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Although the quality control of AOX proteins is expected to have a role in elevated respiration in mitochondria, it remains unclear whether thermogenic plants possess molecular mechanisms for the mitochondrial degradation of AOX. To better understand the mechanism of AOX turnover in mitochondria, we performed a series of in organello AOX degradation assays using mitochondria from various stages of the appendices of Arum maculatum. Our analyses clearly indicated that AOX proteins at certain stages in the appendices are degraded at 30\u00b0C, which is close to the maximum appendix temperature observed during thermogenesis. Interestingly, such temperature-dependent protease activities were specifically inhibited by E-64, a cysteine protease inhibitor. Moreover, purification and subsequent nano LC\u2013MS\/MS analyses of E-64-sensitive and DCG-04-labeled active mitochondrial protease revealed an \u223c30\u2005kDa protein with an identical partial peptide sequence to the cysteine protease 1-like protein from Phoenix dactylifera. Our data collectively suggest that AOX is a potential target for temperature-dependent E-64-sensitive cysteine protease in the appendices of A. maculatum. A possible retrograde signalling cascade mediated by specific degradation of AOX proteins and its physiological significance are discussed.<\/jats:p>","DOI":"10.1042\/bcj20200515","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T16:45:29Z","timestamp":1598892329000},"page":"3417-3431","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Degradation of mitochondrial alternative oxidase in the appendices of <i>Arum maculatum<\/i>"],"prefix":"10.1042","volume":"477","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1217-3462","authenticated-orcid":false,"given":"Kikukatsu","family":"Ito","sequence":"first","affiliation":[{"name":"Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan"},{"name":"Agri-Innovation Center, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan"},{"name":"United Graduate School of Agricultural Science, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Ogata","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanari","family":"Seito","sequence":"additional","affiliation":[{"name":"Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yui","family":"Umekawa","sequence":"additional","affiliation":[{"name":"United Graduate School of Agricultural Science, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kakizaki","sequence":"additional","affiliation":[{"name":"United Graduate School of Agricultural Science, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Osada","sequence":"additional","affiliation":[{"name":"Department of Electrical and Electronic Engineering, Faculty of Science and Engineering, Iwate University, 4-3-5 Ueda, Morioka, Iwate 020-8551, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony L.","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedicine, School of Life Sciences, University of Sussex, Brighton BN1 9QG, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"2021112218125620100_BCJ-2020-0515C1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/S0160-9327(97)80222-0","article-title":"Heat-producing flowers","volume":"21","year":"1997","journal-title":"Endeavour"},{"key":"2021112218125620100_BCJ-2020-0515C2","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/175089a0","article-title":"Cyanide-resistant mitochondria from the spadix of an Arum","volume":"175","year":"1955","journal-title":"Nature"},{"key":"2021112218125620100_BCJ-2020-0515C3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1146\/annurev.pp.26.060175.001001","article-title":"Thermogenic respiration in aroids","volume":"26","year":"1975","journal-title":"Ann. 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