{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T14:22:57Z","timestamp":1782138177181,"version":"3.54.5"},"reference-count":115,"publisher":"Portland Press Ltd.","issue":"16","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,8,15]]},"abstract":"<jats:p>From kinetic data (k, T) we calculated the thermodynamic parameters for various processes (nucleation, elongation, fibrillization, etc.) of proteinaceous diseases that are related to the \u03b2-amyloid protein (Alzheimer's), to tau protein (Alzheimer's, Pick's), to \u03b1-synuclein (Parkinson's), prion, amylin (type II diabetes), and to \u03b1-crystallin (cataract). Our calculations led to \u0394G\u2260 values that vary in the range 92.8\u2013127\u2005kJ\u2005mol\u22121 at 310\u2005K. A value of \u223c10\u201330\u2005kJ\u2005mol\u22121 is the activation energy for the diffusion of reactants, depending on the reaction and the medium. The energy needed for the excitation of O2 from the ground to the first excited state (1\u0394g, singlet oxygen) is equal to 92\u2005kJ\u2005mol\u22121. So, the \u0394G\u2260 is equal to the energy needed for the excitation of ground state oxygen to the singlet oxygen (1\u0394g first excited) state. The similarity of the \u0394G\u2260 values is an indication that a common mechanism in the above disorders may be taking place. We attribute this common mechanism to the (same) role of the oxidative stress and specifically of singlet oxygen, (1\u0394g), to the above-mentioned processes: excitation of ground state oxygen to the singlet oxygen, 1\u0394g, state (92\u2005kJ\u2005mol\u22121), and reaction of the empty \u03c0* orbital with high electron density regions of biomolecules (\u223c10\u201330\u2005kJ\u2005mol\u22121 for their diffusion). The \u0394G\u2260 for cases of heat-induced cell killing (cancer) lie also in the above range at 310\u2005K. The present paper is a review and meta-analysis of literature data referring to neurodegenerative and other disorders.<\/jats:p>","DOI":"10.1042\/bcj20161058","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:10:38Z","timestamp":1501719038000},"page":"2713-2731","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["A meta-analysis and review examining a possible role for oxidative stress and singlet oxygen in diverse diseases"],"prefix":"10.1042","volume":"474","author":[{"given":"Athinoula L.","family":"Petrou","sequence":"first","affiliation":[{"name":"Laboratory of Inorganic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athina","family":"Terzidaki","sequence":"additional","affiliation":[{"name":"Laboratory of Inorganic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,8,2]]},"reference":[{"key":"2021112216492912300_BCJ-2016-1058C1","first-page":"383","article-title":"Protection against FCA induced oxidative stress induced DNA damage as a model of arthritis and in vitro anti-arthritic potential of Costus speciosus rhizome extract","volume":"7","author":"Chandra","year":"2015","journal-title":"Int. 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