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UV absorbance spectroscopy, circular dichroism, \u03b6-potential, dynamic light scattering and steady shear viscosity were all employed to study the influence of oxidative stress on the molecular structure, the surface charges, and the size and shape of fibrinogen molecules. The fibrin morphology obtained was imaged and investigated using atomic force microscopy. The results demonstrated that the cross-linking, branching and height distribution of formed fibrin will be influenced by the oxidative stress of fibrinogen. This study presents new insights into the aggregation behaviour of fibrinogen and will be helpful to understand the formation mechanism of thrombosis under oxidative stress.<\/jats:p>","DOI":"10.1042\/bcj20160702","type":"journal-article","created":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T02:40:14Z","timestamp":1475635214000},"page":"4373-4384","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Study on the influence of oxidative stress on the fibrillization of fibrinogen"],"prefix":"10.1042","volume":"473","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Chemistry, Liaocheng University, Liaocheng 252000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianzhi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Liaocheng University, Liaocheng 252000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaisheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Liaocheng University, Liaocheng 252000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Food Nutrition and Safety, Ministry of Education of China, Tianjin University of Science and Technology, Tianjin 300457, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2016,11,25]]},"reference":[{"key":"2021112216332910000_BCJ-2016-0702C1","first-page":"187","article-title":"Oxidants and antioxidants in human fertility","volume":"9","author":"Agarwal","year":"2004","journal-title":"Middle East Fertil. 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