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Here, we focus on how cocaine impacts mitochondrial function, in particular through alterations in electron transport chain function, reactive oxygen species (ROS) production and oxidative stress (OS), mitochondrial dynamics and mitophagy. Finally, we describe the impact of cocaine on brain energy metabolism in the developing brain following prenatal exposure. The plethora of mitochondrial functions altered following cocaine exposure suggest that therapies maintaining mitochondrial functional integrity may hold promise in mitigating cocaine pathology and addiction.<\/jats:p>","DOI":"10.1042\/bcj20200615","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T17:35:54Z","timestamp":1614188154000},"page":"749-764","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The role of mitochondria in cocaine addiction"],"prefix":"10.1042","volume":"478","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7676-3272","authenticated-orcid":false,"given":"Claire","family":"Thornton","sequence":"first","affiliation":[{"name":"Department of Comparative Biomedical Sciences, Royal Veterinary College, London, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etty","family":"Grad","sequence":"additional","affiliation":[{"name":"Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Yaka","sequence":"additional","affiliation":[{"name":"Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"2021112218191358900_BCJ-2020-0615CC1","unstructured":"EMCDDA (2020) Wastewater analysis and drugs \u2014 a European multi-city study. 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