{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:52:19Z","timestamp":1784073139857,"version":"3.55.0"},"reference-count":22,"publisher":"Portland Press Ltd.","issue":"16","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,8,19]]},"abstract":"<jats:p>Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper-regulatory transcription factor Mac1 was reported to additionally be involved in the control of iron acquisition. However, in the current study, neither growth assays on solid and in liquid media, analysis of siderophore production nor expression analysis of genes involved in iron acquisition indicated the involvement of Mac1 in the regulation of iron uptake in A. fumigatus.<\/jats:p>","DOI":"10.1042\/bcj20200286","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T08:54:46Z","timestamp":1597827286000},"page":"2967-2970","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Absent regulation of iron acquisition by the copper regulator Mac1 in <i>A. fumigatus<\/i>"],"prefix":"10.1042","volume":"477","author":[{"given":"Annie","family":"Yap","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology, Medical University of Innsbruck, A6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Misslinger","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medical University of Innsbruck, A6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2472-9878","authenticated-orcid":false,"given":"Hubertus","family":"Haas","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology, Medical University of Innsbruck, A6020 Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"2022022315540894900_BCJ-2020-0286C1","doi-asserted-by":"publisher","first-page":"e00140-18","DOI":"10.1128\/CMR.00140-18","article-title":"Aspergillus fumigatus and Aspergillosis in 2019","volume":"33","year":"2019","journal-title":"Clin. Microbiol. Rev."},{"key":"2022022315540894900_BCJ-2020-0286C2","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1039\/C4NP00071D","article-title":"Fungal siderophore metabolism with a focus on Aspergillus fumigatus","volume":"10","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"2022022315540894900_BCJ-2020-0286C3","doi-asserted-by":"publisher","first-page":"1980","DOI":"10.3390\/ijms20081980","article-title":"Copper utilization, regulation, and acquisition by Aspergillus fumigatus","volume":"20","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2022022315540894900_BCJ-2020-0286C4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fmicb.2012.00028","article-title":"Iron - a key nexus in the virulence of Aspergillus fumigatus","volume":"3","year":"2012","journal-title":"Front. Microbiol."},{"key":"2022022315540894900_BCJ-2020-0286C5","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1128\/EC.00159-12","article-title":"Structural requirements for the activity of the MirB ferrisiderophore transporter of Aspergillus fumigatus","volume":"11","year":"2012","journal-title":"Eukaryot. Cell"},{"key":"2022022315540894900_BCJ-2020-0286C6","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1042\/BCJ20160066","article-title":"Identification of ferrichrome- and ferrioxamine B-mediated iron uptake by Aspergillus fumigatus","volume":"473","year":"2016","journal-title":"Biochem. J."},{"key":"2022022315540894900_BCJ-2020-0286C7","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.1093\/nar\/gkaa109","article-title":"The fungal CCAAT-binding complex and HapX display highly variable but evolutionary conserved synergetic promoter-specific DNA recognition","volume":"48","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2022022315540894900_BCJ-2020-0286C8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.fgb.2014.09.008","article-title":"Identification of high-affinity copper transporters in aspergillus fumigatus","volume":"73","year":"2014","journal-title":"Fungal Genet. Biol."},{"key":"2022022315540894900_BCJ-2020-0286C9","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.fgb.2017.08.003","article-title":"Cu-sensing transcription factor Mac1 coordinates with the Ctr transporter family to regulate Cu acquisition and virulence in Aspergillus fumigatus","volume":"107","year":"2017","journal-title":"Fungal Genet. Biol."},{"key":"2022022315540894900_BCJ-2020-0286C10","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1042\/BCJ20170191","article-title":"(474AD) Functional characterization of the copper transcription factor AfMac1 from Aspergillus fumigatus","volume":"474","journal-title":"Biochem. J."},{"key":"2022022315540894900_BCJ-2020-0286C11","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1007\/s00294-017-0681-z","article-title":"Transcription factor Afmac1 controls copper import machinery in Aspergillus fumigatus","volume":"63","year":"2017","journal-title":"Curr. Genet."},{"key":"2022022315540894900_BCJ-2020-0286C12","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.celrep.2017.04.019","article-title":"Aspergillus fumigatus copper export machinery and reactive oxygen intermediate defense counter host copper-mediated oxidative antimicrobial offense","volume":"19","year":"2017","journal-title":"Cell Rep."},{"key":"2022022315540894900_BCJ-2020-0286C13","doi-asserted-by":"publisher","first-page":"2831","DOI":"10.1042\/BCJ20180399","article-title":"A copper transcription factor, AfMac1, regulates both iron and copper homeostasis in the opportunistic fungal pathogen Aspergillus fumigatus","volume":"475","year":"2018","journal-title":"Biochem. J."},{"key":"2022022315540894900_BCJ-2020-0286C14","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0065-2660(08)60408-3","article-title":"The genetics of Aspergillus nidulans. I","volume":"5","year":"1953","journal-title":"Adv Genet."},{"key":"2022022315540894900_BCJ-2020-0286C15","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1039\/C8MT00263K","article-title":"Iron-sensing is governed by mitochondrial, not by cytosolic iron\u2013sulfur cluster biogenesis in Aspergillus fumigatus","volume":"10","year":"2018","journal-title":"Metallomics"},{"key":"2022022315540894900_BCJ-2020-0286C16","first-page":"e00785","article-title":"Fungal isocyanide synthases and xanthocillin biosynthesis in Aspergillus fumigatus","volume":"9","year":"2018","journal-title":"MBio"},{"key":"2022022315540894900_BCJ-2020-0286C17","doi-asserted-by":"publisher","first-page":"e1008379","DOI":"10.1371\/journal.pgen.1008379","article-title":"The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus","volume":"15","year":"2019","journal-title":"PLoS Genet."},{"key":"2022022315540894900_BCJ-2020-0286C18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pgen.1007762","article-title":"The Zn2Cys6-type transcription factor LeuB cross-links regulation of leucine biosynthesis and iron acquisition in Aspergillus fumigatus","volume":"14","year":"2018","journal-title":"PLoS Genet."},{"key":"2022022315540894900_BCJ-2020-0286C19","doi-asserted-by":"publisher","first-page":"e1002374","DOI":"10.1371\/journal.pgen.1002374","article-title":"SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus","volume":"7","year":"2011","journal-title":"PLoS Genet."},{"key":"2022022315540894900_BCJ-2020-0286C20","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/0092-8674(94)90346-8","article-title":"The FET3 gene of Saccharomyces cerevisiae encodes a multicopper oxidase required for ferrous iron uptake","volume":"76","year":"1994","journal-title":"Cell"},{"key":"2022022315540894900_BCJ-2020-0286C21","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/j.fgb.2011.07.009","article-title":"The metalloreductase FreB is involved in adaptation of Aspergillus fumigatus to iron starvation","volume":"7","year":"2011","journal-title":"Fungal Genet. Biol."},{"key":"2022022315540894900_BCJ-2020-0286C22","doi-asserted-by":"publisher","first-page":"6469","DOI":"10.1128\/JB.181.20.6469-6477.1999","article-title":"A developmentally regulated gene cluster involved in conidial biosynthesis in Aspergillus fumigatus","volume":"181","year":"1999","journal-title":"J Bacterol."}],"container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/477\/16\/2967\/929277\/bcj-2020-0286.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/477\/16\/2967\/929277\/bcj-2020-0286.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T15:54:50Z","timestamp":1645631690000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/477\/16\/2967\/226139\/Absent-regulation-of-iron-acquisition-by-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,19]]},"references-count":22,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2020,8,19]]}},"URL":"https:\/\/doi.org\/10.1042\/bcj20200286","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,19]]}}}