{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:20:35Z","timestamp":1773127235857,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,12,23]],"date-time":"2010-12-23T00:00:00Z","timestamp":1293062400000},"content-version":"vor","delay-in-days":1056,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biotech and App Biochem"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p>The addition of NT\u20103 (neurotrophin 3) or NT\u20104 to injured nerves improves their regeneration potential and may aid axon guidance. It is not well defined whether NTs (neurotrophins) influence other elements, such as the cell\u2010adhesion molecules, which promote nerve guidance and regeneration. Using poly\u20103\u2010hydroxybutyrate conduits, we applied either NT\u20103 or NT\u20104 to axotomized rat sciatic nerves and monitored nerve regeneration and cell\u2010adhesion molecule expression. Regenerating nerves were stained with antibodies against NCAM (neural cell\u2010adhesion molecule) and N\u2010cadherin 2 weeks after injury and staining intensity was quantified. NCAM, N\u2010cadherin and L1 (L1 cell\u2010adhesion molecule) transcription was measured in the proximal and distal stumps and ipsilateral DRG (dorsal root ganglia) (fourth and fifth DRG) using RT (reverse transcriptase)\u2013PCR. Both NT\u20103 and NT\u20104 increased NCAM and L1 transcript levels in the DRG of axotomized nerves. This is reflected in the increased NCAM expression at the proximal stump and regeneration front. Increased levels of NCAM were also observed in the distal stump. NT\u20104 administration increased N\u2010cadherin levels proximal to the injury, but not distally. Following NT\u20103 administration, N\u2010cadherin expression decreased in proximal and distal stumps compared with the control. In conclusion, NTs differentially alter adhesion molecule expression in regenerating nerves and transcription in the corresponding DRG, although these changes in expression do not alter NT\u2010enhanced regeneration. Thus we propose that retrograde transport of the NTs to the DRG affects adhesion molecule transcription, reflected by protein expression in peripheral nerve axons.<\/jats:p>","DOI":"10.1042\/ba20070040","type":"journal-article","created":{"date-parts":[[2008,1,21]],"date-time":"2008-01-21T12:11:04Z","timestamp":1200917464000},"page":"165-174","source":"Crossref","is-referenced-by-count":20,"title":["Neurotrophins 3 and 4 differentially regulate NCAM, L1 and N\u2010cadherin expression during peripheral nerve regeneration"],"prefix":"10.1002","volume":"49","author":[{"given":"Martin R.","family":"Thornton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan G.","family":"Shawcross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mantovani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul 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