{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:35:23Z","timestamp":1792647323706,"version":"4.5.0"},"reference-count":217,"publisher":"Portland Press Ltd.","issue":"8","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4,30]]},"abstract":"<jats:p>Protein glycosylation represents a nearly ubiquitous post-translational modification, and altered glycosylation can result in clinically significant pathological consequences. Here we focus on O-glycosylation in tumor cells of mice and humans. O-glycans are those linked to serine and threonine (Ser\/Thr) residues via N-acetylgalactosamine (GalNAc), which are oligosaccharides that occur widely in glycoproteins, such as those expressed on the surfaces and in secretions of all cell types. The structure and expression of O-glycans are dependent on the cell type and disease state of the cells. There is a great interest in O-glycosylation of tumor cells, as they typically express many altered types of O-glycans compared with untransformed cells. Such altered expression of glycans, quantitatively and\/or qualitatively on different glycoproteins, is used as circulating tumor biomarkers, such as CA19-9 and CA-125. Other tumor-associated carbohydrate antigens (TACAs), such as the Tn antigen and sialyl-Tn antigen (STn), are truncated O-glycans commonly expressed by carcinomas on multiple glycoproteins; they contribute to tumor development and serve as potential biomarkers for tumor presence and stage, both in immunohistochemistry and in serum diagnostics. Here we discuss O-glycosylation in murine and human cells with a focus on colorectal, breast, and pancreatic cancers, centering on the structure, function and recognition of O-glycans. There are enormous opportunities to exploit our knowledge of O-glycosylation in tumor cells to develop new diagnostics and therapeutics.<\/jats:p>","DOI":"10.1042\/bcj20180103","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T18:12:59Z","timestamp":1588183979000},"page":"1541-1564","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["O-glycan recognition and function in mice and human cancers"],"prefix":"10.1042","volume":"477","author":[{"given":"Gabrielle E.","family":"Cervoni","sequence":"first","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, CLS 11087, 3 Blackfan Circle, Boston, MA 02115, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane J.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, CLS 11087, 3 Blackfan Circle, Boston, MA 02115, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Stackhouse","sequence":"additional","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, CLS 11087, 3 Blackfan Circle, Boston, MA 02115, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Heimburg-Molinaro","sequence":"additional","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, CLS 11087, 3 Blackfan Circle, Boston, MA 02115, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8918-5034","authenticated-orcid":false,"given":"Richard D.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, CLS 11087, 3 Blackfan Circle, Boston, MA 02115, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"2021112218085556200_BCJ-2018-0103CC1","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.sbi.2019.12.002","article-title":"Emerging patterns of tyrosine sulfation and O-glycosylation cross-talk and co-localization","volume":"62","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC2","doi-asserted-by":"publisher","first-page":"101389","DOI":"10.1016\/j.smim.2020.101389","article-title":"Tumor-associated O-glycans of MUC1: carriers of the glyco-code and targets for cancer vaccine design","volume":"47","year":"2020","journal-title":"Semin. Immunol."},{"key":"2021112218085556200_BCJ-2018-0103CC3","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1111\/dgd.12643","article-title":"Effects of Notch glycosylation on health and diseases","volume":"62","year":"2019","journal-title":"Dev. Growth Differ."},{"key":"2021112218085556200_BCJ-2018-0103CC4","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cca.2019.12.015","article-title":"Tumour associated glycans: a route to boost immunotherapy?","volume":"502","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"2021112218085556200_BCJ-2018-0103CC5","doi-asserted-by":"publisher","first-page":"e20182041","DOI":"10.1084\/jem.20182041","article-title":"Sweetening the hallmarks of cancer: galectins as multifunctional mediators of tumor progression","volume":"217","year":"2020","journal-title":"J. Exp. Med."},{"key":"2021112218085556200_BCJ-2018-0103CC6","doi-asserted-by":"publisher","first-page":"E6074","DOI":"10.3390\/ijms20236074","article-title":"Oligosaccharyltransferase: a gatekeeper of health and tumor progression","volume":"20","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2021112218085556200_BCJ-2018-0103CC7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/hepr.13459","article-title":"Functional glycomics: application to medical science and hepatology","volume":"50","year":"2020","journal-title":"Hepatol Res"},{"key":"2021112218085556200_BCJ-2018-0103CC8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/brain\/awz358","article-title":"Disrupted glycosylation of lipids and proteins is a cause of neurodegeneration","year":"2019","journal-title":"Brain"},{"key":"2021112218085556200_BCJ-2018-0103CC9","volume-title":"Essentials of Glycobiology","year":"2017","edition":"3rd edn"},{"key":"2021112218085556200_BCJ-2018-0103CC10","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/bs.acr.2014.11.002","article-title":"Simple sugars to complex disease\u2013mucin-type O-glycans in cancer","volume":"126","year":"2015","journal-title":"Adv. Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC11","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1146\/annurev-pathol-012414-040438","article-title":"Protein glycosylation in cancer","volume":"10","year":"2015","journal-title":"Annu. Rev. Pathol."},{"key":"2021112218085556200_BCJ-2018-0103CC12","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1093\/glycob\/cwv021","article-title":"Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane","volume":"25","year":"2015","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC13","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1074\/jbc.AW119.003226","article-title":"Nutrient regulation of signaling and transcription","volume":"294","year":"2019","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC14","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.tig.2018.03.002","article-title":"Perspectives on glycosylation and its congenital disorders","volume":"34","year":"2018","journal-title":"Trends Genet."},{"key":"2021112218085556200_BCJ-2018-0103CC15","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1038\/emboj.2013.79","article-title":"Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology","volume":"32","year":"2013","journal-title":"EMBO J."},{"key":"2021112218085556200_BCJ-2018-0103CC16","doi-asserted-by":"publisher","first-page":"E544","DOI":"10.3390\/cells8060544","article-title":"Glycosylation in the tumor microenvironment: implications for tumor angiogenesis and metastasis","volume":"8","year":"2019","journal-title":"Cells"},{"key":"2021112218085556200_BCJ-2018-0103CC17","doi-asserted-by":"publisher","first-page":"2120","DOI":"10.3389\/fimmu.2019.02120","article-title":"Altered cell adhesion and glycosylation promote cancer immune suppression and metastasis","volume":"10","year":"2019","journal-title":"Front. Immunol."},{"key":"2021112218085556200_BCJ-2018-0103CC18","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1093\/glycob\/cwr182","article-title":"Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family","volume":"22","year":"2012","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC19","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1002\/anie.201002313","article-title":"The Tn antigen-structural simplicity and biological complexity","volume":"50","year":"2011","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"2021112218085556200_BCJ-2018-0103CC20","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1038\/4371252a","article-title":"Chaperone mutation in Tn syndrome","volume":"437","year":"2005","journal-title":"Nature"},{"key":"2021112218085556200_BCJ-2018-0103CC21","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1093\/glycob\/cwy005","article-title":"Isotopic labeling with cellular O-glycome reporter\/amplification (ICORA) for comparative O-glycomics of cultured cells","volume":"28","year":"2018","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/nmeth.3675","article-title":"Cellular O-glycome reporter\/amplification to explore O-glycans of living cells","volume":"13","year":"2016","journal-title":"Nat. Methods"},{"key":"2021112218085556200_BCJ-2018-0103CC23","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/bs.acr.2014.11.004","article-title":"Glycosylation characteristics of colorectal cancer","volume":"126","year":"2015","journal-title":"Adv. Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC24","doi-asserted-by":"publisher","first-page":"27371","DOI":"10.1074\/jbc.M103554200","article-title":"Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16","volume":"276","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC25","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/ijc.2910290509","article-title":"A monoclonal antibody (B72.3) defines patterns of distribution of a novel tumor-associated antigen in human mammary carcinoma cell populations","volume":"29","year":"1982","journal-title":"Int. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC26","first-page":"5489","article-title":"Identification of the gastrointestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19-9 in the sera of patients as a mucin","volume":"43","year":"1983","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC27","doi-asserted-by":"crossref","first-page":"15286","DOI":"10.1016\/S0021-9258(18)77254-2","article-title":"Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin","volume":"265","year":"1990","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC28","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/ijc.2910450309","article-title":"The locus of the polymorphic epithelial mucin (PEM) tumour antigen on chromosome 1q21 shows a high frequency of alteration in primary human breast tumours","volume":"45","year":"1990","journal-title":"Int. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC29","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nrc1739","article-title":"Biomarkers in cancer staging, prognosis and treatment selection","volume":"5","year":"2005","journal-title":"Nat. Rev. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC30","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1039\/b907931a","article-title":"The repertoire of glycan determinants in the human glycome","volume":"5","year":"2009","journal-title":"Mol. Biosyst."},{"key":"2021112218085556200_BCJ-2018-0103CC31","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.bcp.2013.08.008","article-title":"Role of glycosylation in the anticancer activity of antibacterial peptides against breast cancer cells","volume":"86","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"2021112218085556200_BCJ-2018-0103CC32","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.str.2017.09.003","article-title":"Structural insights into VLR fine specificity for blood group carbohydrates","volume":"25","year":"2017","journal-title":"Structure"},{"key":"2021112218085556200_BCJ-2018-0103CC33","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1186\/s12885-018-4708-8","article-title":"Differential expression of Cosmc, T-synthase and mucins in Tn-positive colorectal cancers","volume":"18","year":"2018","journal-title":"BMC Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC34","doi-asserted-by":"publisher","first-page":"7035","DOI":"10.1158\/1078-0432.Ccr-11-1462","article-title":"Serum galectin-2, -4, and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium","volume":"17","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC35","doi-asserted-by":"publisher","first-page":"245","DOI":"10.17305\/bjbms.2008.2926","article-title":"Optimization of diagnostic ELISA-based tests for the detection of auto-antibodies against tumor antigens in human serum","volume":"8","year":"2008","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"2021112218085556200_BCJ-2018-0103CC36","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/ijc.26354","article-title":"Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients","volume":"131","year":"2012","journal-title":"Int. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC37","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.3892\/or.2016.5180","article-title":"ST3Gal III modulates breast cancer cell adhesion and invasion by altering the expression of invasion-related molecules","volume":"36","year":"2016","journal-title":"Oncol. Rep."},{"key":"2021112218085556200_BCJ-2018-0103CC38","doi-asserted-by":"publisher","first-page":"21052","DOI":"10.1074\/jbc.M111.231191","article-title":"Regulation of sialyl Lewis antigen expression in colon cancer cells by sialidase NEU4","volume":"286","year":"2011","journal-title":"J Biol Chem"},{"key":"2021112218085556200_BCJ-2018-0103CC39","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1074\/mcp.M600171-MCP200","article-title":"A serum glycomics approach to breast cancer biomarkers","volume":"6","year":"2007","journal-title":"Mol. Cell. Proteomics"},{"key":"2021112218085556200_BCJ-2018-0103CC40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.chembiol.2013.12.010","article-title":"The challenge and promise of glycomics","volume":"21","year":"2014","journal-title":"Chem. Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC41","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3390\/biom3010198","article-title":"Recent advances in cellular glycomic analyses","volume":"3","year":"2013","journal-title":"Biomolecules"},{"key":"2021112218085556200_BCJ-2018-0103CC42","doi-asserted-by":"publisher","first-page":"976","DOI":"10.2174\/0929866521666140626111237","article-title":"PNGases as valuable tools in glycoprotein analysis","volume":"21","year":"2014","journal-title":"Protein Pept. Lett."},{"key":"2021112218085556200_BCJ-2018-0103CC43","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/glycob\/cwi061","article-title":"Altered O-glycosylation and sulfation of airway mucins associated with cystic fibrosis","volume":"15","year":"2005","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC44","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1016\/j.jmb.2016.02.010","article-title":"The densely O-glycosylated MUC2 mucin protects the intestine and provides food for the commensal bacteria","volume":"428","year":"2016","journal-title":"J. Mol. Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC45","unstructured":"ACS. Cancer Facts & Figures (2017) https:\/\/www.cancer.org\/research\/cancer-facts-statistics\/all-cancer-facts-figures\/cancer-facts-figures-2017.html"},{"key":"2021112218085556200_BCJ-2018-0103CC46","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3978\/j.issn.2078-6891.2014.112","article-title":"Review of systemic therapies for locally advanced and metastatic rectal cancer","volume":"6","year":"2015","journal-title":"J. Gastrointest. Oncol."},{"key":"2021112218085556200_BCJ-2018-0103CC47","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1080\/17474124.2017.1253474","article-title":"Altered glycosyltransferases in colorectal cancer","volume":"11","year":"2017","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"2021112218085556200_BCJ-2018-0103CC48","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nrc3982","article-title":"Glycosylation in cancer: mechanisms and clinical implications","volume":"15","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC49","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1440-1746.2011.06909.x","article-title":"Mucins in inflammatory bowel diseases and colorectal cancer","volume":"27","year":"2012","journal-title":"J. Gastroenterol. Hepatol."},{"key":"2021112218085556200_BCJ-2018-0103CC50","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/sj.embor.7400705","article-title":"Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functions","volume":"7","year":"2006","journal-title":"EMBO Rep."},{"key":"2021112218085556200_BCJ-2018-0103CC51","doi-asserted-by":"publisher","first-page":"23642","DOI":"10.1038\/srep23642","article-title":"Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer","volume":"6","year":"2016","journal-title":"Sci. Rep."},{"key":"2021112218085556200_BCJ-2018-0103CC52","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1074\/jbc.H117.812826","article-title":"Pleiotropic effects of O-glycosylation in colon cancer","volume":"293","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC53","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1074\/mcp.M114.040204","article-title":"Membrane protein profiling of human colon reveals distinct regional differences","volume":"13","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"2021112218085556200_BCJ-2018-0103CC54","doi-asserted-by":"publisher","first-page":"7050","DOI":"10.1158\/0008-5472.Can-04-1921","article-title":"Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigen","volume":"64","year":"2004","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC55","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1074\/jbc.M117.812826","article-title":"De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium","volume":"293","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC56","doi-asserted-by":"publisher","first-page":"12921","DOI":"10.1073\/pnas.0901454106","article-title":"Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers","volume":"106","year":"2009","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021112218085556200_BCJ-2018-0103CC57","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.2741\/e345","article-title":"ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues","volume":"3","year":"2011","journal-title":"Front. Biosci."},{"key":"2021112218085556200_BCJ-2018-0103CC58","doi-asserted-by":"publisher","first-page":"3586","DOI":"10.1074\/jbc.M511826200","article-title":"The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer","volume":"281","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC59","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1089\/027245700429828","article-title":"Clinical correlations of alpha2,6-sialyltransferase expression in colorectal cancer patients","volume":"19","year":"2000","journal-title":"Hybridoma"},{"key":"2021112218085556200_BCJ-2018-0103CC60","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1111\/jcmm.14740","article-title":"Cosmc overexpression enhances malignancies in human colon cancer","volume":"24","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"2021112218085556200_BCJ-2018-0103CC61","doi-asserted-by":"publisher","first-page":"E62","DOI":"10.1002\/mc.22011","article-title":"The molecular chaperone Cosmc enhances malignant behaviors of colon cancer cells via activation of Akt and ERK","volume":"53","year":"2014","journal-title":"Mol Carcinog"},{"key":"2021112218085556200_BCJ-2018-0103CC62","doi-asserted-by":"publisher","first-page":"130416","DOI":"10.1172\/jci.insight.130416","article-title":"Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell","volume":"4","year":"2019","journal-title":"JCI Insight"},{"key":"2021112218085556200_BCJ-2018-0103CC63","doi-asserted-by":"publisher","first-page":"41523","DOI":"10.1074\/jbc.M112.371989","article-title":"Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen","volume":"287","year":"2012","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC64","doi-asserted-by":"publisher","first-page":"E4066","DOI":"10.1073\/pnas.1406619111","article-title":"Immature truncated O-glycophenotype of cancer directly induces oncogenic features","volume":"111","year":"2014","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021112218085556200_BCJ-2018-0103CC65","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.tcb.2010.11.004","article-title":"Location, location, location: new insights into O-GalNAc protein glycosylation","volume":"21","year":"2011","journal-title":"Trends Cell Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC66","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/j.1432-1033.1994.tb18880.x","article-title":"O-glycan biosynthesis in human colorectal adenoma cells during progression to cancer","volume":"222","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"2021112218085556200_BCJ-2018-0103CC67","first-page":"197","article-title":"Expression of Tn, sialosyl-Tn, and T antigens in human colon cancer","volume":"49","year":"1989","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC68","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1007\/s001090050144","article-title":"Immunoreactive T and Tn epitopes in cancer diagnosis, prognosis, and immunotherapy","volume":"75","year":"1997","journal-title":"J. Mol. Med."},{"key":"2021112218085556200_BCJ-2018-0103CC69","doi-asserted-by":"publisher","first-page":"143","DOI":"10.14670\/HH-15.143","article-title":"The involvement of helix pomatia lectin (HPA) binding N-acetylgalactosamine glycans in cancer progression","volume":"15","year":"2000","journal-title":"Histol. Histopathol."},{"key":"2021112218085556200_BCJ-2018-0103CC70","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3892\/or.15.2.305","article-title":"Study of the expression of Tn antigen in different types of human breast cancer cells using VVA-B4 lectin","volume":"15","year":"2006","journal-title":"Oncol. Rep."},{"key":"2021112218085556200_BCJ-2018-0103CC71","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/0140-6736(91)90071-V","article-title":"Prediction of lymph node involvement in breast cancer by detection of altered glycosylation in the primary tumour","volume":"338","year":"1991","journal-title":"Lancet"},{"key":"2021112218085556200_BCJ-2018-0103CC72","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10549-005-9115-6","article-title":"Expression of vicia villosa agglutinin (VVA)-binding glycoprotein in primary breast cancer cells in relation to lymphatic metastasis: is atypical MUC1 bearing Tn antigen a receptor of VVA?","volume":"98","year":"2006","journal-title":"Breast Cancer Res. Treat."},{"key":"2021112218085556200_BCJ-2018-0103CC73","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(87)90482-X","article-title":"Predictive value of lectin binding on breast-cancer recurrence and survival","volume":"329","year":"1987","journal-title":"Lancet"},{"key":"2021112218085556200_BCJ-2018-0103CC74","doi-asserted-by":"publisher","first-page":"35478","DOI":"10.18632\/oncotarget.8155","article-title":"Hallmarks of glycosylation in cancer","volume":"7","year":"2016","journal-title":"Oncotarget"},{"key":"2021112218085556200_BCJ-2018-0103CC75","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12943-015-0386-1","article-title":"COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer","volume":"14","year":"2015","journal-title":"Mol. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC76","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1093\/glycob\/9.11.1213","article-title":"Cloning and expression of a human gene encoding an N-acetylgalactosamine-\u03b12,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens","volume":"9","year":"1999","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC77","doi-asserted-by":"publisher","first-page":"3199","DOI":"10.1073\/pnas.78.5.3199","article-title":"A spectrum of monoclonal antibodies reactive with human mammary tumor cells","volume":"78","year":"1981","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021112218085556200_BCJ-2018-0103CC78","first-page":"3118","article-title":"Distribution of oncofetal antigen tumor\u2013associated glycoprotein-72 defined by monoclonal antibody B72.3","volume":"46","year":"1986","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC79","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1038\/bjc.1994.486","article-title":"Expression of sialyl-Tn predicts the effect of adjuvant chemotherapy in node-positive breast cancer","volume":"70","year":"1994","journal-title":"Br. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC80","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/jso.2930110204","article-title":"Human carcinoma-associated precursor antigens of the NM blood group system","volume":"11","year":"1979","journal-title":"J. Surg. Oncol."},{"key":"2021112218085556200_BCJ-2018-0103CC81","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1007\/s00418-005-0781-6","article-title":"Characterisation of disseminated tumor cells in the bone marrow of breast cancer patients by the Thomsen-Friedenreich tumor antigen","volume":"123","year":"2005","journal-title":"Histochem. Cell Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC82","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/j.1432-1033.1995.607_2.x","article-title":"Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast cancer cells","volume":"233","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"2021112218085556200_BCJ-2018-0103CC83","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1074\/jbc.M606862200","article-title":"Galectin-3 interaction with Thomsen-Friedenreich disaccharide on cancer-associated MUC1 causes increased cancer cell endothelial adhesion","volume":"282","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC84","first-page":"1553","article-title":"Expression of Lewisa, Lewisb, X, and Y blood group antigens in human colonic tumors and normal tissue and in human tumor-derived cell lines","volume":"46","year":"1986","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC85","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cca.2015.01.007","article-title":"Identification of potential pancreatic cancer serum markers: increased sialyl-Lewis X on ceruloplasmin","volume":"442","year":"2015","journal-title":"Clin. Chim. Acta"},{"key":"2021112218085556200_BCJ-2018-0103CC86","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1074\/mcp.M114.047837","article-title":"Glycan motif profiling reveals plasma sialyl-lewis x elevations in pancreatic cancers that are negative for sialyl-lewis A","volume":"14","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"2021112218085556200_BCJ-2018-0103CC87","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1159\/000048767","article-title":"Overexpression of sialyl Lewis x antigen is associated with formation of extratumoral venous invasion and predicts postoperative development of massive hepatic metastasis in cases with pancreatic ductal adenocarcinoma","volume":"69","year":"2001","journal-title":"Pathobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC88","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3389\/fonc.2016.00093","article-title":"Targeting selectins and their ligands in cancer","volume":"6","year":"2016","journal-title":"Frontiers in Oncology"},{"key":"2021112218085556200_BCJ-2018-0103CC89","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jprot.2013.10.030","article-title":"Discovery of sialyl Lewis A and Lewis X modified protein cancer biomarkers using high density antibody arrays","volume":"96","year":"2014","journal-title":"J. Proteomics"},{"key":"2021112218085556200_BCJ-2018-0103CC90","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1093\/jjco\/hyq190","article-title":"CSLEX (Sialyl Lewis X) is a useful tumor marker for monitoring of breast cancer patients","volume":"41","year":"2011","journal-title":"Jpn. J. Clin. Oncol."},{"key":"2021112218085556200_BCJ-2018-0103CC91","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s10549-019-05258-0","article-title":"Elevated serum levels of sialyl Lewis X (sLe(X)) and inflammatory mediators in patients with breast cancer","volume":"176","year":"2019","journal-title":"Breast Cancer Res. Treat."},{"key":"2021112218085556200_BCJ-2018-0103CC92","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/(sici)1097-0215(19970516)71:4&lt;556::aid-ijc9&gt;3.0.co;2-t","article-title":"Altered mRNA expression of specific molecular species of fucosyl- and sialyl-transferases in human colorectal cancer tissues","volume":"71","year":"1997","journal-title":"Int. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC93","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3892\/ol_00000064","article-title":"Alpha(1,2)fucosylation in human colorectal carcinoma","volume":"1","year":"2010","journal-title":"Oncol. Lett."},{"key":"2021112218085556200_BCJ-2018-0103CC94","doi-asserted-by":"publisher","first-page":"e29180","DOI":"10.1371\/journal.pone.0029180","article-title":"Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers","volume":"6","year":"2011","journal-title":"PLoS ONE"},{"key":"2021112218085556200_BCJ-2018-0103CC95","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1126\/science.aaw3145","article-title":"The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice","volume":"364","year":"2019","journal-title":"Science"},{"key":"2021112218085556200_BCJ-2018-0103CC96","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1158\/0008-5472.CAN-07-2345","article-title":"Human tumor antigens Tn and sialyl Tn arise from mutations in Cosmc","volume":"68","year":"2008","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC97","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1158\/1078-0432.Ccr-05-1257","article-title":"Tumor-associated antigen recognized by the 22-1-1 monoclonal antibody encourages colorectal cancer progression under the scanty CD8+ T cells","volume":"12","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC98","doi-asserted-by":"publisher","first-page":"cwz095","DOI":"10.1093\/glycob\/cwz095","article-title":"Identification of Tn antigen O-GalNAc-expressing glycoproteins in human carcinomas using novel anti-Tn recombinant antibodies","year":"2019","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC99","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nrc1251","article-title":"Mucins in cancer: protection and control of the cell surface","volume":"4","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC100","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/nrc2761","article-title":"Mucins in cancer: function, prognosis and therapy","volume":"9","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC101","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1084\/jem.20061929","article-title":"Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans","volume":"204","year":"2007","journal-title":"J. Exp. Med."},{"key":"2021112218085556200_BCJ-2018-0103CC102","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1172\/jci45538","article-title":"Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice","volume":"121","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2021112218085556200_BCJ-2018-0103CC103","doi-asserted-by":"publisher","first-page":"14636","DOI":"10.1074\/jbc.M113.459479","article-title":"Site-specific O-glycosylation on the MUC2 mucin protein inhibits cleavage by the porphyromonas gingivalis secreted cysteine protease (RgpB)","volume":"288","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC104","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1093\/glycob\/cwt045","article-title":"Mucin-type O-glycans and their roles in intestinal homeostasis","volume":"23","year":"2013","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC105","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/s0925-4439(99)00055-1","article-title":"MUC1 and cancer","volume":"1455","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"2021112218085556200_BCJ-2018-0103CC106","doi-asserted-by":"publisher","first-page":"15064","DOI":"10.1073\/pnas.0803124105","article-title":"The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria","volume":"105","year":"2008","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021112218085556200_BCJ-2018-0103CC107","doi-asserted-by":"publisher","first-page":"G922","DOI":"10.1152\/ajpgi.2001.280.5.G922","article-title":"The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo","volume":"280","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"2021112218085556200_BCJ-2018-0103CC108","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/nrmicro2538","article-title":"Mucin dynamics and enteric pathogens","volume":"9","year":"2011","journal-title":"Nat. Rev. Microbiol."},{"key":"2021112218085556200_BCJ-2018-0103CC109","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1038\/onc.2015.327","article-title":"Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer","volume":"35","year":"2016","journal-title":"Oncogene"},{"key":"2021112218085556200_BCJ-2018-0103CC110","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1136\/gut.2011.239194","article-title":"The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis","volume":"60","year":"2011","journal-title":"Gut"},{"key":"2021112218085556200_BCJ-2018-0103CC111","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1126\/science.1069094","article-title":"Colorectal cancer in mice genetically deficient in the mucin Muc2","volume":"295","year":"2002","journal-title":"Science"},{"key":"2021112218085556200_BCJ-2018-0103CC112","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1248\/bpb.b12-00412","article-title":"Roles of the gel-forming MUC2 mucin and its O-glycosylation in the protection against colitis and colorectal cancer","volume":"35","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"2021112218085556200_BCJ-2018-0103CC113","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1002\/ijc.2910590302","article-title":"Expression of MUC2-mucin in colorectal adenomas and carcinomas of different histological types","volume":"59","year":"1994","journal-title":"Int. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC114","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1053\/j.gastro.2011.01.057","article-title":"Intestinal inflammation and cancer","volume":"140","year":"2011","journal-title":"Gastroenterology"},{"key":"2021112218085556200_BCJ-2018-0103CC115","doi-asserted-by":"publisher","first-page":"5","DOI":"10.4103\/1477-3163.49014","article-title":"Colorectal carcinogenesis: review of human and experimental animal studies","volume":"8","year":"2009","journal-title":"J. Carcinogenesis"},{"key":"2021112218085556200_BCJ-2018-0103CC116","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/978-1-4939-3661-8_14","article-title":"Murine model for colitis-associated cancer of the colon","volume":"1438","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC117","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/carcin\/bgn267","article-title":"Mouse models for the study of colon carcinogenesis","volume":"30","year":"2009","journal-title":"Carcinogenesis"},{"key":"2021112218085556200_BCJ-2018-0103CC118","doi-asserted-by":"publisher","first-page":"658786","DOI":"10.1155\/2012\/658786","article-title":"Development of an inflammation-associated colorectal cancer model and its application for research on carcinogenesis and chemoprevention","volume":"2012","year":"2012","journal-title":"Int. J. Inflam."},{"key":"2021112218085556200_BCJ-2018-0103CC119","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/carcin\/bgh292","article-title":"Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cyclooxygenase-2 and inducible nitric oxide synthase","volume":"26","year":"2005","journal-title":"Carcinogenesis"},{"key":"2021112218085556200_BCJ-2018-0103CC120","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.biocel.2009.09.010","article-title":"Differential expression of alpha-2,3-sialyltransferases and alpha-1,3\/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells","volume":"42","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC121","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1097\/00054725-200411000-00016","article-title":"Interleukin 10-deficient mice exhibit defective colonic Muc2 synthesis before and after induction of colitis by commensal bacteria","volume":"10","year":"2004","journal-title":"Inflamm. Bowel Dis."},{"key":"2021112218085556200_BCJ-2018-0103CC122","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection","volume":"131","year":"2006","journal-title":"Gastroenterology"},{"key":"2021112218085556200_BCJ-2018-0103CC123","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1053\/j.gastro.2016.03.039","article-title":"Defective intestinal mucin-type o-glycosylation causes spontaneous colitis-associated cancer in mice","volume":"151","year":"2016","journal-title":"Gastroenterology"},{"key":"2021112218085556200_BCJ-2018-0103CC124","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/s0065-230x(00)79007-5","article-title":"Biochemistry and pathological importance of mucin-associated antigens in gastrointestinal neoplasia","volume":"79","year":"2000","journal-title":"Adv. Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC125","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1001\/jamasurg.2013.3393","article-title":"Breast cancer: a review for the general surgeon","volume":"148","year":"2013","journal-title":"JAMA Surg."},{"key":"2021112218085556200_BCJ-2018-0103CC126","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1158\/1055-9965.Epi-16-0889","article-title":"Estimation of the number of women living with metastatic breast cancer in the United States","volume":"26","year":"2017","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"2021112218085556200_BCJ-2018-0103CC127","doi-asserted-by":"publisher","first-page":"481","DOI":"10.7326\/0003-4819-155-8-201110180-00004","article-title":"Cumulative probability of false-positive recall or biopsy recommendation after 10 years of screening mammography: a cohort study","volume":"155","year":"2011","journal-title":"Ann. Intern. Med."},{"key":"2021112218085556200_BCJ-2018-0103CC128","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1023\/A:1011331809881","article-title":"O-linked glycosylation in the mammary gland: changes that occur during malignancy","volume":"6","year":"2001","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"2021112218085556200_BCJ-2018-0103CC129","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3233\/CBM-130375","article-title":"The Cosmc connection to the Tn antigen in cancer","volume":"14","year":"2014","journal-title":"Cancer Biomarkers"},{"key":"2021112218085556200_BCJ-2018-0103CC130","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/prca.201300024","article-title":"Tn and sialyl-Tn antigens, aberrant O-glycomics as human disease markers","volume":"7","year":"2013","journal-title":"Proteomics"},{"key":"2021112218085556200_BCJ-2018-0103CC131","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1126\/science.6729450","article-title":"T and Tn, general carcinoma autoantigens","volume":"224","year":"1984","journal-title":"Science"},{"key":"2021112218085556200_BCJ-2018-0103CC132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/bcr2577","article-title":"Tumour-associated carbohydrate antigens in breast cancer","volume":"12","year":"2010","journal-title":"Breast Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC133","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1042\/bst20170483","article-title":"O-linked mucin-type glycosylation in breast cancer","volume":"46","year":"2018","journal-title":"Biochem. Soc. Trans."},{"key":"2021112218085556200_BCJ-2018-0103CC134","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1369\/jhc.5A6783.2005","article-title":"UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 as a new immunohistochemical breast cancer marker","volume":"54","year":"2006","journal-title":"J. Histochem. Cytochem."},{"key":"2021112218085556200_BCJ-2018-0103CC135","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1002\/ijc.21959","article-title":"UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (ppGalNAc-T6) mRNA as a potential new marker for detection of bone marrow-disseminated breast cancer cells","volume":"119","year":"2006","journal-title":"Int. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC136","doi-asserted-by":"publisher","first-page":"53","DOI":"10.2174\/1568009616666160922102641","article-title":"UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase- 6 (pp-GalNAc-T6): role in cancer and prospects as a drug target","volume":"17","year":"2017","journal-title":"Curr. Cancer Drug Targets"},{"key":"2021112218085556200_BCJ-2018-0103CC137","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1158\/0008-5472.CAN-09-3911","article-title":"Critical roles of mucin 1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesis","volume":"70","year":"2010","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC138","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s11010-015-2601-1","article-title":"GalNAc-T4 putatively modulates the estrogen regulatory network through FOXA1 glycosylation in human breast cancer cells","volume":"411","year":"2016","journal-title":"Mol. Cell. Biochem."},{"key":"2021112218085556200_BCJ-2018-0103CC139","first-page":"4710","article-title":"Overexpression of microRNA-365 inhibits breast cancer cell growth and chemo-resistance through GALNT4","volume":"20","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"2021112218085556200_BCJ-2018-0103CC140","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/1471-2407-10-123","article-title":"N-Acetylgalactosaminyltransferase-14 as a potential biomarker for breast cancer by immunohistochemistry","volume":"10","year":"2010","journal-title":"BMC Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC141","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.tranon.2018.01.021","article-title":"EFEMP2 mediates GALNT14-dependent breast cancer cell invasion","volume":"11","year":"2018","journal-title":"Transl. Oncol."},{"key":"2021112218085556200_BCJ-2018-0103CC142","doi-asserted-by":"publisher","first-page":"baq020","DOI":"10.1093\/database\/baq020","article-title":"Genecards version 3: the human gene integrator","volume":"2010","year":"2010","journal-title":"Database"},{"key":"2021112218085556200_BCJ-2018-0103CC143","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13148-015-0089-x","article-title":"The GALNT9, BNC1 and CCDC8 genes are frequently epigenetically dysregulated in breast tumours that metastasise to the brain","volume":"7","year":"2015","journal-title":"Clin. Epigenetics"},{"key":"2021112218085556200_BCJ-2018-0103CC144","doi-asserted-by":"publisher","first-page":"26103","DOI":"10.1074\/jbc.M202921200","article-title":"Recombinant MUC1 probe authentically reflects cell-specific O-glycosylation profiles of endogenous breast cancer mucin. High density and prevalent core 2-based glycosylation","volume":"277","year":"2002","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC145","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep26451","article-title":"Glycosyltransferase gene expression profiles classify cancer types and propose prognostic subtypes","volume":"6","year":"2016","journal-title":"Sci. Rep."},{"key":"2021112218085556200_BCJ-2018-0103CC146","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1093\/glycob\/cws075","article-title":"MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 \u03b21,6-N-acetylglucosaminyltransferase and \u03b2-galactoside \u03b12,3-sialyltransferase","volume":"22","year":"2012","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC147","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1093\/glycob\/cwq085","article-title":"Over-expression of ST3Gal-I promotes mammary tumorigenesis","volume":"20","year":"2010","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC148","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0070-2153(06)78001-2","article-title":"Contribution of membrane mucins to tumor progression through modulation of cellular growth signaling pathways","volume":"78","year":"2007","journal-title":"Curr. Topics Dev. Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC149","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1007\/s00404-019-05292-9","article-title":"The expression of galectin-3 in breast cancer and its association with chemoresistance: a systematic review of the literature","volume":"300","year":"2019","journal-title":"Arch. Gynecol. Obstetrics"},{"key":"2021112218085556200_BCJ-2018-0103CC150","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1007\/PL00006677","article-title":"MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines","volume":"48","year":"2000","journal-title":"Cancer Immunol. Immunother."},{"key":"2021112218085556200_BCJ-2018-0103CC151","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/bcr1505","article-title":"Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835]","volume":"8","year":"2006","journal-title":"Breast Cancer Res"},{"key":"2021112218085556200_BCJ-2018-0103CC152","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.2217\/imt.13.126","article-title":"Up to 15-year clinical follow-up of a pilot phase III immunotherapy study in stage II breast cancer patients using oxidized mannan-MUC1","volume":"5","year":"2013","journal-title":"Immunotherapy"},{"key":"2021112218085556200_BCJ-2018-0103CC153","doi-asserted-by":"publisher","first-page":"20159","DOI":"10.1074\/jbc.M115.654483","article-title":"Loss of core 1-derived O-glycans decreases breast cancer development in mice","volume":"290","year":"2015","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC154","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1093\/glycob\/cwp085","article-title":"A newly generated functional antibody identifies Tn antigen as a novel determinant in the cancer cell-lymphatic endothelium interaction","volume":"19","year":"2009","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC155","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s10585-019-09999-6","article-title":"Breast cancer cells expressing cancer-associated sialyl-Tn antigen have less capacity to develop osteolytic lesions in a mouse model of skeletal colonization","volume":"36","year":"2019","journal-title":"Clin. Exp. Metastasis"},{"key":"2021112218085556200_BCJ-2018-0103CC156","unstructured":"Society, A.C. (2020) Cancer Facts & Figures 2020"},{"key":"2021112218085556200_BCJ-2018-0103CC157","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1083\/jcb.201003055","article-title":"Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymes","volume":"189","year":"2010","journal-title":"J. Cell Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC158","doi-asserted-by":"publisher","first-page":"E3152","DOI":"10.1073\/pnas.1305269110","article-title":"Initiation of GalNAc-type O-glycosylation in the endoplasmic reticulum promotes cancer cell invasiveness","volume":"110","year":"2013","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021112218085556200_BCJ-2018-0103CC159","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/s0014-5793(02)03007-7","article-title":"Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12","volume":"524","year":"2002","journal-title":"FEBS Lett."},{"key":"2021112218085556200_BCJ-2018-0103CC160","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1083\/jcb.200711151","article-title":"Regulation of protein O-glycosylation by the endoplasmic reticulum-localized molecular chaperone Cosmc","volume":"182","year":"2008","journal-title":"J. Cell Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC161","doi-asserted-by":"publisher","first-page":"16613","DOI":"10.1073\/pnas.262438199","article-title":"A unique molecular chaperone Cosmc required for activity of the mammalian core 1 3-galactosyltransferase","volume":"99","year":"2002","journal-title":"Proc. Natl Acad. Sci. U.S.A."},{"key":"2021112218085556200_BCJ-2018-0103CC162","doi-asserted-by":"publisher","first-page":"4843","DOI":"10.1038\/onc.2011.194","article-title":"Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth","volume":"30","year":"2011","journal-title":"Oncogene"},{"key":"2021112218085556200_BCJ-2018-0103CC163","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.acthis.2007.02.009","article-title":"Immunolocalisation of members of the polypeptide N-acetylgalactosaminyl transferase (ppGalNAc-T) family is consistent with biologically relevant altered cell surface glycosylation in breast cancer","volume":"109","year":"2007","journal-title":"Acta Histochem."},{"key":"2021112218085556200_BCJ-2018-0103CC164","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1038\/bjc.2016.116","article-title":"Loss of N-acetylgalactosaminyltransferase 3 in poorly differentiated pancreatic cancer: augmented aggressiveness and aberrant ErbB family glycosylation","volume":"114","year":"2016","journal-title":"Br. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC165","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/ijc.24355","article-title":"An integrated humoral and cellular response is elicited in pancreatic cancer by alpha-enolase, a novel pancreatic ductal adenocarcinoma-associated antigen","volume":"125","year":"2009","journal-title":"Int. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC166","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.2353\/ajpath.2007.060850","article-title":"Tissue plasminogen activator induces pancreatic cancer cell proliferation by a non-catalytic mechanism that requires extracellular signal-regulated kinase 1\/2 activation through epidermal growth factor receptor and annexin A2","volume":"170","year":"2007","journal-title":"Am. J. Pathol."},{"key":"2021112218085556200_BCJ-2018-0103CC167","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/labinvest.2008.2","article-title":"A new tumor-specific variant of GRP78 as target for antibody-based therapy","volume":"88","year":"2008","journal-title":"Lab. Invest."},{"key":"2021112218085556200_BCJ-2018-0103CC168","doi-asserted-by":"publisher","first-page":"3734","DOI":"10.1158\/1078-0432.Ccr-09-3411","article-title":"High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma","volume":"16","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC169","doi-asserted-by":"publisher","first-page":"21652","DOI":"10.1074\/jbc.271.35.21652","article-title":"Interaction of the fibrinolytic receptor, annexin II, with the endothelial cell surface. Essential role of endonexin repeat 2","volume":"271","year":"1996","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC170","doi-asserted-by":"publisher","first-page":"e69354","DOI":"10.1371\/journal.pone.0069354","article-title":"Surface alpha-enolase promotes extracellular matrix degradation and tumor metastasis and represents a new therapeutic target","volume":"8","year":"2013","journal-title":"PLoS ONE"},{"key":"2021112218085556200_BCJ-2018-0103CC171","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1158\/1078-0432.Ccr-12-2991","article-title":"Inhibition of established micrometastases by targeted drug delivery via cell surface-associated GRP78","volume":"19","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC172","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.1016\/j.febslet.2013.08.012","article-title":"Protein interactions between surface annexin A2 and S100A10 mediate adhesion of breast cancer cells to microvascular endothelial cells","volume":"587","year":"2013","journal-title":"FEBS Lett."},{"key":"2021112218085556200_BCJ-2018-0103CC173","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/bf00916897","article-title":"Monoclonal antibody detection of a circulating tumor-associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric, and pancreatic carcinoma","volume":"2","year":"1982","journal-title":"J. Clin. Immunol."},{"key":"2021112218085556200_BCJ-2018-0103CC174","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1126\/science.7209516","article-title":"A monosialoganglioside is a monoclonal antibody-defined antigen of colon carcinoma","volume":"212","year":"1981","journal-title":"Science (New York, N.Y.)"},{"key":"2021112218085556200_BCJ-2018-0103CC175","doi-asserted-by":"crossref","first-page":"14365","DOI":"10.1016\/S0021-9258(19)45389-1","article-title":"A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II","volume":"257","year":"1982","journal-title":"J. Biol. Chem."},{"key":"2021112218085556200_BCJ-2018-0103CC176","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1203\/00006450-199511000-00026","article-title":"Tumor markers CA 125 and CA 19-9 in cord blood and during infancy: developmental changes and use in pediatric germ cell tumors","volume":"38","year":"1995","journal-title":"Pediatr. Res."},{"key":"2021112218085556200_BCJ-2018-0103CC177","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.ejso.2006.10.004","article-title":"Systematic review of carbohydrate antigen (CA 19-9) as a biochemical marker in the diagnosis of pancreatic cancer","volume":"33","year":"2007","journal-title":"Eur. J. Surg. Oncol."},{"key":"2021112218085556200_BCJ-2018-0103CC178","first-page":"3605","article-title":"Characterization of CA 19-9 bearing mucins as physiological exocrine pancreatic secretion products","volume":"46","year":"1986","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC179","first-page":"5501","article-title":"Relationship of carbohydrate antigen 19-9 and Lewis antigens in pancreatic cancer","volume":"47","year":"1987","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC180","first-page":"5422","article-title":"Expression of blood group-related antigens ABH, Lewis A, Lewis B, Lewis X, Lewis Y, and CA 19-9 in pancreatic cancer cells in comparison with the patient's blood group type","volume":"48","year":"1988","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC181","first-page":"4079","article-title":"Expression of MUC1 mucin on activated human T cells: implications for a role of MUC1 in normal immune regulation","volume":"58","year":"1998","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC182","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1146\/annurev.ph.57.030195.003135","article-title":"Epithelial mucin genes","volume":"57","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"2021112218085556200_BCJ-2018-0103CC183","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1189\/jlb.72.4.692","article-title":"MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells","volume":"72","year":"2002","journal-title":"J. Leuk. Biol."},{"key":"2021112218085556200_BCJ-2018-0103CC184","doi-asserted-by":"crossref","first-page":"962","DOI":"10.4049\/jimmunol.145.3.962","article-title":"DF3 antigen, a human epithelial cell mucin, inhibits adhesion of eosinophils to antibody-coated targets","volume":"145","year":"1990","journal-title":"J. Immunol."},{"key":"2021112218085556200_BCJ-2018-0103CC185","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1006\/cimm.1997.1085","article-title":"A MUC1 mucin secreted from a colon carcinoma cell line inhibits target cell lysis by natural killer cells","volume":"176","year":"1997","journal-title":"Cell. Immunol."},{"key":"2021112218085556200_BCJ-2018-0103CC186","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0968-0004(90)90014-3","article-title":"Why are proteins O-glycosylated?","volume":"15","year":"1990","journal-title":"Trends Biochem. Sci."},{"key":"2021112218085556200_BCJ-2018-0103CC187","first-page":"2457","article-title":"Human B-cell immune response to the polymorphic epithelial mucin","volume":"53","year":"1993","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC188","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/(sici)1097-0215(20000601)86:5&lt;702::aid-ijc16&gt;3.0.co;2-1","article-title":"Reactivity of natural and induced human antibodies to MUC1 mucin with MUC1 peptides and n-acetylgalactosamine (GalNAc) peptides","volume":"86","year":"2000","journal-title":"Int. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC189","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1200\/jco.2000.18.3.574","article-title":"Survival in early breast cancer patients is favorably influenced by a natural humoral immune response to polymorphic epithelial mucin","volume":"18","year":"2000","journal-title":"J. Clin. Oncol."},{"key":"2021112218085556200_BCJ-2018-0103CC190","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1158\/1078-0432.CCR-12-2662","article-title":"Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer","volume":"19","year":"2013","journal-title":"Clin Cancer Res"},{"key":"2021112218085556200_BCJ-2018-0103CC191","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/cncr.21913","article-title":"Diagnostic utility of mucin profile in fine-needle aspiration specimens of the pancreas: an immunohistochemical study with surgical pathology correlation","volume":"108","year":"2006","journal-title":"Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC192","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1097\/00006676-199411000-00002","article-title":"Serological pancreatic tumor markers and the MUC1 apomucin","volume":"9","year":"1994","journal-title":"Pancreas"},{"key":"2021112218085556200_BCJ-2018-0103CC193","doi-asserted-by":"publisher","first-page":"1052","DOI":"10.1053\/gast.2002.36018","article-title":"Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas","volume":"123","year":"2002","journal-title":"Gastroenterology"},{"key":"2021112218085556200_BCJ-2018-0103CC194","first-page":"305","article-title":"Isolation and properties of a human pancreatic adenocarcinoma-associated antigen, DU-PAN-2","volume":"45","year":"1985","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC195","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1177\/002215540305101213","article-title":"Expression of gastric gland mucous cell-type mucin in normal and neoplastic human tissues","volume":"51","year":"2003","journal-title":"J. Histochem. Cytochem."},{"key":"2021112218085556200_BCJ-2018-0103CC196","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/ijc.2910470204","article-title":"Blood group and blood-group-related antigens in normal pancreas and pancreas cancer: enhanced expression of precursor type 1, Tn and sialyl-Tn in pancreas cancer","volume":"47","year":"1991","journal-title":"Int. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC197","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1074\/mcp.M900135-MCP200","article-title":"The prevalence and nature of glycan alterations on specific proteins in pancreatic cancer patients revealed using antibody-lectin sandwich arrays","volume":"8","year":"2009","journal-title":"Mol. Cell. Proteomics"},{"key":"2021112218085556200_BCJ-2018-0103CC198","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nmeth1035","article-title":"Multiplexed analysis of glycan variation on native proteins captured by antibody microarrays","volume":"4","year":"2007","journal-title":"Nat. Methods"},{"key":"2021112218085556200_BCJ-2018-0103CC199","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1053\/j.gastro.2018.08.007","article-title":"Disruption of C1galt1 gene promotes development and metastasis of pancreatic adenocarcinomas in mice","volume":"155","year":"2018","journal-title":"Gastroenterology"},{"key":"2021112218085556200_BCJ-2018-0103CC200","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/nrd1751","article-title":"Glycans in cancer and inflammation\u2013potential for therapeutics and diagnostics","volume":"4","year":"2005","journal-title":"Nat. Rev. Drug Discov."},{"key":"2021112218085556200_BCJ-2018-0103CC201","doi-asserted-by":"publisher","first-page":"385","DOI":"10.2217\/fon.13.209","article-title":"Preclinical studies with JAA-F11 anti-Thomsen-Friedenreich monoclonal antibody for human breast cancer","volume":"10","year":"2014","journal-title":"Future Oncol."},{"key":"2021112218085556200_BCJ-2018-0103CC202","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1634\/theoncologist.2010-0307","article-title":"Phase III multicenter clinical trial of the sialyl-TN (STn)-keyhole limpet hemocyanin (KLH) vaccine for metastatic breast cancer","volume":"16","year":"2011","journal-title":"Oncologist"},{"key":"2021112218085556200_BCJ-2018-0103CC203","doi-asserted-by":"publisher","first-page":"CT202","DOI":"10.1158\/1538-7445.am2014-ct202","article-title":"Abstract CT202: a Phase I study of a first-in-man carbohydrate mimetic-peptide vaccine in Stage IV breast cancer subjects","volume":"8","year":"2014","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC204","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.immuni.2016.06.010","article-title":"Driving CARs into sweet roads: targeting glycosylated antigens in cancer","volume":"44","year":"2016","journal-title":"Immunity"},{"key":"2021112218085556200_BCJ-2018-0103CC205","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2019.01149","article-title":"CAR t cells targeting the tumor MUC1 glycoprotein reduce triple-negative breast cancer growth","volume":"10","year":"2019","journal-title":"Front. Immunol."},{"key":"2021112218085556200_BCJ-2018-0103CC206","doi-asserted-by":"publisher","first-page":"536","DOI":"10.18632\/genesandcancer.134","article-title":"A tumor specific antibody to aid breast cancer screening in women with dense breast tissue","volume":"8","year":"2017","journal-title":"Genes Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC207","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.bbagen.2007.09.010","article-title":"Mucin-type O-glycosylation and its potential use in drug and vaccine development","volume":"1780","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"2021112218085556200_BCJ-2018-0103CC208","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1038\/sj.bjc.6690288","article-title":"Specificity analysis of sera from breast cancer patients vaccinated with MUC1-KLH plus QS-21","volume":"79","year":"1999","journal-title":"Br. J. Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC209","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/bf01789125","article-title":"Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene: effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene","volume":"36","year":"1993","journal-title":"Cancer Immunol. Immunother."},{"key":"2021112218085556200_BCJ-2018-0103CC210","first-page":"1693","article-title":"Vaccination of high-risk breast cancer patients with mucin-1 (MUC1) keyhole limpet hemocyanin conjugate plus QS-21","volume":"6","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC211","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1006\/jsre.1996.0264","article-title":"A phase I trial of a synthetic mucin peptide vaccine. induction of specific immune reactivity in patients with adenocarcinoma","volume":"63","year":"1996","journal-title":"J. Surg. Res."},{"key":"2021112218085556200_BCJ-2018-0103CC212","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3816\/clc.2001.n.018","article-title":"Phase I study of the BLP25 (MUC1 peptide) liposomal vaccine for active specific immunotherapy in stage IIIB\/IV non-small-cell lung cancer","volume":"3","year":"2001","journal-title":"Clin. Lung Cancer"},{"key":"2021112218085556200_BCJ-2018-0103CC213","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s00262-004-0581-1","article-title":"Phase I study of a MUC1 vaccine composed of different doses of MUC1 peptide with SB-AS2 adjuvant in resected and locally advanced pancreatic cancer","volume":"54","year":"2005","journal-title":"Cancer Immunol. Immunother."},{"key":"2021112218085556200_BCJ-2018-0103CC214","doi-asserted-by":"publisher","first-page":"6555","DOI":"10.4049\/jimmunol.166.11.6555","article-title":"Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection","volume":"166","year":"2001","journal-title":"J. Immunol."},{"key":"2021112218085556200_BCJ-2018-0103CC215","first-page":"3315","article-title":"Augmenting the immunogenicity of synthetic MUC1 peptide vaccines in mice","volume":"56","year":"1996","journal-title":"Cancer Res."},{"key":"2021112218085556200_BCJ-2018-0103CC216","doi-asserted-by":"publisher","first-page":"53r","DOI":"10.1093\/glycob\/cwh122","article-title":"History of lectins: from hemagglutinins to biological recognition molecules","volume":"14","year":"2004","journal-title":"Glycobiology"},{"key":"2021112218085556200_BCJ-2018-0103CC217","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1158\/1535-7163.Mct-17-0232","article-title":"A novel therapeutic strategy for pancreatic cancer: targeting cell surface glycan using rBC2LC-N lectin-drug conjugate (LDC)","volume":"17","year":"2018","journal-title":"Mol. Cancer Ther."}],"container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/477\/8\/1541\/872986\/bcj-2018-0103c.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/477\/8\/1541\/872986\/bcj-2018-0103c.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T13:14:35Z","timestamp":1696079675000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/477\/8\/1541\/222859\/O-glycan-recognition-and-function-in-mice-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,29]]},"references-count":217,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,4,30]]}},"URL":"https:\/\/doi.org\/10.1042\/bcj20180103","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,29]]}}}