{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T12:51:25Z","timestamp":1781787085451,"version":"3.54.5"},"reference-count":78,"publisher":"Portland Press Ltd.","issue":"17","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"abstract":"<jats:p>Arthritis is a chronic inflammatory disease which reduces the life quality of affected individuals. Therapeutic tools used for treating inflammatory pain are associated with several undesirable effects. Buddleja thyrsoides Lam., known as \u2018Barbasco\u2019 or \u2018Cambara\u2019, is mostly used in several disorders and possesses antirheumatic, anti-inflammatory, and analgesic properties. Here, we investigated the antinociceptive and anti-inflammatory effects of the B. thyrsoides crude extract applied orally and topically in acute pain models and an arthritic pain model induced by complete Freund's adjuvant (CFA) paw injection in male mice (25\u201330\u2005g). The high-performance liquid chromatography (HPLC) of the B. thyrsoides extract crude revealed the presence of the lupeol, stigmasterol, and \u03b2-sitosterol. The stability study of the B. thyrsoides gel did not show relevant changes at low temperatures. The oral treatment with the B. thrysoides extract prevented the capsaicin-induced spontaneous nociception and the acetic acid-induced abdominal writhing, but did not alter the thermal threshold in the tail immersion test. The B. thyrsoides antinociceptive effect was not reversed by naloxone in the capsaicin test. The B. thyrsoides oral or topical treatment reversed the CFA-induced mechanical allodynia and thermal hyperalgesia with maximum inhibition (Imax) of 69\u2009\u00b1\u20096 and 68\u2009\u00b1\u20095% as well as 78\u2009\u00b1\u200915 and 87\u2009\u00b1\u200912%, respectively. Moreover, the topical but not oral treatment inhibited the CFA-induced cell infiltration, but did not reduce the paw edema significantly. The oral treatment with B. thyrsoides did not cause adverse effects. These findings suggest that the oral or topical treatment with B. thyrsoides presents antinociceptive actions in an arthritic pain model without causing adverse effects.<\/jats:p>","DOI":"10.1042\/bcj20170008","type":"journal-article","created":{"date-parts":[[2017,7,25]],"date-time":"2017-07-25T00:10:14Z","timestamp":1500941414000},"page":"2993-3010","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>Buddleja thyrsoides<\/i>Lam. crude extract presents antinociceptive effect on an arthritic pain model in mice"],"prefix":"10.1042","volume":"474","author":[{"given":"Maria Fernanda Pessano","family":"Fialho","sequence":"first","affiliation":[{"name":"Neurotoxicity and Psychopharmacology Laboratory, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil"},{"name":"Graduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indiara","family":"Brusco","sequence":"additional","affiliation":[{"name":"Neurotoxicity and Psychopharmacology Laboratory, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil"},{"name":"Graduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"da Silva Brum","sequence":"additional","affiliation":[{"name":"Neurotoxicity and Psychopharmacology Laboratory, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil"},{"name":"Graduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Piana","sequence":"additional","affiliation":[{"name":"Phytochemical Research Laboratory, Department of Industrial Pharmacy, Federal University of Santa Maria, Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Augusti","family":"Boligon","sequence":"additional","affiliation":[{"name":"Phytochemical Research Laboratory, Department of Industrial Pharmacy, Federal University of Santa Maria, Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Trevisan","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Marchesan","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Neurotoxicity and Psychopharmacology Laboratory, Center of Natural and Exact Sciences, Federal University of Santa Maria, Santa Maria, RS, Brazil"},{"name":"Graduate Program in Biological Sciences: Biochemistry Toxicology, Federal University of Santa Maria, Santa Maria, RS, Brazil"},{"name":"Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Av. 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