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Most tissues throughout the body are capable of BCAA oxidation, and the flux of oxidative BCAA disposal in each tissue is influenced by three key factors: 1. tissue-specific preference for BCAA oxidation relative to other fuels, 2. the overall oxidative activity of mitochondria within a tissue, and 3. total tissue mass. Perturbations in BCAA oxidation have been implicated in many disease contexts, underscoring the importance of BCAA homeostasis in overall health.<\/jats:p>","DOI":"10.1042\/bcj20200686","type":"journal-article","created":{"date-parts":[[2021,2,24]],"date-time":"2021-02-24T17:35:48Z","timestamp":1614188148000},"page":"765-776","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Whole-body metabolic fate of branched-chain amino acids"],"prefix":"10.1042","volume":"478","author":[{"given":"Megan C.","family":"Blair","sequence":"first","affiliation":[{"name":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Neinast","sequence":"additional","affiliation":[{"name":"Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1368-2453","authenticated-orcid":false,"given":"Zoltan","family":"Arany","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2021,2,24]]},"reference":[{"key":"2021112218191461100_BCJ-2020-0686CC1","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1093\/jn\/123.5.947","article-title":"Amino acid compositions of body and milk protein change during the suckling period in rats","volume":"123","year":"1993","journal-title":"J. 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