{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:54:32Z","timestamp":1791258872777,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T00:00:00Z","timestamp":1293062400000},"content-version":"vor","delay-in-days":1970,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p>The antitumour properties of two fatty acid esters of maltotriose, 6\u2033\u2010<jats:italic>O<\/jats:italic>\u2010dodecanoylmaltotriose and 6\u2033\u2010<jats:italic>O<\/jats:italic>\u2010palmitoylmaltotriose, in which the 6\u2010OH at the non\u2010reducing end of the maltotriose has been regioselectively acylated, were studied. Both compounds were synthesized by transesterification of vinyl laurate or vinyl palmitate with maltotriose, in the presence of immobilized lipase from <jats:italic>Thermomyces lanuginosus<\/jats:italic>. A mixture of 2\u2010methylbutan\u20102\u2010ol and DMSO (80:20, v\/v) was the reaction medium. Their cytotoxic activities against two human cancer cell lines, Hep\u2010G2 and HeLa, were studied. 6\u2033\u2010<jats:italic>O<\/jats:italic>\u2010palmitoylmaltotriose showed IC<jats:sub>50<\/jats:sub> values of 2.3 \u03bcM (1.7 \u03bcg\/ml) for Hep\u2010G2 and 3.6 \u03bcM (2.7 \u03bcg\/ml) for HeLa cells, whereas 6\u2033\u2010<jats:italic>O<\/jats:italic>\u2010dodecanoylmaltotriose displayed a lower inhibitory effect. 6\u2033\u2010<jats:italic>O<\/jats:italic>\u2010palmitoylmaltotriose showed a marginal cytotoxicity to rat hepatocytes, confirming its potential as a new antitumour agent.<\/jats:p>","DOI":"10.1042\/ba20040122","type":"journal-article","created":{"date-parts":[[2005,7,22]],"date-time":"2005-07-22T11:54:17Z","timestamp":1122033257000},"page":"35-39","source":"Crossref","is-referenced-by-count":38,"title":["Antitumour activity of fatty acid maltotriose esters obtained by enzymatic synthesis"],"prefix":"10.1002","volume":"42","author":[{"given":"Manuel","family":"Ferrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Plou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 V.","family":"Castell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ballesteros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,12,23]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11743-001-0196-y"},{"key":"e_1_2_6_3_2","first-page":"1883","volume":"9","author":"Benrezzak O.","year":"1989","journal-title":"Anticancer Res."},{"key":"e_1_2_6_4_2","first-page":"13","volume":"13","author":"Benrezzak O.","year":"1992","journal-title":"Cancer Biochem. 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