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Over the years, chemical intervention for the up-regulation of the endogenous posttranslational modification (PTM) O-GlcNAc has been proposed as a potential strategy to slow down the progression of neurodegeneration. Through the development and application of tools that allow dissection of the mechanistic roles of this PTM, there is now a growing body of evidence that O-GlcNAc influences a variety of important neurodegeneration-pertinent mechanisms, with an overall protective effect. As a PTM that is appended onto numerous proteins that participate in protein quality control and homeostasis, metabolism, bioenergetics, neuronal communication, inflammation, and programmed death, O-GlcNAc has demonstrated beneficence in animal models of neurodegenerative diseases, and its up-regulation is now being pursued in multiple clinical studies.<\/jats:p>","DOI":"10.1042\/bcj20200609","type":"journal-article","created":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T14:40:18Z","timestamp":1627051218000},"page":"2733-2758","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Mechanistic roles for altered <i>O<\/i>-GlcNAcylation in neurodegenerative disorders"],"prefix":"10.1042","volume":"478","author":[{"given":"Aaron T.","family":"Balana","sequence":"first","affiliation":[{"name":"Departments of Chemistry, University of Southern California, Los Angeles, CA 90089, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-5615","authenticated-orcid":false,"given":"Matthew R.","family":"Pratt","sequence":"additional","affiliation":[{"name":"Departments of Chemistry, University of Southern California, Los Angeles, CA 90089, U.S.A."},{"name":"Biological Sciences, University of Southern California, Los Angeles, CA 90089, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"2021112218240707300_BCJ-2020-0609CC1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1582-4934.2010.01010.x","article-title":"Basic mechanisms of neurodegeneration: a critical update","volume":"14","year":"2010","journal-title":"J. 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