{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:37:27Z","timestamp":1789760247090,"version":"4.0.1"},"reference-count":73,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,17]]},"abstract":"<jats:p>Posterior capsule opacification (PCO) is a complication after cataract surgery that can disrupt vision. The epithelial to mesenchymal transition (EMT) of lens epithelial cells (LECs) in response to transforming growth factor \u03b22 (TGF\u03b22) has been considered an obligatory mechanism for PCO. In this study, we tested the efficacy of aspirin in inhibiting the TGF\u03b22-mediated EMT of human LECs, LECs in human lens capsular bags, and lensectomized mice. In human LECs, the levels of the EMT markers \u03b1-smooth muscle actin (\u03b1-SMA) and fibronectin were drastically reduced by treatment with 2\u2005mM aspirin. Aspirin also halted the EMT response of TGF\u03b22 when introduced after EMT initiation. In human capsular bags, treatment with 2\u2005mM aspirin significantly suppressed posterior capsule wrinkling and the expression \u03b1-SMA in capsule-adherent LECs. The inhibition of TGF\u03b22-mediated EMT in human LECs was not dependent on Smad phosphorylation or MAPK and AKT-mediated signaling. We found that aspirin significantly increased the acetylation of K56 and K122 in histone H3 of human LECs. Chromatin immunoprecipitation assays using acetyl-H3K56 or acetyl-H3K122 antibody revealed that aspirin blocked the TGF\u03b22-induced acetylation of H3K56 and H3K122 at the promoter regions of ACTA2 and COL1A1. After lensectomy in mice, we observed an increase in the proliferation and \u03b1-SMA expression of the capsule-adherent LECs, which was ameliorated by aspirin administration through drinking water. Taken together, our results showed that aspirin inhibits TGF\u03b22-mediated EMT of LECs, possibly from epigenetic down-regulation of EMT-related genes.<\/jats:p>","DOI":"10.1042\/bcj20190540","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T13:14:17Z","timestamp":1578489257000},"page":"75-97","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Aspirin inhibits TGF\u03b22-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3"],"prefix":"10.1042","volume":"477","author":[{"given":"Mi-Hyun","family":"Nam","sequence":"first","affiliation":[{"name":"Sue Anschutz-Rodgers Eye Center and Department of Ophthalmology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.O.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of East Anglia, Norwich, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina B.","family":"Pantcheva","sequence":"additional","affiliation":[{"name":"Sue Anschutz-Rodgers Eye Center and Department of Ophthalmology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko Uoon","family":"Park","sequence":"additional","affiliation":[{"name":"Sue Anschutz-Rodgers Eye Center and Department of Ophthalmology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"IV","given":"Joseph A.","family":"Brzezinski","sequence":"additional","affiliation":[{"name":"Sue Anschutz-Rodgers Eye Center and Department of Ophthalmology, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Galligan","sequence":"additional","affiliation":[{"name":"Vanderbilt Institute of Chemical Biology, Vanderbilt University Medical Center, Nashville, TN 37232, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristofer","family":"Fritz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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