{"key":"2021112215083418800_B235","first-page":"1559","article-title":"Nucleophosmin-anaplastic lymphoma kinase (NPM-ALK), a novel Hsp90-client tyrosine kinase: down-regulation of NPM-ALK expression and tyrosine phosphorylation in ALK+ CD30+ lymphoma cells by the Hsp90 antagonist 17-allylamino,17-demethoxygeldanamycin","volume":"62","author":"Bonvini","year":"2002","journal-title":"Cancer Res."},{"key":"2021112215083418800_B236","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1056\/NEJMra043186","article-title":"Trastuzumab: mechanism of action and use in clinical practice","volume":"357","author":"Hudis","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"2021112215083418800_B237","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1182\/blood-2003-04-1050","article-title":"ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma","volume":"102","author":"De\u00a0Paepe","year":"2003","journal-title":"Blood"}],"container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/420\/3\/345\/657032\/bj4200345.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/420\/3\/345\/657032\/bj4200345.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T18:38:56Z","timestamp":1739126336000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/420\/3\/345\/44525\/Anaplastic-lymphoma-kinase-signalling-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,27]]},"references-count":237,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,6,15]]}},"URL":"https:\/\/doi.org\/10.1042\/bj20090387","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,27]]}}}