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In the present study, mPEG [methoxypoly(ethylene glycol)] with two molecular masses of 5 and 10 kDa, activated with SC (succinimidyl carbonate), was grafted on to the surface of pancreatic islets at a polymer concentration of 22 mg\/ml. It was found that PEGylated islets were viable and active, and no morphological changes on the collagen capsule of islets were observed. The amount of interleukin\u20102 secretion from lymphocytes co\u2010cultured with islets PEGylated with mPEG\u2010SC of 5 and 10 kDa was 112.12\u00b123.09 pg\/ml and 172.75\u00b127.94 pg\/ml respectively. Thus mPEG\u2010SC (SC\u2010activated mPEG) with higher molecular mass was more suitable for camouflaging islets from the immune system.<\/jats:p>","DOI":"10.1042\/ba20100145","type":"journal-article","created":{"date-parts":[[2010,8,25]],"date-time":"2010-08-25T13:05:19Z","timestamp":1282741519000},"page":"25-30","source":"Crossref","is-referenced-by-count":5,"title":["Effect of molecular mass of methoxypoly(ethylene glycol) activated with succinimidyl carbonate on camouflaging pancreatic islets"],"prefix":"10.1002","volume":"57","author":[{"given":"Leila","family":"Barani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebrahim","family":"Vasheghani\u2010Farahani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamideh Aghajani","family":"Lazarjani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameereh","family":"Hashemi\u2010Najafabadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Atyabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,12,23]]},"reference":[{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(01)00050-6"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00586274"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-0895(199607)12:2<137::AID-DMR161>3.0.CO;2-1"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.5.1635"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.8.747"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.20047"},{"key":"e_1_2_13_8_2","first-page":"63","volume-title":"Biomaterials and Drug Delivery Toward New Millennium","author":"Kozlowski A.","year":"2000"},{"key":"e_1_2_13_9_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/088391159501000205","volume":"10","author":"Hooftman G.","year":"1995","journal-title":"J. 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