{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:05:47Z","timestamp":1792371947930,"version":"4.4.0"},"reference-count":278,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,3,1]]},"abstract":"<jats:p>Venoms are integrated phenotypes that evolved independently in, and are used for predatory and defensive purposes by, a wide phylogenetic range of organisms. The same principles that contribute to the evolutionary success of venoms, contribute to making the study of venoms of great interest in such diverse fields as evolutionary ecology and biotechnology. Evolution is profoundly contingent, and nature also reinvents itself continuosly. Changes in a complex phenotypic trait, such as venom, reflect the influences of prior evolutionary history, chance events, and selection. Reconstructing the natural history of venoms, particularly those of snakes, which will be dealt with in more detail in this review, requires the integration of different levels of knowledge into a meaningful and comprehensive evolutionary framework for separating stochastic changes from adaptive evolution. The application of omics technologies and other disciplines have contributed to a qualitative and quantitative advance in the road map towards this goal. In this review we will make a foray into the world of animal venoms, discuss synergies and complementarities of the different approaches used in their study, and identify current bottlenecks that prevent inferring the evolutionary mechanisms and ecological constraints that molded snake venoms to their present-day variability landscape.<\/jats:p>","DOI":"10.1042\/bcj20160577","type":"journal-article","created":{"date-parts":[[2017,2,20]],"date-time":"2017-02-20T12:05:11Z","timestamp":1487592311000},"page":"611-634","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":188,"title":["Venomics: integrative venom proteomics and beyond"],"prefix":"10.1042","volume":"474","author":[{"given":"Juan J.","family":"Calvete","sequence":"first","affiliation":[{"name":"Structural and Functional Venomics Laboratory, Instituto de Biomedicina de Valencia, CSIC, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"2021112216494533600_BCJ-2016-0577CC1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.genom.9.081307.164356","article-title":"The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms","volume":"10","author":"Fry","year":"2009","journal-title":"Annu. 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Asymmetrical selection on predators and prey may be reduced when prey are dangerous","volume":"49","author":"Brodie","year":"1999","journal-title":"BioScience"},{"key":"2021112216494533600_BCJ-2016-0577CC22","first-page":"1","volume":"1","author":"Van Valen","year":"1973","journal-title":"A new evolutionary law"},{"key":"2021112216494533600_BCJ-2016-0577CC23","doi-asserted-by":"crossref","first-page":"13415","DOI":"10.1073\/pnas.0901224106","article-title":"The evolutionary origins of beneficial alleles during the repeated adaptation of garter snakes to deadly prey","volume":"106","author":"Feldman","year":"2009","journal-title":"Proc. Natl Acad. Sci. 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J."},{"key":"2021112216494533600_BCJ-2016-0577CC40","first-page":"447","volume-title":"Treatise on the Venom of the Viper, on the American Poisons, and on the Cherry Laurel, and Some Other Vegetable Poisons","author":"Fontana","year":"1787"},{"key":"2021112216494533600_BCJ-2016-0577CC41","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s00239-003-2573-8","article-title":"Cobra (Naja spp.) nicotinc acetylcholine receptor exhibits resistance to erabu sea snake (Laticauda semifasciata) short-chain \u03b1-neurotoxin","volume":"58","author":"Takacs","year":"2004","journal-title":"J. Mol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC42","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1093\/icb\/ics043","article-title":"The integrated phenotype","volume":"52","author":"Murren","year":"2012","journal-title":"Integr. Comp. 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Genet."},{"key":"2021112216494533600_BCJ-2016-0577CC47","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1007\/s00239-003-2461-2","article-title":"Molecular evolution and phylogeny of elapid snake venom three-finger toxins","volume":"57","author":"Fry","year":"2003","journal-title":"J. Mol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2012.01.009","article-title":"Venom evolution through gene duplications","volume":"496","author":"Wong","year":"2012","journal-title":"Gene"},{"key":"2021112216494533600_BCJ-2016-0577CC49","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tree.2012.10.020","article-title":"Complex cocktails: the evolutionary novelty of venoms","volume":"28","author":"Casewell","year":"2013","journal-title":"Trends Ecol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC50","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/molbev\/mss068","article-title":"Extensive and continuous duplication facilitates rapid evolution and diversification of gene families","volume":"29","author":"Chang","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC51","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.genet.38.072902.092831","article-title":"Duplication and divergence: the evolution of new genes and old ideas","volume":"38","author":"Taylor","year":"2004","journal-title":"Annu. Rev. Genet."},{"key":"2021112216494533600_BCJ-2016-0577CC52","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-86659-3","volume-title":"Evolution by Gene Duplication","author":"Ohno","year":"1970"},{"key":"2021112216494533600_BCJ-2016-0577CC53","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0169-5347(03)00033-8","article-title":"Evolution by gene duplication: an update","volume":"18","author":"Zhang","year":"2003","journal-title":"Trends Ecol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC54","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.cellbio.18.020402.140619","article-title":"Gene co-option in physiological and morphological evolution","volume":"18","author":"True","year":"2002","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2021112216494533600_BCJ-2016-0577CC55","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrg2487","article-title":"RNA-based gene duplication: mechanistic and evolutionary insights","volume":"10","author":"Kaessmann","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"2021112216494533600_BCJ-2016-0577CC56","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1073\/pnas.0511307103","article-title":"Evolutionary fate of retroposed gene copies in the human genome","volume":"103","author":"Vinckenbosch","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021112216494533600_BCJ-2016-0577CC57","doi-asserted-by":"crossref","first-page":"20651","DOI":"10.1073\/pnas.1314702110","article-title":"The king cobra genome reveals dynamic gene evolution and adaptation in the snake venom system","volume":"110","author":"Vonk","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021112216494533600_BCJ-2016-0577CC58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2045-3701-4-1","article-title":"The Mesobuthus martensii genome reveals the molecular diversity of scorpion toxins","volume":"4","author":"Ma","year":"2014","journal-title":"Cell Biosci."},{"key":"2021112216494533600_BCJ-2016-0577CC59","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/molbev\/msr180","article-title":"A limited role for gene duplications in the evolution of platypus venom","volume":"29","author":"Wong","year":"2012","journal-title":"Mol. Biol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC60","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/gbe\/evv253","article-title":"Effects of gene duplication, positive selection, and shifts in gene expression on the evolution of the venom gland transcriptome in widow spiders","volume":"8","author":"Haney","year":"2016","journal-title":"Genome Biol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC61","doi-asserted-by":"crossref","first-page":"E216","DOI":"10.3390\/toxins8070216","article-title":"Insights into the evolution of a snake venom multi-gene family from the genomic organization of Echis ocellatus SVMP genes","volume":"8","author":"Sanz","year":"2016","journal-title":"Toxins"},{"key":"2021112216494533600_BCJ-2016-0577CC62","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1101\/gr.7149808","article-title":"Defensins and the convergent evolution of platypus and reptile venom genes","volume":"18","author":"Whittington","year":"2008","journal-title":"Genome Res."},{"key":"2021112216494533600_BCJ-2016-0577CC63","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s00018-015-1844-z","article-title":"Privileged frameworks from snake venom","volume":"72","author":"Reeks","year":"2015","journal-title":"Cell. Mol. Life. Sci."},{"key":"2021112216494533600_BCJ-2016-0577CC64","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.str.2015.05.003","article-title":"Weaponization of a hormone: convergent recruitment of hyperglycemic hormone into the venom of arthropod predators","volume":"23","author":"Undheim","year":"2015","journal-title":"Structure"},{"key":"2021112216494533600_BCJ-2016-0577CC65","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1101\/gr.3228405","article-title":"From genome to \u2018venome\u2019: molecular origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences and related body proteins","volume":"15","author":"Fry","year":"2005","journal-title":"Genome Res."},{"key":"2021112216494533600_BCJ-2016-0577CC66","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jmb.2006.03.017","article-title":"Structural classification of small, disulfide-rich protein domains","volume":"359","author":"Cheek","year":"2006","journal-title":"J. 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Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC102","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.toxicon.2013.03.020","article-title":"Snake venomics: from the inventory of toxins to biology","volume":"75","author":"Calvete","year":"2013","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC103","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1534\/genetics.114.172437","article-title":"Contrasting modes and tempos of venom expression evolution in two snake species","volume":"199","author":"Margres","year":"2015","journal-title":"Genetics"},{"key":"2021112216494533600_BCJ-2016-0577CC104","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.toxicon.2015.02.015","article-title":"The transcriptomic and proteomic basis for the evolution of a novel venom phenotype within the timber rattlesnake (Crotalus horridus)","volume":"98","author":"Rokyta","year":"2015","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.toxicon.2016.05.005","article-title":"Functional characterizations of venom phenotypes in the eastern diamondback rattlesnake (Crotalus adamanteus) and evidence for expression-driven divergence in toxic activities among populations","volume":"119","author":"Margres","year":"2016","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC106","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1086\/282379","article-title":"Morphological variation and width of ecological niche","volume":"99","author":"Van Valen","year":"1965","journal-title":"Am. 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Ecol."},{"key":"2021112216494533600_BCJ-2016-0577CC113","doi-asserted-by":"crossref","first-page":"29030","DOI":"10.1074\/jbc.M605850200","article-title":"Denmotoxin, a three-finger toxin from the colubrid snake Boiga dendrophila (Mangrove catsnake) with bird-specific activity","volume":"281","author":"Pawlak","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2021112216494533600_BCJ-2016-0577CC114","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1096\/fj.08-113555","article-title":"Irditoxin, a novel covalently linked heterodimeric three-finger toxin with high taxon-specific neurotoxicity","volume":"23","author":"Pawlak","year":"2008","journal-title":"FASEB J."},{"key":"2021112216494533600_BCJ-2016-0577CC115","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.biochi.2013.06.025","article-title":"Identification and characterization of a taxon-specific three-finger toxin from the venom of the green vinesnake (Oxybelis fulgidus, family colubridae)","volume":"95","author":"Heyborne,","year":"2013","journal-title":"Biochimie"},{"key":"2021112216494533600_BCJ-2016-0577CC116","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.toxicon.2013.10.005","article-title":"Biochemical characterization of the venom of the coral snake micrurus tener and comparative biological activities in the mouse and a reptile model","volume":"77","author":"B\u00e9nard-Valle","year":"2014","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC117","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1093\/icb\/icw110","article-title":"Understanding biological roles of venoms among the caenophidia: the importance of rear-fanged snakes","volume":"56","author":"Mackessy","year":"2016","journal-title":"Integr. 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Herpetol."},{"key":"2021112216494533600_BCJ-2016-0577CC128","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/azo.12031","article-title":"Morphological adaptations to arboreal habitats and heart position in species of the neotropical whipsnakes genus chironius","volume":"95","author":"Guimar\u00e2es","year":"2014","journal-title":"Acta Zoologica (Stockholm)"},{"key":"2021112216494533600_BCJ-2016-0577CC129","first-page":"107","volume-title":"Biology of the Pitvipers","author":"Green","year":"1992"},{"key":"2021112216494533600_BCJ-2016-0577CC130","first-page":"365","volume-title":"Snakes: the Evolution of Mystery in Nature","author":"Green","year":"2000"},{"key":"2021112216494533600_BCJ-2016-0577CC131","first-page":"307","volume-title":"Biology of the Vipers","author":"Martins","year":"2002"},{"key":"2021112216494533600_BCJ-2016-0577CC132","first-page":"32","article-title":"Notes on the use of caudal lures by arboreal green pitvipers","volume":"28","author":"Green","year":"1972","journal-title":"Herpetologica"},{"key":"2021112216494533600_BCJ-2016-0577CC133","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0041-0101(00)00162-8","article-title":"Twenty years of dendrotoxins","volume":"39","author":"Harvey","year":"2001","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC134","first-page":"232","article-title":"Fasciculins, anticholinesterase toxins from the venom of the green mamba dendroaspis angusticeps","volume":"79","author":"Karlsson","year":"1984","journal-title":"J. Physiol."},{"key":"2021112216494533600_BCJ-2016-0577CC135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1254\/jphs.94.1","article-title":"Three-finger \u03b1-neurotoxins and the nicotinic acetylcholine receptor, forty years on","volume":"94","author":"Nirthanan","year":"2004","journal-title":"J. Pharmacol. Sci."},{"key":"2021112216494533600_BCJ-2016-0577CC136","first-page":"318","volume-title":"Venomous Reptiles and Their Toxins: Evolution, Pathophysiology and Biodiscovery","author":"Fry","year":"2015"},{"key":"2021112216494533600_BCJ-2016-0577CC137","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.2307\/1383163","article-title":"Optimal foraging and risk of predation: effects on behavior and social structure in ungulates","volume":"80","author":"Kie","year":"1999","journal-title":"J. Mammalogy"},{"key":"2021112216494533600_BCJ-2016-0577CC138","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/j.1420-9101.2006.01126.x","article-title":"Morphological integration and adaptation in the snake feeding system: a comparative phylogenetic study","volume":"19","author":"Vincent","year":"2006","journal-title":"J. Evol. Biol."},{"key":"2021112216494533600_BCJ-2016-0577CC139","first-page":"302","volume-title":"Snakes: Ecology and Evolutionary Biology","author":"Mushinsky","year":"1987"},{"key":"2021112216494533600_BCJ-2016-0577CC140","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1655\/HERPETOLOGICA-D-11-00008.1","article-title":"Diet and feeding ecology of the red diamond rattlesnake","volume":"68","author":"Dugan","year":"2012","journal-title":"Herpetologica"},{"key":"2021112216494533600_BCJ-2016-0577CC141","first-page":"87","volume-title":"Snakes: Ecology and Behavior","author":"Arnold","year":"1993"},{"key":"2021112216494533600_BCJ-2016-0577CC142","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/jmor.20305","article-title":"Induction of phenotypic plasticity in rattlesnake trophic morphology by diet manipulation","volume":"275","author":"Smith","year":"2014","journal-title":"J. Morphol."},{"key":"2021112216494533600_BCJ-2016-0577CC143","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1439-0310.1976.tb00473.x","article-title":"Scale overlap, a directional sign stimulus for prey ingestion by ophiophagous snakes","volume":"41","author":"Greene","year":"1976","journal-title":"J. Comp. Ethology"},{"key":"2021112216494533600_BCJ-2016-0577CC144","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1139\/z06-073","article-title":"Is headfirst ingestion essential in gape-limited predators? Prey-handling behavior of the anurophagous Snake Rhabdophis tigrinus (Colubridae)","volume":"84","author":"Mori","year":"2006","journal-title":"Can. J. Zool."},{"key":"2021112216494533600_BCJ-2016-0577CC145","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev.es.02.110171.002101","article-title":"Theory of feeding strategies","volume":"2","author":"Schoener","year":"1971","journal-title":"Annu. Rev. Ecol. Syst."},{"key":"2021112216494533600_BCJ-2016-0577CC146","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev.es.16.110185.001413","article-title":"Predation, competition, and prey communities: a review of field experiments","volume":"16","author":"Sih","year":"1985","journal-title":"Annu. Rev. Ecol. Syst."},{"key":"2021112216494533600_BCJ-2016-0577CC147","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1086\/physzool.69.3.30164211","article-title":"Ontogenetic limits on locomotor performance","volume":"69","author":"Carrier","year":"1996","journal-title":"Physiol. Zool."},{"key":"2021112216494533600_BCJ-2016-0577CC148","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1469-7998.2005.00014.x","article-title":"Do juvenile gape-limited predators compensate for their small size when feeding?","volume":"268","author":"Vincent","year":"2006","journal-title":"J. Zool."},{"key":"2021112216494533600_BCJ-2016-0577CC149","first-page":"200","article-title":"Relationship of venom ontogeny and diet in bothrops","volume":"55","author":"Andrade","year":"1999","journal-title":"Herpetologica"},{"key":"2021112216494533600_BCJ-2016-0577CC150","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.toxicon.2006.01.007","article-title":"Venom of the brown treesnake, Boiga irregularis: ontogenetic shifts and taxa-specific toxicity","volume":"47","author":"Mackessy","year":"2006","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC151","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1021\/pr901027r","article-title":"Analysis of the ontogenetic variation in the venom proteome\/peptidome of Bothrops jararaca reveals different strategies to deal with prey","volume":"9","author":"Zelanis","year":"2010","journal-title":"J. Proteome Res."},{"key":"2021112216494533600_BCJ-2016-0577CC152","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1643\/HA03-037.1","article-title":"Ontogenetic variation in venom composition and diet of Crotalus oreganus concolor: a case of venom paedomorphosis?","volume":"2003","author":"Mackessy","year":"2003","journal-title":"Copeia"},{"key":"2021112216494533600_BCJ-2016-0577CC153","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jprot.2009.07.013","article-title":"Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Per\u00fa and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism","volume":"73","author":"N\u00fa\u00f1ez","year":"2009","journal-title":"J. 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Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC155","first-page":"495","volume-title":"The Biology of Rattlesnakes","author":"Mackessy","year":"2008"},{"key":"2021112216494533600_BCJ-2016-0577CC156","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.toxicon.2010.02.028","article-title":"Evolutionary trends in venom composition in the western rattlesnakes (Crotalus viridis sensu lato): toxicity vs tenderizers","volume":"55","author":"Mackessy","year":"2010","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC157","first-page":"629","article-title":"Proteomics in venom research: a focus on PLA2 molecules","volume":"58","author":"Calvete","year":"2011","journal-title":"Acta. Chim. Slov."},{"key":"2021112216494533600_BCJ-2016-0577CC158","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/0041-0101(91)90201-2","article-title":"Biochemical and pharmacological similarities between the venoms of newborn Crotalus durissus durissus and adult Crotalus durissus terrificus rattlesnakes","volume":"29","author":"Guti\u00e9rrez","year":"1991","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC159","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1670\/103-03N","article-title":"A quantitative analysis of the ancestral area of rattlesnakes","volume":"38","author":"Place","year":"2004","journal-title":"J. Herpetol."},{"key":"2021112216494533600_BCJ-2016-0577CC160","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1111\/j.1365-294X.2006.03007.x","article-title":"Evolution of rattlesnakes (Viperidae, crotalus) in the warm deserts of western North America shaped by neogene vicariance and quaternary climate change","volume":"15","author":"Douglas","year":"2006","journal-title":"Mol. Ecol."},{"key":"2021112216494533600_BCJ-2016-0577CC161","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/j.1365-294X.2005.02471.x","article-title":"Tracing an invasion: landbridges, refugia and the phylogeography of the neotropical rattlesnake (Serpentes: Viperidae: Crotalus durissus)","volume":"14","author":"W\u00fcster","year":"2005","journal-title":"Mol. Ecol."},{"key":"2021112216494533600_BCJ-2016-0577CC162","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/1471-2164-14-234","article-title":"Integrated \u2018omics\u2019 profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus","volume":"14","author":"Durban","year":"2013","journal-title":"BMC Genomics"},{"key":"2021112216494533600_BCJ-2016-0577CC163","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1021\/pr9008749","article-title":"Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along crotalus dispersal in South America","volume":"9","author":"Calvete","year":"2010","journal-title":"J. Proteome Res."},{"key":"2021112216494533600_BCJ-2016-0577CC164","first-page":"511","volume-title":"The Biology of Rattlesnakes","author":"Werman","year":"2008"},{"key":"2021112216494533600_BCJ-2016-0577CC165","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.cub.2016.07.038","article-title":"The deep origin and recent loss of venom toxin genes in rattlesnakes","volume":"26","author":"Dowell","year":"2016","journal-title":"Curr. Biol."},{"key":"2021112216494533600_BCJ-2016-0577CC166","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ympev.2008.08.019","article-title":"A nesting of vipers: phylogeny and historical biogeography of the viperidae (Squamata: Serpentes)","volume":"49","author":"W\u00fcster","year":"2008","journal-title":"Mol. Phylogenet. Evol"},{"key":"2021112216494533600_BCJ-2016-0577CC167","doi-asserted-by":"crossref","first-page":"R849","DOI":"10.1016\/j.cub.2016.07.082","article-title":"Venom evolution: gene loss shapes phenotypic adaptation","volume":"26","author":"Casewell","year":"2016","journal-title":"Curr. Biol."},{"key":"2021112216494533600_BCJ-2016-0577CC168","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1420-9101.2011.02426.x","article-title":"Niche divergence and lineage diversification among closely related sistrurus rattlesnakes","volume":"25","author":"Wooten","year":"2012","journal-title":"J. Evol. Biol."},{"key":"2021112216494533600_BCJ-2016-0577CC169","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1016\/j.jprot.2012.02.035","article-title":"Venom variability and envenoming severity outcomes of the Crotalus scutulatus scutulatus (Mojave rattlesnake) from southern Arizona","volume":"75","author":"Massey","year":"2012","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC170","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1107\/S0907444913018003","article-title":"Structure of the polypeptide crotamine from the Brazilian rattlesnake Crotalus durissus terrificus","volume":"69","author":"Coronado","year":"2013","journal-title":"Acta Crystallogr. D Biol Crystallogr."},{"key":"2021112216494533600_BCJ-2016-0577CC171","first-page":"365","article-title":"Estudos sobre venenos de serpentes brasileiras. II. Crotalus terrificus crotaminicus, subespecie biologica","volume":"28","author":"Gon\u00e7alves","year":"1956","journal-title":"Ann. Acad. Bras. Cienc."},{"key":"2021112216494533600_BCJ-2016-0577CC172","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1126\/science.129.3359.1361","article-title":"Geographical pattern of crotamine distribution in the same rattlesnake subspecies","volume":"129","author":"Schenberg","year":"1959","journal-title":"Science"},{"key":"2021112216494533600_BCJ-2016-0577CC173","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.gene.2009.05.015","article-title":"Intraspecific variation of the crotamine and crotasin genes in Crotalus durissus rattlesnakes","volume":"446","author":"Oguiura","year":"2009","journal-title":"Gene"},{"key":"2021112216494533600_BCJ-2016-0577CC174","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/0041-0101(88)90248-6","article-title":"Detection of myotoxin A-like proteins in various snake venoms","volume":"26","author":"Bober","year":"1988","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC175","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/j.jprot.2010.06.001","article-title":"Snake venomics and antivenomics of Crotalus durissus subspecies from Brazil: assessment of geographic variation and its implication on snakebite management","volume":"73","author":"Boldrini-Fran\u00e7a","year":"2010","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC176","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jprot.2015.03.015","article-title":"Comparative venomics of the prairie rattlesnake (Crotalus viridis viridis) from Colorado: identification of a novel pattern of ontogenetic changes in venom composition and assessment of the immunoreactivity of the commercial antivenom croFab\u00ae","volume":"121","author":"Saviola","year":"2015","journal-title":"J. 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Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC181","doi-asserted-by":"crossref","first-page":"4091","DOI":"10.1016\/j.jprot.2012.05.026","article-title":"Snake venomics of two poorly known hydrophiinae: comparative proteomics of the venoms of terrestrial Toxicocalamus longissimus and marine Hydrophis cyanocinctus","volume":"75","author":"Calvete","year":"2012","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC182","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1186\/1471-2148-7-175","article-title":"Expression pattern of three-finger toxin and phospholipase A2 genes in the venom glands of two sea snakes, Lapemis curtus and Acalyptophis peronii: comparison of evolution of these toxins in land snakes, sea kraits and sea snakes","volume":"7","author":"Pahari","year":"2007","journal-title":"BMC Evol. Biol."},{"key":"2021112216494533600_BCJ-2016-0577CC183","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.ympev.2007.11.013","article-title":"Molecular evidence for a rapid late-Miocene radiation of Australasian venomous snakes","volume":"46","author":"Sanders","year":"2008","journal-title":"Mol. Phylogenet. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC184","doi-asserted-by":"crossref","first-page":"150277","DOI":"10.1098\/rsos.150277","article-title":"Diversification rates and phenotypic evolution in venomous snakes (Elapidae)","volume":"3","author":"Lee","year":"2016","journal-title":"R. Soc. Open Sci."},{"key":"2021112216494533600_BCJ-2016-0577CC185","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ympev.2012.09.021","article-title":"Multilocus phylogeny and recent rapid radiation of the viviparous sea snakes (Elapidae: Hydrophiinae)","volume":"66","author":"Sanders","year":"2013","journal-title":"Mol. Phylogenet. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC186","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.toxicon.2016.09.008","article-title":"Venoms of micrurus coral snakes: evolutionary trends in compositional patterns emerging from proteomic analyses","volume":"122","author":"Lomonte","year":"2016","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC187","doi-asserted-by":"crossref","first-page":"R73","DOI":"10.1016\/j.cub.2015.11.023","article-title":"Balancing selection: walking a tightrope","volume":"26","author":"Gloss","year":"2016","journal-title":"Curr. Biol."},{"key":"2021112216494533600_BCJ-2016-0577CC188","volume-title":"Emergent Evolution","author":"Morgan","year":"1923"},{"key":"2021112216494533600_BCJ-2016-0577CC189","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1525\/9780520328389-009","volume-title":"The Galapagos: Proceedings of the Symposia of the Galapagos International Scientific Project","author":"Bartholomew","year":"1966"},{"key":"2021112216494533600_BCJ-2016-0577CC190","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2307\/4444260","article-title":"Nothing in biology makes sense except in the light of evolution","volume":"35","author":"Dobzhansky","year":"1973","journal-title":"Am. Biol. Teach."},{"key":"2021112216494533600_BCJ-2016-0577CC191","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.toxicon.2014.10.020","article-title":"Toxins and drug discovery","volume":"92","author":"Harvey","year":"2014","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC192","doi-asserted-by":"crossref","DOI":"10.1039\/9781849737876","volume-title":"Venoms to Drugs: Venom as A Source for the Development of Human Therapeutics","author":"King","year":"2015"},{"key":"2021112216494533600_BCJ-2016-0577CC193","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/1471-2164-13-312","article-title":"The venom-gland transcriptome of the eastern diamondback rattlesnake (Crotalus adamanteus)","volume":"13","author":"Rokyta","year":"2012","journal-title":"BMC Genomics"},{"key":"2021112216494533600_BCJ-2016-0577CC194","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/1471-2164-14-394","article-title":"The genesis of an exceptionally lethal venom in the timber rattlesnake (Crotalus horridus) revealed through comparative venom-gland transcriptomics","volume":"14","author":"Rokyta","year":"2013","journal-title":"BMC Genomics"},{"key":"2021112216494533600_BCJ-2016-0577CC195","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/1471-2164-14-531","article-title":"The venom-gland transcriptome of the eastern coral Snake (Micrurus fulvius) reveals high venom complexity in the intragenomic evolution of venoms","volume":"14","author":"Margres","year":"2013","journal-title":"BMC Genomics"},{"key":"2021112216494533600_BCJ-2016-0577CC196","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxicon.2014.10.022","article-title":"Venom gland transcriptomics for identifying, cataloging, and characterizing venom proteins in snakes","volume":"93","author":"Brahma","year":"2015","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC197","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1586\/14789450.2014.900447","article-title":"Next-generation snake venomics: protein-locus resolution through venom proteome decomplexation","volume":"11","author":"Calvete","year":"2014","journal-title":"Expert Rev. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC198","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1586\/14789450.2015.1073590","article-title":"Constructing comprehensive venom proteome reference maps for integrative venomics","volume":"12","author":"Eichberg","year":"2015","journal-title":"Expert Rev. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC199","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1021\/acs.jproteome.5b00305","article-title":"Venom proteomics of Indonesian king cobra, Ophiophagus hannah: integrating top-down and bottom-up approaches","volume":"14","author":"Petras","year":"2015","journal-title":"J. Proteome Res."},{"key":"2021112216494533600_BCJ-2016-0577CC200","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1074\/mcp.M115.056523","article-title":"Mapping proteoforms and protein complexes from king cobra venom using both denaturing and native top-down proteomics","volume":"15","author":"Melani","year":"2016","journal-title":"Mol. Cell. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC201","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jprot.2016.06.018","article-title":"Top-down venomics of the east african Green mamba, Dendroaspis angusticeps, and the black mamba, Dendroaspis polylepis, highlight the complexity of their toxin arsenals","volume":"146","author":"Petras","year":"2016","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC202","doi-asserted-by":"crossref","first-page":"9699","DOI":"10.1021\/acs.analchem.6b02585","article-title":"Elemental mass spectrometry for absolute intact protein quantification without protein-Specific standards: application to snake venomics","volume":"88","author":"Calder\u00f3n-Celis","year":"2016","journal-title":"Anal. Chem."},{"key":"2021112216494533600_BCJ-2016-0577CC203","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.jprot.2008.10.003","article-title":"Combined snake venomics and venom gland transcriptomic analysis of the ocellated carpet viper, Echis ocellatus","volume":"71","author":"Wagstaff","year":"2009","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC204","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1186\/1471-2164-14-790","article-title":"Quantitative high-throughput profiling of snake venom gland transcriptomes and proteomes (Ovophis okinavensis and Protobothrops flavoviridis)","volume":"14","author":"Aird","year":"2013","journal-title":"BMC Genomics"},{"key":"2021112216494533600_BCJ-2016-0577CC205","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jprot.2013.11.001","article-title":"Linking the transcriptome and proteome to characterize the venom of the eastern diamondback rattlesnake (Crotalus adamanteus)","volume":"96","author":"Margres","year":"2014","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC206","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jprot.2014.07.019","article-title":"Combined venom gland cDNA sequencing and venomics of the New Guinea small-eyed snake, micropechis ikaheka","volume":"110","author":"Pa\u00efva","year":"2014","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC207","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1186\/s12864-015-1832-6","article-title":"Snake venoms are integrated systems, but abundant venom proteins evolve more rapidly","volume":"16","author":"Aird","year":"2015","journal-title":"BMC Genomics"},{"key":"2021112216494533600_BCJ-2016-0577CC208","doi-asserted-by":"crossref","first-page":"9205","DOI":"10.1073\/pnas.1405484111","article-title":"Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms","volume":"111","author":"Casewell","year":"2014","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021112216494533600_BCJ-2016-0577CC209","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1093\/molbev\/msv050","article-title":"Evolution of an ancient venom: recognition of a novel family of cnidarian toxins and the common evolutionary origin of sodium and potassium neurotoxins in sea anemone","volume":"32","author":"Jouiaei","year":"2015","journal-title":"Mol. Biol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC210","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.toxicon.2015.10.024","article-title":"A bright future for integrative venomics","volume":"107","author":"Calvete","year":"2015","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC211","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jprot.2016.01.020","article-title":"Ecological proteomics: is the field ripe for integrating proteomics into evolutionary ecology research?","volume":"135","author":"Diz","year":"2016","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC212","first-page":"1","article-title":"The challenge of integrating proximate and ultimate causes to reconstruct the natural histories of venoms: the evolutionary link","volume":"8","author":"Calvete","year":"2016","journal-title":"Expert Rev. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC213","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3390\/toxins8090263","article-title":"A tricky trait: applying the fruits of the \u201cfunction debate\u201d in the philosophy of biology to the \"venom debate\" in the science of toxinology","volume":"8","author":"Jackson","year":"2016","journal-title":"Toxins"},{"key":"2021112216494533600_BCJ-2016-0577CC214","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jprot.2015.09.015","article-title":"Ecological venomics: how genomics, transcriptomics and proteomics can shed new light on the ecology and evolution of venom","volume":"135","author":"Sunagar","year":"2016","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC215","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.jprot.2011.05.027","article-title":"Ending the drought: new strategies for improving the flow of affordable, effective antivenoms in Asia and Africa","volume":"74","author":"Williams","year":"2011","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC216","first-page":"38","article-title":"New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India","volume":"138","author":"Warrell","year":"2013","journal-title":"Indian J. Med. Res."},{"key":"2021112216494533600_BCJ-2016-0577CC217","doi-asserted-by":"crossref","first-page":"h5378","DOI":"10.1136\/bmj.h5378","article-title":"Snake bite: a global failure to act costs thousands of lives each year","volume":"351","author":"Williams","year":"2015","journal-title":"BMJ"},{"key":"2021112216494533600_BCJ-2016-0577CC218","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/537026a","article-title":"Vipers, mambas and taipans: the escalating health crisis over snakebites","volume":"537","author":"Arnold","year":"2016","journal-title":"Nature"},{"key":"2021112216494533600_BCJ-2016-0577CC219","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/molbev\/msh091","article-title":"Assembling an arsenal: origin and evolution of the snake venom proteome inferred from phylogenetic analysis of toxin sequences","volume":"21","author":"Fry","year":"2004","journal-title":"Mol. Biol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC220","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nature04328","article-title":"Early evolution of the venom system in lizards and snakes","volume":"439","author":"Fry","year":"2006","journal-title":"Nature"},{"key":"2021112216494533600_BCJ-2016-0577CC221","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.toxicon.2012.02.013","article-title":"The structural and functional diversification of the toxicofera reptile venom system","volume":"60","author":"Fry","year":"2012","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC222","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12862-015-0358-5","article-title":"The origin of snakes: revealing the ecology, behavior, and evolutionary history of early snakes using genomics, phenomics, and the fossil record","volume":"15","author":"Hsiang","year":"2015","journal-title":"BMC Evol. Biol."},{"key":"2021112216494533600_BCJ-2016-0577CC223","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1558-5646.2011.01437.x","article-title":"Extinction, ecological opportunity, and the origins of global Snake diversity","volume":"66","author":"Pyron","year":"2012","journal-title":"Evolution"},{"key":"2021112216494533600_BCJ-2016-0577CC224","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1126\/science.aaa9208","article-title":"Evolution. A four-legged snake from the early Cretaceous of Gondwana","volume":"349","author":"Martill","year":"2015","journal-title":"Science"},{"key":"2021112216494533600_BCJ-2016-0577CC225","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1093\/gbe\/evu166","article-title":"Restriction and recruitment-gene duplication and the origin and evolution of snake venom toxins","volume":"6","author":"Hargreaves","year":"2014","journal-title":"Genome Biol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC226","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/molbev\/msu294","article-title":"Expression of venom gene homologs in diverse python tissues suggests a new model for the evolution of snake venom","volume":"32","author":"Reyes-Velasco","year":"2015","journal-title":"Mol. Biol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC227","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/1471-2148-13-93","article-title":"A phylogeny and revised classification of squamata, including 4161 species of lizards and snakes","volume":"13","author":"Pyron","year":"2013","journal-title":"BMC Evol. 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Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC238","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/284325","article-title":"Phylogenies and the comparative method","volume":"125","author":"Felsenstein","year":"1985","journal-title":"Am. Nat."},{"key":"2021112216494533600_BCJ-2016-0577CC239","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1073\/pnas.94.15.7799","article-title":"Evolution by the birth-and-death process in multigene families of the vertebrate immune system","volume":"94","author":"Nei","year":"1997","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021112216494533600_BCJ-2016-0577CC240","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1093\/molbev\/msi242","article-title":"Selectionism and neutralism in molecular evolution","volume":"22","author":"Nei","year":"2005","journal-title":"Mol. Biol. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC241","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2148-7-2","article-title":"Inventing an arsenal: adaptive evolution and neofunctionalization of snake venom phospholipase A2 genes","volume":"7","author":"Lynch","year":"2007","journal-title":"BMC Evol. Biol."},{"key":"2021112216494533600_BCJ-2016-0577CC242","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2307\/1564018","article-title":"Venoms and morphology of western diamondback\/Mojave rattlesnake hybrids","volume":"23","author":"Aird","year":"1989","journal-title":"J. Herpetol."},{"key":"2021112216494533600_BCJ-2016-0577CC243","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0041-0101(09)80008-1","article-title":"Venom characteristics as an indicator of hybridisation between Crotalus viridis viridis and Crotalus scutulatus scutulatus in New Mexico","volume":"28","author":"Glenn","year":"1990","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC244","doi-asserted-by":"crossref","first-page":"e1194","DOI":"10.1371\/journal.pone.0001194","article-title":"Reappraisal of Vipera aspis venom neurotoxicity","volume":"2","author":"Ferquel","year":"2007","journal-title":"PLoS ONE."},{"key":"2021112216494533600_BCJ-2016-0577CC245","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/mec.12671","article-title":"Hybridization at an ecotone: ecological and genetic barriers between three iberian vipers","volume":"23","author":"Tarroso","year":"2014","journal-title":"Mol. Ecol."},{"key":"2021112216494533600_BCJ-2016-0577CC246","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.cub.2016.04.056","article-title":"Historical contingency in a multigene family facilitates adaptive evolution of toxin resistance","volume":"26","author":"McGlothlin","year":"2016","journal-title":"Curr. Biol."},{"key":"2021112216494533600_BCJ-2016-0577CC247","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511535499","volume-title":"Life's Solution","author":"Morris","year":"2003"},{"key":"2021112216494533600_BCJ-2016-0577CC248","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1021\/pr800332p","article-title":"Snake venomics of the lancehead pitviper Bothrops asper: geographic, individual, and ontogenetic variations","volume":"7","author":"Alape-Gir\u00f3n","year":"2008","journal-title":"J. Proteome Res."},{"key":"2021112216494533600_BCJ-2016-0577CC249","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jprot.2012.09.003","article-title":"Snake venomics across genus lachesis. Ontogenetic changes in the venom composition of Lachesis stenophrys and comparative proteomics of the venoms of adult Lachesis melanocephala and Lachesis acrochorda","volume":"77","author":"Madrigal","year":"2012","journal-title":"J. Proteomics"},{"key":"2021112216494533600_BCJ-2016-0577CC250","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jprot.2013.05.028","article-title":"Snake venomics of Lachesis muta rhombeata and genus-wide antivenomics assessment of the paraspecific immunoreactivity of two antivenoms evidence the high compositional and immunological conservation across Lachesis","volume":"89","author":"Pla","year":"2013","journal-title":"J. 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Proteome Res."},{"key":"2021112216494533600_BCJ-2016-0577CC253","first-page":"93","volume-title":"Biology of the Vipers","author":"Parkinson","year":"2002"},{"key":"2021112216494533600_BCJ-2016-0577CC254","first-page":"51","volume-title":"Biology of the Vipers","author":"Gutberlet","year":"2002"},{"key":"2021112216494533600_BCJ-2016-0577CC255","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ympev.2005.12.014","article-title":"Bayesian mixed models and the phylogeny of pit vipers (Viperidae: Serpentes)","volume":"39","author":"Castoe","year":"2006","journal-title":"Mol. Phylogenet. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC256","first-page":"601","volume-title":"Snakes of the Agkistrodon Complex: A Monographic Review","author":"Van Devender","year":"1990"},{"key":"2021112216494533600_BCJ-2016-0577CC257","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1365-2699.2008.01991.x","article-title":"Comparative phylogeography of pit vipers suggests a consensus of ancient middle American highland biogeography","volume":"36","author":"Castoe","year":"2009","journal-title":"J. Biogeograph."},{"key":"2021112216494533600_BCJ-2016-0577CC258","first-page":"634","volume-title":"The Venomous Reptiles of the Western Hemisphere","author":"Gutberlet","year":"2004"},{"key":"2021112216494533600_BCJ-2016-0577CC259","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1046\/j.1365-294x.2000.00854.x","article-title":"Phylogeography of the pit viper clade Agkistrodon: historical ecology, species status, and conservation of cantils","volume":"9","author":"Parkinson","year":"2000","journal-title":"Mol. Ecol."},{"key":"2021112216494533600_BCJ-2016-0577CC260","first-page":"49","volume-title":"Biology of the Pit Vipers","author":"Knight","year":"1992"},{"key":"2021112216494533600_BCJ-2016-0577CC261","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ympev.2004.02.008","article-title":"A phylogeny of four mitochondrial gene regions suggests a revised taxonomy for Asian pit vipers (Trimeresurus and ovophis)","volume":"32","author":"Malhotra","year":"2004","journal-title":"Mol. Phylogenet. Evol."},{"key":"2021112216494533600_BCJ-2016-0577CC262","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.toxicon.2014.07.012","article-title":"Proteomic and toxicological profiling of the venom of Bothrocophias campbelli, a pitviper species from Ecuador and Colombia","volume":"90","author":"Salazar-Valenzuela","year":"2014","journal-title":"Toxicon"},{"key":"2021112216494533600_BCJ-2016-0577CC263","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jprot.2013.11.005","article-title":"Proteomic and functional profiling of the venom of Bothrops ayerbei from Cauca, Colombia, reveals striking interspecific variation with bothrops asper venom","volume":"96","author":"Mora-Obando","year":"2014","journal-title":"J. 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Trop."},{"key":"2021112216494533600_BCJ-2016-0577CC268","volume-title":"Handbook of Toxinology: Venom Genomics and Proteomics","author":"Shaney","year":"2014"},{"key":"2021112216494533600_BCJ-2016-0577CC269","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1146\/annurev-animal-090414-014900","article-title":"The genome 10 K project and the state of vertebrate genomics: a way forward","volume":"3","author":"Koepfli","year":"2015","journal-title":"Ann. Rev. Anim. Biosci"},{"key":"2021112216494533600_BCJ-2016-0577CC270","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1146\/annurev.es.18.110187.002421","article-title":"Intraspecific phylogeography: the mitochondrial DNA bridge between population genetics and systematics","volume":"18","author":"Avise","year":"1987","journal-title":"Ann. Rev. Ecol. 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