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In SKOV-3 cells, it was phosphorylated and was inhibited by Lapatinib and CP7274714. LASP-1 co-immunoprecipitated with ErbB2 in SKOV-3 cells, suggesting a direct interaction. This interaction and phosphorylation were independent of the kinase activity of ErbB2. Moreover, the binding of LASP-1 to ErbB2 was independent of the tyrosine phosphorylation of LASP-1. LASP-1 was neither expressed on the surface epithelium of the normal ovary nor in the fallopian tube. It was expressed in 28% of ovarian tumours (n\u2009=\u2009101) that did not significantly correlate with other clinical factors. In tumours from patients with invasive ductal carcinoma of the breast who had ErbB2 amplification (3+), LASP-1 was expressed in 3\/20 (P\u2009&amp;lt;\u20090.001). Analysis of the expression of an independent dataset of ovarian and breast tumours from TCGA showed the significant co-occurrence of ErbB2 and LASP-1 (P\u2009&amp;lt;\u20090.01). These results suggest that LASP-1 and ErbB2 interaction could be important in the pathogenesis of ovarian cancer.<\/jats:p>","DOI":"10.1042\/bcj20210173","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T10:37:16Z","timestamp":1639046236000},"page":"23-38","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["LASP-1 interacts with ErbB2 in ovarian cancer cells"],"prefix":"10.1042","volume":"479","author":[{"given":"Chirukandath","family":"Sidhanth","sequence":"first","affiliation":[{"name":"Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute(WIA), 38 Sardar Patel Road, Guindy, Chennai 600036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadhanandhan","family":"Bindhya","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute(WIA), 38 Sardar Patel Road, Guindy, Chennai 600036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aboo","family":"Shabna","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute(WIA), 38 Sardar Patel Road, Guindy, Chennai 600036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shyama","family":"Krishnapriya","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute(WIA), 38 Sardar Patel Road, Guindy, Chennai 600036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pacharla","family":"Manasa","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute(WIA), 38 Sardar Patel Road, Guindy, Chennai 600036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit Pravin","family":"Nagare","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute(WIA), 38 Sardar Patel Road, Guindy, Chennai 600036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanda","family":"Joshua","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute(WIA), 38 Sardar Patel Road, Guindy, Chennai 600036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smarkan","family":"Sneha","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute(WIA), 38 Sardar Patel Road, Guindy, Chennai 600036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanchan","family":"Murhekar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Cancer Institute (WIA), 38 Sardar Patel Road, Guindy, Chennai 600036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4671-8099","authenticated-orcid":false,"given":"Trivadi Sundaram","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Laboratory for Cancer Biology, Departments of Medical Oncology and Clinical Research, Cancer Institute(WIA), 38 Sardar Patel Road, Guindy, Chennai 600036, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"2022010613510586600_BCJ-2021-0173C1","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1002\/ijc.21109","article-title":"Geographic pathology revisited: development of an atlas of cancer in India","volume":"116","year":"2005","journal-title":"Int. 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