{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T11:09:44Z","timestamp":1710846584251},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,1,9]],"date-time":"2012-01-09T00:00:00Z","timestamp":1326067200000},"content-version":"vor","delay-in-days":1834,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biology of the Cell"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:italic>Background information<\/jats:italic>. Prolonged copper deprivation in rats followed by refeeding with a normal diet has previously been used to induce the appearance of hepatocyte\u2010like cells in the pancreas, but the effects on islet size and morphology have not been determined.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. In the present study we investigated the distribution of pancreatic \u03b1\u2010 and \u03b2\u2010cells and of hepatocytes in adult rats fed a copper\u2010deficient diet followed by refeeding with a normal diet. Immunohistochemical staining for insulin and glucagon showed that the islets of the copper\u2010deficient group were up to 2.4 times larger in mass compared with controls. The islets were disorganized, with \u03b1\u2010cells found in multiple layers at the periphery of the islet and sometimes deep in the core. Isolated \u03b1\u2010 and \u03b2\u2010cells were also found in increased numbers in the ductular system. Copper deprivation caused almost complete ablation of the acinar cells, and refeeding induced adipogenesis, acinar regeneration and hepatocyte\u2010like cells. Ductular proliferation and nerve hyperplasia were also present. The hepatocytes tended to be associated with islets or with ducts, rather than with residual pancreatic exocrine tissue.<\/jats:p><jats:p><jats:italic>Conclusions<\/jats:italic>. These data show that copper deficiency in rats, as well as inducing the appearance of hepatocytes, is capable of causing islet hyperplasia.<\/jats:p>","DOI":"10.1042\/bc20060050","type":"journal-article","created":{"date-parts":[[2006,12,15]],"date-time":"2006-12-15T11:58:01Z","timestamp":1166183881000},"page":"37-44","source":"Crossref","is-referenced-by-count":10,"title":["Copper deprivation in rats induces islet hyperplasia and hepatic metaplasia in the pancreas"],"prefix":"10.1111","volume":"99","author":[{"given":"David","family":"Tosh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Ning","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm R.","family":"Alison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine E.","family":"Sarraf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M.W.","family":"Slack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,1,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.42.12.1715"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.2.232"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19981115)43:4<332::AID-JEMT7>3.0.CO;2-1"},{"key":"e_1_2_7_5_1","first-page":"1633","article-title":"Transcription factor and liver\u2010specific mRNA expression in facultative epithelial progenitor cells of liver and pancreas","volume":"147","author":"Dabeva M.D.","year":"1995","journal-title":"Am. J. Pathol."},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.14.7356"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5656"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)00033-2"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199312000-00019"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1997.10718696"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.118.1.33"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/dev.129.10.2447","article-title":"Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from gut progenitors","volume":"129","author":"Gu G.","year":"2002","journal-title":"Development"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65315-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4322"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.140.5.2353"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(88)80814-3"},{"key":"e_1_2_7_17_1","first-page":"1069","article-title":"Role of ductular and periductular epithelial cells of the adult rat pancreas in pancreatic hepatocyte lineage","volume":"134","author":"Rao M.S.","year":"1989","journal-title":"Am. J. Pathol."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.6.2082"},{"key":"e_1_2_7_19_1","first-page":"75","article-title":"Induction of endocrine cell differentiation: a new approach to management of diabetes","volume":"114","author":"Rosenberg L.","year":"1989","journal-title":"J. Lab. Clin. Med."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3448-8_11"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-3448-8_10"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/35046522"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1242\/dev.121.6.1569","article-title":"Development biology of the pancreas","volume":"121","author":"Slack J.M.W.","year":"1995","journal-title":"Development"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.2.1200"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116708"}],"container-title":["Biology of the Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1042%2FBC20060050","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1042\/BC20060050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T08:51:55Z","timestamp":1697014315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1042\/BC20060050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1042\/BC20060050"],"URL":"https:\/\/doi.org\/10.1042\/bc20060050","archive":["Portico"],"relation":{},"ISSN":["0248-4900","1768-322X"],"issn-type":[{"value":"0248-4900","type":"print"},{"value":"1768-322X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}