{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:14:19Z","timestamp":1783080859718,"version":"3.54.6"},"reference-count":60,"publisher":"Portland Press Ltd.","issue":"14","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7,31]]},"abstract":"<jats:p>The mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) are serine\/threonine protein kinases that are activated by the ERK1\/2 (extracellular regulated kinase) and p38\u03b1\/\u03b2 MAPK pathways. The MNKs have previously been implicated in metabolic disease and shown to mediate diet-induced obesity. In particular, knockout of MNK2 in mice protects from the weight gain induced by a high-fat diet. These and other data suggest that MNK2 regulates the expansion of adipose tissue (AT), a stable, long-term energy reserve that plays an important role in regulating whole-body energy homeostasis. Using the well-established mouse 3T3-L1 in vitro model of adipogenesis, the role of the MNKs in adipocyte differentiation and lipid storage was investigated. Inhibition of MNK activity using specific inhibitors failed to impair adipogenesis or lipid accumulation, suggesting that MNK activity is not required for adipocyte differentiation and does not regulate lipid storage. However, small-interfering RNA (siRNA) knock-down of MNK2 did reduce lipid accumulation and regulated the levels of two major lipogenic transcriptional regulators, ChREBP (carbohydrate response element-binding protein) and LPIN1 (Lipin-1). These factors are responsible for controlling the expression of genes for proteins involved in de novo lipogenesis and triglyceride synthesis. The knock-down of MNK2 also increased the expression of hormone-sensitive lipase which catalyses the breakdown of triglyceride. These findings identify MNK2 as a regulator of adipocyte metabolism, independently of its catalytic activity, and reveal some of the mechanisms by which MNK2 drives AT expansion. The development of an MNK2-targeted therapy may, therefore, be a useful intervention for reducing weight caused by excessive nutrient intake.<\/jats:p>","DOI":"10.1042\/bcj20200433","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T12:29:57Z","timestamp":1594384197000},"page":"2735-2754","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["MAPK-interacting kinase 2 (MNK2) regulates adipocyte metabolism independently of its catalytic activity"],"prefix":"10.1042","volume":"477","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4644-7022","authenticated-orcid":false,"given":"James E.","family":"Merrett","sequence":"first","affiliation":[{"name":"Lifelong Health, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia"},{"name":"Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0588-8016","authenticated-orcid":false,"given":"Jianling","family":"Xie","sequence":"additional","affiliation":[{"name":"Lifelong Health, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Psaltis","sequence":"additional","affiliation":[{"name":"Lifelong Health, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia"},{"name":"Adelaide Medical School, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0704-6442","authenticated-orcid":false,"given":"Christopher G.","family":"Proud","sequence":"additional","affiliation":[{"name":"Lifelong Health, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia"},{"name":"Department of Molecular and Biomedical Science, University of Adelaide, Adelaide, South Australia, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"2021112218110248400_BCJ-2020-0433C1","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1146\/annurev-biochem-052110-115718","article-title":"Adipogenesis: from stem cell to adipocyte","volume":"81","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"2021112218110248400_BCJ-2020-0433C2","doi-asserted-by":"crossref","first-page":"22243","DOI":"10.1016\/S0021-9258(18)41516-5","article-title":"Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue","volume":"268","year":"1993","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.diabet.2013.08.002","article-title":"Adipose tissue and adipocyte dysregulation","volume":"40","year":"2014","journal-title":"Diabetes Metab."},{"key":"2021112218110248400_BCJ-2020-0433C4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0092-8674(75)90087-2","article-title":"An established preadipose cell line and its differentiation in culture. II. factors affecting the adipose conversion","volume":"5","year":"1975","journal-title":"Cell"},{"key":"2021112218110248400_BCJ-2020-0433C5","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1146\/annurev.bi.64.070195.002021","article-title":"Transcriptional regulation of gene expression during adipocyte differentiation","volume":"64","year":"1995","journal-title":"Annu. Rev. Biochem."},{"key":"2021112218110248400_BCJ-2020-0433C6","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0092-8674(76)90260-9","article-title":"Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells","volume":"7","year":"1976","journal-title":"Cell"},{"key":"2021112218110248400_BCJ-2020-0433C7","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0092-8674(74)90116-0","article-title":"An established pre-adipose cell line and its differentiation in culture","volume":"3","year":"1974","journal-title":"Cell"},{"key":"2021112218110248400_BCJ-2020-0433C8","doi-asserted-by":"crossref","first-page":"4745","DOI":"10.1016\/S0021-9258(19)85559-X","article-title":"Induction of fatty acid synthetase synthesis in differentiating 3T3-L1 preadipocytes","volume":"255","year":"1980","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C9","doi-asserted-by":"crossref","first-page":"7256","DOI":"10.1016\/S0021-9258(17)34493-9","article-title":"Selective changes in microsomal enzymes of triacylglycerol phosphatidylcholine, and phosphatidylethanolamine biosynthesis during differentiation of 3T3-L1 preadipocytes","volume":"253","year":"1978","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C10","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev.biochem.77.061307.091829","article-title":"Fat and beyond: the diverse biology of PPARgamma","volume":"77","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"2021112218110248400_BCJ-2020-0433C11","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.1101\/gad.501108","article-title":"Genome-wide profiling of PPARgamma:RXR and RNA polymerase II occupancy reveals temporal activation of distinct metabolic pathways and changes in RXR dimer composition during adipogenesis","volume":"22","year":"2008","journal-title":"Genes Dev."},{"key":"2021112218110248400_BCJ-2020-0433C12","doi-asserted-by":"publisher","first-page":"23476","DOI":"10.1038\/srep23476","article-title":"MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways","volume":"6","year":"2016","journal-title":"Sci. Rep."},{"key":"2021112218110248400_BCJ-2020-0433C13","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2020.1796361","article-title":"Identification of DNA response elements regulating expression of CCAAT\/enhancer-binding protein (C\/EBP) \u03b2 and \u03b4 during early adipogenesis","year":"2020","journal-title":"bioRxiv"},{"key":"2021112218110248400_BCJ-2020-0433C14","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1093\/emboj\/16.8.1909","article-title":"Mitogen-activated kinases activate the serine\/threonine kinases Mnk1 and Mnk2","volume":"16","year":"1997","journal-title":"EMBO J."},{"key":"2021112218110248400_BCJ-2020-0433C15","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1093\/emboj\/16.8.1921","article-title":"Mnk1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates","volume":"16","year":"1997","journal-title":"EMBO J."},{"key":"2021112218110248400_BCJ-2020-0433C16","doi-asserted-by":"publisher","first-page":"5359","DOI":"10.2741\/3086","article-title":"The mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)","volume":"13","year":"2008","journal-title":"Front. Biosci."},{"key":"2021112218110248400_BCJ-2020-0433C17","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1128\/MCB.19.3.1871","article-title":"Phosphorylation of the cap-binding protein eukaryotic translation factor 4E by protein kinase Mnk1 in vivo","volume":"19","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"2021112218110248400_BCJ-2020-0433C18","doi-asserted-by":"publisher","first-page":"9373","DOI":"10.1074\/jbc.273.16.9373","article-title":"The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses and cytokines is mediated by distinct MAP kinase pathways","volume":"273","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C19","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1042\/BJ20090228","article-title":"The C-terminal domain of Mnk1a plays a dual role in tightly regulating its activity","volume":"423","year":"2009","journal-title":"Biochem. J."},{"key":"2021112218110248400_BCJ-2020-0433C20","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1128\/MCB.21.3.743-754.2001","article-title":"The MAP kinase signal-integrating kinase Mnk2 is an eIF4E kinase with high basal activity in mammalian cells","volume":"21","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"2021112218110248400_BCJ-2020-0433C21","doi-asserted-by":"publisher","first-page":"5692","DOI":"10.1128\/MCB.23.16.5692-5705.2003","article-title":"The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization","volume":"23","year":"2003","journal-title":"Mol. Cell. Biol."},{"key":"2021112218110248400_BCJ-2020-0433C22","doi-asserted-by":"publisher","first-page":"6539","DOI":"10.1128\/MCB.24.15.6539-6549.2004","article-title":"Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development","volume":"24","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"2021112218110248400_BCJ-2020-0433C23","doi-asserted-by":"publisher","first-page":"21684","DOI":"10.1074\/jbc.270.37.21684","article-title":"Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells","volume":"270","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C24","doi-asserted-by":"publisher","first-page":"3516","DOI":"10.1021\/acs.jmedchem.7b01795","article-title":"Structure-based design of pyridone-Aminal eFT508 targeting dysregulated translation by selective mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1\/2) inhibition","volume":"61","year":"2018","journal-title":"J. Med. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C25","doi-asserted-by":"publisher","first-page":"5083","DOI":"10.1093\/nar\/gku130","article-title":"Impairing the production of ribosomal RNA activates mammalian target of rapamycin complex\u20091 signalling and downstream translation factors","volume":"42","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2021112218110248400_BCJ-2020-0433C26","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03491-1","article-title":"Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"key":"2021112218110248400_BCJ-2020-0433C27","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s42255-018-0007-6","article-title":"Interaction between hormone-sensitive lipase and ChREBP in fat cells controls insulin sensitivity","volume":"1","year":"2019","journal-title":"Nat. Metab."},{"key":"2021112218110248400_BCJ-2020-0433C28","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1038\/83685","article-title":"Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin","volume":"27","year":"2001","journal-title":"Nat. Genet."},{"key":"2021112218110248400_BCJ-2020-0433C29","doi-asserted-by":"publisher","first-page":"29558","DOI":"10.1074\/jbc.M403506200","article-title":"Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro","volume":"279","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C30","doi-asserted-by":"publisher","first-page":"14628","DOI":"10.1074\/jbc.M110.117747","article-title":"Characterization of the human LPIN1-encoded phosphatidate phosphatase isoforms","volume":"285","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C31","doi-asserted-by":"publisher","first-page":"3450","DOI":"10.1074\/jbc.M610745200","article-title":"Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns","volume":"282","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C32","doi-asserted-by":"publisher","first-page":"32883","DOI":"10.1074\/jbc.M503885200","article-title":"Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis","volume":"280","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C33","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.1016\/j.bbalip.2017.06.010","article-title":"How lipid droplets \u201cTAG\u201d along: Glycerolipid synthetic enzymes and lipid storage","volume":"1862","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"2021112218110248400_BCJ-2020-0433C34","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.plipres.2012.06.001","article-title":"Acyl-CoA:diacylglycerol acyltransferase: molecular biology, biochemistry and biotechnology","volume":"51","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"2021112218110248400_BCJ-2020-0433C35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s12858-018-0103-y","article-title":"Identification of the major diacylglycerol acyltransferase mRNA in mouse adipocytes and macrophages","volume":"19","year":"2018","journal-title":"BMC Biochem."},{"key":"2021112218110248400_BCJ-2020-0433C36","doi-asserted-by":"publisher","first-page":"e4369","DOI":"10.1371\/journal.pone.0004369","article-title":"ACC2 is expressed at high levels in human white adipose and has an isoform with a novel N-terminus [corrected]","volume":"4","year":"2009","journal-title":"PLoS One"},{"key":"2021112218110248400_BCJ-2020-0433C37","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1073\/pnas.97.4.1444","article-title":"The subcellular localization of acetyl-CoA carboxylase 2","volume":"97","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112218110248400_BCJ-2020-0433C38","doi-asserted-by":"publisher","first-page":"10207","DOI":"10.1073\/pnas.1733877100","article-title":"Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat\/high-carbohydrate diets","volume":"100","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112218110248400_BCJ-2020-0433C39","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1146\/annurev-nutr-071813-105410","article-title":"The perilipins: Major cytosolic lipid droplet-Associated proteins and their roles in cellular lipid storage, mobilization, and systemic homeostasis","volume":"36","year":"2016","journal-title":"Annu. Rev. Nutr."},{"key":"2021112218110248400_BCJ-2020-0433C40","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/MCO.0000000000000536","article-title":"Lipoprotein lipase: new roles for an \u2018old\u2019 enzyme","volume":"22","year":"2019","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"2021112218110248400_BCJ-2020-0433C41","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/00075197-200203000-00004","article-title":"Role of CD36 in membrane transport of long-chain fatty acids","volume":"5","year":"2002","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"2021112218110248400_BCJ-2020-0433C42","doi-asserted-by":"publisher","first-page":"30413","DOI":"10.1074\/jbc.R300017200","article-title":"Glyceroneogenesis and the triglyceride\/fatty acid cycle","volume":"278","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C43","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1042\/bst0311125","article-title":"Fatty acid recycling in adipocytes: a role for glyceroneogenesis and phosphoenolpyruvate carboxykinase","volume":"31","year":"2003","journal-title":"Biochem. Soc. Trans."},{"key":"2021112218110248400_BCJ-2020-0433C44","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1016\/S0021-9258(18)99631-6","article-title":"Phosphoenolpyruvate carboxykinase and the synthesis of glyceride-glycerol from pyruvate in adipose tissue","volume":"242","year":"1967","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C45","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.tem.2008.09.002","article-title":"Adipogenesis and WNT signalling","volume":"20","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"2021112218110248400_BCJ-2020-0433C46","doi-asserted-by":"publisher","first-page":"e81","DOI":"10.1371\/journal.pgen.0020081","article-title":"Changes in gene expression foreshadow diet-induced obesity in genetically identical mice","volume":"2","year":"2006","journal-title":"PLoS Genet."},{"key":"2021112218110248400_BCJ-2020-0433C47","doi-asserted-by":"publisher","first-page":"609","DOI":"10.2337\/db08-1180","article-title":"Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt\/beta-catenin signaling network","volume":"58","year":"2009","journal-title":"Diabetes"},{"key":"2021112218110248400_BCJ-2020-0433C48","first-page":"E241","article-title":"Diet-induced up-regulation of gene expression in adipocytes without changes in DNA methylation","volume":"54","year":"2009","journal-title":"Kobe J. Med. Sci."},{"key":"2021112218110248400_BCJ-2020-0433C49","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1126\/science.1188280","article-title":"Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity","volume":"329","year":"2010","journal-title":"Science"},{"key":"2021112218110248400_BCJ-2020-0433C50","doi-asserted-by":"publisher","first-page":"4333","DOI":"10.1073\/pnas.95.8.4333","article-title":"ADD1\/SREBP1 activates PPARgamma through the production of endogenous ligand","volume":"95","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021112218110248400_BCJ-2020-0433C51","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1101\/gad.10.9.1096","article-title":"ADD1\/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism","volume":"10","year":"1996","journal-title":"Genes Dev."},{"key":"2021112218110248400_BCJ-2020-0433C52","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cmet.2017.07.004","article-title":"Sweet sixteenth for ChREBP: Established roles and future goals","volume":"26","year":"2017","journal-title":"Cell Metab."},{"key":"2021112218110248400_BCJ-2020-0433C53","doi-asserted-by":"publisher","first-page":"E424","DOI":"10.1152\/ajpendo.00568.2003","article-title":"Modulation of carbohydrate response element-binding protein gene expression in 3T3-L1 adipocytes and rat adipose tissue","volume":"287","year":"2004","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021112218110248400_BCJ-2020-0433C54","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.bbalip.2011.07.016","article-title":"ChREBP expression in the liver, adipose tissue and differentiated preadipocytes in human obesity","volume":"1811","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"2021112218110248400_BCJ-2020-0433C55","doi-asserted-by":"publisher","first-page":"4008","DOI":"10.1210\/EN.2015-1209","article-title":"The glucose sensor ChREBP links De novo lipogenesis to PPARgamma activity and adipocyte differentiation","volume":"156","year":"2015","journal-title":"Endocrinology"},{"key":"2021112218110248400_BCJ-2020-0433C56","doi-asserted-by":"publisher","first-page":"e0147411","DOI":"10.1371\/journal.pone.0147411","article-title":"ChREBP regulates itself and metabolic genes implicated in lipid accumulation in beta-Cell line","volume":"11","year":"2016","journal-title":"PLoS One"},{"key":"2021112218110248400_BCJ-2020-0433C57","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1210\/en.2014-1666","article-title":"Genome-Wide analysis of ChREBP binding sites on male mouse liver and white adipose chromatin","volume":"156","year":"2015","journal-title":"Endocrinology"},{"key":"2021112218110248400_BCJ-2020-0433C58","doi-asserted-by":"publisher","first-page":"24665","DOI":"10.1074\/jbc.273.38.24665","article-title":"Overexpression of perilipin A and B blocks the ability of tumor necrosis factor alpha to increase lipolysis in 3T3-L1 adipocytes","volume":"273","year":"1998","journal-title":"J. Biol. Chem."},{"key":"2021112218110248400_BCJ-2020-0433C59","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.cell.2011.06.034","article-title":"mTOR complex\u20091 regulates lipin 1 localization to control the SREBP pathway","volume":"146","year":"2011","journal-title":"Cell"},{"key":"2021112218110248400_BCJ-2020-0433C60","doi-asserted-by":"publisher","first-page":"4827","DOI":"10.1128\/MCB.22.13.4827-4835.2002","article-title":"Distinct cellular functions of MK2","volume":"22","year":"2002","journal-title":"Mol. Cell. Biol."}],"container-title":["Biochemical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/477\/14\/2735\/907261\/bcj-2020-0433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/biochemj\/article-pdf\/477\/14\/2735\/907261\/bcj-2020-0433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,23]],"date-time":"2021-11-23T02:31:00Z","timestamp":1637634660000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/biochemj\/article\/477\/14\/2735\/225760\/MAPK-interacting-kinase-2-MNK2-regulates-adipocyte"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":60,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2020,7,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bcj20200433","relation":{},"ISSN":["0264-6021","1470-8728"],"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]}}}