{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:20:44Z","timestamp":1773296444348,"version":"3.50.1"},"reference-count":82,"publisher":"Portland Press Ltd.","issue":"24","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,12,15]]},"abstract":"<jats:p>Hearing loss, including noise-induced hearing loss, is highly prevalent and severely hinders an individual's quality of life, yet many of the mechanisms that cause hearing loss are unknown. The pannexin (Panx) channel proteins, Panx1 and Panx3, are regionally expressed in many cell types along the auditory pathway, and mice lacking Panx1 in specific cells of the inner ear exhibit hearing loss, suggesting a vital role for Panxs in hearing. We proposed that Panx1 and\/or Panx3 null mice would exhibit severe hearing loss and increased susceptibility to noise-induced hearing loss. Using the auditory brainstem response, we surprisingly found that Panx1\u2212\/\u2212 and Panx3\u2212\/\u2212 mice did not harbor hearing or cochlear nerve deficits. Furthermore, while Panx1\u2212\/\u2212 mice displayed no protection against loud noise-induced hearing loss, Panx3\u2212\/\u2212 mice exhibited enhanced 16- and 24-kHz hearing recovery 7 days after a loud noise exposure (NE; 12\u2005kHz tone, 115\u2005dB sound pressure level, 1\u2005h). Interestingly, Cx26, Cx30, Cx43, and Panx2 were up-regulated in Panx3\u2212\/\u2212 mice compared with wild-type and\/or Panx1\u2212\/\u2212 mice, and assessment of the auditory tract revealed morphological changes in the middle ear bones of Panx3\u2212\/\u2212 mice. It is unclear if these changes alone are sufficient to provide protection against loud noise-induced hearing loss. Contrary to what we expected, these data suggest that Panx1 and Panx3 are not essential for baseline hearing in mice tested, but the therapeutic targeting of Panx3 may prove protective against mid-high-frequency hearing loss caused by loud NE.<\/jats:p>","DOI":"10.1042\/bcj20160668","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T01:10:36Z","timestamp":1477530636000},"page":"4665-4680","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Differential effects of pannexins on noise-induced hearing loss"],"prefix":"10.1042","volume":"473","author":[{"given":"Julia M.","family":"Abitbol","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Barr","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada"},{"name":"Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley L.","family":"Schormans","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dale W.","family":"Laird","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada"},{"name":"Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian L.","family":"Allman","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, The University of Western Ontario, London, Ontario N6A 5C1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2016,12,9]]},"reference":[{"key":"2021112216325605000_BCJ-2016-0668C1","doi-asserted-by":"publisher","first-page":"367","DOI":"10.2471\/BLT.13.128728","article-title":"The global burden of disabling hearing impairment: a call to action","volume":"92","author":"Olusanya","year":"2014","journal-title":"Bull. 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